Abstract: Purifying target biomolecules, such as nucleic acids or proteins, from a biological source is a time intensive process and is typically performed by a skilled technician or scientist owing to the highly technical nature of the work. Systems, devices, and methods disclosed herein enable the automated bioprocessing and purification of target biomolecules from a biological source. For example, an instrument and disposable cartridge are provided for automatedly isolating and purifying nucleic acids (such as plasmid DNA from a bacterial culture) or for isolating protein from any biological sample. Such an exemplary instrument and cartridge can work in concert to timely release, mix, and move the target biomolecule and various reagents and buffers through a target biomolecule purification process, resulting in a purified target biomolecule with less manual oversight than traditional approaches.

Abstract: Electroporation is a technique in which an electrical field is applied to cells in order to increase the permeability of the cell membrane. This allows for chemicals, drugs, and/or macromolecules such as proteins and nucleic acids to be introduced into the cells. Embodiments relate to an electroporation apparatus. The electroporation apparatus comprises: a plurality of chambers configured to store a plurality of cells during an electroporation process; a plurality of electrodes configured to generate a plurality of electric fields within the plurality of chambers during the electroporation process, each electric field of the plurality of electric fields corresponding to one chamber of the plurality of chambers; a flow channel configured to transport the plurality cells during a cell collection process after the electroporation process; and a plurality of valves connecting the plurality of chambers to the flow channel.

Abstract: A calibration device comprising: a plurality of magnetic sensors positioned at the calibration device, the plurality of magnetic sensors defining a space; a controller configured to be positioned in the space defined by the plurality of magnetic sensors, wherein the controller includes a magnetic transmitter; and one or more processors configured to: cause the magnetic transmitter to generate magnetic fields; receive signals from the plurality of magnetic sensors that are based on characteristics of the magnetic fields received at the plurality of magnetic sensors; calculate, based on the signals received from the plurality of magnetic sensors, positions and orientations of the plurality of magnetic sensors relative to a position and orientation of the magnetic transmitter; and determine whether the calculated positions and orientations of the plurality of magnetic sensors are within one or more threshold limits of known positions and orientations of the plurality of magnetic sensors.

Abstract: A magnetic tracking system is configured to determine an object pose of a tracked object in an environment of the magnetic tracking system. The tracking system includes a transmitter assembly that includes a transmitting coil configured to generate a magnetic signal indicative of an object pose of a tracked object with respect to the transmitter assembly and a marker that visually identifies a pose of the transmitter assembly with respect to a camera device. The camera device captures at least one image of the transmitter assembly. A computing device determines, based on the image, a pose for the transmitter assemblies in the image. Based on the magnetic signal and the pose associated with the transmitter assembly, the computing device determines the object pose of the tracked object in the environment.

Abstract: A calibration system comprising: a Helmholtz device comprising thee pairs of coils defining an inner volume, wherein each of the three pairs of coils is configured to generate a magnetic field that is uniform throughout the inner volume; a mount configured to accept a device that includes a magnetic sensor, wherein at least a portion of the mount is positioned within the inner volume such that the magnetic sensor is positioned at or near a center of the inner volume when the device is positioned on the mount; and a computer system configured to communicate with the Helmholtz device and the magnetic sensor, wherein the computer system is configured to: provide instructions to cause each of the three pairs of coils to generate a magnetic field; receive signals from the magnetic sensor that are based on characteristics of the magnetic fields received at the magnetic sensor; measure, based on the signals received from the magnetic sensor, one or more characteristics of the magnetic sensor; and determine, using a

Abstract: A device for storing kinetic energy, which has a flywheel in a housing. The flywheel is mounted in the housing via a shaft. A motor-generator unit is provided for storing energy as well as for energy recovery. In order to improve efficiency, a vacuum pump for evacuating the interior is arranged in the housing. The vacuum pump is disposed on the shaft.

Abstract: A powder coating composition grindable at non-cryogenic temperatures includes: (a) a first polymer having a number average molecular weight (Mn) of more than 1,000 and a Tg of at least 40° C.; (b) a second polymer having a Tm of at least 100° C.; and optionally (c) a cross-linker. The first polymer and the second polymer are different from one another, and each of the first and second polymers have less than 25 wt % fluorine-containing monomeric units, with wt % based on the total weight of the monomeric units in each polymer. Upon grinding at a temperature above 4° C. the coating composition has an average particle size from 15 to 150 microns. Further coating compositions, methods of preparing coating compositions, coating systems, and substrates coated with a powder coating composition are also disclosed.

Abstract: Aspects of the technology described herein relate to techniques for guiding an operator to use an ultrasound device. Thereby, operators with little or no experience operating ultrasound devices may capture medically relevant ultrasound images and/or interpret the contents of the obtained ultrasound images. For example, some of the techniques disclosed herein may be used to identify a particular anatomical view of a subject to image with an ultrasound device, guide an operator of the ultrasound device to capture an ultrasound image of the subject that contains the particular anatomical view, and/or analyze the captured ultrasound image to identify medical information about the subject.

Abstract: Aspects of the technology described herein relate to prolonging battery life in an electronic device, such as ultrasound devices. A system may include an ultrasound device and a package. The ultrasound device may include magnetic sensing circuitry. The package may include a lid, and the lid may include a magnet. The magnetic sensing circuitry may control power received by communication circuitry in the ultrasound device based on detecting a magnet that is external to the ultrasound device. For example, the magnetic sensing circuitry may disable power rails in the power circuitry that provide power to communication circuitry when the magnetic sensing circuitry detects the magnet. When the magnetic sensing circuitry cannot detect the magnet, the power circuitry may enter a default state in which power rails provide power to the communication circuitry. The ultrasound device may include an indicator that enters a turn-on sequence when the lid is removed from the package.

Abstract: A calibration device comprising: a plurality of magnetic sensors positioned at the calibration device, the plurality of magnetic sensors defining a space; a controller configured to be positioned in the space defined by the plurality of magnetic sensors, wherein the controller includes a magnetic transmitter; and one or more processors configured to: cause the magnetic transmitter to generate magnetic fields; receive signals from the plurality of magnetic sensors that are based on characteristics of the magnetic fields received at the plurality of magnetic sensors; calculate, based on the signals received from the plurality of magnetic sensors, positions and orientations of the plurality of magnetic sensors relative to a position and orientation of the magnetic transmitter; and determine whether the calculated positions and orientations of the plurality of magnetic sensors are within one or more threshold limits of known positions and orientations of the plurality of magnetic sensors.

Abstract: Aspects of the technology described herein relate to techniques for guiding an operator to use an ultrasound device. Thereby, operators with little or no experience operating ultrasound devices may capture medically relevant ultrasound images and/or interpret the contents of the obtained ultrasound images. For example, some of the techniques disclosed herein may be used to identify a particular anatomical view of a subject to image with an ultrasound device, guide an operator of the ultrasound device to capture an ultrasound image of the subject that contains the particular anatomical view, and/or analyze the captured ultrasound image to identify medical information about the subject.

Abstract: A method includes receiving, at a magnetic sensor, a series of transmitter signals that are detected as a series of signals corresponding to different locations and/or orientations of a magnetic transmitter emitting a magnetic field, calculating, receiving, at the magnetic sensor, a measurement transmitter signal that is detected as a signal corresponding to a magnetic field provided by the magnetic transmitter, and calculating, based at least on the received measurement sensor signal and the calibration matrix, one or both of an orientation matrix indicative of an orientation of the magnetic sensor relative to the magnetic transmitter and a positional matrix indicative of a position of the magnetic sensor relative to the magnetic transmitter, wherein the series of transmitter signals are transmitted from the same physical location relative to the magnetic sensor.

Abstract: A system comprising: a sensor configured to be introduced into a clearance hole of a surgical implant, wherein the sensor is configured to be introduced in proximity to a generated magnetic field and cause distortion of the magnetic field; and one or more field measuring coils configured to: measure a characteristic of the magnetic field when the sensor is in proximity to the magnetic field; and provide, to a computing device, a signal representative of the measured characteristic of the magnetic field, wherein the computing device is configured to determine one or both of a position and an orientation of the sensor and the clearance hole based on the measured characteristic of the magnetic field.

Abstract: Aspects of the technology described herein relate to techniques for guiding an operator to use an ultrasound device. Thereby, operators with little or no experience operating ultrasound devices may capture medically relevant ultrasound images and/or interpret the contents of the obtained ultrasound images. For example, some of the techniques disclosed herein may be used to identify a particular anatomical view of a subject to image with an ultrasound device, guide an operator of the ultrasound device to capture an ultrasound image of the subject that contains the particular anatomical view, and/or analyze the captured ultrasound image to identify medical information about the subject.

Abstract: A method of processing a volumetric dataset for imaging includes receiving a volumetric dataset comprising data for imaging and determining an irradiance value at a given point in the volumetric dataset. In an embodiment, the method includes performing a selection process to select one or more of a plurality of irradiance data structures and storing the irradiance value in the or each selected irradiance data structure.

Abstract: The present disclosure is a handheld apparatus that vaporizes plant-based or synthetic compounds, for the purpose of inhalation, or diffusion into an external environment. More specifically, the disclosure describes a handheld apparatus wherein a laser beam from an internal laser unit heats compounds, such as dried plant, tinctures, resins, or essential oils, to the compound's vaporization temperature for inhalation, or diffusion as part of aromatherapy or other holistic therapeutic treatments.

Abstract: A method of reducing data transfer while increasing image information over an 802.15.4 network includes obtaining an image with a sensor, modulating a representation of the image using a first 802.15.4 modem, sending the representation of the image to a coordinator, demodulating the representation of the image using a second 802.15.4 modem, and digitally enhancing at least one of the representation of the image and the image. A system for communication over an 802.15.4 network includes a sensor for obtaining data, the size of the data being at least an order of magnitude greater than the size of an 802.15.4 packet, a first 802.15.4 modem coupled to the sensor, a buffer for temporarily storing the data to allow transmission of portions of the data; the buffer being coupled to the sensor, a coordinator coupled to the sensor, the coordinator being capable of communicating with a computer, and a second 802.15.4 modem coupled to the coordinator.

Abstract: Aspects of the technology described herein relate to techniques for guiding an operator to use an ultrasound device. Thereby, operators with little or no experience operating ultrasound devices may capture medically relevant ultrasound images and/or interpret the contents of the obtained ultrasound images. For example, some of the techniques disclosed herein may be used to identify a particular anatomical view of a subject to image with an ultrasound device, guide an operator of the ultrasound device to capture an ultrasound image of the subject that contains the particular anatomical view, and/or analyze the captured ultrasound image to identify medical information about the subject.

Abstract: A corrosion inhibitor can include (a) an inorganic alkali and/or alkaline earth metal compound and (b) an aldehyde and/or ketone component comprising at least one aromatic ring comprising a ketone and/or aldehyde group and at least one pendant group represented by —OR1. Each R1 is independently selected from hydrogen, an alkyl group, or an aryl group. The coating composition can be used in a multi-layer coating with additional coating layers. Methods of preparing coating compositions with corrosion inhibitors and substrates at least partially coating with such compositions are also included.

Abstract: The present disclosure is a handheld apparatus that vaporizes plant-based or synthetic compounds, for the purpose of inhalation, or diffusion into an external environment. More specifically, the disclosure describes a handheld apparatus wherein a laser beam from an internal laser unit heats compounds, such as dried plant, tinctures, resins, or essential oils, to the compound's vaporization temperature for inhalation, or diffused as part of aromatherapy or other holistic therapeutic treatments.