Patents by Inventor Robert Silverman

Robert Silverman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Deuterated derivatives of ruxolitinib
    Patent number: 9249149
    Abstract: The present invention in one embodiment provides a compound of Formula A: or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising the compound; and methods of treating the indications disclosed herein.
    Type: Grant
    Filed: May 8, 2015
    Date of Patent: February 2, 2016
    Assignee: Concert Pharmaceuticals, Inc.
    Inventors: I. Robert Silverman, Julie F. Liu, Adam J. Morgan, Bhaumik Pandya, Scott L. Harbeson
  • Derivatives of Pyrazole-Substituted Amino-Heteroaryl Compounds
    Publication number: 20150366853
    Abstract: This invention relates to novel pyrazole-substituted amino-heteroaryl compounds of Formula I: and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering an inhibitor of anaplastic lymphoma kinase (ALK).
    Type: Application
    Filed: August 31, 2015
    Publication date: December 24, 2015
    Applicant: CONCERT PHARMACEUTICALS, INC.
    Inventors: Bhaumik A. Pandya, Craig E. Masse, Ian Robert Silverman, Roger D. Tung
  • DEUTERATED MOMELOTINIB
    Publication number: 20150361051
    Abstract: The present invention in one embodiment provides a compound of Formula I, or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formula I are as defined in the specification.
    Type: Application
    Filed: January 8, 2014
    Publication date: December 17, 2015
    Inventor: Robert Silverman
  • MORPHINAN COMPOUNDS
    Publication number: 20150336899
    Abstract: This invention relates to novel morphinan compounds and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a ?1 receptor agonist that also has NMDA antagonist activity.
    Type: Application
    Filed: June 1, 2015
    Publication date: November 26, 2015
    Inventors: Philip B. Graham, I. Robert Silverman
  • Derivatives of pyrazole-substituted amino-heteroaryl compounds
    Patent number: 9145390
    Abstract: This invention relates to novel pyrazole-substituted amino-heteroaryl compounds of Formula I: and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering an inhibitor of anaplastic lymphoma kinase (ALK).
    Type: Grant
    Filed: September 3, 2013
    Date of Patent: September 29, 2015
    Assignee: Concert Pharmaceuticals, Inc.
    Inventors: Bhaumik Pandya, Craig E. Masse, Ian Robert Silverman, Roger Tung
  • Deuterated Derivatives of Ruxolitinib
    Publication number: 20150239896
    Abstract: The present invention in one embodiment provides a compound of Formula A: or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising the compound; and methods of treating the indications disclosed herein.
    Type: Application
    Filed: May 8, 2015
    Publication date: August 27, 2015
    Inventors: I. Robert Silverman, Julie F. Liu, Adam J. Morgan, Bhaumik Pandya, Scott L. Harbeson
  • DEUTERATED 4-HYDROXYBUTYRIC ACID ANALOGS
    Publication number: 20150210624
    Abstract: This invention relates to novel derivatives of 4-hydroxybutyric acid and prodrugs thereof, and pharmaceutically acceptable salts of the foregoing. This invention also provides pharmaceutical compositions comprising a compound of this invention and the use of such compositions in methods of treating narcolepsy, fibromyalgia, other disorders or conditions that are beneficially treated by improving nocturnal sleep or by administering sodium oxybate.
    Type: Application
    Filed: August 22, 2013
    Publication date: July 30, 2015
    Inventors: Roger D. Tung, I. Robert Silverman
  • DEUTERATED DERIVATIVES OF RUXOLITINIB
    Publication number: 20150197525
    Abstract: The present invention in one embodiment provides a compound of Formula A: or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising the compound; and methods of treating the indications disclosed herein.
    Type: Application
    Filed: December 15, 2014
    Publication date: July 16, 2015
    Inventors: I. Robert Silverman, Julie F. Liu, Adam J. Morgan, Bhaumik Pandya, Scott L. Harbeson
  • MORPHINAN COMPOUNDS
    Publication number: 20150073009
    Abstract: This invention relates to novel morphinan compounds and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a ?1 receptor agonist that also has NMDA antagonist activity.
    Type: Application
    Filed: November 18, 2014
    Publication date: March 12, 2015
    Applicant: CONCERT PHARMACEUTICALS, INC.
    Inventors: Philip B. Graham, I. Robert Silverman
  • Morphinan compounds
    Patent number: 8916582
    Abstract: This invention relates to novel morphinan compounds and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a ?1 receptor agonist that also has NMDA antagonist activity.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: December 23, 2014
    Assignee: Concert Pharmaceuticals, Inc.
    Inventors: Philip B. Graham, I. Robert Silverman
  • 4-HYDROXYBUTYRIC ACID ANALOGS
    Publication number: 20140343119
    Abstract: This invention relates to novel derivatives of 4-hydroxybutyric acid and prodrugs thereof, and pharmaceutically acceptable salts of the foregoing. This invention also provides pharmaceutical compositions comprising a compound of this invention and the use of such compositions in methods of treating narcolepsy, fibromyalgia, other disorders or conditions that are beneficially treated by improving nocturnal sleep or by administering sodium oxybate.
    Type: Application
    Filed: April 17, 2014
    Publication date: November 20, 2014
    Applicant: Concert Pharmaceuticals, Inc.
    Inventors: Roger D. Tung, Adam J. Morgan, I. Robert Silverman
  • SYNTHESIS OF DEUTERATED CATECHOLS AND BENZO[D][1,3]DIOXOLES AND DERIVATIVES THEREOF
    Publication number: 20140336387
    Abstract: The present invention provides a convenient and efficient process for the synthesis of d2-benzo[d][1,3]dioxoles.
    Type: Application
    Filed: July 24, 2014
    Publication date: November 13, 2014
    Applicant: CONCERT PHARMACEUTICALS, INC.
    Inventors: Andrew D. Jones, Robert E. Zelle, I. Robert Silverman
  • MORPHINAN COMPOUNDS
    Publication number: 20140315940
    Abstract: This invention relates to novel morphinan compounds and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a ?1 receptor agonist that also has NMDA antagonist activity.
    Type: Application
    Filed: March 13, 2014
    Publication date: October 23, 2014
    Applicant: Concert Pharmaceuticals, Inc.
    Inventors: Philip B. Graham, I. Robert Silverman
  • Synthesis of deuterated catechols and benzo[D][1,3]dioxoles and derivatives thereof
    Patent number: 8822498
    Abstract: The present invention provides a convenient and efficient process for the synthesis of d2-benzo[d][1,3]dioxoles.
    Type: Grant
    Filed: September 12, 2008
    Date of Patent: September 2, 2014
    Assignee: Concert Pharmaceuticals, Inc.
    Inventors: Andrew D. Jones, Robert E. Zelle, I. Robert Silverman
  • Morphinan compounds
    Patent number: 8710072
    Abstract: This invention relates to novel morphinan compounds and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a ?1 receptor agonist that also has NMDA antagonist activity.
    Type: Grant
    Filed: September 18, 2009
    Date of Patent: April 29, 2014
    Assignee: Concert Pharmaceuticals, Inc.
    Inventors: Philip B. Graham, I. Robert Silverman
  • DERIVATIVES OF PYRAZOLE-SUBSTITUTED AMINO-HETEROARYL COMPOUNDS
    Publication number: 20140005211
    Abstract: This invention relates to novel pyrazole-substituted amino-heteroaryl compounds of Formula I: and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering an inhibitor of anaplastic lymphoma kinase (ALK).
    Type: Application
    Filed: September 3, 2013
    Publication date: January 2, 2014
    Applicant: CONCERT PHARMACEUTICALS, INC.
    Inventors: Bhaumik Pandya, Craig E. Masse, Ian Robert Silverman, Roger Tung
  • 2-AMINO-NAPHTHYRIDINE DERIVATIVES
    Publication number: 20130338184
    Abstract: The invention in one embodiment is directed to a compound of Formula A: as defined herein, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: August 22, 2013
    Publication date: December 19, 2013
    Inventor: I. Robert Silverman
  • COMBINATION VIROTHERAPY FOR CANCER
    Publication number: 20130071432
    Abstract: One aspect of the present disclosure relates to a method for treating a subject with cancer. The method includes administering an oncolytic virus simultaneously, sequentially, or separately in combination with an immunomodulatory agent in an amount effective to suppress both antiviral immunity and angiogenesis associated with the cancer.
    Type: Application
    Filed: September 18, 2012
    Publication date: March 21, 2013
    Applicant: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Robert Silverman, Babal Kant Jha
  • 4-HYDROXYBUTYRIC ACID ANALOGS
    Publication number: 20130012565
    Abstract: This invention relates to novel derivatives of 4-hydroxybutyric acid and prodrugs thereof, and pharmaceutically acceptable salts of the foregoing. This invention also provides pharmaceutical compositions comprising a compound of this invention and the use of such compositions in methods of treating narcolepsy, fibromyalgia, other disorders or conditions that are beneficially treated by improving nocturnal sleep or by administering sodium oxybate.
    Type: Application
    Filed: February 14, 2012
    Publication date: January 10, 2013
    Applicant: Concert Pharmaceuticals Inc.
    Inventors: Roger D. Tung, Adam J. Morgan, I. Robert Silverman
  • MORPHINAN COMPOUNDS
    Publication number: 20120029007
    Abstract: This invention relates to novel morphinan compounds and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a ?1 receptor agonist that also has NMDA antagonist activity.
    Type: Application
    Filed: June 8, 2011
    Publication date: February 2, 2012
    Inventors: Philip B. Graham, I. Robert Silverman