Abstract: The present invention relates to methods of targeting RNA and is particularly useful for inhibiting infection by RNA viruses with complexes of an activator of RNase L and an oligonucleotide that is capable of binding to the genome, antigenome or mRNAs of a target RNA (e.g. a negative strand RNA virus) to specifically cleave the genomic or antigenomic RNA strand of the target RNA (e.g. the virus). The invention in one embodiment relates to a covalently linked complex of an oligonucleotide that is capable of binding to the genomic or antigenomic template RNA strand of a negative strand RNA virus and/or binding to an mRNA of a viral protein (an “antisense oligonucleotide”) coupled to an activator of RNase L. In a preferred embodiment of the present invention, the oligonucleotide component of the complex is complementary to a region of the viral genomic RNA strand characterized by repeated or consensus sequences.

Abstract: Methods and apparatus are disclosed for demonstrating that a public/private key pair is cryptographically strong without revealing information sufficient to compromise the private key. A key pair can be shown to be cryptographically strong by demonstrating that its modulus N is the product of two relatively large prime numbers. In addition, a key pair can be shown to be cryptographically strong by demonstrating that N is cryptographically strong against Pollard factoring attacks, Williams factoring attacks, Bach-Shallit factoring attacks, and weighted difference of squares factoring attacks.

Abstract: This invention relates to the use of urine ABP measurement in the diagnosis of serious systemic infection, and in the determination of increased chance of mortality.

Abstract: A method of using a chimeric molecule made up of an antisense oligonucleotide attached to a 2',5'-oligoadenylate molecule to specifically cleave a sense strand of RNA, wherein the antisense oligonucleotide of the chimeric molecule is hybridized to the sense strand of RNA in the presence of 2',5'-dependent RNase.

Abstract: A method of using a chimeric molecule made up of an antisense oligonucleotide attached to a 2',5'-oligoadenylate molecule to specifically cleave a sense strand of RNA, wherein the antisense oligonucleotide of the chimeric molecule is hybridized to the sense strand of RNA in the presence of 2',5'-dependent RNase.

Abstract: Photographic elements particularly adapted for forming direct-positive images are disclosed in which a radiation-sensitive core-shell emulsion layer and a silver halide emulsion layer incapable of forming a surface latent image within the direct-positive exposure latitude of the first emulsion layer and containing a grain population capable of internally trapping photolytically generated electrons are both present. The photographic elements are capable of exhibiting increased covering power, greater maximum density, and increased speed.

Abstract: Blended emulsions for use in forming a direct-positive image are disclosed. The emulsions are comprised of a first, radiation-sensitive core-shell grain population having a relatively low coefficient of variation and a second, substantially smaller size grain population capable of internally trapping photolytically generated electrons. Photographic elements incorporating the blended emulsions exhibit improved covering power and can exhibit enhanced speed.

Abstract: Photographic elements particularly adapted for forming direct-positive images are disclosed in which a radiation-sensitive core-shell emulsion layer and a silver halide emulsion layer incapable of forming a surface latent image within the direct-positive exposure latitude of the first emulsion layer and containing a grain population capable of internally trapping photolytically generated electrons are both present. The photographic elements are capable of exhibiting increased covering power, greater maximum density, and increased speed.

Abstract: Photographic elements are disclosed containing a hydrophilic colloid layer hardened with a compound having the structural formula:XCH.sub.2 CH.sub.2 SO.sub.2 Q(OQ).sub.m SO.sub.2 CH.sub.2 CH.sub.2 Xwherein X in each occurrence is halogen, Q is an aliphatic or phenyl substituted aliphatic divalent hydrocarbon radical having from 1 to 6 aliphatic carbon atoms and m is an integer of from 0 to 3 inclusive. The hardener also serves as an anti-foggant in photographic applications. Preferred are novel hardening and anti-fogging compounds having the structural formula: ##EQU1## in which X is halogen and R is hydrogen, phenyl or alkyl having from 1 to 6 carbon atoms.

Abstract: Photographic elements are disclosed containing a hydrophilic colloid layer hardened with a compound having two vinylsulfonyl radicals coupled through a divalent hydrocarbon radical chosen from the group consisting of (1) an aliphatic radical having from 1 to 6 carbon atoms, (2) --X--Y--X-- in which X is an alkylene group having 1 or 2 carbon atoms and Y is a phenylene group and (3) a phenyl-substituted methylene group. The compounds may be utilized generally in hardenable hydrophilic colloid compositions. Except for those compounds incorporating an alkylene divalent hydrocarbon radical, the hardeners are new compounds. .Iadd.

Abstract: Blended emulsions for use in forming a direct-positive image are disclosed. The emulsions are comprised of a first, radiation-sensitive core-shell grain population having a relatively low coefficient of variation and a second, substantially smaller size grain population capable of .Iadd.internally forming a latent image by .Iaddend.internally trapping photolytically generated electrons. Photographic elements incorporating the blended emulsions exhibit improved covering power and can exhibit enhanced speed.

Abstract: Photographic elements particularly adapted for forming direct-positive images are disclosed in which a radiation-sensitive core-shell emulsion layer and a silver halide emulsion layer incapable of forming a surface latent image within the direct-positive exposure latitude of the first emulsion layer and containing a grain population capable of internally .Iadd.forming a latent image by internally .Iaddend.trapping photolytically generated electrons are both present. The photographic elements are capable of exhibiting increased covering power, greater maximum density, and increased speed.

Abstract: Compounds for control of insects and arcarids are disclosed and exemplified which are N-(arylalkyl)-4-[bis(substituted aryl)hydroxymethyl]azabicyclo[3.3. 1 .]nonanes and [3.2.1.]octanes, including N-oxides thereof, N-(substituted-oxy) derivatives thereof, and agriculturally acceptable salts thereof, having the formula: ##STR1## Certain novel intermediates for these pesticidal compounds are also disclosed.