Patents by Inventor Robert Snow
Robert Snow has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20040086571Abstract: This invention discloses an orally administered pharmaceutical composition for the treatment of elevated levels of cholesterol and related conditions comprising a statin and fenofibrate in the form of microparticles of solid fenofibrate that are stabilized by phospholipid as a surface active substance, wherein a therapeutically effective amount of the composition provides the statin and a quantity of fenofibrate to a fasted human patient that is greater than 80% of the quantity of fenofibrate provided by the same amount of the composition when administered to the same patient who has been fed a high fat meal.Type: ApplicationFiled: March 17, 2003Publication date: May 6, 2004Applicant: SKYEPHARMA CANADA INC.Inventors: Pol-Henri Guivarc'h, Indu Parikh, Robert A. Snow
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Patent number: 6726919Abstract: A sterile, injectable homogenized dispersion of micromatrices or microdroplets having a mean diameter from about 50 nm to about 1000 nm comprising about 1% to about 7.5% of propofol, about 1% to about 8% of a propofol-soluble diluent, and about 0.67% to about 5% of a surface stabilizing amphiphilic agent suspended in an aqueous medium containing a synergetic quantity of antimicrobial agent and a tonicity modifying amount of a pharmaceutically acceptable water-soluble hydroxyl-group-containing excipient, wherein the ratio of propofol to diluent is in the range of about 0.25 to about 7.5 while the ratio of propofol to amphiphilic agent is in the range from about 0.4 to about 1.5, and wherein the viscosity of the dispersion is in the range of 1.1 to 8 cps, processes for the formation of the dispersion, and methods of use are disclosed.Type: GrantFiled: June 14, 2001Date of Patent: April 27, 2004Assignee: RTP Pharma, Inc.Inventors: Gary W. Pace, Michael G. Vachon, Awadesh K. Mishra, Robert A. Snow
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Publication number: 20040052576Abstract: The invention relates, in one embodiment, to a clamp assembly for attaching a hub structure to an axle. The clamp assembly includes a tubular structure having a longitudinal axis. The clamp assembly also includes a hub attachment mechanism and an axle clamping mechanism. The axle clamping mechanism includes an expansion slot and a clamping fastener. And the expansion slot includes a neutral position, a compression range, and an expansion range. When the clamping fastener is moved in a first lateral direction, the clamping fastener compresses the expansion slot to a position in the compression range. When the clamping fastener is moved in a second lateral direction by a first amount allows, the expansion slot is allowed to expand back to the neutral position. And, any movement thereafter expands expands the expansion slot to a position in the expansion range.Type: ApplicationFiled: September 18, 2002Publication date: March 18, 2004Inventor: Robert Snow
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Patent number: 6696084Abstract: The present invention relates to a novel spray drying process for the preparation of pharmaceutical compositions containing small particles of phospholipid-stabilized fenofibrate. This invention also relates to spray dried powdered compositions prepared according to this process, and to dosage forms of fenofibrate (capsules, tablets, powders, granules, and dispersions) prepared from these powdered compositions. The powdered compositions and dosage forms are useful in the treatment of dyslipidemia and dyslipoproteinemia and have the advantage that they provide reduced in vivo variability in the bioavailability of fenofibrate active species among fed and fasted patients when administered orally.Type: GrantFiled: April 20, 2001Date of Patent: February 24, 2004Assignee: RTP Pharma Inc.Inventors: Gary W. Pace, Awadesh K. Mishra, Robert A. Snow, Indu Parikh, Pol-Henri W. Guivarc'h
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Patent number: 6689043Abstract: Radioactive sources, preferably radioactive seeds, for use in brachytherapy comprising a radioisotope within a sealed biocompatible container, wherein at least one part of a surface of the container is roughened, shaped or otherwise treated so that it is no longer smooth. The surface treatment may enhance the ultrasound visibility of the source and/or reduce the tendency of the source to migrate once implanted in a patient's body. Preferred radioisotopes are palladium-103 and iodine-125.Type: GrantFiled: July 23, 2001Date of Patent: February 10, 2004Assignee: Amersham PLCInventors: Gregory McIntire, Robert Snow, Edward Bacon, Morten Eriksen, Auden Tornes, Geraldine Cooney, Christopher Black, Joel Cornacoff, Virginia Ann Gates
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Publication number: 20030209291Abstract: A method for the immobilisation of a radioactive anion on the surface of a metal substrate, said method comprising treating the substrate with an oxidising agent in the presence of a solution of a radioactive anion which forms an insoluble salt with ions of said metal. Preferably, a binding agent will also be present. Preferably, the metal is silver, the radioactive anion is 125I− and the binding agent comprises bromide ions.Type: ApplicationFiled: June 2, 2003Publication date: November 13, 2003Inventors: Robert Snow, Gregory Mclntire, Edward Bacon, Evan Gustow
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Patent number: 6634576Abstract: A process for milling a solid substrate in the milling chamber of a dispersion or media mill in the presence of a two or more compositions of milling media bodies is disclosed wherein all milling media bodies contribute to the grinding of the solid substrate and wherein at least one composition of media bodies provides fragments of milling media bodies that are retained with the milled solid substrate particles in the form of a synergetic commixture produced in the milling process.Type: GrantFiled: August 29, 2001Date of Patent: October 21, 2003Assignee: RTP Pharma Inc.Inventors: Frank Verhoff, Gary W. Pace, Robert A. Snow, Fay Millar
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Publication number: 20030194442Abstract: This invention discloses an orally administered pharmaceutical composition comprising microparticles of solid fenofibrate that are stabilized by a phospholipid surface active substance that is present during the preparation of the microparticles, wherein a therapeutically effective amount of the composition provides a quantity of fenofibrate active species to a fasted human patient in need of treatment by fenofibrate that is greater than 80% of the quantity of fenofibrate active species provided by the same amount of the composition when administered to the same patient who has been fed a high fat meal consisting of at least 1000 calories, 50% of which are from fat.Type: ApplicationFiled: May 19, 2003Publication date: October 16, 2003Applicant: SKYEPHARMA CANADA INCInventors: Pol-Henri Guivarch, Gary W. Pace, Robert A. Snow, Awadesh K. Mishra
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Patent number: 6632176Abstract: Radioactive sources, preferably radioactive seeds, for use in brachytherapy comprising a radioisotope within a sealed biocompatible container, wherein at least one part of a surface of the container is roughened, shaped or otherwise treated so that it is no longer smooth. The surface treatment may enhance the ultrasound visibility of the source and/or reduce the tendency of the source to migrate once implanted in a patient's body. Preferred radioisotopes are palladium-103 and iodine-125.Type: GrantFiled: May 17, 2001Date of Patent: October 14, 2003Assignee: Amersham PLCInventors: Gregory McIntire, Robert Snow, Edward Bacon, Morten Eriksen, Auden Tornes, Geraldine Cooney, Virginia Ann Gates, Joel Cornacoff, Christopher Black
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Patent number: 6604698Abstract: This invention describes a process for preparing a dispersion of solid particles of a milled substrate in a fluid carrier comprising the steps of (a) providing a plurality of large size milling media to the milling chamber of a media mill and forming a depth filter therefrom on an exit screen or separator in the milling chamber; (b) adding to said milling chamber a plurality of small size milling media optionally containing additional large size milling media, a conglomerate of a solid substance comprising a substrate to be milled and optionally one or more than one surface active substance, and a fluid carrier; (c) milling said conglomerate in said milling chamber to produce very small milled substrate product particles; and (d) separating said milled substrate particles suspended in said fluid carrier from the media through said depth filter; wherein the exit screen comprises openings of size S0; the large size media have a size distribution S1 of which all are larger than S0; the small size media have a siType: GrantFiled: May 10, 2001Date of Patent: August 12, 2003Assignee: SkyePharma Canada, Inc.Inventors: Frank H. Verhoff, Robert A. Snow, Gary W. Pace
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Patent number: 6596097Abstract: A method for the immobilization of a radioactive anion on the surface of a metal substrate, said method comprising treating the substrate with an oxidizing agent in the presence of a solution of a radioactive anion which forms an insoluble salt with ions of said metal. Preferably, a binding agent will also be present. Preferably, the metal is silver, the radioactive anion is 125I− and the binding agent comprises bromide ions.Type: GrantFiled: May 24, 2000Date of Patent: July 22, 2003Assignee: Amersham, PLCInventors: Robert Snow, Gregory McIntire, Edward Bacon, Evan Gustow
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Patent number: 6534088Abstract: This invention discloses an orally administered pharmaceutical composition for the treatment of elevated levels of cholesterol and related conditions comprising a statin and fenofibrate in the form of microparticles of solid fenofibrate that are stabilized by phospholipid as a surface active substance, wherein a therapeutically effective amount of the composition provides the statin and a quantity of fenofibrate to a fasted human patient that is greater than 80% of the quantity of fenofibrate provided by the same amount of the composition when administered to the same patient who has been fed a high fat meal.Type: GrantFiled: April 20, 2001Date of Patent: March 18, 2003Assignee: SkyePharma Canada Inc.Inventors: Pol-Henri W. Guivarc'h, Indu Parikh, Robert A. Snow
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Publication number: 20020161032Abstract: This invention discloses an orally administered pharmaceutical composition for the treatment of elevated levels of cholesterol and related conditions comprising a statin and fenofibrate in the form of microparticles of solid fenofibrate that are stabilized by phospholipid as a surface active substance, wherein a therapeutically effective amount of the composition provides the statin and a quantity of fenofibrate to a fasted human patient that is greater than 80% of the quantity of fenofibrate provided by the same amount of the composition when administered to the same patient who has been fed a high fat meal.Type: ApplicationFiled: April 20, 2001Publication date: October 31, 2002Inventors: Pol-Henri W. Guivarc'h, Indu Parikh, Robert A. Snow
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Patent number: 6465016Abstract: Pharmaceutical compositions containing solid cyclic oligopeptide cyclosporine microparticles are prepared by applying energy input to solid cyclic oligopeptide cyclosporine in the presence of phospholipid and one or more non-ionic, anionic or cationic second surface modifiers. The microparticles consist essentially of a solid cyclic oligopeptide cyclosporine core coated with a combination of phospholipid and at least one second surface modifier. The combination of phospholipid and second surface modifier(s) provide volume-weighted mean particle size values of solid cyclic oligopeptide cyclosporine particles that are about 50% smaller than cyclic oligopeptide cyclosporine particles produced in the presence of the phospholipid and without the presence of the second surface modifier(s) using the same energy input.Type: GrantFiled: December 29, 2000Date of Patent: October 15, 2002Assignee: Research Triangle PharmaceuticalsInventors: Indu Parikh, Robert A. Snow
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Publication number: 20020058065Abstract: This invention discloses an orally administered pharmaceutical composition comprising microparticles of solid fenofibrate that are stabilized by a phospholipid surface active substance that is present during the preparation of the microparticles, wherein a therapeutically effective amount of the composition provides a quantity of fenofibrate active species to a fasted human patient in need of treatment by fenofibrate that is greater than 80% of the quantity of fenofibrate active species provided by the same amount of the composition when administered to the same patient who has been fed a high fat meal consisting of at least 1000 calories, 50% of which are from fat.Type: ApplicationFiled: April 20, 2001Publication date: May 16, 2002Inventors: Pol-Henri Guivarc'h, Gary W. Pace, Robert A. Snow, Awadesh K. Mishra
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Publication number: 20020056206Abstract: The present invention relates to a novel spray drying process for the preparation of pharmaceutical compositions containing small particles of phospholipid-stabilized fenofibrate. This invention also relates to spray dried powdered compositions prepared according to this process, and to dosage forms of fenofibrate (capsules, tablets, powders, granules, and dispersions) prepared from these powdered compositions. The powdered compositions and dosage forms are useful in the treatment of dyslipidemia and dyslipoproteinemia and have the advantage that they provide reduced in vivo variability in the bioavailability of fenofibrate active species among fed and fasted patients when administered orally.Type: ApplicationFiled: April 20, 2001Publication date: May 16, 2002Inventors: Gary W. Pace, Awadesh K. Mishra, Robert A. Snow, Indu Parikh, Pol-Henri W. Guivarc'h
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Publication number: 20020047058Abstract: A process for milling a solid substrate in the milling chamber of a dispersion or media mill in the presence of a two or more compositions of milling media bodies is disclosed wherein all milling media bodies contribute to the grinding of the solid substrate and wherein at least one composition of media bodies provides fragments of milling media bodies that are retained with the milled solid substrate particles in the form of a synergetic commixture produced in the milling process.Type: ApplicationFiled: August 29, 2001Publication date: April 25, 2002Inventors: Frank Verhoff, Gary W. Pace, Robert A. Snow, Fay Millar
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Publication number: 20020022781Abstract: Radioactive sources, preferably radioactive seeds, for use in brachytherapy comprising a radioisotope within a sealed biocompatible container, wherein at least one part of a surface of the container is roughened, shaped or otherwise treated so that it is no longer smooth. The surface treatment may enhance the ultrasound visibility of the source and/or reduce the tendency of the source to migrate once implanted in a patient's body. Preferred radioisotopes are palladium-103 and iodine-125.Type: ApplicationFiled: May 17, 2001Publication date: February 21, 2002Inventors: Gregory Mclntire, Robert Snow, Edward Bacon, Morten Eriksen, Audon Tornes, Geraldine Cooney, Virginia Ann Gates, Joel Cornacoff, Christopher Black
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Publication number: 20020022667Abstract: A sterile, injectable homogenized dispersion of micromatrices or microdroplets having a mean diameter from about 50 nm to about 1000 nm comprising about 1% to about 7.5% of propofol, about 1% to about 8% of a propofol-soluble diluent, and about 0.67% to about 5% of a surface stabilizing amphiphilic agent suspended in an aqueous medium containing a synergetic quantity of antimicrobial agent and a tonicity modifying amount of a pharmaceutically acceptable water-soluble hydroxyl-group-containing excipient, wherein the ratio of propofol to diluent is in the range of about 0.25 to about 7.5 while the ratio of propofol to amphiphilic agent is in the range from about 0.4 to about 1.5, and wherein the viscosity of the dispersion is in the range of 1.1 to 8 cps, processes for the formation of the dispersion, and methods of use are disclosed.Type: ApplicationFiled: June 14, 2001Publication date: February 21, 2002Inventors: Gary W. Pace, Michael G. Vachon, Awadesh K. Mishra, Robert A. Snow
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Publication number: 20020013271Abstract: Pharmaceutical compositions containing solid cyclic oligopeptide cyclosporine microparticles are prepared by applying energy input to solid cyclic oligopeptide cyclosporine in the presence of phospholipid and one or more non-ionic, anionic or cationic second surface modifiers. The microparticles consist essentially of a solid cyclic oligopeptide cyclosporine core coated with a combination of phospholipid and at least one second surface modifier. The combination of phospholipid and second surface modifier(s) provide volume-weighted mean particle size values of solid cyclic oligopeptide cyclosporine particles that are about 50% smaller than cyclic oligopeptide cyclosporine particles produced in the presence of the phospholipid and without the presence of the second surface modifier(s) using the same energy input.Type: ApplicationFiled: December 29, 2000Publication date: January 31, 2002Inventors: Indu Parikh, Robert A. Snow