Abstract: Provided herein are IL-2 muteins, IL-2 mutein Fc-fusion molecules, anti-IL-2 antibodies, and complexes comprising an anti IL-2 antibody bound to an IL-2 cytokine that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgG1 Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also provided herein are linker peptides that are glycosylated when expressed in mammalian cells. Also provided herein are methods of making and using the compositions of the present invention.

Abstract: A system has a gas supply and at least one tank defining an interior. A first port is positioned within the interior of each tank of the at least one tank and is in selective fluid communication with the gas supply. A conduit extends between and provides fluid communication between the gas supply and the first port. A first valve is fluidly positioned between the gas supply and the first port. The first valve is configured to selectively permit fluid communication between the gas supply and the first port. A pressure sensor is in fluid communication with the conduit. The computing device is configured to: cause the first valve to open, receive a first signal from the pressure sensor indicative of pressure within the conduit, and determine a quantity of fluid in the tank based on the first signal from the pressure sensor.

Abstract: A vacuum therapy device for treatment of a defect internal of a human or animal body, the device comprising: a suction tube extending from: (i) a proximal portion for coupling to a source of negative pressure outside the body, to (ii) a distal portion for providing suction proximal to the defect when inserted into the body; a porous medium coupled to the distal portion of the suction tube to provide suction to the defect when inserted into the body for treatment thereof; and a constraining sleeve for selective compression of the porous medium, the constraining sleeve having a proximal end and a distal end, wherein the constraining sleeve is movable relative to the porous medium between: an insertion position in which the proximal and distal ends of the sleeve are arranged at the distal portion of the suction tube so that the sleeve at least partially surrounds the porous medium to retain the porous medium in a compressed state during insertion into the body; and a treatment position in which the porous medium

Abstract: Provided are modified arginine deiminase (ADI) proteins, including ADI proteins that comprise one or more substitutions which increase expression in bacteria as insoluble and refoldable inclusion bodies. Also provided are methods of producing the modified ADI proteins, compositions comprising the ADI proteins, and related methods of treating arginine-dependent and related diseases such as cancer.

Abstract: Disclosed are systems and methods for improving image recognition by using information from sensor data. In one embodiment, the method comprises receiving one or more sensor records, the sensor records representing timestamped sensor data collected by a sensor recording device; selecting an event based on the sensor records; identifying a time associated with the event; retrieving a plurality of timestamped video frames; synchronizing the sensor records and the video frames, wherein synchronizing the sensor records and the video frames comprises synchronizing the timestamped sensor data with individual frames of the timestamped video frames according to a common timeframe; and selecting a subset of video frames from the plurality of timestamped video frames based on the selected event.

Abstract: Disclosed are systems and methods for improving image recognition by using information from sensor data. In one embodiment, the method comprises receiving one or more sensor records, the sensor records representing timestamped sensor data collected by a sensor recording device; selecting an event based on the sensor records; identifying a time associated with the event; retrieving a plurality of timestamped video frames; synchronizing the sensor records and the video frames, wherein synchronizing the sensor records and the video frames comprises synchronizing the timestamped sensor data with individual frames of the timestamped video frames according to a common timeframe; and selecting a subset of video frames from the plurality of timestamped video frames based on the selected event.

Abstract: An optical device includes a unitary substrate of optically transparent material. The unitary substrate has formed therein at least one collection lens and channel, the channel for receiving an optical fibre and arranged to align the optical fibre inserted therein such that the collection lens couples light collected by the collection lens into the optical fibre.

Abstract: A telemetry method transmits data from a downhole location to a surface location. During transmission an event is detected that makes it desirable to change a transmitted data stream. A downhole processor processes the detected event in combination with a predefined event database and downhole measurement data using a frame building algorithm to compute a digital data stream. Synchronization markers are added to the data stream to obtain a synchronized data stream in which the synchronization markers identify the detected event. The synchronized data stream is transmitted to the surface location using a downhole telemetry tool and received at the surface location to obtain a decoded data stream. A surface processor processes the synchronization markers to identify the detected event and further processes the detected event in combination with a predefined event database and the decoded data stream using the frame building algorithm to obtain the downhole measurements.

Abstract: Disclosed are systems and methods for improving image recognition by using information from sensor data. In one embodiment, the method comprises receiving one or more sensor records, the sensor records representing timestamped sensor data collected by a sensor recording device; selecting an event based on the sensor records; identifying a time associated with the event; retrieving a plurality of timestamped video frames; synchronizing the sensor records and the video frames, wherein synchronizing the sensor records and the video frames comprises synchronizing the timestamped sensor data with individual frames of the timestamped video frames according to a common timeframe; and selecting a subset of video frames from the plurality of timestamped video frames based on the selected event.

Abstract: There is provided a computer implemented method of managing access in a collaborative data sharing platform, the platform comprising blockchain nodes. The method comprises receiving a read transaction request and processing the transaction request with a consensus algorithm. The transaction is then recorded onto the blockchain.

Abstract: There is provided a computer implemented method of managing access in a collaborative data sharing platform, the platform comprising blockchain nodes. The method comprises receiving a read transaction request and processing the transaction request with a consensus algorithm. The transaction is then recorded onto the blockchain.

Abstract: Disclosed are systems and methods for improving image recognition by using information from sensor data. In one embodiment, the method comprises receiving one or more sensor records, the sensor records representing timestamped sensor data collected by a sensor recording device; selecting an event based on the sensor records; identifying a time associated with the event; retrieving a plurality of timestamped video frames; synchronizing the sensor records and the video frames, wherein synchronizing the sensor records and the video frames comprises synchronizing the timestamped sensor data with individual frames of the timestamped video frames according to a common timeframe; and selecting a subset of video frames from the plurality of timestamped video frames based on the selected event.

Abstract: A telemetry method transmits data from a downhole location to a surface location. During transmission an event is detected that makes it desirable to change a transmitted data stream. A downhole processor processes the detected event in combination with a predefined event database and downhole measurement data using a frame building algorithm to compute a digital data stream. Synchronization markers are added to the data stream to obtain a synchronized data stream in which the synchronization markers identify the detected event. The synchronized data stream is transmitted to the surface location using a downhole telemetry tool and received at the surface location to obtain a decoded data stream. A surface processor processes the synchronization markers to identify the detected event and further processes the detected event in combination with a predefined event database and the decoded data stream using the frame building algorithm to obtain the downhole measurements.

Abstract: An optical device includes a unitary substrate of optically transparent material. The unitary substrate has formed therein at least one collection lens and channel, the channel for receiving an optical fibre and arranged to align the optical fibre inserted therein such that the collection lens couples light collected by the collection lens into the optical fibre.

Abstract: Embodiments relate to a medical simulator system configured to be powered and/or charged via induction technology. The medical simulator system includes a medical simulator having a simulator induction coil in connection with electrical circuitry and/or a power supply. The system also includes a charging station induction coil. The charging station may be stationary or mobile. When the simulator induction coil is placed proximate the charging station induction coil, or vice versa, inductive coupling causes a voltage to be generated in the simulator induction coil. This voltage is used to provide electrical power to the electrical circuitry and/or charge the power supply.

Abstract: Systems and methods to calibrate a gyroscope based on a motion of a predetermined characteristic. Data representing gyro sensor signals during a period of time is stored. A portion of the time period is identified, during which portion the gyroscope is subjected to a motion of the predetermined characteristic. Using the stored data the gyro signals are integrated with respect to time to calculate orientation of the gyroscope as a function of time. Deviation of a characteristic of the orientation of the gyroscope as the function of time during the portion of time period for the motion of the predetermined characteristic is determined to identify a component of bias in the gyro signals. The bias component is removed from the data to re-calculate the gyroscope orientation, and possible to further calculate the deviation in the re-calculated orientation and to identify a further bias component in the gyro signals.

Abstract: Embodiments of the present disclosure help identify athletic maneuvers performed by actors and/or their sports equipment using data from sensors, including data from at least one gyroscopic sensor. Among other things, various embodiments can help judges and spectators of extreme sports to identify and assess athletic maneuvers more easily and accurately compared to conventional methods.

Abstract: Disclosed are systems and methods for improving image recognition by using information from sensor data. In one embodiment, the method comprises receiving one or more sensor records, the sensor records representing timestamped sensor data collected by a sensor recording device; selecting an event based on the sensor records; identifying a time associated with the event; retrieving a plurality of timestamped video frames; synchronizing the sensor records and the video frames, wherein synchronizing the sensor records and the video frames comprises synchronizing the timestamped sensor data with individual frames of the timestamped video frames according to a common timeframe; and selecting a subset of video frames from the plurality of timestamped video frames based on the selected event.

Abstract: Disclosed are systems and methods for improving image recognition by using information from sensor data. In one embodiment, the method comprises receiving one or more sensor records, the sensor records representing timestamped sensor data collected by a sensor recording device; selecting an event based on the sensor records; identifying a time associated with the event; retrieving a plurality of timestamped video frames; synchronizing the sensor records and the video frames, wherein synchronizing the sensor records and the video frames comprises synchronizing the timestamped sensor data with individual frames of the timestamped video frames according to a common timeframe; and selecting a subset of video frames from the plurality of timestamped video frames based on the selected event.