Abstract: The present disclosure provides powerful technologies for the development, production, characterization, and/or use of stapled peptide compositions. Among other things, the present disclosure provides strategies for defining amino acid sequences particularly amenable or useful for stapling, as well as technologies, reagents, and systems for developing, producing, characterizing, and/or using stapled peptides having such amino acid sequences. In some embodiments, the present disclosure provides stapled peptide agents and uses thereof including for treating various conditions, disorders or diseases.

Abstract: A method for assisting an operator in operating a machine. The method includes receiving, by a controller, a selection of a task of a plurality of tasks, each task associated with a corresponding movement pattern of the machine; sensing, by a sensor unit, at least one condition of at least one component of the machine associated with the selected task; and determining, by the controller, whether the condition is within a predetermined set of parameters associated with the selected task. In response to determining that the condition is not within the predetermined set of parameters, the method further includes generating, by the controller, an audible or a haptic signal associated with at least one of the condition or the at least one component.

Abstract: The disclosure provides compounds useful for treating alpha-1 antitrypsin deficiency (AATD), according to formula (I): tautomers thereof, pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable salts of the tautomers, deuterated derivatives of the compounds, deuterated derivatives of the tautomers, and deuterated derivatives of the salts, solid forms of those compounds and processes for making those compounds.

Abstract: Provided herein are IL-2 muteins, IL-2 mutein Fc-fusion molecules, anti-IL-2 antibodies, and complexes comprising an anti IL-2 antibody bound to an IL-2 cytokine that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgG1 Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also provided herein are linker peptides that are glycosylated when expressed in mammalian cells. Also provided herein are methods of making and using the compositions of the present invention.

Abstract: A method of generating organic fertilizer material may include generating biologically produced sulfuric acid by passing an aqueous solution including sulfur over a material that may include sulfur oxidizing microorganisms. The operations may further include, recirculating the aqueous solution over the material until an amount of biologically produced sulfuric acid in the aqueous solution may reach a predefined threshold. The operations may further include extracting the biologically produced sulfuric acid from the aqueous solution. Further, the operations may include generating the organic fertilizer material using the extracted biologically produced sulfuric acid and an organic feedstock.

Abstract: Disclosed are systems and methods for improving image recognition by using information from sensor data. In one embodiment, the method comprises receiving one or more sensor records, the sensor records representing timestamped sensor data collected by a sensor recording device; selecting an event based on the sensor records; identifying a time associated with the event; retrieving a plurality of timestamped video frames; synchronizing the sensor records and the video frames, wherein synchronizing the sensor records and the video frames comprises synchronizing the timestamped sensor data with individual frames of the timestamped video frames according to a common timeframe; and selecting a subset of video frames from the plurality of timestamped video frames based on the selected event.

Abstract: Disclosed are systems and methods for improving image recognition by using information from sensor data. In one embodiment, the method comprises receiving one or more sensor records, the sensor records representing timestamped sensor data collected by a sensor recording device; selecting an event based on the sensor records; identifying a time associated with the event; retrieving a plurality of timestamped video frames; synchronizing the sensor records and the video frames, wherein synchronizing the sensor records and the video frames comprises synchronizing the timestamped sensor data with individual frames of the timestamped video frames according to a common timeframe; and selecting a subset of video frames from the plurality of timestamped video frames based on the selected event.

Abstract: An optical device includes a unitary substrate of optically transparent material. The unitary substrate has formed therein at least one collection lens and channel, the channel for receiving an optical fibre and arranged to align the optical fibre inserted therein such that the collection lens couples light collected by the collection lens into the optical fibre.

Abstract: A telemetry method transmits data from a downhole location to a surface location. During transmission an event is detected that makes it desirable to change a transmitted data stream. A downhole processor processes the detected event in combination with a predefined event database and downhole measurement data using a frame building algorithm to compute a digital data stream. Synchronization markers are added to the data stream to obtain a synchronized data stream in which the synchronization markers identify the detected event. The synchronized data stream is transmitted to the surface location using a downhole telemetry tool and received at the surface location to obtain a decoded data stream. A surface processor processes the synchronization markers to identify the detected event and further processes the detected event in combination with a predefined event database and the decoded data stream using the frame building algorithm to obtain the downhole measurements.

Abstract: Disclosed are systems and methods for improving image recognition by using information from sensor data. In one embodiment, the method comprises receiving one or more sensor records, the sensor records representing timestamped sensor data collected by a sensor recording device; selecting an event based on the sensor records; identifying a time associated with the event; retrieving a plurality of timestamped video frames; synchronizing the sensor records and the video frames, wherein synchronizing the sensor records and the video frames comprises synchronizing the timestamped sensor data with individual frames of the timestamped video frames according to a common timeframe; and selecting a subset of video frames from the plurality of timestamped video frames based on the selected event.

Abstract: There is provided a computer implemented method of managing access in a collaborative data sharing platform, the platform comprising blockchain nodes. The method comprises receiving a read transaction request and processing the transaction request with a consensus algorithm. The transaction is then recorded onto the blockchain.

Abstract: There is provided a computer implemented method of managing access in a collaborative data sharing platform, the platform comprising blockchain nodes. The method comprises receiving a read transaction request and processing the transaction request with a consensus algorithm. The transaction is then recorded onto the blockchain.

Abstract: Disclosed are systems and methods for improving image recognition by using information from sensor data. In one embodiment, the method comprises receiving one or more sensor records, the sensor records representing timestamped sensor data collected by a sensor recording device; selecting an event based on the sensor records; identifying a time associated with the event; retrieving a plurality of timestamped video frames; synchronizing the sensor records and the video frames, wherein synchronizing the sensor records and the video frames comprises synchronizing the timestamped sensor data with individual frames of the timestamped video frames according to a common timeframe; and selecting a subset of video frames from the plurality of timestamped video frames based on the selected event.

Abstract: A telemetry method transmits data from a downhole location to a surface location. During transmission an event is detected that makes it desirable to change a transmitted data stream. A downhole processor processes the detected event in combination with a predefined event database and downhole measurement data using a frame building algorithm to compute a digital data stream. Synchronization markers are added to the data stream to obtain a synchronized data stream in which the synchronization markers identify the detected event. The synchronized data stream is transmitted to the surface location using a downhole telemetry tool and received at the surface location to obtain a decoded data stream. A surface processor processes the synchronization markers to identify the detected event and further processes the detected event in combination with a predefined event database and the decoded data stream using the frame building algorithm to obtain the downhole measurements.

Abstract: An optical device includes a unitary substrate of optically transparent material. The unitary substrate has formed therein at least one collection lens and channel, the channel for receiving an optical fibre and arranged to align the optical fibre inserted therein such that the collection lens couples light collected by the collection lens into the optical fibre.

Abstract: Embodiments relate to a medical simulator system configured to be powered and/or charged via induction technology. The medical simulator system includes a medical simulator having a simulator induction coil in connection with electrical circuitry and/or a power supply. The system also includes a charging station induction coil. The charging station may be stationary or mobile. When the simulator induction coil is placed proximate the charging station induction coil, or vice versa, inductive coupling causes a voltage to be generated in the simulator induction coil. This voltage is used to provide electrical power to the electrical circuitry and/or charge the power supply.

Abstract: Systems and methods to calibrate a gyroscope based on a motion of a predetermined characteristic. Data representing gyro sensor signals during a period of time is stored. A portion of the time period is identified, during which portion the gyroscope is subjected to a motion of the predetermined characteristic. Using the stored data the gyro signals are integrated with respect to time to calculate orientation of the gyroscope as a function of time. Deviation of a characteristic of the orientation of the gyroscope as the function of time during the portion of time period for the motion of the predetermined characteristic is determined to identify a component of bias in the gyro signals. The bias component is removed from the data to re-calculate the gyroscope orientation, and possible to further calculate the deviation in the re-calculated orientation and to identify a further bias component in the gyro signals.

Abstract: Embodiments of the present disclosure help identify athletic maneuvers performed by actors and/or their sports equipment using data from sensors, including data from at least one gyroscopic sensor. Among other things, various embodiments can help judges and spectators of extreme sports to identify and assess athletic maneuvers more easily and accurately compared to conventional methods.

Abstract: Disclosed are systems and methods for improving image recognition by using information from sensor data. In one embodiment, the method comprises receiving one or more sensor records, the sensor records representing timestamped sensor data collected by a sensor recording device; selecting an event based on the sensor records; identifying a time associated with the event; retrieving a plurality of timestamped video frames; synchronizing the sensor records and the video frames, wherein synchronizing the sensor records and the video frames comprises synchronizing the timestamped sensor data with individual frames of the timestamped video frames according to a common timeframe; and selecting a subset of video frames from the plurality of timestamped video frames based on the selected event.