Abstract: The present invention relates to breast cancer and methods for identifying therapeutics and diagnosis. In general, methods for identifying therapeutic agents directed to calcium flow arc disclosed. Also provided arc methods for diagnosis of breast cancer and/or a predisposition to breast cancer and methods of treatment of breast cancer. The methods include identifying therapeutic agents which modulate a CRAC channel and/or a glycoprotein activator of a CRAC channel. Also provided arc diagnostic methods that ultilise a CRAC channel and/or a glycoprotein activator of a CRAC channel.

Abstract: A simulator is disclosed for training a responder to react in situations that have the potential for the use of force when encountering a main character, such as a person, whom a police officer might encounter during a routine stop and search. The simulator is equipped with natural language recognition and processing such that the main character reacts to voice commands from the trainee. In addition, feedback from the weapon and the weapon aimpoint alters the behavior of the main character. The dynamic scenario architecture is responsive to the language and weapon and interacts with the main character to affect the main character's behavior. The main character is equipped with a behavioral model to vary behavior in a given scenario.

Abstract: A delivery system for a medicament or well-being enhancing composition, comprising a flexible member, means for attaching the flexible member to fabric to form a pocket and an absorbent pad for impregnation with the medicament or well-being enhancing composition arranged such that when the flexible member is attached to a piece of fabric a pocket is formed shaped and sized such the pad may be received and held securely within the pocket but is removable therefrom. The fabric is typically part of a garment or bed-linen.

Abstract: An optical sensor assembly comprising a plurality of optical fibre sensor coils optically coupled by optical fibre; and an elongate support element, on which said plurality of optical fibre sensor coils and optically coupling optical fibre are mounted is disclosed. The support element has an elastic limit such that when said support element is bent from the elongate axis, the optical fibre fracture limit is reached before the elastic limit is reached. An array of these optical sensor assemblies, the mandrel on which the sensing coils are mounted and their method of manufacture are also disclosed.

Abstract: The present invention relates to a wave energy conversion device (1), for use in relatively shallow water, which has a base portion (2) for anchoring to the bed of a body of water (6) and an upstanding flap portion (8) pivotally connected (12) to the base portion. The flap portion is biased to the vertical and oscillates, backwards and forwards about the vertical in response to wave motion acting on its faces. Power extraction means extract energy from the movement of the flap portion. When the base portion (2) is anchored to the bed of a body of water (6) with the flap portion (8) facing the wave motion, the base portion (2) and the flap portion (8) extend vertically through at least the entire depth of the water, to present a substantially continuous surface to the wave motion throughout the full depth of water from the wave crest to the sea bed. A plurality of devices can be interconnected to form one system. The distance between the plurality of flaps is dependent on the wavelength.

Abstract: A method for designing a computational device or circuit having one or more desired characteristics, preferably input and/or output characteristics. The method involves using an inner, iterative search that is preferably used within one or more genetic operators. As a first step, one of a population of computational circuits or devices is selected. Once this is done a point in the selected circuit or device is chosen and characterised in terms of the circuit inputs and/or outputs. A parameter or characteristic associated with the selected point is then modified and the point is re-characterised. This is repeated to provide characterisations for a plurality of modified versions of the circuit. Then, the circuit that has characteristics closest to the desired characteristics is identified and added to the population of circuits, and the inner search loop is repeated for another one of the population.

Abstract: A safety-related control system (SRCS) designed to safeguard personnel operating hazardous production equipment. The SRCS integrates the safety-related part of a machine into one homogenous system for the purpose of increasing safety. In so doing, the SRCS monitors the machine, the operator, and itself for safe operation. The SRCS utilizes a non-material barrier to sense the intrusion of a person's body into a hazardous area of a machine. The SRCS uses machine feedback and/or operator interface to determine whether a hazardous condition is present. If such condition is present, the hazard is rendered harmless by the time the intruding body member can reach the potential danger area. The system includes separable means for stopping motion of the moving parts of the equipment, starting movement of the movable parts, and detecting faults in sections of the system.

Abstract: A DNA sequence encoding the CarR gene product or a homologue or variant thereof which, on expression in bacteria, is capable of activating gene expression, especially of a gene coding for a carbapenem antibiotic. A polypeptide coded for by such DNA.

Abstract: A photodetection system and related circuitry designed to sense the intrusion of an opaque object in a light plane. Upon sensing the intrusion, the system quickly initiates a machine-stopping sequence prior to the opaque object coming into contact with the machine while that machine is operating. The system comprises a SYSTEM microcontroller and a WATCHDOG microcontroller, both of which operate an output control device of the light curtain switch of the invention, wherein the output control device comprises a plurality of electromechanical relays. Both microcontrollers also perform system hardware and software integrity checks. Furthermore, the WATCHDOG microcontroller evaluates the performance of the SYSTEM microcontroller by transmitting a false intrusion signal to a photosource, determining whether the false signal has been detected, and then verifying that the SYSTEM microcontroller has initiated the machine-stopping sequence.

Abstract: A method and apparatus are disclosed for pneumatically controlling the velocity of flow of liquid metal from a tundish into a continuous casting machine through a nozzle. A chamber encloses the nozzle outlet, and at least a portion of the continuous casting machine, and a pressurized gas is supplied to the chamber. The flow velocity of the liquid metal at the nozzle outlet is controlled by controlling the gas pressure in the chamber in response to the level of the liquid metal in the tundish, and the measured atmospheric pressure acting on the liquid metal in the tundish.

Abstract: A method and apparatus are disclosed for pneumatically controlling the velocity of flow of liquid metal from a tundish into a continuous casting machine through a nozzle. A chamber encloses the nozzle outlet, and at least a portion of the continuous casting machine, and a pressurized gas is supplied to the chamber. The flow velocity of the liquid metal at the nozzle outlet is controlled by controlling the gas pressure in the chamber in response to the level of the liquid metal in the tundish, and the measured atmospheric pressure acting on the liquid metal in the tundish.

Abstract: A battery terminal connector having a molded metal body member forming a clamp portion for clamping to the terminal post of a storage battery and a base portion for connection to a primary battery cable and a non-molded metal support brace molded within the body member and having a plurality of electrical connector terminals projecting from the molded body member to provide auxiliary battery connections.

Abstract: A photodetection system and related circuitry designed to sense the intrusion of an opaque object in a light plane. Upon sensing the intrusion, the system quickly initiates a machine-stopping sequence prior to the opaque object coming into contact with the machine while that machine is operating. The system comprises a SYSTEM microcontroller and a WATCHDOG microcontroller, both of which operate an output control device of the light curtain switch of the invention, wherein the output control device comprises a plurality of electromechanical relays. Both microcontrollers also perform system hardware and software integrity checks. Furthermore, the WATCHDOG microcontroller evaluates the performance of the SYSTEM microcontroller by transmitting a false intrusion signal to a photosource, determining whether the false signal has been detected, and then verifying that the SYSTEM microcontroller has initiated the machine-stopping sequence.

Abstract: This invention relates to a method for administering drugs. In particular a lipophilic drug is solubilized by a food, such as chocolate, and admixed with an oil-based carrier. The lipid soluble drug is thus conveyed to the gastrointestinal tract. Because this type of food is digested readily, the drug is absorbed as intended, and the dose is not subject to day-to-day variations.

Abstract: Disclosed are a system and a method useful in fields such as architecture, space planning, interior design and corporate facility management, for efficiently designing and allocating space to the various subdivisions of an organization. Manipulation of colors is used in addition to numerical values to allow the user to determine at a glance the relative priorities of various departments and the affinities between pairs of departments at various stages of the space allocation process, and thereby speed the process and reduce the chance for errors.

Abstract: Elongated members of reactive metals and alloys thereof, for example, uranium and alloys thereof, are cast from a crucible containing the molten metal blanketed with an inert gas and non-reactive prepared molten slag, directly into a mould protruding from the crucible. The cast metal is spray cooled with inert gas, which may be liquefied, as it emerges from an outlet end of the mould and is pulled, for example by rollers, into and possibly through an inert gas flushed container directly connected to the mould outlet end.