Abstract: The present invention provides methods and compositions comprising a population of alphavirus replicon particles comprising two or more isolated nucleic acids selected from 1) an isolated nucleic acid encoding an env gene product or an immunogenic fragment thereof of a human immunodeficiency virus, 2) an isolated nucleic acid encoding a gag gene product or an immunogenic fragment thereof of a human immunodeficiency virus, wherein the gag gene product or immunogenic fragment thereof is modified to inhibit formation of virus-like particles containing the gag gene product or the immunogenic fragment thereof and their release from a cell, and 3) an isolated nucleic acid encoding a pol gene product or an immunogenic fragment thereof of a human immunodeficiency virus, wherein the pol gene product or immunogenic fragment thereof is modified to inhibit protease, integrase, RNase H and/or reverse transcriptase activity, and wherein the nucleic acids are each contained within a separate alphavirus replicon particle.

Abstract: Methods for producing fragments of a food product are disclosed. The method includes providing an amount of a formable food product, dividing a single input flow of the formable food product into multiple output streams, extruding the formable food product through an orifice to form strands and cutting the strands of formable food product into pieces. The method may be used be used to produce fragments of cheese that have an appearance similar to cheese that has been shredded. A method is also disclosed for applying the fragments of food product to a base food product, such as a sandwich or pizza.

Abstract: A controller for providing user input of a desired direction of motion or orientation for a transporter. The controller has an input for receiving specification by a user of a value based on a detected body orientation of the user. User-specified input may be conveyed by the user using any of a large variety of input modalities, including: ultrasonic body position sensing; foot force sensing; handlebar lean; active handlebar; mechanical sensing of body position; and linear slide directional input. An apparatus that may include an active handlebar is provided for prompting a rider to be positioned on a vehicle in such a manner as to reduce lateral instability due to lateral acceleration of the vehicle.

Abstract: This invention relates to a method for assessing risk of prostate cancer. Specifically, it relates to utilizing both Pro108 and Prostate Specific Antigen (PSA) in combination to determine the risk of prostate cancer. In addition, it is directed to a method for assessing risk of ovarian, colon, breast or stomach cancer utilizing Pro108 or specific antibodies to Pro108. The invention provides isolated anti-prostate, ovarian, colon, breast or stomach cancer antigen (Pro108) antibodies that bind to Pro108 on a mammalian cell in vivo. The invention also encompasses compositions comprising an anti-Pro108 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-Pro108 antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-Pro108 antibodies. The invention encompasses a method of producing the anti-Pro108 antibodies.

Abstract: A fitting for attaching ENT tubing to a concrete form has an inverted cup-like configuration with a bottom opening and an internal cavity within a fitting wall. A flange extends outwardly from the fitting wall around the bottom opening and has fastener-receiving holes for attaching the fitting to a plane surface of a concrete form. A socket extends through the fitting wall into the cavity for receiving an end portion of an ENT tube. The socket has a plurality of circumferentially-spaced resilient fingers that are inclined inwardly toward the socket axis for gripping an ENT tube. A pair of opposite fingers have teeth that are receivable in an annular groove in an end portion of a corrugated ENT tube. The teeth have rounded ends to facilitate ratcheting movement of the ENT tube end portion both into and out of the socket.

Abstract: The present invention provides amino substituted pyridinyl methanone compounds; pharmaceutical compositions comprising the compounds and methods of synthesis thereof. The compounds, which are cyclin dependent kinase (CDK) inhibitors, can be used to treat or ameliorate CDK mediated disorders. The invention thus also provides the therapeutic or prophylactic use of the compounds and/or pharmaceutical compositions to treat such disorders.

Abstract: Disclosed herein are methods for detecting a water leak in a locomotive engine cooling system comprising numerous components, each being a potential source of leakage of water. The method typically comprises performing at least one inspection providing an indication of a water leak from an engine cooling system of the locomotive. The step of performing at least one inspection may comprise at least one of several steps including performing a visual inspection to determine if water is leaking from a portion of the cooling system external to the engine; performing a visual inspection of exhaust of the engine to detect an indication of water vapor in the exhaust; performing a visual inspection to detect an indication of water leaking into an intake air manifold 30 of the engine; performing an engine oil analysis to detect water in the engine lubricant; reviewing a fault log history for the locomotive; and checking a level of a cooling system sight glass.

Abstract: A method of manufacturing an airbag assembly and a trim component for vehicle including the step of providing a first mold structure having a first surface formed therein, a second mold structure having a second surface formed therein and a third mold structure having a third surface formed therein. The first mold structure and the second mold structure are positioned to define a first cavity. A first material is introduced into the first cavity to form a substrate. The substrate and the third mold structure are positioned to define a second cavity. A second material is introduced into the second cavity to form at least one of a portion of an airbag assembly and an outer layer overmolded onto the substrate. Additionally, a scrim material may be disposed within the second cavity to produce a hinge having an embedded layer of scrim material.

Abstract: An apparatus compensates for voltage and temperature variations on an integrated circuit with: a voltage sensor having a digital voltage output; a temperature sensor having a digital temperature output; a register coupled to the voltage sensor and the temperature sensor, the register adapted to concatenate the digital voltage output and the temperature output into an address output; and a memory device having an address input coupled to the address output of the register, the memory device being adapted to store one or more corrective vectors.

Abstract: A method, apparatus, system, and signal-bearing medium that, in an embodiment, position inverting buffers to improve placement of a logic circuit. An inverting buffer, within a netlist, is moved from a source region to a sink region, where the source region and the sink region are connected via inverting and non-inverting routes. Moving the inverting buffer eliminates one of the routes from the source region to the sink region. In this way, routing congestion and total wire length may be reduced.

Abstract: The use of a treatment composition for a cigarette to reduce at least one constituent of mainstream smoke from a burning cigarette, the treatment composition comprising, in combination, an oxygen storage and donor metal oxide oxidation catalyst and an essentially non-combustible finely divided porous particulate adjunct.

Abstract: A quick release mounting means for a storage box in the bed of a pickup truck. The mounting means includes an aid in locating the necessary hole to be bored in the box for mounting; guides in the subsequent placement of the box; and allows a tool-less removal and replacement of the box, when necessary.

Abstract: The invention features integrated membrane assemblies for selectively transferring a constituent to or from a fluid. The assemblies include two or more flat sheet membrane elements and at least one common manifold connected to the interior regions of the membrane elements.

Abstract: A method and apparatus for use in a flow through assay process is disclosed. The method is characterised by a “pre-incubation step” in which the sample which is to be analysed, (typically for the presence of a particular protein), and a detection analyte (typically an antibody bound to colloidal gold or a fluorescent tag) which is known to bind to the particular protein may bind together for a desired period of time. This pre incubation step occurs before the mixture of sample and detection analyte come into contact with a capture analyte bound to a membrane. The provision of the pre-incubation step has the effect of both improving the sensitivity of the assay and reducing the volume of sample required for an assay. An apparatus for carrying out the method is disclosed defining a pre-incubation chamber for receiving the sample and detection analyte having a base defined by a membrane and a second membrane to which a capture analyte is bound.

Abstract: An apparatus is provided for thermally processing substrates held in a carrier. The apparatus includes an injection system which provides for selectable injection of gases to the process chamber. The injection system comprises one or more elongated injection tubes having a plurality of injection ports or orifices distributed in the tubes for directing flow of reactant and other gases across the surface of each substrate. The elongated injection tubes are rotatable about an axis in 360 degrees.

Abstract: The present invention relates to liquid coating compositions that absorb near infrared electromagnetic radiation. The coating compositions include a near infrared absorbing agent, a carrier vehicle, and a solvent system. The invention is also directed to a method of reducing the reflection of near infrared radiation from a surface in which a liquid coating composition comprising a near infrared absorbing agent, a carrier vehicle, and a solvent system is applied to the surface and the solvent system is removed, leaving a coating with a thickness of about 0.25 mils to 2 mils. The present invention further relates to a surface having a coating comprised of a near infrared absorbing compound and a carrier vehicle.

Abstract: Systems and methods for presenting a merged view of remotely installed applications to which a user has terminal server (TS) based access are described. In one aspect, a client computing device generates one or more shortcuts to one or more respective applications. Each of the applications is installed at one or more installation points in an Intranet. The client computing device is external to the Intranet. The one or more shortcuts are aggregated to present a merged view of the applications. The merged view is transparent of whether the applications are managed by different information sources on the Intranet and/or configured for remote TS-based execution by different ones of one or more installation points.

Abstract: A system facilitates the design and implementation of large-scale applications, such as Internet Services and Websites, for distributed computer systems, such as server data centers, Internet data centers (IDCs), Web farms, and the like. The system has a modeling system and a deployment system. The modeling system permits developers to architect the hardware and software used to implement the applications in an abstract manner. The modeling system defines a set of components used to describe the functionality of an application. The model components are arranged and interconnected to form a scale-independent logical model of the application. Once a logical model is created, the deployment system uses the logical model to automatically deploy various computer/software resources to implement the application. The deployment system converts each of the model components into one or more instances that correspond to physical resources.

Abstract: Third-party call control functionality from a user's application platform makes use of existing feature logic and feature interactions within the telephony switch controlling the telephonic device being proxied. A PC coupled to a web-based server and a phone are provided at the user end. An interface includes a server. At the switch end, there is signaling proxy equipment such as a CSTA Manager and a local signaling manager. A call processing core is made up of a Call Engine that may include a 3rd Party Make Call Control (3PCC) API. Call services are provided through the switch, which may include a CSTA service as well as other services.

Abstract: A method of generating a truncated scan test pattern for an integrated circuit design includes steps of: (a) receiving as input an integrated circuit design; (b) estimating a number of transition delay fault test patterns and a corresponding number of top-off stuck-at fault patterns to achieve maximum stuck-at fault and transition delay fault coverage; (c) truncating the estimated number of transition delay fault patterns to generate a truncated set of transition delay fault patterns so that the truncated set of transition delay fault patterns and the corresponding number of top-off stuck-at fault patterns achieve maximum stuck-at fault and transition delay fault coverage within a selected scan memory limit; and (d) generating as output the truncated set of transition delay fault patterns and the corresponding number of top-off stuck-at fault patterns.