Patents by Inventor Robert W. Dugger

Robert W. Dugger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Piperidine compounds useful as PPAR activators
    Patent number: 7199243
    Abstract: PPAR alpha activators, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases, in mammals, including humans.
    Type: Grant
    Filed: November 24, 2003
    Date of Patent: April 3, 2007
    Assignees: Pfizer Inc., Pfizer Products Inc.
    Inventors: Scott W. Bagley, Thomas A. Brandt, Robert W. Dugger, William A. Hada, Cheryl M. Hayward, Zhengyu Liu
  • Processes and intermediates useful in preparing ?3-adrenergic receptor agonists
    Patent number: 6919460
    Abstract: The present invention provides processes useful in the preparation of certain ?3-adrenergic receptor agonists of the structural formula the pharmaceutically acceptable salts thereof, and the hydrates of said pharmaceutically acceptable salts, wherein HET is as described herein. The invention further provides intermediates useful in the preparation of such agonists, and processes useful in the production of such intermediates.
    Type: Grant
    Filed: October 9, 2003
    Date of Patent: July 19, 2005
    Assignee: Pfizer Inc,
    Inventors: Robert J. Chambers, Robert W. Dugger, Ming Kang, Yong Tao, John W. Wong
  • PPAR activators
    Publication number: 20040157885
    Abstract: PPAR alpha activators, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases, in mammals, including humans.
    Type: Application
    Filed: November 24, 2003
    Publication date: August 12, 2004
    Applicant: Pfizer Inc
    Inventors: Scott W. Bagley, Thomas A. Brandt, Robert W. Dugger, William A. Hada, Cheryl M. Hayward, Zhengyu Liu
  • Processes and intermediates useful in preparing beta-3-adrenergic receptor agonists
    Publication number: 20040077871
    Abstract: The present invention provides processes useful in the preparation of certain &bgr;3-adrenergic receptor agonists of the structural formula 1
    Type: Application
    Filed: October 9, 2003
    Publication date: April 22, 2004
    Applicant: Pfizer Inc
    Inventors: Robert J. Chambers, Robert W. Dugger, Ming Kang, Yong Tao, John W. Wong
  • Methods for preparing CETP inhibitors
    Patent number: 6706881
    Abstract: This invention relates to methods for preparing certain cholesteryl ester transfer protein (CETP) inhibitors and intermediates useful in the preparation of said CETP inhibitors.
    Type: Grant
    Filed: April 18, 2003
    Date of Patent: March 16, 2004
    Assignee: Pfizer, Inc.
    Inventors: David B. Damon, Robert W. Dugger, Robert W. Scott
  • Processes and intermediates useful in preparing &bgr;3-adrenergic receptor agonists
    Patent number: 6689888
    Abstract: The present invention provides processes useful in the preparation of certain &bgr;3-adrenergic receptor agonists of the structural formula the pharmaceutically acceptable salts thereof, and the hydrates of said pharmaceutically acceptable salts, wherein HET is as described herein. The invention further provides intermediates useful in the preparation of such agonists, and processes useful in the production of such intermediates.
    Type: Grant
    Filed: February 20, 2003
    Date of Patent: February 10, 2004
    Assignee: Pfizer Inc.
    Inventors: Robert J. Chambers, Robert W. Dugger, Ming Kang, Yong Tao, John W. Wong
  • Intermediates of CETP inhibitors
    Patent number: 6689897
    Abstract: This invention relates to intermediates useful in the preparation of CETP inhibitors and methods of preparation thereof.
    Type: Grant
    Filed: April 30, 2002
    Date of Patent: February 10, 2004
    Assignee: Pfizer Inc.
    Inventors: David B. Damon, Robert W. Dugger, Robert W. Scott
  • Methods for preparing CETP inhibitors
    Publication number: 20030216576
    Abstract: This invention relates to methods for preparing certain cholesteryl ester transfer protein (CETP) inhibitors and intermediates useful in the preparation of said CETP inhibitors.
    Type: Application
    Filed: April 18, 2003
    Publication date: November 20, 2003
    Applicant: Pfizer Inc.
    Inventors: David B. Damon, Robert W. Dugger, Robert W. Scott
  • Processes and intermediates useful in preparing beta3-adrenergic receptor agonists
    Publication number: 20030199046
    Abstract: The present invention provides processes useful in the preparation of certain &bgr;3-adrenergic receptor agonists of the structural formula 1
    Type: Application
    Filed: February 20, 2003
    Publication date: October 23, 2003
    Inventors: Robert J. Chambers, Robert W. Dugger, Ming Kang, Yong Tao, John W. Wong
  • Methods for preparing CETP inhibitors
    Patent number: 6600045
    Abstract: This invention relates to methods for preparing certain cholesteryl ester transfer protein (CETP) inhibitors and intermediates useful in the preparation of said CETP inhibitors.
    Type: Grant
    Filed: April 30, 2002
    Date of Patent: July 29, 2003
    Assignee: Pfizer Inc.
    Inventors: David B. Damon, Robert W. Dugger, Robert W. Scott
  • Methods for preparing CETP inhibitors
    Publication number: 20030073843
    Abstract: This invention relates to methods for preparing certain cholesteryl ester transfer protein (CETP) inhibitors and intermediates useful in the preparation of said CETP inhibitors.
    Type: Application
    Filed: April 30, 2002
    Publication date: April 17, 2003
    Inventors: David B. Damon, Robert W. Dugger, Robert W. Scott
  • Intermediates of CETP inhibitors
    Publication number: 20020177716
    Abstract: This invention relates to intermediates useful in the preparation of CETP inhibitors and methods of preparation thereof.
    Type: Application
    Filed: April 30, 2002
    Publication date: November 28, 2002
    Inventors: David B. Damon, Robert W. Dugger, Robert W. Scott
  • Processes and intermediates for preparing substituted chromanol derivatives
    Patent number: 6444826
    Abstract: The invention relates to processes for preparing a compound of the formula and the enantiomer of said compound, wherein the benzoic acid moiety is attached at position 6 or 7 of the chroman ring, and R1, R2, and R3 are as defined herein. The invention further relates to intermediates that are useful in the preparation of the compound of formula X above.
    Type: Grant
    Filed: October 31, 2001
    Date of Patent: September 3, 2002
    Assignee: Pfizer Inc.
    Inventors: Anthony Piscopio, Joel M. Hawkins, Stephane Caron, Sarah E. Kelly, Jeffrey W. Raggon, Michael J. Castaldi, Robert W. Dugger, Sally G. Ruggeri
  • Processesand intermediatesfor preparing substitutedchromanol derivatives
    Publication number: 20020099227
    Abstract: The invention relates to processes for preparing a compound of the formula 1
    Type: Application
    Filed: October 31, 2001
    Publication date: July 25, 2002
    Inventors: Anthony Piscopio, Joel M. Hawkins, Stephane Caron, Sarah E. Kelly, Jeffrey W. Raggon, Michael J. Castaldi, Robert W. Dugger, Sally G. Ruggeri
  • Processesand intermediatesfor preparing substitutedchromanol derivatives
    Publication number: 20020042526
    Abstract: The invention relates to processes for preparing a compound of the formula 1
    Type: Application
    Filed: March 21, 2001
    Publication date: April 11, 2002
    Inventors: Anthony Piscopio, Joel M. Hawkins, Stephanie Caron, Sarah E. Kelly, Jeffrey W. Raggon, Michael J. Castaldi, Robert W. Dugger, Sally G. Ruggeri
  • Processes and intermediates for preparing substituted chromanol derivatives
    Patent number: 6355825
    Abstract: The invention relates to processes for preparing a compound of the formula and the enantiomer of said compound, wherein the benzoic acid moiety is attached at position 6 or 7 of the chroman ring, and R1, R2, and R3 are as defined herein. The invention further relates to intermediates that are useful in the preparation of the compound of formula X above.
    Type: Grant
    Filed: March 21, 2001
    Date of Patent: March 12, 2002
    Assignee: Pfizer Inc.
    Inventors: Anthony Piscopio, Joel M. Hawkins, Stephanie Caron, Sarah E. Kelly, Jeffrey W. Raggon, Michael J. Castaldi, Robert W. Dugger, Sally G. Ruggeri
  • Method for making 4-carboxyamino-2-substituted-1,2,3,4-tetrahydroquinoline
    Patent number: 6313142
    Abstract: Methods of preparing CETP inhibitors are disclosed.
    Type: Grant
    Filed: October 10, 2000
    Date of Patent: November 6, 2001
    Assignee: Pfizer Inc.
    Inventors: David B. Damon, Robert W. Dugger
  • Processes and intermediates for preparing substituted chromanol derivatives
    Patent number: 6288242
    Abstract: The invention relates to processes for preparing a compound of the formula and the enantiomer of said compound, wherein the benzoic acid moiety is attached at position 6 or 7 of the chroman ring, and R1, R2, and R3 are as defined herein. The invention further relates to intermediates that are useful in the preparation of the compound of formula X above.
    Type: Grant
    Filed: February 23, 2000
    Date of Patent: September 11, 2001
    Assignee: Pfizer Inc.
    Inventors: Anthony Piscopio, Joel M. Hawkins, Stephanie Caron, Sarah E. Kelly, Jeffrey W. Raggon, Michael J. Castaldi, Robert W. Dugger, Sally G. Ruggeri
  • Processes for preparing substituted chromanol derivatives
    Patent number: 6096906
    Abstract: The invention relates to processes for preparing a compound of the formula (X) and the enantiomer of said compound, wherein the benzoic acid moiety is attached at position 6 or 7 of the chroman ring, and R.sup.1, R.sup.2 and R.sup.3 are as defined herein. The invention further relates to intermediates that are useful in the preparation of the compound of formula (X).
    Type: Grant
    Filed: March 5, 1999
    Date of Patent: August 1, 2000
    Assignee: Pfizer Inc.
    Inventors: Anthony Piscopio, Joel M. Hawkins, Stephane Caron, Sarah E. Kelly, Jeffrey W. Raggon, Michael J. Castaldi, Robert W. Dugger, Sally G. Ruggeri
  • Resolution of (R)-2-benzylsuccinic acid 4-[4-(N-t-butoxycarbonylmethylamino)-piperidine] amide
    Patent number: 5420283
    Abstract: This invention relates to with a novel synthesis of (R)-2-benzylsuccinic acid 4-[4-(N-t-butoxycarbonyl-methylamino)-piperidine]amide from racemic intermediates. The racemic (R)-2-benzylsuccinic acid 4-[4-(N-t-butoxycarbonyl-methylamino)piperidine]amine is resolved through the formation of diasteromic salts with (S)-cyclohexylethylamine or (R)-cyclohexylethylamine. The pure diasteromic salt can be subsequently hydrolyzed with dilute acid to yield the pure enantiomer of (R)-2-benzylsuccinic acid 4-[4-(N-t-butoxycarbonyl-methylamino) piperidine]amide.
    Type: Grant
    Filed: August 2, 1993
    Date of Patent: May 30, 1995
    Assignee: Pfizer Inc.
    Inventor: Robert W. Dugger