Patents by Inventor Robert W. Hergenrother
Robert W. Hergenrother has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11246963Abstract: Disclosed herein is a delivery composition for administering a hydrophobic active agent. In one embodiment, a delivery composition for local administration of a hydrophobic active agent to a tissue or organ of a patient is disclosed. In one embodiment, the delivery composition includes a cationic delivery agent, a therapeutically effective amount of a hydrophobic active agent and a pharmaceutically acceptable aqueous carrier. In one embodiment, the cationic delivery agent includes polyethyleneimine (PEI). In an embodiment, the invention includes a drug delivery device including a substrate; and coated therapeutic agent particles disposed on the substrate, the coated therapeutic agent particles comprising a particulate hydrophobic therapeutic agent; and a vinyl amine polymer. Methods of making the delivery composition, as well as kits and methods of use are also included herein.Type: GrantFiled: May 16, 2014Date of Patent: February 15, 2022Assignee: Surmodics, Inc.Inventors: Joram Slager, Dale G. Swan, Darin DuMez, Joseph Ventura, Shannon Wadman, Joseph Schmidt McGonigle, Robert W. Hergenrother
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Patent number: 11174447Abstract: Embodiments herein include coated medical devices and coatings with salt groups. In an embodiment, a coated medical device is included, the coated medical device including a substrate and a polymeric layer disposed over the substrate. The polymeric layer includes a polymer and has an exterior surface. The coated medical device further includes a plurality of salt groups bonded to the polymer of the polymeric layer and disposed on the exterior surface of the polymeric layer. The salt groups can be the reaction product of a reactive group with an acid or base. In an embodiment, a method of making a medical device is included. Other embodiments are also included herein.Type: GrantFiled: July 8, 2019Date of Patent: November 16, 2021Assignee: Surmodics, Inc.Inventors: David E. Babcock, Joram Slager, Robert W. Hergenrother
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Publication number: 20210178129Abstract: The present invention is an implantable medical device comprising (i) a base coat layer having an inner and outer surface, the inner surface of the base coat layer contacting the implantable medical device; (ii) a top-coat layer of a hydrophilic polymer chemically crosslinked and covalently bonded to the outer surface of the base coat layer, the hydrophilic polymer comprising an anionic polyelectrolyte; and (iii) an amount of a hydrophilic cationic drug agent added to the top-coat layer sufficient to provide an effective dosage of the drug agent for delivery to a patient, whereby the hydrophilic cationic drug agent is initially adsorbed into the anionic polyelectrolyte of the top-coat layer and the hydrophilic cationic drug agent having a release rate after the medical device is implanted within a patient's body.Type: ApplicationFiled: December 10, 2020Publication date: June 17, 2021Inventors: William James Work, Raymond Joseph Gould, Dhruv Patel, Robert W Hergenrother
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Patent number: 10800931Abstract: The invention includes conductive polymeric coatings, medical device, coating solutions and methods of making the same. A coating solution for forming a conductive polymer layer can include a conductive monomer, at least one photoreactive component comprising an anionic photoreactive cross-linking agent or an anionic photoreactive hydrophilic polymer, and a solvent. A medical device can include an electrode and an electrically conductive coating disposed over the electrode. The electrically conductive coating can include a reaction product of the conductive monomer and the at least one photoreactive component. Other aspects are included herein.Type: GrantFiled: August 25, 2014Date of Patent: October 13, 2020Assignee: Heraeus Medical Components LLCInventors: Jeffrey L. Hendricks, Sarah M. Richardson-Burns, Kyle Mallires, Sarah A. Spanninga, Nathan A. Lockwood, Robert W. Hergenrother, Bruce M. Jelle
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Publication number: 20190330551Abstract: Embodiments herein include coated medical devices and coatings with salt groups. In an embodiment, a coated medical device is included, the coated medical device including a substrate and a polymeric layer disposed over the substrate. The polymeric layer includes a polymer and has an exterior surface. The coated medical device further includes a plurality of salt groups bonded to the polymer of the polymeric layer and disposed on the exterior surface of the polymeric layer. The salt groups can be the reaction product of a reactive group with an acid or base. In an embodiment, a method of making a medical device is included. Other embodiments are also included herein.Type: ApplicationFiled: July 8, 2019Publication date: October 31, 2019Inventors: David E. Babcock, Joram Slager, Robert W. Hergenrother
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Patent number: 10342898Abstract: Embodiments herein include coated medical devices and coatings with salt groups. In an embodiment, a coated medical device is included, the coated medical device including a substrate and a polymeric layer disposed over the substrate. The polymeric layer includes a polymer and has an exterior surface. The coated medical device further includes a plurality of salt groups bonded to the polymer of the polymeric layer and disposed on the exterior surface of the polymeric layer. The salt groups can be the reaction product of a reactive group with an acid or base. In an embodiment, a method of making a medical device is included. Other embodiments are also included herein.Type: GrantFiled: December 12, 2016Date of Patent: July 9, 2019Assignee: Surmodics, Inc.Inventors: David E. Babcock, Joram Slager, Robert W. Hergenrother
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Patent number: 10080688Abstract: Embodiments of the invention include wound packing devices and methods of making and using the same. In an embodiment, the invention includes a wound packing device including a plurality of spacing elements capable of absorbing exudate, wherein the surface of the spacing elements resist colonization by microorganisms. The wound packing device can also include a connector connecting the plurality of spacing elements to one another. Other embodiments are also included herein.Type: GrantFiled: August 6, 2015Date of Patent: September 25, 2018Assignee: SURMODICS, INC.Inventors: Shawn Fuller, Bryan A. Claseman, Joram Slager, Jeffrey J. Missling, Gary Maharaj, Gary W. Opperman, Nathan A. Lockwood, Robert W. Hergenrother, Charles Olson
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Patent number: 9999675Abstract: Disclosed herein is a delivery composition for administering a hydrophobic active agent. In one embodiment, a delivery composition for local administration of a hydrophobic active agent to a tissue or organ of a patient is disclosed. In one embodiment, the delivery composition includes a cationic delivery agent, a therapeutically effective amount of a hydrophobic active agent and a pharmaceutically acceptable aqueous carrier. In one embodiment, the cationic delivery agent includes polyethyleneimine (PEI). In a more specific embodiment, the cationic delivery agent includes branched PEI. Methods of making the delivery composition, as well as kits and methods of use are also disclosed.Type: GrantFiled: November 21, 2016Date of Patent: June 19, 2018Assignee: Surmodics, Inc.Inventors: Joseph Ventura, Shannon Wadman, Joram Slager, Joseph Schmidt McGonigle, Robert W. Hergenrother
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Publication number: 20170182224Abstract: Embodiments herein include coated medical devices and coatings with salt groups. In an embodiment, a coated medical device is included, the coated medical device including a substrate and a polymeric layer disposed over the substrate. The polymeric layer includes a polymer and has an exterior surface. The coated medical device further includes a plurality of salt groups bonded to the polymer of the polymeric layer and disposed on the exterior surface of the polymeric layer. The salt groups can be the reaction product of a reactive group with an acid or base. In an embodiment, a method of making a medical device is included. Other embodiments are also included herein.Type: ApplicationFiled: December 12, 2016Publication date: June 29, 2017Inventors: David E. Babcock, Joram Slager, Robert W. Hergenrother
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Publication number: 20170072057Abstract: Disclosed herein is a delivery composition for administering a hydrophobic active agent. In one embodiment, a delivery composition for local administration of a hydrophobic active agent to a tissue or organ of a patient is disclosed. In one embodiment, the delivery composition includes a cationic delivery agent, a therapeutically effective amount of a hydrophobic active agent and a pharmaceutically acceptable aqueous carrier. In one embodiment, the cationic delivery agent includes polyethyleneimine (PEI). In a more specific embodiment, the cationic delivery agent includes branched PEI. Methods of making the delivery composition, as well as kits and methods of use are also disclosed.Type: ApplicationFiled: November 21, 2016Publication date: March 16, 2017Inventors: Joseph Ventura, Shannon Wadman, Joram Slager, Joseph Schmidt McGonigle, Robert W. Hergenrother
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Patent number: 9555119Abstract: Disclosed herein is a delivery composition for administering a hydrophobic active agent. In one embodiment, a delivery composition for local administration of a hydrophobic active agent to a tissue or organ of a patient is disclosed. In one embodiment, the delivery composition includes a cationic delivery agent, a therapeutically effective amount of a hydrophobic active agent and a pharmaceutically acceptable aqueous carrier. In one embodiment, the cationic delivery agent includes polyethyleneimine (PEI). In a more specific embodiment, the cationic delivery agent includes branched PEI. Methods of making the delivery composition, as well as kits and methods of use are also disclosed.Type: GrantFiled: November 5, 2013Date of Patent: January 31, 2017Assignee: Surmodics, Inc.Inventors: Joseph Ventura, Shannon Wadman, Joram Slager, Joseph Schmidt McGonigle, Robert W. Hergenrother
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Publication number: 20160208114Abstract: The invention includes conductive polymeric coatings, medical device, coating solutions and methods of making the same. A coating solution for forming a conductive polymer layer can include a conductive monomer, at least one photoreactive component comprising an anionic photoreactive cross-linking agent or an anionic photoreactive hydrophilic polymer, and a solvent. A medical device can include an electrode and an electrically conductive coating disposed over the electrode. The electrically conductive coating can include a reaction product of the conductive monomer and the at least one photoreactive component. Other aspects are included herein.Type: ApplicationFiled: August 25, 2014Publication date: July 21, 2016Inventors: Jeffrey L. Hendricks, Sarah M. Richardson-Burns, Kyle Mallires, Sarah A. Spanninga, Nathan A. Lockwood, Robert W. Hergenrother, Bruce M. Jelle
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Publication number: 20160022502Abstract: Embodiments of the invention include wound packing devices and methods of making and using the same. In an embodiment, the invention includes a wound packing device including a plurality of spacing elements capable of absorbing exudate, wherein the surface of the spacing elements resist colonization by microorganisms. The wound packing device can also include a connector connecting the plurality of spacing elements to one another. Other embodiments are also included herein.Type: ApplicationFiled: August 6, 2015Publication date: January 28, 2016Inventors: Shawn Fuller, Bryan A. Claseman, Joram Slager, Jeffrey J. Missling, Gary Maharaj, Gary W. Opperman, Nathan A. Lockwood, Robert W. Hergenrother, Charles Olson
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Patent number: 9155671Abstract: Embodiments of the invention include wound packing devices and methods of making and using the same. In an embodiment, the invention includes a wound packing device including a plurality of spacing elements capable of absorbing exudate, wherein the surface of the spacing elements resist colonization by microorganisms. The wound packing device can also include a connector connecting the plurality of spacing elements to one another. Other embodiments are also included herein.Type: GrantFiled: October 16, 2013Date of Patent: October 13, 2015Assignee: SurModics, Inc.Inventors: Shawn Fuller, Bryan A. Claseman, Joram Slager, Jeffrey J. Missling, Gary Maharaj, Gary W. Opperman, Nathan Lockwood, Robert W. Hergenrother, Charles Olson
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Patent number: 8968782Abstract: The present invention relates to relates to combination degradable and non-degradable matrices and related methods. In an embodiment, the invention includes an active agent delivery matrix including a degradable polymer network, a non-degradable polymer network, the non-degradable polymer network interspersed within the degradable polymer network, and an active agent. In an embodiment, the invention includes an active agent elution control matrix including a degradable polymer; and a non-degradable polymer interspersed with the degradable polymer. In an embodiment, the invention includes a method of making an active agent delivery matrix including mixing a degradable polymer with a first solvent to form a degradable polymer solution; mixing a non-degradable polymer with a second solvent to form a non-degradable polymer solution; and simultaneously depositing the degradable polymer solution and the non-degradable polymer solution onto a substrate.Type: GrantFiled: June 28, 2007Date of Patent: March 3, 2015Assignee: SurModics, Inc.Inventors: Ralph A. Chappa, Robert W. Hergenrother, Paula Bushendorf, Joram Slager
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Publication number: 20140336571Abstract: Disclosed herein is a delivery composition for administering a hydrophobic active agent. In one embodiment, a delivery composition for local administration of a hydrophobic active agent to a tissue or organ of a patient is disclosed. In one embodiment, the delivery composition includes a cationic delivery agent, a therapeutically effective amount of a hydrophobic active agent and a pharmaceutically acceptable aqueous carrier. In one embodiment, the cationic delivery agent includes polyethyleneimine (PEI). In an embodiment, the invention includes a drug delivery device including a substrate; and coated therapeutic agent particles disposed on the substrate, the coated therapeutic agent particles comprising a particulate hydrophobic therapeutic agent; and a vinyl amine polymer. Methods of making the delivery composition, as well as kits and methods of use are also included herein.Type: ApplicationFiled: May 16, 2014Publication date: November 13, 2014Applicant: SurModics, Inc.Inventors: Joram Slager, Dale G. Swan, Darin DuMez, Joseph Ventura, Shannon Wadman, Joseph Schmidt McGonigle, Robert W. Hergenrother
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Publication number: 20140200411Abstract: Disclosed herein are activatable conductive compositions and methods of making and using activatable conductive compositions. In particular, activatable conductive monomers polymers are described and electrically conductive coatings that include activatable conductive polymers.Type: ApplicationFiled: January 10, 2014Publication date: July 17, 2014Applicant: SurModics, Inc.Inventors: Bruce M. Jelle, Aleksey V. Kurdyumov, Joseph Schmidt McGonigle, Robert W. Hergenrother, Nathan A. Lockwood, Joseph Ventura, Sean M. Stucke
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Publication number: 20140180229Abstract: Embodiments of the invention include wound packing devices and methods of making and using the same. In an embodiment, the invention includes a wound packing device including a plurality of spacing elements capable of absorbing exudate, wherein the surface of the spacing elements resist colonization by microorganisms. The wound packing device can also include a connector connecting the plurality of spacing elements to one another. Other embodiments are also included herein.Type: ApplicationFiled: October 16, 2013Publication date: June 26, 2014Inventors: Shawn Fuller, Bryan A. Claseman, Joram Slager, Jeffrey J. Missling, Gary Maharaj, Gary W. Opperman, Nathan Lockwood, Robert W. Hergenrother, Charles Olson
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Publication number: 20140142166Abstract: Disclosed herein is a delivery composition for administering a hydrophobic active agent. In one embodiment, a delivery composition for local administration of a hydrophobic active agent to a tissue or organ of a patient is disclosed. In one embodiment, the delivery composition includes a cationic delivery agent, a therapeutically effective amount of a hydrophobic active agent and a pharmaceutically acceptable aqueous carrier. In one embodiment, the cationic delivery agent includes polyethyleneimine (PEI). In a more specific embodiment, the cationic delivery agent includes branched PEI. Methods of making the delivery composition, as well as kits and methods of use are also disclosed.Type: ApplicationFiled: November 5, 2013Publication date: May 22, 2014Applicant: SurModics, Inc.Inventors: Joseph Ventura, Shannon Wadman, Joram Slager, Joseph Schmidt McGonigle, Robert W. Hergenrother
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Patent number: 8697106Abstract: A wound spacer device comprising multiple beads connected by non-absorbable suture material is disclosed. The device can be applied, for example, by a first responder to an injured individual, or can be applied by a trauma treatment facility, such as a Level 2 medical unit. In typical embodiments the device allows for site-specific controlled elution of an antimicrobial agent, such as Tobramycin, including defined elution over a period of time, such as 48 or 72 hours.Type: GrantFiled: September 23, 2011Date of Patent: April 15, 2014Assignee: SurModics, Inc.Inventors: Tim M. Kloke, Steven J. Keough, Nathan Lockwood, Margaret R. Gardner, Robert W. Hergenrother, Ralph A. Chappa