Patents by Inventor Robert W. Hergenrother
Robert W. Hergenrother has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8685421Abstract: A wound spacer device comprising multiple beads connected by non-absorbable suture material is disclosed. The device can be applied, for example, by a first responder to an injured individual, or can be applied by a trauma treatment facility, such as a Level 2 medical unit. In typical embodiments the device allows for site-specific controlled elution of an antimicrobial agent, such as Tobramycin, including defined elution over a period of time, such as 48 or 72 hours.Type: GrantFiled: July 6, 2007Date of Patent: April 1, 2014Assignee: SurModics, Inc.Inventors: Tim M. Kloke, Steven J. Keough, Nathan Lockwood, Margaret R. Gardner, Robert W. Hergenrother, Ralph A. Chappa
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Patent number: 8663673Abstract: The present invention relates to devices, articles, coatings, and methods for controlled active agent release and/or for providing a hemocompatible surface. More specifically, the present invention relates to copolymer compositions and devices, articles, and methods regarding the same for controlled active agent release. In an embodiment, the present invention includes a copolymer composition. The copolymer composition can include a copolymer and an active agent. In an embodiment, the copolymer includes an effective portion of a monomeric unit including a polar moiety. The active agent can be polar. The active agent can be charged. The active agent can be non-polar. In an embodiment, the copolymer composition includes a random copolymer. In an embodiment, the random copolymer includes butyl methacrylate-co-acrylamido-methyl-propane sulfonate copolymer, which can provide reduced platelet adhesion.Type: GrantFiled: July 26, 2006Date of Patent: March 4, 2014Assignee: Surmodics, Inc.Inventors: Timothy M. Kloke, Robert W. Hergenrother, Laurie R. Lawin
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Patent number: 8496954Abstract: Described are coating systems for the controlled delivery of hydrophilic bioactive agents, for example, from implantable medical devices. The coating systems of the invention comprise (a) a polymeric basecoat layer containing one or more hydrophilic bioactive agents; and (b) an elution-controlling topcoat layer that comprises a poly(ethylene-co-vinyl acetate) copolymer. The elution rate of the hydrophilic bioactive agent can be controlled by varying the vinyl acetate concentration in the elution-controlling topcoat layer.Type: GrantFiled: April 17, 2009Date of Patent: July 30, 2013Assignee: Surmodics, Inc.Inventors: Ralph A. Chappa, Robert W. Hergenrother, Shannon A. Wadman, Klaus R. Wormuth
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Publication number: 20120148852Abstract: The present invention relates to coating systems and coating systems on substrates. In an embodiment, the invention includes an article including a substrate, a base layer disposed on the substrate, the base layer comprising a silane compound with a photoreactive group, or the reaction product of a silane compound with a photoreactive group, and a polymer layer disposed on the base layer, the polymer layer comprising a polymer terminally anchored to the base layer. In an embodiment, the invention includes a coating for an article. In an embodiment, the invention includes a method of depositing a coating onto a substrate.Type: ApplicationFiled: February 15, 2012Publication date: June 14, 2012Applicant: SURMODICS, INC.Inventors: Bruce M. Jelle, Sara Macklin, Robert W. Hergenrother
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Publication number: 20120021038Abstract: A wound spacer device comprising multiple beads connected by non-absorbable suture material is disclosed. The device can be applied, for example, by a first responder to an injured individual, or can be applied by a trauma treatment facility, such as a Level 2 medical unit. In typical embodiments the device allows for site-specific controlled elution of an antimicrobial agent, such as Tobramycin, including defined elution over a period of time, such as 48 or 72 hours.Type: ApplicationFiled: September 23, 2011Publication date: January 26, 2012Applicant: Surmodics, Inc.Inventors: Tim M. Kloke, Steven J. Keough, Nathan Lockwood, Margaret R. Gardner, Robert W. Hergenrother, Ralph A. Chappa
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Publication number: 20110144373Abstract: Described herein is a degradable linking agent that includes a core molecule with one or more charged groups; and one or more photoreactive groups covalently attached to the core molecule by one or more degradable linkers.Type: ApplicationFiled: December 10, 2010Publication date: June 16, 2011Applicant: SurModics, Inc.Inventors: Dale G. Swan, Emily Rose Rolfes Meyering, Aleksey V. Kurdyumov, Peter H. Duquette, Robert W. Hergenrother, Toni M. Heyer
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Publication number: 20110054417Abstract: A coating composition in the form of a one or multi-part system, and method of applying such a composition under conditions of controlled humidity, for use in coating device surfaces to control and/or improve their ability to release bioactive agents in aqueous systems. The coating composition is particularly adapted for use with medical devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a first polymer component such as polyalkyl(meth)acrylate, polyaryl(meth)acrylate, polyaralkyl(meth)acrylate, or polyaryloxyalkyl(meth)acrylate and a second polymer component such as poly(ethylene-co-vinyl acetate).Type: ApplicationFiled: November 8, 2010Publication date: March 3, 2011Applicant: SurModics, Inc.Inventors: Ralph A. Chappa, Robert W. Hergenrother, Aron B. Anderson, Linh V. Tran, Laurie R. Lawin, Ronald F. Ofstead
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Patent number: 7833548Abstract: A coating composition in the form of a one or multi-part system, and method of applying such a composition under conditions of controlled humidity, for use in coating device surfaces to control and/or improve their ability to release bioactive agents in aqueous systems. The coating composition is particularly adapted for use with medical devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a first polymer component such as polyalkyl(meth)acrylate, polyaryl(meth)acrylate, polyaralkyl(meth)acrylate, or polyaryloxyalkyl(meth)acrylate and a second polymer component such as poly(ethylene-co-vinyl acetate).Type: GrantFiled: August 19, 2005Date of Patent: November 16, 2010Assignee: Surmodics, Inc.Inventors: Ralph A. Chappa, Robert W. Hergenrother, Aron B. Anderson, Linh V. Tran, Laurie R. Lawin, Ronald F. Ofstead
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Publication number: 20100158799Abstract: A composition for bioactive agent release in vivo. The composition includes the bioactive agent in combination with a mixture of a first polymer component such as poly(butyl methacrylate) and a second polymer component such as poly(ethylene-co-vinyl acetate).Type: ApplicationFiled: March 3, 2010Publication date: June 24, 2010Applicant: SurModics, Inc.Inventors: Stephen J. Chudzik, Timothy M. Kloke, Laurie R. Lawin, Ronald F. Ofstead, Ralph A. Chappa, Robert W. Hergenrother, Aron B. Anderson, Linh V. Tran
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Publication number: 20100008966Abstract: Embodiments of the invention include devices for the release of nucleic acids and related methods. In an embodiment, the invention includes an active agent eluting coating including a polymeric matrix, a cationic carrier agent disposed with the matrix, and an active agent disposed within the matrix, the active agent including nucleic acids substantially uncomplexed with the cationic carrier agent. In an embodiment, the invention includes a method of making an implantable medical device including selecting a concentration of a cationic carrier agent corresponding to a desired elution profile, combining a matrix forming polymer, an active agent, a solvent, and the cationic carrier agent to form a coating composition having the selected concentration of the cationic carrier agent, the active agent comprising nucleic acids, and depositing the coating composition onto the surface of a substrate. Other embodiments are included herein.Type: ApplicationFiled: July 14, 2009Publication date: January 14, 2010Applicant: SURMODICS, INC.Inventors: Joram Slager, Joseph Schmidt McGonigle, Aron Brent Anderson, Robert W. Hergenrother
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Publication number: 20090280155Abstract: Described are coating systems for the controlled delivery of hydrophilic bioactive agents, for example, from implantable medical devices. The coating systems of the invention comprise (a) a polymeric basecoat layer containing one or more hydrophilic bioactive agents; and (b) an elution-controlling topcoat layer that comprises a poly(ethylene-co-vinyl acetate) copolymer. The elution rate of the hydrophilic bioactive agent can be controlled by varying the vinyl acetate concentration in the elution-controlling topcoat layer.Type: ApplicationFiled: April 17, 2009Publication date: November 12, 2009Inventors: Ralph A. Chappa, Robert W. Hergenrother, Shannon A. Wadman, Klaus R. Wormuth
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Publication number: 20070248637Abstract: A coating composition in the form of a one or multi-part system, and method of applying such a composition under conditions of controlled humidity, for use in coating device surfaces to control and/or improve their ability to release bioactive agents in aqueous systems. The coating composition is particularly adapted for use with medical devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a first polymer component such as polyalkyl(meth)acrylate, polyaryl(meth)acrylate, polyaralkyl(meth)acrylate, or polyaryloxyalkyl(meth)acrylate and a second polymer component such as poly(ethylene-co-vinyl acetate).Type: ApplicationFiled: August 19, 2005Publication date: October 25, 2007Inventors: Ralph A. Chappa, Robert W. Hergenrother, Aron B. Anderson, Linh V. Tran, Laurie R. Lawin, Ronald F. Ofstead
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Patent number: 7097850Abstract: A coating composition in the form of a one or multi-part system, and method of applying such a composition under conditions of controlled humidity, for use in coating device surfaces to control and/or improve their ability to release bioactive agents in aqueous systems. The coating composition is particularly adapted for use with medical devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a first polymer component such as polyalkyl(meth)acrylate, polyaryl(meth)acrylate, polyaralkyl(meth)acrylate, or polyaryloxyalkyl(meth)acrylate and a second polymer component such as poly(ethylene-co-vinyl acetate).Type: GrantFiled: June 18, 2002Date of Patent: August 29, 2006Assignee: SurModics, Inc.Inventors: Ralph A. Chappa, Robert W. Hergenrother, Aron B. Anderson, Linh V. Tran, Laurie R. Lawin, Ronald F. Ofstead
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Publication number: 20030232122Abstract: A coating composition in the form of a one or multi-part system, and method of applying such a composition under conditions of controlled humidity, for use in coating device surfaces to control and/or improve their ability to release bioactive agents in aqueous systems. The coating composition is particularly adapted for use with medical devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a first polymer component such as polyalkyl(meth)acrylate, polyaryl(meth)acrylate, polyaralkyl(meth)acrylate, or polyaryloxyalkyl(meth)acrylate and a second polymer component such as poly(ethylene-co-vinyl acetate).Type: ApplicationFiled: June 18, 2002Publication date: December 18, 2003Inventors: Ralph A. Chappa, Robert W. Hergenrother, Aron B. Anderson, Linh V. Tran, Laurie R. Lawin, Ronald F. Ofstead
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Publication number: 20030232087Abstract: A coating composition, and method of applying such a composition under conditions of controlled humidity, for use in coating device surfaces to control and/or improve their ability to release bioactive agents in aqueous systems. The coating composition is particularly adapted for use with medical devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a combination of a first polymer component such as polyaryl(meth)acrylate, polyaralkyl(meth)acrylate, or polyaryloxyalkyl(meth)acrylate and a second polymer component such as poly(ethylene-co-vinyl acetate).Type: ApplicationFiled: June 18, 2002Publication date: December 18, 2003Inventors: Laurie R. Lawin, Ronald F. Ofstead, Ralph A. Chappa, Robert W. Hergenrother, Aron B. Anderson, Linh V. Tran
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Publication number: 20020188037Abstract: A coating composition, and method of applying such a composition under conditions of controlled humidity, for use in coating device surfaces to control and/or improve their ability to release bioactive agents in aqueous systems. The coating composition is particularly adapted for use with medical devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a combination of a first polymer component such as polyalyl(meth)acrylate, polyaryl(meth)acrylate, polyaralkyl(meth)acrylate, or polyaryloxyalkyl(meth)acrylate and a second polymer component such as poly(ethylene-co-vinyl acetate).Type: ApplicationFiled: June 18, 2002Publication date: December 12, 2002Inventors: Stephen J. Chudzik, Timothy M. Kloke, Laurie R. Lawin, Ronald F. Ofstead, Ralph A. Chappa, Robert W. Hergenrother, Aron B. Anderson, Linh V. Tran