Abstract: An example variable transmission system is provided. As an example, a variable transmission system may include a frame, an output hub coupled to the frame, a first linear actuator coupled to the frame, and a second linear actuator coupled to the frame. The variable transmission system may also include a tension-bearing element positioned around the output hub. A first end of the tension-bearing element may be coupled to the first linear actuator, and a second end of the tension-bearing element may be coupled to the second linear actuator. The tension-bearing element may include a variable stiffness profile such that a transmission ratio of the output hub may be adjusted based on a position of the second linear actuator relative to the output hub.

Abstract: The present invention relates to non-naturally occurring polypeptides useful for preparing armodafinil, polynucleotides encoding the polypeptides, and methods of using the polypeptides. The non-naturally occurring polypeptides of the present invention are effective in carrying out biocatalytic conversion of the (i) 2-(benzhydrylsulfinyl)acetamide to (?)-2-[(R)-(diphenylmethyl)sulfinyl]acetamide (armodafinil), or (ii) benzhydryl-thioacetic acid to (R)-2-(benzhydrylsulfinyl)acetic acid, which is a pivotal intermediate in the synthesis of armodafinil, in enantiomeric excess.

Abstract: A winder for winding a web to produce a rolled product is provided. Included in one exemplary embodiment is a plurality of independent winding modules. The winding modules may be configured to wind the web to form a rolled product by center winding, surface winding, and/or combinations of center and surface winding. In accordance with the present disclosure, at least one tail sealing apparatus is present in the system. The tail sealing apparatus includes an applicator device that transfers adhesive to a web being wound prior to completion of the roll. In one embodiment, the applicator device remains in contact with the wound roll during the completion of the winding cycle in order to have an ironing effect on the finished roll.

Abstract: The present invention relates to non-naturally occurring polypeptides useful for preparing armodafinil, polynucleotides encoding the polypeptides, and methods of using the polypeptides. The non-naturally occurring polypeptides of the present invention are effective in carrying out biocatalytic conversion of the (i) 2-(benzhydrylsulfinyl)acetamide to (?)-2-[(R)-(diphenylmethyl)sulfinyl]acetamide (armodafinil), or (ii) benzhydryl-thioacetic acid to (R)-2-(benzhydrylsulfinyl)acetic acid, which is a pivotal intermediate in the synthesis of armodafinil, in enantiomeric excess.

Abstract: The present invention provides a perforating station comprising two or more discrete perforating stations, the stations synchronized with one another to cut a line of perforations across a web, such as a web of tissue paper, moving at high speeds. By providing two or more synchronized perforating stations the perforating station may increase the number of impacts per minute compared to prior art perforating devices.

Abstract: A process for improving a recovery from a bottoms stream from a vacuum tower. The bottom stream is passed to a first cracking zone and unconverted material from the first cracking zone is passed to a second cracking zone. The first cracking zone may include a visbreaking reactor. The second cracking zone may include a slurry hydrocracking reactor.

Abstract: A fishing reel, such as a spincast reel, that includes a body having a frame that defines a thumb button attachment member on a rear side of the frame. A spool and spinner head are rotatably mounted forward of a front side of the frame. A front cover is secured to a front side of the frame to enclose components. A thumb button is pivotally secured to the thumb button attachment member. The thumb button has an actuating post that extends forwardly for applying force to a rearward end of a center shaft when the thumb button is depressed. A back cover is affixed to the rear side of the frame. The back cover defines a thumb button orifice for allowing a user to access the thumb button when the back cover is secured to the frame.

Abstract: The present invention relates to non-naturally occurring polypeptides useful for preparing armodafinil, polynucleotides encoding the polypeptides, and methods of using the polypeptides. The non-naturally occurring polypeptides of the present invention are effective in carrying out biocatalytic conversion of the (i) 2-(benzhydrylsulfinyl)acetamide to (?)-2-[(R)-(diphenyl-methyl)sulfinyl]acetamide (armodafinil), or (ii) benzhydryl-thioacetic acid to (R)-2-(benzhydrylsulfinyl)acetic acid, which is a pivotal intermediate in the synthesis of armodafinil, in enantiomeric excess.

Abstract: The invention provides kinase inhibitors of Formula I: wherein either: (1) R1 is H, and (a) R2 is (3-chlorobenzyl)oxy- and R3 is chloro; (b) R2 and R3, together with the carbon atoms to which they are attached, form 1-(3-fluorobenzyl)-1H-pyrazole; (c) R2 is 2-pyridinylmethoxy and R3 is chloro; (d) R2 and R3 are both chloro; (e) R2 is chloro and R3 is bromo; (f) R2 and R3 are both bromo; (g) R2 is fluoro and R3 is ethynyl; (h) R2 is chloro and R3 is ethynyl; (i) R2 is bromo and R3 is ethynyl; (j) other than when R2 is in the 3-position in combination with R3 in the 4-position, R2 is bromo and R3 is fluoro; (k) R2 is 2-pyridinylmethoxy and R3 is fluoro; or (l) R2 is 2-pyridinylmethoxy and R3 is bromo; or (2) at least one of R1, R2 and R3 is selected from benzyloxy, 3-chlorobenzyloxy and 2-pyridinylmethoxy and when at least one of R1, R2 and R3 is not benzyloxy, 3-chlorobenzyloxy or 2-pyridinylmethoxy, each of the others is independently selected from H, halogen, and C2-C4 alkynyl, with the proviso that

Abstract: The disclosure generally pertains to an interactive unit (IU) comprising a housing and a container. The IU can operate with at least one device enabling network connectivity. An end user device can connect to the IU to activate voice and/or video, and interact with the IU. A user can use the end user device to control the IU to dispense a treat, food, or product from the container. In at least one embodiment, a user will use the IU to connect with an animal located at the IU in order to communicate, bond, and train the animal.

Abstract: A dry polymer cement overlay for trafficked pavement substrates (both asphalt and concrete). The dry polymer cement overlay is a thin overlay that can handle the load of traffic in a relatively short time and has a relatively long life cycle. Moreover, the dry polymer cement overlay can hold aggregate that is applied on the surface of dry polymer cement overlay before it cures in order to provide a friction surface. A stencil is used during application of a dry polymer cement layer to provide a patterned overlay that includes patterns separated by gullies. The patterned dry polymer cement overlay exhibits improved performance including short and long term substrate adhesion, reduced risk of delamination, safety through improved surface runoff and enhanced visibility, improved macro and micro friction, reflective crack management, and withstands higher deflections under heavy loads. The patterned dry polymer cement overlay may also reduce noise and improve aesthetics.

Abstract: The invention provides novel prodrug compounds comprising a kinase inhibitor and a reductively-activated fragmenting aromatic nitroheterocycle or aromatic nitrocarbocycle trigger, where the compound carries a positive charge. In preferred embodiments, the compounds are of Formula I: where: X is any negatively charged counterion; R1 is a group of the formula —(CH2)nTr, where Tr is an aromatic nitroheterocyde or aromatic nitrocarbocycle and —(CH2)nTr acts as a reductively-activated fragmenting trigger; and n is an integer from 0 to 6; R2, R3 and R4 may each independently be selected from aliphatic or aromatic groups of a tertiary amine kinase inhibitor (R2)(R3)(R4)N, or two of R2, R3, and R4 may form an aliphatic or aromatic heterocyclic amine ring of a kinase inhibitor, or one of R2, R3, and R4 may be absent and two of R2, R3 and R4 form an aromatic heterocyclic amine ring of a kinase inhibitor. The compounds of the invention are useful in treating proliferative diseases such as cancer.

Abstract: The disclosure relates to medical tubes and methods of manufacturing medical tubes. The tube may be a composite structure made of two or more distinct components that are spirally wound to form an elongate tube. For example, one of the components may be a spirally wound elongate hollow body, and the other component may be an elongate structural component also spirally wound between turns of the spirally wound hollow body The tube need not be made from distinct components, however. For instance, an elongate hollow body formed (e.g., extruded) from a single material may be spirally wound to form an elongate tube. The elongate hollow body itself may in transverse cross-section have a thin wall portion and a relatively thicker or more rigid reinforcement portion. The tubes can be incorporated into a variety of medical circuits or may be employed for other medical uses.

Abstract: A method is presented for communicating data in multibeam satellite system utilizing frequency re-use. The method comprises establishing uplink service beams and downlink service beams between a satellite and a plurality of subscriber terminals. A plurality of the uplink service beams are transmitted to the satellite by re-using at least one common uplink frequency channel. A plurality of the downlink service beams are transmitted from the satellite by re-using at least one common downlink frequency channel. The method further comprises establishing at least one uplink feeder beam and at least one downlink feeder beam between the satellite and a gateway terminal. The at least one uplink feeder beam is transmitted to the satellite by further re-using the at least one common uplink frequency channel. The at least one downlink feeder beam is transmitted from the satellite by further re-using the at least one common downlink frequency channel.

Abstract: An apparatus for perforating sheet materials is disclosed. The apparatus includes a perforation blade that defines a plurality of teeth for perforating sheet materials, such as tissue products. Each tooth on the perforation blade is defined by a pair of opposing side walls. The teeth are separated along an edge of the perforation blade by a plurality of recesses. In accordance with the present disclosure, the side walls have a non-zero angle with respect to the length direction of the blade. In one embodiment, each recess can have a slanted U-shape such that all of the side walls are parallel. In an alternative embodiment, the recesses can have a V-shape such that adjacent side walls extend in divergent directions. Perforation blades made according to the present disclosure prevent snagging and picking when a material is perforated.

Abstract: An interface apparatus is disclosed for interfacing a testing device to a plurality of safety switches at a switch location, wherein each safety switch is connected to an electrical load circuit including at least an active line and a neutral return line. The interface apparatus comprises a plurality of actuating devices each being connectable to a respective safety switch, and a controller for controlling each actuating device to selectively connect the associated safety switch to the testing device. Each safety switch may include an RCD or RCCB device. A method of interfacing a testing device to a plurality of safety switches is also disclosed.

Abstract: In some embodiments, a headlamp assembly can comprise: a reflector, a mounting bracket, a housing, and a light source. The reflector can have a lip at a light source opening and a peripheral rim with a reflector portion extending from the lip to a peripheral rim. The mounting bracket can be configured to attach to the reflector. The mounting bracket can comprise attachment structures configured to mate with the lip, and adjustment features that enable horizontal, vertical, and pivotal adjustment. The light source can extend into the reflector through the light source opening.

Abstract: A winder for winding a web to produce a rolled product is provided. Included in one exemplary embodiment is a plurality of independent winding modules. The winding modules may be configured to wind the web to form a rolled product by center winding, surface winding, and/or combinations of center and surface winding. In accordance with the present disclosure, at least one tail sealing apparatus is present in the system. The tail sealing apparatus includes an applicator device that transfers adhesive to a web being wound prior to completion of the roll. In one embodiment, the applicator device remains in contact with the wound roll during the completion of the winding cycle in order to have an ironing effect on the finished roll.

Abstract: The invention provides kinase inhibitors of Formula I: wherein either: (1) R1 is H, and (a) R2 is (3-chlorobenzyl)oxy-and R3 is chloro; (b) R2 and R3, together with the carbon atoms to which they are attached, form 1-(3-fluorobenzyl)-1H-pyrazole; (c) R2 is 2-pyridinylmethoxy and R3 is chloro; (d) R2 and R3 are both chloro; (e) R2 is chloro and R1 is bromo; (f) R2 and R3 are both bromo; (g) R2 is fluoro and R3 is ethynyl; (h) R2 is chloro and R3 is ethynyl; (i) R2 is bromo and R3 is ethynyl; (j) other than when R1 is in the 3-position in combination with R3, in the 4-position, R2 is bromo and R3 is fluoro; (k) R2 is 2-pyridinylmethoxy and R3 is fluoro; or (l) R2 is 2-pyridinylmethoxy and R1 is bromo; or (2) at least one of R1, R2 and R3 is selected from benzyloxy, 3-chlorobenzyloxy and 2-pyridinylmethoxy and when at least one of R1, R2 and R3 is not benzyloxy, 3-chlorobenzyloxy or 2-pyridinylmethoxy, each of the others is independently selected from H, halogen, and C2-C4 alkynyl, with the proviso that

Abstract: A printing system including a printing device operable for applying one or more inks onto a substrate, and a heating device operable for heating the substrate prior to application of the one or more inks onto the substrate.