Abstract: This application relates to processes and intermediates for the preparation of the PD-1/PD-L1 inhibitor (R)-1-((7-cyano-2-(3?-((2-(difluoromethyl)-7-((3-hydroxypyrrolidin-1-yl)methyl)pyrido[3,2-d]pyrimidin-4-yl)amino)-2,2?-dimethyl-[1,1?-biphenyl]-3-yl)benzo[d]oxazol-5-yl)methyl)piperidine-4-carboxylic acid, and salts and crystalline forms thereof, where the PD-1/PD-L1 inhibitor and solid forms and salt forms thereof are useful in the treatment of various diseases including infectious diseases and cancer.

Abstract: A method of transmitting rendering data of a computer image to a client terminal via a communication channel includes: receiving rendering results of the computer image from at least one computer of a plurality of computers; identifying a partial region of the computer image based on transmission information; processing a subset of the rendering results, the subset corresponding to the identified partial region of the computer image; and transmitting, at a particular time, the processed subset of the rendering results to the client terminal via the communication channel.

Abstract: A device is disclosed for the preparation of nebulised droplets, for inhalation. The device has: a surface acoustic wave (SAW) transmission surface; a SAW transducer adapted to generate and propagate SAWs along the SAW transmission surface; and an array of cavities opening at the SAW transmission surface for containing a liquid. In operation, SAWs propagating along the SAW transmission surface interact with the liquid in the cavities to produce nebulised droplets of the liquid. Operation of the device results in a nebulised plume of droplets of average diameter in the range 1-5 ?m.

Abstract: Roofing substrates, including shingles, provide for protection of the structure it is covering as well as aesthetics. Shingles come in various types including asphalt, clay, and metal. The shingles may have a dry polymer modified cement mixture applied on top of current shingles or may be used to replace certain layers of, for example, asphalt shingles. The dry polymer modified cement may be applied before or after installation. The dry polymer modified cement may be colored to provide desired aesthetics and lower absorption of the sun's radiation (e.g., visible spectrum, infrared spectrum). The dry polymer modified cement may add minimum weight to the shingles while providing protection to the underlying substrate from environmental deterioration and weathering, thus increasing life of the shingle. The dry polymer modified cement mixture is prepared by mixing a dry polymer modified cement blend (ordinary Portland cement, aggregate and polymer powders) with water.

Abstract: Trafficked pavement substrates utilize markings to segregate traffic (e.g., divide lanes traveling in the same direction, divide sides of the road traveling in opposite directions). A dry polymer modified cement mixture may be used to provide the markings. The dry polymer modified cement mixture is prepared by mixing a dry polymer modified cement blend (ordinary Portland cement, aggregate and polymer powders) with water. The location of the lines is identified, and the dry polymer modified cement mixture is applied onto the identified areas as a thin layer. The dry polymer modified cement blend may include polymers to provide colored markings. Glass beads may be embedded into the dry polymer modified mixture before it cures to retroreflect light shined thereon. The trafficked pavement substrate may have troughs formed therein and the dry polymer modified cement markings may be formed therewithin so that the markings are flush.

Abstract: Shaving systems are disclosed that include a replaceable shaving assembly and a cartridge connecting structure for connecting the shaving assembly to a handle. In preferred implementations, the cartridge connecting structure has a magnetic portion configured to help draw the cartridge onto the handle and retain the cartridge in place when the razor is not in contact with the skin, and a mechanical engagement that provides the necessary retention forces required to keep the system intact during shaving.

Abstract: Some embodiments provide for an inspiratory limb for a breathing circuit that includes a first segment that comprises a first heater wire circuit and a second segment that comprises a second heater wire circuit. The inspiratory limb can include an intermediate connector that includes a connection circuit that electrically couples the first heater wire circuit to the second heater wire circuit. The inspiratory limb can be configured to operate in two modes wherein, in a first mode, electrical power passes through the first electrical connection to provide power to the first heater wire circuit without providing power to the second heater wire circuit, and in a second mode, electrical power pass through the first electrical connection to provide power to both the first heater wire circuit and the second heater wire circuit.

Abstract: A Digital Transaction Processing Unit (DTPU) operable to host one or more transaction applications, each transaction application for digitally transacting with a Digital Transaction Device (DTD), the DTPU further operable to be reversibly placed into a disabled state such that the DTPU is inoperable for a digital transaction with a DTD.

Abstract: A provisioning agent for provisioning a Digital Payment Device (DPD) which includes a Digital Transaction Processing Unit (DTPU) operable to host one or more transaction applications, the DTPU being further operable to adopt at least one transaction application selected from the one or more transaction applications, the DPD operable for a digital transaction with a Digital Transaction Device (DTD) using the adopted at least one transaction application, the provisioning agent being operable to provide provisioning data to the DPD, the DPD further including apparatus operable to receive the provisioning data, the provisioning data being operable to provide one or more functions to the DPD, the provisioning agent being operable to: prepare one or more first digital objects, receive one or more second digital objects from a second provisioning agent, include at least one of the one or more first digital objects and at least one of the one or more second digital objects in the provisioning data.

Abstract: A Digital Transaction Processing Unit (DTPU) including one or more transaction applications operable for a digital transaction with a Digital Transaction Device (DTD), each of the one or more transaction applications being associated with identifying information, the identifying information being capable of identifying a subset of at least one transaction application within the one or more transaction applications, wherein the DTPU is operable, when conducting a transaction with the DTD, to communicate to the DTD the identifying information associated with one of the one or more transaction applications involved in the transaction.

Abstract: An attachment system for a portable electronic device includes a clip unit including a clip magnet disposed between a base plate and a top cover and a clip lip formed on the top cover; and an attachment adapter for attached to a back side of the base plate and configured for attachment of the clip unit to an article. The clip magnet is positioned to be aligned with a magnet in the portable electronic device when mated with the portable electronic device. The attachment system enables the portable electronic device to be quickly and easily attached to a desired article and further enable quick release of the portable electronic device from the attachment system.

Abstract: A Digital Transaction Processing Unit (DTPU) operable to host one or more transaction applications, the DTPU further operable to reversibly unlock at least one of the one or more transaction applications, wherein each unlocked transaction application is operable for a digital transaction with a Digital Transaction Device (DTD).

Abstract: A Digital Transaction Processing Unit (DTPU) including a plurality of transaction applications operable for a digital transaction with a Digital Transaction Device (DTD), each of the plurality of transaction applications being associated with a tokenised primary identifier.

Abstract: An apparatus for a Digital Payment Device (DPD) operable for a digital transaction with a Digital Transaction Device (DTD), the apparatus being operable to provide transaction application identifier information for communication from the DPD to the DTD in a digital transaction, the apparatus including: an application selection module; on the DPD, a Digital Transaction Processing Unit (DTPU) operable to host one or more Personalized Digital Transaction Packages (PDTPs), each PDTP associated with at least one transaction application having a transaction application identifier; the DPD being operable to select at least one hosted PDTP to be operable for a digital transaction with the DTD; wherein the apparatus is operable to receive one or more commands to cause the application selection module to be set with a transaction application identifier for each transaction application associated with the selected at least one PDTP, such that the application selection module is operable to include, in the transaction ap

Abstract: A Digital Transaction Processing Unit (DTPU) operable to host one or more transaction applications for digitally transacting with a Digital Transaction Device (DTD), the DTPU including a security hierarchy for hosting the one or more transaction applications, wherein the security hierarchy is configured to host at least one transaction application for transacting in contact digital transactions.

Abstract: A Digital Transaction Processing Unit (DTPU) operable to host one or more containers, the DTPU further operable to host one or more transaction applications operable for digital transactions with a Digital Transaction Device (DTD), each transaction application derived from one of the one or more containers for installation on the DTPU, wherein the DTPU is operable to reversibly place at least one of the one or more containers into an inactive state such that the at least one container is inoperable to be used to install a transaction application on the DTPU.

Abstract: A Digital Payment Device (DPD) including a Digital Transaction Processing Unit (DTPU), wherein the DPD includes a first cryptographic key stored in a secure storage area of the DPD, wherein the first cryptographic key matches a second cryptographic key stored on the DTPU, the second cryptographic key being associated with a security domain of the DTPU, wherein the first cryptographic key enables encryption for a digital object, such that the digital object is authenticatable against the second cryptographic key.

Abstract: A Digital Payment Device (DPD) including a Digital Transaction Processing Unit (DTPU), a Microcontroller Unit (MCU), and a command generation unit, wherein the command generation unit is operable to generate a DTPU command capable of being authenticated against a targeted security domain of the DTPU, the DTPU command including a payload capable of being executed by the DTPU; and the MCU is operable to communicate the DTPU command to the DTPU for execution by the DTPU.

Abstract: An electronic construction collaboration system for managing a construction project is provided. The electronic construction collaboration system includes an Enterprise Resource Planning (ERP) sub-system including a contract engine configured to generate at least one project contract including a contract data set and ERP metadata corresponding to Building Information Modeling (BIM) metadata included in a structural object of a construction project model in a BIM sub-system and an interconnection engine configured to associatively link the ERP metadata and the BIM metadata and send the contract data set to the BIM sub-system in response to associatively linking the ERP metadata and the BIM metadata.

Abstract: Shaving systems are disclosed that include a replaceable shaving assembly and a cartridge connecting structure for connecting the shaving assembly to a handle. In preferred implementations, the cartridge connecting structure has a magnetic portion configured to help draw the cartridge onto the handle and retain the cartridge in place when the razor is not in contact with the skin, and a mechanical engagement that provides the necessary retention forces required to keep the system intact during shaving.