Abstract: Provided herein are nucleic acid trans-splicing molecules (e.g., pre-mRNA trans-splicing molecules (RTMs); RNA exon editing molecules) capable of correcting mutations in the ABCA4 gene. Such molecules are useful in the treatment of disorders such as ABCA4-associated retinal dystrophies (e.g., Stargardt Disease or cone-rod dystrophy). Also described herein are methods of using the nucleic acid trans-splicing molecules described herein to correct mutations in ABCA4, thereby treating disorders associated with mutations in ABCA4 and use of the nucleic acid trans-splicing molecules described herein for treating disorders associated with mutations in ABCA4 and in the preparation of medicaments for the treatment of disorders associated with mutations in ABCA4.

Abstract: A computer-implemented system and method for planning recurring events is provided. Event objects for events are stored in a database. A trigger notifying the beginning of an event is received and an event object representing the event is generated in response to the trigger. An event class is associated with a set of parameters and is assigned to the event object. A set of activity data is created for the event object and each activity data includes structured and unstructured data describing an event activity occurred during the event. At least one event object is retrieved from the database as a model and the parameter values of the model event object are displayed. At least one of the parameter values of the model event object is modified and the modification is reflected against other parameter values of the model event object that are dependent on the modified parameter value.

Abstract: The invention provides a transgenic Glycine max event MON87751, plants, plant cells, seeds, plant parts, progeny plants, and commodity products comprising event MON87751. The invention also provides polynucleotides specific for event MON87751, plants, plant cells, seeds, plant parts, and commodity products comprising polynucleotides for event MON87751. The invention also provides methods related to event MON87751.

Abstract: The present invention provides anti-HtrA1 antibodies (including bispecific anti-HtrA1 anti-Factor D antibodies) and methods of making and using the same, for example, in methods of treating HtrA1-associated disorders, ocular disorders, and/or complement-associated disorders.

Abstract: The present disclosure introduces, among other things, an electronic device, e.g. an integrated circuit (IC). The IC includes a semiconductor substrate comprising a first doped layer of a first conductivity type. A second doped layer of the first conductivity type is located within the first doped layer. The second doped layer has first and second layer portions with a greater dopant concentration than the first doped layer, with the first layer portion being spaced apart from the second layer portion laterally with respect to a surface of the substrate. The IC further includes a lightly doped portion of the first doped layer, the lightly doped portion being located between the first and second layer portions. A dielectric isolation structure is located between the first and second layer portions, and directly contacts the lightly doped portion.

Abstract: Systems and methods for filtering time-varying data for filtering and extracting a predicted physiological signal. A method including: segmenting the time-varying data into temporal windows; using a trained filter machine learning model, predicting an error for each prediction of the physiological signal for each window of time-varying data, the filter machine learning model trained using physiological signal predictions based on training time-varying data and known values of the physiological signal for the training time-varying data; discarding each window of time-varying data when the predicted error for such window is greater than a threshold; and where the window of time-varying data is not discarded, outputting at least one of the window of time-varying data and the predicted error for each prediction of the physiological signal.

Abstract: A method for operating a shearing tool that includes: operating a first switch to control a drive unit to drive a blade of a blade set; and operating a second switch to cause the drive unit to operate in an anti-binding mode in which a direction of an input to the drive unit is alternated at least twice. A shearing tool is also provided.

Abstract: A method for operating a shearing tool that includes: operating a first switch to control a drive unit to drive a blade of a blade set; and operating a second switch to cause the drive unit to operate in an anti-binding mode in which a direction of an input to the drive unit is alternated at least twice. A shearing tool is also provided.

Abstract: A method for operating a shearing tool that includes: operating a first switch to control a drive unit to drive a blade of a blade set; and operating a second switch to cause the drive unit to operate in an anti-binding mode in which a direction of an input to the drive unit is alternated at least twice. A shearing tool is also provided.

Abstract: A method for operating a shearing tool that includes: operating a first switch to control a drive unit to drive a blade of a blade set; and operating a second switch to cause the drive unit to operate in an anti-binding mode in which a direction of an input to the drive unit is alternated at least twice. A shearing tool is also provided.

Abstract: A scanning probe microscope (SPM) system and associated method. The SPM system having a probe adapted to interact with nanoscale features of a sample and scan within a target region to produce a three-dimensional image of that target region, the system maintaining location information for a plurality of features of interest of the sample according to a sample-specific coordinate system, wherein the SPM system is configured to adjust positioning of the probe relative to the sample according to a SPM coordinate system, the SPM system further configured to manage a dynamic relationship between the sample-specific coordinate system and the SPM coordinate system by determining a set of alignment errors between the sample-specific coordinate system and the SPM coordinate system and apply corrections to the SPM coordinate system to offset the determined alignment errors.

Abstract: Provided is a plasma-resistant member which can be recycled and does not easily produce particles even when exposed to plasma. Specifically provided is a plasma-resistant member which has a predetermined surface profile and is used within a plasma etching chamber. The plasma-resistant member comprises: a first SiC layer (12) that is formed by a CVD method and has a corroded surface by having been exposed to plasma etching; and a second SiC layer (13) that is laminated on the corroded surface of the first SiC layer (12) by a CVD method and has a surface that is machined so as to have the predetermined surface profile.

Abstract: The present invention relates to a dual layer golf club grip including an inner layer grip and an outer layer grip adhered on an outer surface of the inner layer grip. The inner and outer layer grips of the dual layer golf club grip are respectively composed of plastic or rubber with different properties, and the outer layer grip is transparent. The dual layer golf club grip has a practical efficiency and is also speciously designed.

Abstract: A showerhead for use in a capacitively-coupled plasma chamber and made of low resistivity bulk layer coated with CVD SiC. The bulk low resitivity material may be, for example, graphite, Silicon Carbide (SiC), converted graphite, SiC+C, etc. Sintered SiC may be used as the bulk material coated with CVD SiC to provide a showerhead that is suitable for use in a capacitively-coupled plasma chamber.

Abstract: A method for installing a grip member onto a shaft includes: (a) providing the grip member with a surrounding wall that defines an insert space; (b) injecting a gas into the insert space to expand the surrounding wall; (c) moving the shaft into the insert space; and (d) allowing the surrounding wall to contract so that the grip member is fitted around the shaft. A structure of the grip member is also disclosed.

Abstract: There is provided a system and method of enhancing capacity of a wireless communication channel compromising the steps of modulating data in accordance with first modulation scheme transforming the modulated data from a frequency domain symbol to a time domain version and encoding bits in a wireless communication timeslot independence upon the time domain version whereby capacity of the wireless communication channel is enhanced. The system and method further comprises the steps of: means for receiving the timeslot means for decoding the timeslot and means for transforming the decoded bits from time domain to frequency domain to recover the data. GSM capacity is enhanced between two and six times.

Abstract: A showerhead for use in a capacitively-coupled plasma chamber and made of low resistivity bulk layer coated with CVD SiC. The bulk low resitivity material may be, for example, graphite, Silicon Carbide (SiC), converted graphite, SiC+C, etc. Sintered SiC may be used as the bulk material coated with CVD SiC to provide a showerhead that is suitable for use in a capacitively-coupled plasma chamber.

Abstract: A storage and data management system establishes a data transfer pipeline between an application and a storage media using a source data mover and a destination data mover. The data movers are modular software entities which compartmentalize the differences between operating systems and media types. In addition, they independently interact to perform encryption, compression, etc., based on the content of a file as it is being communicated through the pipeline. Headers and chunking of data occurs when beneficial without the application ever having to be aware. Faster access times and storage mapping offer enhanced user interaction.

Abstract: A sputtering target comprising a concentration-graded alloy is utilized to achieve a uniform seed layer across a microelectronic wafer for the formation of microelectronic device interconnects. The concentration-graded alloy sputtering target achieves the substantially uniform seed layer by counteracting the affects of a sputtering system which would normally result in a non-inform seed layer if a single/uniform concentration sputtering target were used.

Abstract: A water-soluble reference standard is useful for immunoassays of a lipophilic drugs. The reference standard is a compound of formula (I): G-(L)n-Y??(I); where G is a lipophilic drug, L is a linker which is an alkyl group or heteroalkyl group containing from 1 to 20 carbon atoms, n is 0 or 1, and Y is a water-solubilizing group such as —SO3?, —NR—SO3?, —P(?O)(OH)(O?), or —O—P(?O)(OH)(O?), where R is H or an alkyl group of 1 to 10 carbon atoms.