Abstract: The present disclosure includes engineering methods and polypeptide libraries that are useful for introducing non-native binding sites into polypeptides. Also provided herein are polypeptides that bind to a CD98hc or transferrin receptor (TfR) protein, methods of generating such polypeptides, and methods of using the polypeptides to target a composition across the blood-brain barrier or to a CD98hc-expressing or TfR-expressing cell.

Abstract: Disclosed is sublingual administration of riluzole. In particular, a method for treating a neuropsychiatric disorder or symptom by administering a sublingual formulation of riluzole is provided. In addition, a method of relieving or reducing oral pain using the sublingual formulation of riluzole is disclosed.

Abstract: A method for determining a trust indicator is provided. The method may include interpreting, via an Internet of Things Universal Identifier (IoT UID) processing circuit, an IoT UID corresponding to a device and identifying, via a record management circuit and based at least in part on the IoT UID, a record in a database corresponding to the device. The method may further include determining, via a trust analysis circuit and based at least in part on the record, a risk indicator of the device and transmitting, via an indicator provisioning circuit, the risk indicator.

Abstract: In one embodiment, an apparatus for docking vehicles includes a housing structure comprising two side portions and a top portion connecting the two side portions, the two side portions and the top portion forming a cavity for receiving a portion of a vehicle, an electrically-powered locking assembly, carried by the housing structure, for securing the housing structure to the vehicle in response to the portion of the vehicle being received by the cavity of the housing structure, an electrically-powered communication device, coupled to the housing structure, for enabling data communication over a network, and a solar panel, carried by an external surface of one of the side portions of the housing structure, for independently converting light received by the solar panel into electrical energy.

Abstract: A power system includes an energy storage system having a rechargeable energy storage element and a converter connected to the rechargeable energy storage element and configured to connect to a bus so that the energy storage system is connected in parallel with a load and a main power supply system. The energy storage system may cooperate with the main power supply system to supply power to the load with each of the energy storage system and the main power supply system configured as a voltage source with a corresponding droop function. The system may include a control circuit configured to monitor a voltage of the bus and control the converter to either charge or discharge the rechargeable energy storage element based on the voltage of the bus.

Abstract: A load shed module configured to be connected in series between a power supply and a load is disclosed. A separate load shed module is connected in series between each load and the power supply. The load shed module determines the frequency of the voltage supplied from the power supply. Based on the frequency, the load shed module determines if utility power is connected or if a generator is connected. If the generator is connected and the frequency of the voltage goes outside of a desired operating range for a preset time, the load shed module disconnects the load from the power supply. Each load shed module includes a priority setting and reconnects its corresponding load after a predetermined time corresponding to the priority setting.

Abstract: An energy recovery ventilation unit includes an energy recovery ventilation core and a dehumidification system comprising an evaporation unit and a condensing unit. The energy recovery ventilation core receives a first and second airflow and discharges the first and second airflow after the first and second airflow experience heat and mass transfer. The evaporation unit generates a first output airflow comprising a lower relative humidity than the first airflow and directs the first output airflow into a building. The condensing unit generates a second output airflow at a higher temperature than the second airflow and discharges the second output airflow to an unconditioned space.

Abstract: A power system comprises an energy storage system including a rechargeable energy storage element and a converter connected to the rechargeable energy storage element and configured to connect to a bus so that the energy storage system is connected in parallel with a load and a main power supply system. The energy storage system cooperates with the main power supply system to supply power to the load. The power system may include a control circuit configured to monitor a voltage of the bus and control the converter to either charge or discharge the rechargeable energy storage element based on the voltage of the bus. The control circuit may also monitor a status of a state of charge (SOC) of the rechargeable energy storage element and a system load condition.

Abstract: A frame apparatus, a kit of parts which includes multiple frames and a connector bracket for connecting the frames together, and a method of interconnecting a plurality of frames and hanging the same from a support surface. The frame apparatus may be a front-loading frame whereby display items are inserted into a display cavity of the frame through an opening in the front surface of the frame through which the display cavity is viewed. The frame may include an outer annular wall that defines the display cavity, an inner annular wall that is spaced apart from the outer annular wall, and a floor that extends between the inner and outer annular walls. The floor may comprise a plurality of apertures to allow for attachment of the frame to various accessories including hanging brackets, connector brackets, trays, and the like.

Abstract: An application may receive a prompt from a user related to an input for a text field of digital content. An application may generate context data about the digital content. An application may provide the prompt and the context data to a generative language model. An application may receive a response generated by the generative language model and provide the response as a suggestion for the input for the text field.

Abstract: The present application provides the preparation and use of a 3,4-dihydroxyl-N-(1?-benzyl-2?-hydroxyethyl)-2-methyl pyridine chloride. According to the present application, a 3,4-dihydroxyl-N-(1?-benzyl-2?-hydroxyethyl)-2-methyl pyridine chloride is directly synthesized by a one-step reaction, and the compound includes a pharmaceutically acceptable salt thereof. 3,4-dihydroxyl-N-(1?-benzyl-2?-hydroxyethyl)-2-methyl pyridine chloride has been proved to have a good antiparkinsonian activity by animal tests, and it is a class of novel antiparkinsonian drug candidates.

Abstract: A method for registering one or more Greenfield devices via a virtual Internet of Things Universal Identifier (IoT UID) is provided. The method includes identifying one or more Brownfield devices, generating device property data based at least in part on the one or more Brownfield devices, and transmitting, to an IoT device registrar server, a registration request that includes the device property data. The method further includes interpreting one or more IoT UIDs generated in response to the transmitting of the registration request.

Abstract: A method comprises generating, via a pulse generator, a first pressure pulse in a fluid in a pipe and detecting, via a transducer, a first reflected pressure pulse based on the first pressure pulse, wherein the first pressure pulse is reflected by a pipe feature to generate the first reflected pressure pulse. The method comprises generating, with the pulse generator, a second pressure pulse at a later time relative to generating the first pressure pulse, wherein timing of generating of the second pressure pulse is such that the second pressure pulse is superposed with the first reflected pressure pulse such that an amplitude of the second pressure pulse is greater than an amplitude of the first pressure pulse. The method comprises detecting, via the transducer, a second reflected pressure pulse based on the second pressure pulse, and detecting a pipe feature based on the second reflected pressure pulse.

Abstract: A data processing system for generating predictive maintenance models is disclosed, including one or more processors, a memory, and a plurality of instructions stored in the memory. The instructions are executable to receive a historical dataset relating to each of a plurality of systems, including maintenance data and operational data. The instructions are further executable to display one or more algorithm templates and one or more data features calculated from the operational data, in a graphical user interface. The instructions are further executable to receive a selection of an algorithm template, a data feature, and a value of a parameter associated with the algorithm template, and to train and evaluate the selected algorithm template on the selected data feature according to the received value. The instructions are further executable to display a result of a metric of the evaluation, and generate a predictive maintenance model using the selected algorithm template.

Abstract: Embodiments of an overlay network with innovative virtual network switches and related network interface controllers are disclosed. According to one embodiment, the overlay network may comprise at least one virtual network switch (VNS), wherein each VNS is installed within a corresponding first processing endpoint which is logically above a network of virtual machines. And, the VNS may be configured to intercept data packets transmitted on a network layer logically below the network of virtual machines. The VNS may comprise: (a) a manager element configured to connect to at least one virtual network interface controller (VNIC), each VNIC being installed within a corresponding second processing endpoint which is also logically above the network of virtual machines; (b) a replicator node configured to replicate and route the data packets; and (c) a switch controller configured to control the first replicator node.

Abstract: A method and a system for impact detection in a stationary vehicle are provided. The method includes putting a telematics device into a sleep mode and performing a first micro wakeup. In response to determining that a first value read from a sensor during the micro wakeup is greater than a noise threshold, increasing a frequency of the micro wakeups and a sampling rate of the sensor. The method also includes reading a second value from the sensor during a second wakeup, performing a regular wakeup, and sending the first and second values during the regular wakeup.

Abstract: A method and system for photopolymerization 3D printing is provided. The system includes a processing device, a micro light emitting diode (microLED) array including one or more individually addressable microLED emitters, and a printing component. The processing device is configured to determine one or more printing layers of an object. The microLED array is configured to generate light for each of the one or more printing layers. The printing component is configured to print the one or more printing layers. To generate the light for each of the one or more printing layers, the processing device is further configured to dynamically determine one or more microLED regions in the microLED array, determine one or more region printing parameters for each of the one or more microLED regions; and determine one or more control signals for the one or more individually addressable microLED emitters included in each of the one or more microLED regions based on the one or more region printing parameters.

Abstract: In the embodiments of the present disclosure, additive manufacturing devices and methods are provided. The additive manufacturing device includes a light source, a building device, and a light scattering member. The light source is configured to provide light to cure photocurable resins. The building device includes a resin tank configured to store the photocurable resins. The building device has a building surface on which the photocurable resins are cured. The light scattering member is arranged between the light source and the building surface.