Patents by Inventor Robin Douglas Clark

Robin Douglas Clark has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BENZOXAZINE DERIVATIVES AND USES THEREOF
    Publication number: 20130123251
    Abstract: The present invention provides a compound of the formula: a pharmaceutically acceptable salt or a prodrug thereof, where R1, R2, R3, R4, R5, R6, R7, R8, R9, Y, Z1, m, n, and p are as defined herein. The present invention also provides compositions comprising, methods for using, and methods for preparing Compound of Formula I.
    Type: Application
    Filed: December 13, 2012
    Publication date: May 16, 2013
    Applicant: ROCHE PALO ALTO LLC
    Inventors: Jacob Berger, Robin Douglas Clark, Shu-Hai Zhao
  • Benzoxazine derivatives and uses thereof
    Patent number: 8377931
    Abstract: The present invention provides a compound of the formula: a pharmaceutically acceptable salt or a prodrug thereof, where R1, R2, R3, R4, R5, R6, R7, R8, R9, Y, Z1, m, n, and p are as defined herein. The present invention also provides compositions comprising, methods for using, and methods for preparing Compound of Formula I.
    Type: Grant
    Filed: September 4, 2009
    Date of Patent: February 19, 2013
    Assignee: Roche Palo Alto LLC
    Inventors: Jacob Berger, Robin Douglas Clark, Shu-Hai Zhao
  • Benzoxazine derivatives and uses thereof
    Publication number: 20090325950
    Abstract: The present invention provides a compound of the formula: a pharmaceutically acceptable salt or a prodrug thereof, where R1, R2, R3, R4, R5, R6, R7, R8, R9, Y, Z1, m, n, and p are as defined herein. The present invention also provides compositions comprising, methods for using, and methods for preparing Compound of Formula I.
    Type: Application
    Filed: September 4, 2009
    Publication date: December 31, 2009
    Inventors: Jacob Berger, Robin Douglas Clark, Shu-Hai Zhao
  • Tetrahydroquinazolines and dihydrocyclopentapyrimidines as CRF antagonists
    Patent number: 7223767
    Abstract: Compounds of the formula (I): and pharmaceutically acceptable salts or prodrugs thereof, wherein m, R1, R2, R3, R4, R5 and R6 are as defined herein. The invention also provides methods for preparing, compositions comprising, and methods for using compounds of formula (I).
    Type: Grant
    Filed: August 11, 2004
    Date of Patent: May 29, 2007
    Assignee: Roche Palo Alto LLC
    Inventors: Robin Douglas Clark, Richard Leo Cournoyer, Counde O′Yang
  • Benzoxazine derivatives and uses thereof
    Patent number: 7202241
    Abstract: Compounds of the formula (I): or pharmaceutically acceptable salts, solvates or prodrugs thereof, where R1, R2, R3, R4, R5, R6, R7, R8, R9, X, Y and m are as defined herein. Also provided are compositions comprising, methods for using, and methods for preparing compound of formula (I).
    Type: Grant
    Filed: December 9, 2004
    Date of Patent: April 10, 2007
    Assignee: Roche Palo Alto LLC
    Inventors: Jacob Berger, Robin Douglas Clark, Shu-Hai Zhao
  • 2-(substituted-phenyl)amino-imidazoline derivatives
    Patent number: 7141584
    Abstract: This invention relates to IP receptor antagonists selected from the group of compounds represented by Formula I: where: R1 is a group represented by formula (A), (B) or (C); and other substituents as defined in the specification, and their pharmaceutically acceptable salts or crystal forms thereof; and pharmaceutical compositions containing them; and methods for their use as therapeutic agents.
    Type: Grant
    Filed: December 9, 2003
    Date of Patent: November 28, 2006
    Assignee: Roche Palo Alto LLC
    Inventors: Keith Roger Bley, Robin Douglas Clark, Alam Jahangir, Bruce Andrew Kowalczyk, Francisco Javier Lopez-Tapia, Alexander Victor Muehldorf, Counde O'Yang, Thomas Weitao Sun
  • Spiro tetrahydroquinazolines and dihydrocyclopentapyrimidines as CRF antagonists
    Patent number: 7135476
    Abstract: Compounds of the formula (I): and pharmaceutically acceptable salts or prodrugs thereof, wherein m, n, R1, R2, R3, R4, R5, R6, R7, R8, and R9 are as defined herein. The invention also provides methods for preparing, compositions comprising, and methods for using compounds of formula I.
    Type: Grant
    Filed: August 11, 2004
    Date of Patent: November 14, 2006
    Assignee: Roche Palo Alto LLC
    Inventor: Robin Douglas Clark
  • Thiophenylaminoimidazolines as IP antagonists
    Patent number: 7078401
    Abstract: Methods for treatment of IP antagonist mediated diseases or conditions by administration to a subject in need thereof a compound of formula (I) wherein R1, R2, A and X are as defined herein. Also disclosed are compounds and related compositions.
    Type: Grant
    Filed: July 9, 2004
    Date of Patent: July 18, 2006
    Assignee: Roche Palo Alto LLC
    Inventors: Keith Roger Bley, Robin Douglas Clark, Alam Jahangir
  • 4-piperazinyl benzenesulfonyl indoles and uses thereof
    Patent number: 7022708
    Abstract: This invention relates to compounds which have generally 5-HT6 receptor affinity and which are represented by Formula I: wherein R1, R2, R3, R4, and R5 are as defined herein; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and methods of preparation thereof.
    Type: Grant
    Filed: October 16, 2003
    Date of Patent: April 4, 2006
    Assignee: Roche Palo Alto LLC
    Inventors: Robin Douglas Clark, Ralph New Harris, III, David Bruce Repke
  • Benzoxazine derivatives and uses thereof
    Patent number: 6867204
    Abstract: Compounds of the formula: or pharmaceutically acceptable salts or prodrugs thereof, where each of n and p independently is 2 or 3, Y is —SO2— or —SO2—N(R10)—, Z1 is CH or N, and R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 are as defined herein. The compounds have selective 5-HT6 affinity and are useful in the treatment of certain CNS disorders. Also provided are compositions comprising, methods for using, and methods for preparing Compounds of Formula I.
    Type: Grant
    Filed: May 9, 2003
    Date of Patent: March 15, 2005
    Assignee: Roche Palo Alto LLC
    Inventors: Jacob Berger, Robin Douglas Clark, Shu-Hai Zhao
  • New indole derivatives with 5-HT6 receptor affinity
    Publication number: 20040248902
    Abstract: This invention relates to compounds which have generally 5-HT6 receptor affinity and which are represented by Formula I: 1
    Type: Application
    Filed: June 25, 2004
    Publication date: December 9, 2004
    Inventors: Colin Charles Beard, Robin Douglas Clark, Lawrence Emerson Fisher, Ralph New Harris, David Bruce Repke
  • Arylsulfonyl derivatives with 5-HT6 receptor affinity
    Patent number: 6825202
    Abstract: This invention relates to compounds which have generally 5-HT6 receptor affinity and which are represented by Formula (I): wherein Ar, R1, R2, R3 or R4 are as defined in the specification, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and methods of preparation thereof.
    Type: Grant
    Filed: August 9, 2002
    Date of Patent: November 30, 2004
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Jacob Berger, Robin Douglas Clark, Shu-Hai Zhao
  • 4-piperazinylindole derivatives with 5-HT6 receptor affinity
    Patent number: 6790848
    Abstract: This invention relates to compounds which have generally 5-HT6 receptor affinity and which are represented by Formula I: wherein R3 is SO2—Ar, Ar is aryl or heteroaryl; and R1, R2, R4 and R5 are as defined herein; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and methods of preparation thereof.
    Type: Grant
    Filed: June 14, 2002
    Date of Patent: September 14, 2004
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Andrew John Briggs, Robin Douglas Clark, Ralph New Harris, III, David Bruce Repke, Douglas Leslie Wren
  • Indole derivatives with 5HT6 receptor affinity
    Patent number: 6787535
    Abstract: This invention relates to compounds which have generally 5-HT6 receptor affinity and which are represented by Formula I: wherein one of R5, R6 or R7 is a group of general Formula B, wherein W is a —CH— group or a nitrogen atom, and the other substituents are as defined herein; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and methods of preparation thereof.
    Type: Grant
    Filed: June 6, 2002
    Date of Patent: September 7, 2004
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Colin Charles Beard, Robin Douglas Clark, Lawrence Emerson Fisher, Ralph New Harris, III, David Bruce Repke, David George Putman
  • 1-sulfonyl-4-aminoalkoxy indole derivatives and uses thereof
    Patent number: 6774241
    Abstract: The present invention provides a compound of the formula: a pharmaceutically acceptable salt or a prodrug thereof, where R1, R2, R3, R4, R5, R6, and n are as defined herein. The present invention also provides compositions comprising, methods for using, and methods for preparing Compound of Formula I.
    Type: Grant
    Filed: June 4, 2003
    Date of Patent: August 10, 2004
    Assignee: Roche Palo Alto LLC
    Inventors: Robin Douglas Clark, Shu-Hai Zhao
  • 2-(substituted-phenyl)amino-imidazoline derivatives
    Publication number: 20040122053
    Abstract: This invention relates to IP receptor antagonists selected from the group of compounds represented by Formula I: 1
    Type: Application
    Filed: December 9, 2003
    Publication date: June 24, 2004
    Inventors: Keith Roger Bley, Robin Douglas Clark, Alam Jahangir, Bruce Andrew Kowalczyk, Francisco Javier Lopez-Tapia, Alexander Victor Muehldorf, Counde O'Yang, Thomas Weitao Sun
  • 4-Piperazinyl benzenesulfonyl indoles and uses thereof
    Publication number: 20040087593
    Abstract: This invention relates to compounds which have generally 5-HT6 receptor affinity and which are represented by Formula I: 1
    Type: Application
    Filed: October 16, 2003
    Publication date: May 6, 2004
    Inventors: Robin Douglas Clark, Ralph New Harris, David Bruce Repke
  • 2-(substituted-phenyl)amino-imidazoline derivatives
    Patent number: 6693200
    Abstract: This invention relates to IP receptor antagonists selected from the group of compounds represented by Formula I: where: R1 is a group represented by formula (A), (B) or (C); and other substituents as defined in the specification, and their pharmaceutically acceptable salts or crystal forms thereof; and pharmaceutical compositions containing them; and methods for their use as therapeutic agents.
    Type: Grant
    Filed: April 29, 2003
    Date of Patent: February 17, 2004
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Keith Roger Bley, Robin Douglas Clark, Alam Jahangir, Bruce Andrew Kowalczyk, Francisco Javier Lopez-Tapia, Alexander Victor Muehldorf, Counde O'Yang, Thomas Weitao Sun
  • Benzoxazine derivatives and uses thereof
    Publication number: 20030232825
    Abstract: The present invention provides a compound of the formula: 1
    Type: Application
    Filed: May 9, 2003
    Publication date: December 18, 2003
    Applicant: Roche Palo Alto LLC
    Inventors: Jacob Berger, Robin Douglas Clark, Shu-Hai Zhao
  • 2-(Substituted-phenyl)amino-imidazoline derivatives
    Publication number: 20030229123
    Abstract: This invention relates to IP receptor antagonists selected from the group of compounds represented by Formula I: 1
    Type: Application
    Filed: April 29, 2003
    Publication date: December 11, 2003
    Inventors: Keith Roger Bley, Robin Douglas Clark, Alam Jahangir, Bruce Andrew Kowalczyk, Francisco Javier Lopez-Tapia, Alexander Victor Muehldorf, Counde O'Yang, Thomas Weitao Sun