Patents by Inventor Robin Douglas Clark

Robin Douglas Clark has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 1-Sulfonyl-4-aminoalkoxy indole derivatives and uses thereof
    Publication number: 20030229069
    Abstract: The present invention provides a compound of the formula: 1
    Type: Application
    Filed: June 4, 2003
    Publication date: December 11, 2003
    Applicant: Roche Palo Alto LLC
    Inventors: Robin Douglas Clark, Shu-Hai Zhao
  • 2-(substituted-phenyl)amino-imidazoline derivatives
    Patent number: 6596876
    Abstract: This invention relates to IP receptor antagonists selected from the group of compounds represented by Formula I: where: R1 is a group represented by formula (A), (B) or (C);  and other substituents as defined in the specification, and their pharmaceutically acceptable salts or crystal forms thereof; and pharmaceutical compositions containing them; and methods and their use as therapeutic agents.
    Type: Grant
    Filed: May 31, 2002
    Date of Patent: July 22, 2003
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Keith Roger Bley, Robin Douglas Clark, Alam Jahangir, Bruce Andrew Kowalczyk, Francisco Javier Lopez-Tapia, Alexander Victor Muehldorf, Counde O'Yang, Thomas Weitao Sun
  • New indole derivatives with 5HT6 receptor affinity
    Publication number: 20030073700
    Abstract: This invention relates to compounds which have generally 5-HT6 receptor affinity and which are represented by Formula I: 1
    Type: Application
    Filed: June 6, 2002
    Publication date: April 17, 2003
    Inventors: Colin Charles Beard, Robin Douglas Clark, Lawrence Emerson Fisher, Ralph New Harris, David Bruce Repke
  • New arylsulfonyl derivatives with 5-HT6 receptor affinity
    Publication number: 20030069254
    Abstract: This invention relates to compounds which have generally 5-HT6 receptor affinity and which are represented by Formula (I): 1
    Type: Application
    Filed: August 9, 2002
    Publication date: April 10, 2003
    Inventors: Jacob Berger, Robin Douglas Clark, Shu-Hai Zhao
  • 4-piperazinylindole derivatives with 5-HT6 receptor affinity
    Publication number: 20030045527
    Abstract: This invention relates to compounds which have generally 5-HT6 receptor affinity and which are represented by Formula I: 1
    Type: Application
    Filed: June 14, 2002
    Publication date: March 6, 2003
    Inventors: Andrew John Briggs, Robin Douglas Clark, Ralph New Harris, David Bruce Repke, Douglas Leslie Wren
  • 2-(substituted-phenyl)amino-imidazoline derivatives
    Publication number: 20030036655
    Abstract: This invention relates to IP receptor antagonists selected from the group of compounds represented by Formula I: 1
    Type: Application
    Filed: May 31, 2002
    Publication date: February 20, 2003
    Inventors: Keith Roger Bley, Robin Douglas Clark, Alam Jahangir, Bruce Andrew Kowalczyk, Francisco Javier Lopez-Tapia, Alexander Victor Muehldorf, Counde O'Yang, Thomas Weitao Sun
  • 2-(substituted-phenyl)amino-imidazoline derivatives
    Patent number: 6472536
    Abstract: This invention relates to IP receptor antagonists selected from the group of compounds represented by Formula I: where: R1 is a group represented by formula (A), (B) or (C); and other substituents as defined in the specification, and their pharmaceutically acceptable salts or crystal forms thereof; and pharmaceutical compositions containing them; and methods for their use as therapeutic agents.
    Type: Grant
    Filed: September 19, 2000
    Date of Patent: October 29, 2002
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Keith Roger Bley, Robin Douglas Clark, Alam Jahangir, Bruce Andrew Kowalczyk, Francisco Javier Lopez-Tapia, Alexander Victor Muehldorf, Counde O'Yang, Thomas Weitao Sun
  • Substituted 2-(4-piperidyl)-4(3H)-quinazolinones and 2-(4-piperidyl)-4(3H)-azaquinazolinones
    Patent number: 6376500
    Abstract: This invention relates to compounds which are generally alpha1A/B-receptor antagonists and which are represented by Formula I: wherein the substituents are as defined in the specification; or pharmaceutically acceptable salts, hydrates, or N-oxides thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and a process for their preparation.
    Type: Grant
    Filed: March 8, 2001
    Date of Patent: April 23, 2002
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Robin Douglas Clark, Counde O'Yang
  • Substituted 2-(4-piperidyl)-4(3H)-quinazolinones and 2-(4-piperidyl)- 4(3H)-azaquinazolinones
    Publication number: 20010051627
    Abstract: This invention relates to compounds which are generally alpha1A/B-receptor antagonists and which are represented by Formula I: 1
    Type: Application
    Filed: March 8, 2001
    Publication date: December 13, 2001
    Inventors: Robin Douglas Clark, Counde O'Yang
  • 2-arylethyl-(piperidin-4-ylmethyl)amine derivatives
    Patent number: 6319920
    Abstract: This invention relates to muscarinic receptor antagonist compounds selected from the group of compounds represented by Formula I: wherein the substituents are as defined in the specification; and their pharmaceutically acceptable salts, individual isomers or a racemic or non-racemic mixture; pharmaceutical compositions containing them; and methods for their use as therapeutic agents.
    Type: Grant
    Filed: February 1, 1999
    Date of Patent: November 20, 2001
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Joan Marie Caroon, Robin Douglas Clark, Michael Patrick Dillon, Ralph New Harris, III, Sharathchandra Surendra Hegde, Clara Jeou Jen Lin, Hans Maag, David Bruce Repke
  • Substituted 2(4-piperidyl)-4(3H)-quinazolinones and 2-(4-piperidyl)-4(3H)-azaquinazolinones
    Patent number: 6258819
    Abstract: This invention relates to compounds which are generally alpha1A/B-receptor antagonists and which are represented by Formula I: wherein the substituents are as defined in the specification; or pharmaceutically acceptable salts, hydrates, or N-oxides thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and a process for their preparation.
    Type: Grant
    Filed: July 27, 2000
    Date of Patent: July 10, 2001
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Robin Douglas Clark, Counde O'Yang
  • 2-(substituted-phenyl)amino-imidazoline derivatives
    Patent number: 6184242
    Abstract: This invention relates to IP receptor antagonists selected from the group of compounds represented by Formula I: where: R1 is a group represented by formula (A), (B) or (C); and other substituents as defined in the specification, and their pharmaceutically acceptable salts or crystal forms thereof; and pharmaceutical compositions containing them; and methods for their use as therapeutic agents.
    Type: Grant
    Filed: August 20, 1998
    Date of Patent: February 6, 2001
    Assignee: Syntex USA (LLC)
    Inventors: Keith Roger Bley, Robin Douglas Clark, Alam Jahangir, Bruce Andrew Kowalczyk, Francisco Javier Lopez-Tapia, Alexander Victor Muehldorf, Counde O'Yang, Thomas Weitao Sun
  • Dihydrobenzodioxine carboxamide and ketone derivatives
    Patent number: 6172062
    Abstract: This invention relates to certain 5-HT4 receptor modulators, particularly 5-HT4 receptor antagonists, represented by Formula I: wherein Z is formula (A) or (B): wherein R1, R2, R3, R4, and R5 and the other substituents are as defined in the specification; or individual isomers, racemic or non-racemic mixtures of isomers, and pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds and methods for their use as therapeutic agents.
    Type: Grant
    Filed: September 2, 1999
    Date of Patent: January 9, 2001
    Assignee: Syntex (USA) LLC
    Inventors: Robin Douglas Clark, Alam Jahangir
  • 1-phenylalkanone 5-HT.sub.4 receptor ligands
    Patent number: 5763458
    Abstract: The present invention relates to novel 5-HT.sub.4 receptor ligands which are 1-(5-halo-4-aminophenyl) (C.sub.2-6)alkan-1-one derivatives in which the 5-halo-4-aminophenyl group is substituted at its 2-position with (C.sub.1-4)alkyloxy or phenyl(C.sub.1-4)alkyloxy and optionally substituted at its 3-position with (C.sub.1-4)alkyloxy or substituted at its 2- and 3-positions together with methylenedioxy or ethylenedioxy and the highest numbered carbon of the (C.sub.2-6)alkan-1-one is substituted with di(C.sub.1-4)alkylamino, morpholin-1-yl or pyrrolidin-1-yl or optionally substituted piperidin-1-yl, piperidin-4-yl, azacyclohept-1-yl, azabicyclo?2.2.1!hept-3-yl, azabicylo?2.2.2!oct-3-yl or azabicylo?3.2.2!non-3-yl; and the pharmaceutically acceptable salts, individual isomers and mixtures of isomers and methods of using and making such derivatives.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: June 9, 1998
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Robin Douglas Clark, Richard Malcolm Eglen, John Otis Gardner, Alam Jahangir, Aaron Bayne Miller