Abstract: A message processing facility is described. The facility receives user input defining a textual message intended for an addressee service principal. Before sending the defined textual message, the facility analyzes the defined textual message to determine a textual message category to which the defined textual message belongs among a plurality of textual message categories.

Abstract: The present invention relates to the prevention and/or treatment of retinal disorders, such as cone dystrophies, cone-rod dystrophies, in particular Achromatopsia.

Abstract: The described invention provides compositions and methods for treating a fibrotic condition in a subject. The methods include administering a therapeutic amount of a pharmaceutical composition comprising synthetic extracellular vesicles (EVs) and a pharmaceutically acceptable carrier.

Abstract: The described invention provides compositions and methods for treating a fibrotic condition in a subject. The methods include administering a therapeutic amount of a pharmaceutical composition comprising synthetic extracellular vesicles (EVs) and a pharmaceutically acceptable carrier.

Abstract: The described invention provides compositions and methods for treating a fibrotic condition in a subject. The methods include administering a therapeutic amount of a pharmaceutical composition comprising synthetic extracellular vesicles (EVs) and a pharmaceutically acceptable carrier.

Abstract: A method for fabricating an optical waveguide comprises: providing a sample of lithium niobate doped with magnesium oxide and having at least one grating of periodic domain inversion defined therein; applying a layer of metallic zinc to a surface of the sample over the at least one grating using sputter deposition; heating the sample in an atmosphere of pure oxygen to cause the zinc to indiffuse into the lithium niobate to form a waveguiding layer of increased refractive index under the surface of the sample; and using a dicing blade to cut two substantially parallel channels along a length direction of the at least one grating, to define a ridge waveguide between the two channels.

Abstract: A fluid transfer apparatus is illustrated and described. The fluid transfer apparatus includes a fluid inlet, a fluid outlet and a fluid transfer device. The fluid inlet is associated with a fluid receptacle receiving portion, and the fluid receptacle receiving portion is configured to receive and engage at least a portion of a fluid receptacle. The fluid transfer apparatus is configurable between a first isolation state, in which the fluid transfer device is isolated from the fluid receptacle, such that the fluid container is fluidically isolated from the fluid inlet, to a second coupled state, in which the fluid transfer device is engaged with the fluid receptacle, such that the fluid receptacle is in fluid communication with the fluid inlet.

Abstract: The described invention provides compositions and methods for treating a fibrotic condition in a subject. The methods include administering a therapeutic amount of a pharmaceutical composition comprising synthetic extracellular vesicles (EVs) and a pharmaceutically acceptable carrier.

Abstract: A method of forming an optical fibre assembly, comprises providing a planar substrate made of a first material; positioning an optical fibre with an outer layer of a first glass material on a surface of the substrate to form a pre-assembly; depositing a further glass material such as silica soot onto the pre-assembly, over at least a part of the optical fibre and adjacent parts of the substrate surface; and heating the pre-assembly to consolidate the further glass material into an amorphous volume in contact with at least parts of the surface of the substrate and the outer layer of the optical fibre, thereby bonding the optical fibre to the substrate to create the optical fibre assembly.

Abstract: Described herein are various embodiments of systems, methods, and apparatus that allow a user to share data, such as one or more files from within an application with one or more other (not necessarily co-located) computing devices using a gesture-based sharing function. In a particular example, systems, methods, and apparatus described herein may be used to share graphical representations of chemical structures within a chemical structure rendering application between two or more user devices. By offering a user a quick and visually intuitive option for sharing a file with other user(s) without exiting a current application, the systems, methods, and apparatus described herein provide efficient and engaging tools for sharing work product in real time between two or more users.

Abstract: An injector having a two stage injection comprising: an outer housing having a first end and a second end; and a plunger assembly for being received within the outer housing and comprising a barrel having a needle disposed at an end thereof and a plunger for dispensing a fluid through the needle; in use the plunger assembly being moveable within the outer housing between a retracted position wherein the needle is at least partially housed within the outer housing and an engaged position wherein the needle projects outwardly of a needle opening located at the first end of the outer housing and whereby a rotary inhibiting mechanism interacts with the plunger assembly to inhibit movement of the plunger within the barrel until the plunger assembly has reached the engaged position.

Abstract: A multi-purpose personal watercraft for deployment in different configurations as desired by a user. The multi-purpose personal watercraft comprises a base frame which forms a watercraft base which includes side extensions, an aft floor board, and a bow portion, as well as two opposing mirror image side floats with which the base frame is selectively integrated. When in place, the opposing side floats form the multi-purpose personal watercraft's U shaped hull and enable the selective attachment of a rudder assembly behind the multi-purpose personal watercraft's stern. With respect to propulsion, base frame is configured to enable the selective deployment of pedal propellers, a user's legs, or a trolling motor. A dual steering system enables the control of up to two discrete steering mechanisms from a single position on the watercraft.

Abstract: A method for compensating perturbed measurements comprises: obtaining measurements with respect to time of a signal representing a parameter modified by a perturbing influence and a signal representing the perturbing influence and storing the measurements for each time in a data array as parameter data and perturbation data respectively; for each of the parameter data and the perturbation data: fitting a mathematical model to the data with respect to time; determining an error between the model and the data at each time; storing the errors in the data array as normalised parameter data and normalised perturbation data respectively; fitting a mathematical model to the normalised parameter data against the normalised perturbation data to obtain a correlation function representing correlation between the parameter data and the perturbation data; using the correlation function to calculate a correction factor representing the modification of the parameter data by the perturbing influence; using the correction fac

Abstract: The present invention relates to an improvement to the treatment of needles for safe disposal. The device comprises a support member having at least one recess. Each said at least one recess is configured to receive a needle contained in a corresponding plastic needle cap. The device further comprises a heating element configured to heat the support member, such that the plastic material of the needle cap softens and flows to encapsulate the corresponding needle. Each said at least one recess has dimensions such that, after heating, the needle is fully encapsulated by the plastic material of the corresponding needle cap. A corresponding method is disclosed.

Abstract: A system and method for language instruction for implementation on a language instruction system that includes a computer system, is disclosed, wherein the method may include identifying a speech segment in a target language, that is susceptible to mispronunciation by language learners; selecting an auditory attribute for use in playing the identified speech segment by the language instruction system; altering a level of the auditory attribute to differ from a naturally occurring level of the attribute; and playing a first text sequence by the language instruction system, including at least one instance of the identified speech segment, using the altered level of the auditory attribute.

Abstract: An apparatus for removal of an animal body part, the apparatus comprising a ligature applicator, the ligature applicator being configured to move a ligature between a first, extended state in which the ligature can be passed over the animal body part to a selected application position, and a second, retracted state in which the ligature applies a compressive force at the application position to restrict blood flow in the animal body part; and a substance applicator, the substance applicator being configured to deliver a substance to the animal.

Abstract: A multi-purpose personal watercraft for deployment in different configurations as desired by a user. The multi-purpose personal watercraft comprises a base frame which forms a watercraft base which includes side extensions, an aft floor board, and a bow portion, as well as two opposing mirror image side floats with which the base frame is selectively integrated. When in place, the opposing side floats form the multi-purpose personal watercraft's U shaped hull and enable the selective attachment of a rudder assembly behind the multi-purpose personal watercraft's stern. With respect to propulsion, base frame is configured to enable the selective deployment of pedal propellers, a user's legs, or a trolling motor. A dual steering system enables the control of up to two discrete steering mechanisms from a single position on the watercraft.

Abstract: A method of controlling additive delivery during a bioreaction in a bioreactor comprises running a bioreaction in a bioreactor including adding additive into the bioreactor during spaced-apart feed events, where contents of the bioreactor equilibrate during a stabilisation period after a feed event; making in situ measurements of a bulk physical property of the bioreactor contents during the bioreaction to obtain process trend data; calculating a derivative of process trend data obtained over a measurement period beginning after a stabilisation period, the derivative being a metabolic rate index (MRI); and using the MRI to determine a time for starting a next feed event. A controller for a bioreactor and a bioreactor system are configured to operate according to the method.

Abstract: A multi-purpose personal watercraft for deployment in different configurations as desired by a user. The multi-purpose personal watercraft comprises a base frame defining a watercraft base which includes selectively foldable side extensions, a removable aft floor board, and a bow portion, as well as two opposing side floats with which the base frame is selectively integrated. When in place, the opposing side floats defines form the multi-purpose personal watercraft's U shaped hull and enable the selective attachment of a rudder assembly. With respect to propulsion, base frame is configured to enable the selective deployment of pedal propellers, a user's legs, or a trolling motor. A dual steering system enables the control of up to two discrete steering mechanisms from a single position on the watercraft.

Abstract: A method of forming an optical fibre assembly, comprises providing a planar substrate made of a first material; positioning an optical fibre with an outer layer of a first glass material on a surface of the substrate to form a pre-assembly; depositing a further glass material such as silica soot onto the pre-assembly, over at least a part of the optical fibre and adjacent parts of the substrate surface; and heating the pre-assembly to consolidate the further glass material into an amorphous volume in contact with at least parts of the surface of the substrate and the outer layer of the optical fibre, thereby bonding the optical fibre to the substrate to create the optical fibre assembly.