Abstract: The described invention provides compositions and methods for treating a fibrotic condition in a subject. The methods include administering a therapeutic amount of a pharmaceutical composition comprising synthetic extracellular vesicles (EVs) and a pharmaceutically acceptable carrier.

Abstract: The present disclosure provides a composition containing a purified population of plant-derived exosome-like nanoparticles isolated from tissue of a vascular plant, wherein the exosome-like nanoparticles comprise a tuned cargo comprising a protein signature and an miRNA signature, wherein the tuned cargo of the plant-derived exosome-like nanoparticles is a result of exposure of the plant to combinations of abiotic stress conditions that cause the plant to modulate its signaling pathways and metabolism to ensure its survival in a challenging environment. The tuned cargo of the plant-derived exosome-like nanoparticles can modulate bioactivities of mammalian cells directly or indirectly.

Abstract: The described invention provides compositions and methods for treating a susceptible subject at risk of pulmonary complications of an acute lung injury caused by a severe infection with a respiratory virus and for restoring lung function to donor lungs. The methods include administering a therapeutic amount of a pharmaceutical composition comprising extracellular vesicles (EVs) comprising one or more miRNAs and a pharmaceutically acceptable carrier. The population of EVs can be derived from a patient who has recovered from an infection with the respiratory virus or has been exposed to anti-viral antibodies through treatment, can be derived from MSCs of a normal healthy individual, can be modified by a viral vector, or can be synthetic.

Abstract: The described invention provides compositions and methods for treating a susceptible subject at risk of pulmonary complications of an acute lung injury caused by a severe infection with a respiratory virus and for restoring lung function to donor lungs. The methods include administering a therapeutic amount of a pharmaceutical composition comprising extracellular vesicles (EVs) comprising one or more miRNAs and a pharmaceutically acceptable carrier. The population of EVs can be derived from a patient who has recovered from an infection with the respiratory virus or has been exposed to anti-viral antibodies through treatment, can be derived from MSCs of a normal healthy individual, can be modified by a viral vector, or can be synthetic.

Abstract: The described invention provides compositions and methods for treating a fibrotic condition in a subject. The methods include administering a therapeutic amount of a pharmaceutical composition comprising synthetic extracellular vesicles (EVs) and a pharmaceutically acceptable carrier.

Abstract: The described invention provides compositions and methods for treating a fibrotic condition in a subject. The methods include administering a therapeutic amount of a pharmaceutical composition comprising synthetic extracellular vesicles (EVs) and a pharmaceutically acceptable carrier.

Abstract: The described invention provides compositions and methods for treating a fibrotic condition in a subject. The methods include administering a therapeutic amount of a pharmaceutical composition comprising synthetic extracellular vesicles (EVs) and a pharmaceutically acceptable carrier.

Abstract: A fluid transfer apparatus is illustrated and described. The fluid transfer apparatus includes a fluid inlet, a fluid outlet and a fluid transfer device. The fluid inlet is associated with a fluid receptacle receiving portion, and the fluid receptacle receiving portion is configured to receive and engage at least a portion of a fluid receptacle. The fluid transfer apparatus is configurable between a first isolation state, in which the fluid transfer device is isolated from the fluid receptacle, such that the fluid container is fluidically isolated from the fluid inlet, to a second coupled state, in which the fluid transfer device is engaged with the fluid receptacle, such that the fluid receptacle is in fluid communication with the fluid inlet.

Abstract: The described invention provides compositions and methods for treating a fibrotic condition in a subject. The methods include administering a therapeutic amount of a pharmaceutical composition comprising synthetic extracellular vesicles (EVs) and a pharmaceutically acceptable carrier.

Abstract: Described herein are various embodiments of systems, methods, and apparatus that allow a user to share data, such as one or more files from within an application with one or more other (not necessarily co-located) computing devices using a gesture-based sharing function. In a particular example, systems, methods, and apparatus described herein may be used to share graphical representations of chemical structures within a chemical structure rendering application between two or more user devices. By offering a user a quick and visually intuitive option for sharing a file with other user(s) without exiting a current application, the systems, methods, and apparatus described herein provide efficient and engaging tools for sharing work product in real time between two or more users.

Abstract: An injector having a two stage injection comprising: an outer housing having a first end and a second end; and a plunger assembly for being received within the outer housing and comprising a barrel having a needle disposed at an end thereof and a plunger for dispensing a fluid through the needle; in use the plunger assembly being moveable within the outer housing between a retracted position wherein the needle is at least partially housed within the outer housing and an engaged position wherein the needle projects outwardly of a needle opening located at the first end of the outer housing and whereby a rotary inhibiting mechanism interacts with the plunger assembly to inhibit movement of the plunger within the barrel until the plunger assembly has reached the engaged position.

Abstract: A multi-purpose personal watercraft for deployment in different configurations as desired by a user. The multi-purpose personal watercraft comprises a base frame which forms a watercraft base which includes side extensions, an aft floor board, and a bow portion, as well as two opposing mirror image side floats with which the base frame is selectively integrated. When in place, the opposing side floats form the multi-purpose personal watercraft's U shaped hull and enable the selective attachment of a rudder assembly behind the multi-purpose personal watercraft's stern. With respect to propulsion, base frame is configured to enable the selective deployment of pedal propellers, a user's legs, or a trolling motor. A dual steering system enables the control of up to two discrete steering mechanisms from a single position on the watercraft.

Abstract: A system and method for language instruction for implementation on a language instruction system that includes a computer system, is disclosed, wherein the method may include identifying a speech segment in a target language, that is susceptible to mispronunciation by language learners; selecting an auditory attribute for use in playing the identified speech segment by the language instruction system; altering a level of the auditory attribute to differ from a naturally occurring level of the attribute; and playing a first text sequence by the language instruction system, including at least one instance of the identified speech segment, using the altered level of the auditory attribute.

Abstract: An apparatus for removal of an animal body part, the apparatus comprising a ligature applicator, the ligature applicator being configured to move a ligature between a first, extended state in which the ligature can be passed over the animal body part to a selected application position, and a second, retracted state in which the ligature applies a compressive force at the application position to restrict blood flow in the animal body part; and a substance applicator, the substance applicator being configured to deliver a substance to the animal.

Abstract: A multi-purpose personal watercraft for deployment in different configurations as desired by a user. The multi-purpose personal watercraft comprises a base frame which forms a watercraft base which includes side extensions, an aft floor board, and a bow portion, as well as two opposing mirror image side floats with which the base frame is selectively integrated. When in place, the opposing side floats form the multi-purpose personal watercraft's U shaped hull and enable the selective attachment of a rudder assembly behind the multi-purpose personal watercraft's stern. With respect to propulsion, base frame is configured to enable the selective deployment of pedal propellers, a user's legs, or a trolling motor. A dual steering system enables the control of up to two discrete steering mechanisms from a single position on the watercraft.

Abstract: A multi-purpose personal watercraft for deployment in different configurations as desired by a user. The multi-purpose personal watercraft comprises a base frame defining a watercraft base which includes selectively foldable side extensions, a removable aft floor board, and a bow portion, as well as two opposing side floats with which the base frame is selectively integrated. When in place, the opposing side floats defines form the multi-purpose personal watercraft's U shaped hull and enable the selective attachment of a rudder assembly. With respect to propulsion, base frame is configured to enable the selective deployment of pedal propellers, a user's legs, or a trolling motor. A dual steering system enables the control of up to two discrete steering mechanisms from a single position on the watercraft.

Abstract: A multi-purpose personal watercraft for deployment in different configurations as desired by a user. The multi-purpose personal watercraft comprises a base frame defining a watercraft base which includes selectively foldable side extensions, a removable aft floor board, and a bow portion, as well as two opposing side floats with which the base frame is selectively integrated. When in place, the opposing side floats defines form the multi-purpose personal watercraft's U shaped hull and enable the selective attachment of a rudder assembly. With respect to propulsion, base frame is configured to enable the selective deployment of pedal propellers, a user's legs, or a trolling motor. A dual steering system enables the control of up to two discrete steering mechanisms from a single position on the watercraft.

Abstract: A method of growing III-N material on a silicon substrate includes the steps of epitaxially growing a single crystal rare earth oxide on a silicon substrate, epitaxially growing a single crystal rare earth nitride on the single crystal rare earth oxide, and epitaxially growing a layer of single crystal III-N material on the single crystal rare earth nitride.

Abstract: Rare earth semiconductor and ferromagnetic material epitaxially grown on a silicon substrate includes a buffer of single crystal epitaxial rare earth/aluminum nitride positioned on a single crystal silicon substrate and a single crystal epitaxial rare earth oxide positioned on the single crystal epitaxial aluminum nitride. A layer of single crystal epitaxial semiconductor and ferromagnetic rare earth nitride is positioned on the buffer. A layer of III-V semiconductive material may be optionally positioned on the rare earth nitride layer.

Abstract: Rare earth oxy-nitride buffered III-N on silicon includes a silicon substrate with a rare earth oxide (REO) structure, including several REO layers, is deposited on the silicon substrate. A layer of single crystal rare earth oxy-nitride is deposited on the REO structure. The REO structure is stress engineered to approximately crystal lattice match the layer of rare earth oxy-nitride so as to provide a predetermined amount of stress in the layer of rare earth oxy-nitride. A III oxy-nitride structure, including several layers of single crystal rare earth oxy-nitride, is deposited on the layer of rare earth oxy-nitride. A layer of single crystal III-N nitride is deposited on the III oxy-nitride structure. The III oxy-nitride structure is chemically engineered to approximately crystal lattice match the layer of III-N nitride and to transfer the predetermined amount of stress in the layer of rare earth oxy-nitride to the layer of III-N nitride.