Patents by Inventor Roderick Alan Porter

Roderick Alan Porter has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • N-AROYL CYCLIC AMINES
    Publication number: 20090029986
    Abstract: Disclosed are N-aroyl cyclic amine derivatives having the formula: wherein the substituent variables are as defined herein, and their use as pharmaceuticals.
    Type: Application
    Filed: October 29, 2007
    Publication date: January 29, 2009
    Inventors: Clive Leslie BRANCH, Steven Coulton, Amanda Johns, Christopher Norbert Johnson, Roderick Alan Porter, Geoffrey Stemp, Kevin Thewlis
  • N-AROYL CYCLIC AMINES
    Publication number: 20090012073
    Abstract: Disclosed are N-aroyl cyclic amine derivatives having the formula: wherein the substituent variables are as defined herein, and their use as pharmaceuticals.
    Type: Application
    Filed: October 26, 2007
    Publication date: January 8, 2009
    Inventors: Clive Leslie BRANCH, Steven Coulton, Amanda Johns, Christopher Norbert Johnson, Roderick Alan Porter, Geoffrey Stemp, Kevin Thewlis
  • N-AROYL CYCLIC AMINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS
    Publication number: 20090012122
    Abstract: Disclosed are N-aroyl cyclic amine derivatives having the formula: where the variables are as define herein, and their use as pharmaceuticals, specifically as orexin receptor antagonists.
    Type: Application
    Filed: October 30, 2007
    Publication date: January 8, 2009
    Inventors: Clive Leslie BRANCH, Wai Ngor Chan, Amanda Johns, Christopher Norbert Johnson, David John Nash, Riccardo Novelli, Jean-Pierre Pilleux, Roderick Alan Porter, Rachel Elizabeth, Anne Stead, Geoffrey Stemp
  • N-AROYL CYCLIC AMINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS
    Publication number: 20090012083
    Abstract: Disclosed are N-aroyl cyclic amine derivatives having the formula: where the variables are as define herein, and their use as pharmaceuticals, specifically as orexin receptor antagonists.
    Type: Application
    Filed: October 29, 2007
    Publication date: January 8, 2009
    Inventors: Clive Leslie BRANCH, Wai Ngor Chan, Amanda Johns, Christopher Norbert Johnson, David John Nash, Riccardo Novelli, Jean-Pierre Pilleux, Roderick Alan Porter, Rachel Elizabeth, Anne Stead, Geoffrey Stemp
  • N-aroyl cyclic amine derivatives as orexin receptor antagonists
    Patent number: 7470710
    Abstract: This invention relates to N-aroyl cyclic amine derivatives of formula (I), wherein X represents a bond, oxygen, NR3 or a group (CH2), wherein n represents 1, 2 or 3; Y represents CH2, CO, CH(OH), or CH2CH(OH); Het is an optionally substituted bicyclic heteroaryl group containing up to 4 heteroatoms selected from N, O and S; Ar2 represents an optionally substituted phenyl or a 5- or 6-membered heterocyclyl group containing up to 3 heteroatoms selected from N, O and S and their use as pharmaceuticals, specifically as orexin receptor antagonists.
    Type: Grant
    Filed: June 25, 2002
    Date of Patent: December 30, 2008
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Clive Leslie Branch, Wai Ngor Chan, Amanda Johns, Christopher Norbert Johnson, David John Nash, Riccardo Novelli, Jean-Pierre Pilleux, Roderick Alan Porter, Rachel Elizabeth Anne Stead, Geoffrey Stemp
  • N-AROYL CYCLIC AMINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS
    Publication number: 20080318944
    Abstract: Disclosed are N-aroyl cyclic amine derivatives having the formula: where the variables are as define herein, and their use as pharmaceuticals, specifically as orexin receptor antagonists.
    Type: Application
    Filed: October 29, 2007
    Publication date: December 25, 2008
    Inventors: Clive Leslie BRANCH, Wai Ngor Chan, Amanda Johns, Christopher Norbert Johnson, David John Nash, Riccardo Novelli, Jean-Pierre Pilleux, Roderick Alan Porter, Rachel Elizabeth, Anne Stead, Geoffrey Stemp
  • Ethylene diamine derivatives and their use as orexin-receptor antagonists
    Patent number: 7468367
    Abstract: This invention relates to heterocyclic substituted ethylene diamine derivatives and their use as pharmaceuticals.
    Type: Grant
    Filed: December 13, 2002
    Date of Patent: December 23, 2008
    Assignee: Smithkline Beecham p.l.c.
    Inventors: Steven Coulton, Amanda Johns, Roderick Alan Porter
  • Glycine Transport Inhibitors
    Publication number: 20080287547
    Abstract: The present invention relates to compounds of formula (I), or to salts or solvates thereof, their use in the manufacture of medicaments for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof.
    Type: Application
    Filed: December 21, 2005
    Publication date: November 20, 2008
    Inventors: Daniel Marcus Bradley, Clive Leslie Branch, Wai Ngor Chan, Steven Coulton, Martin Leonard Gilpin, Andrew Jonathan Harris, Albert Andrzej Jaxa-Chamiec, Justine Yeun Quai Lai, Jacqueline Anne Macritchie, Howard Robert Marshall, David John Nash, Roderick Alan Porter, Simone Spada, Kevin Michael Thewlis, Simon Edward Ward
  • Acylated Piperidines as Glycine Transporter Inhibitors
    Publication number: 20080255144
    Abstract: The invention provides a compound of formula (I) or a salt or solvate thereof: wherein R1, n, X, Y and Z are as defined in the specification, and uses of such compounds. The compounds inhibit GlyT1 transporters and are useful in the treatment of certain neurological and neuropsychiatric disorders, including schizophrenia.
    Type: Application
    Filed: March 9, 2006
    Publication date: October 16, 2008
    Inventors: Daniel Marcus Bradley, Clive Leslie Branch, Wai Ngor Chan, Steven Coulton, Anthony William Dean, Paul Martin Doyle, Brian Evans, Martin Leonard Gilpin, Sharon Lisa Gough, Jacqueline Anne Macritchie, Howard Robert Marshall, David John Nash, Roderick Alan Porter, Simon Edward Ward
  • N-aroyl cyclic amines
    Patent number: 7432270
    Abstract: This invention relates to N-aroyl cyclic amine derivatives and their use as orexin antagonists wherein: Y represents a bond, oxygen, or a group (CH2)n, wherein n represents 1, 2 or 3; m represents 1, 2, or 3; p represents ) or 1; X is NR, wherein R is H or (C1-4)alkyl; Ar1 is aryl, or a mono or bicyclic heteroaryl group containing up to 3 heteroatoms selected from N, O and S; any of which may be optionally substituted; A2 represents phenyl or a 5- or 6-membered heterocyclyl group containing up to 3 heteroatoms selected from N, O and S, wherein the phenyl or heterocyclyl group is substituted by R1 and further optional substituents; or Ar2 represents an optionally substituted bicyclic aromatic or bicyclic heteroaromatic group containing up to 3 heteroatoms selected from N, O and S; R1 represents hydrogen, optionally substituted (C1-4)alkoxy, halo, cyano, optionally substituted (C1-6)alkyl, optionally substituted phenyl, or an optionally substituted 5- or 6-membered heterocyclyl group containing up to 4 het
    Type: Grant
    Filed: May 2, 2002
    Date of Patent: October 7, 2008
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Clive Leslie Branch, Steven Coulton, Amanda Johns, Christopher Norbert Johnson, Roderick Alan Porter, Geoffrey Stemp, Kevin Thewlis
  • Glyt1 Transporter Inhibitors and Uses Thereof in Treatment of Neurological and Neuropsychiatric Disorders
    Publication number: 20080221185
    Abstract: The invention provides a compound of formula (I) or a solvate thereof: wherein R1, R2, R3, R4, R5, R6, and n are as defined in the specification, and uses of such compounds. The compounds inhibit GlyT1 transporters and are useful in the treatment of certain neurological and neuropsychiatric disorders, including schizophrenia.
    Type: Application
    Filed: July 31, 2006
    Publication date: September 11, 2008
    Inventors: Anthony William Dean, Roderick Alan Porter
  • Piperidine compounds for use as orexin receptor antagoinst
    Patent number: 7423052
    Abstract: A invention relates to N aroyl cyclic amine derivatives and their use as pharmaceuticals, specifically as orexin receptor antagonists.
    Type: Grant
    Filed: June 25, 2002
    Date of Patent: September 9, 2008
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Wai Ngor Chan, Amanda Johns, Christopher Norbert Johnson, Riccardo Novelli, Roderick Alan Porter
  • Compounds Having Activity At Nk3 Receptor And Uses Thereof In Medicine
    Publication number: 20080103173
    Abstract: The present invention relates to compounds of formula (I), a pharmaceutically acceptable salt or solvate thereof: wherein n, m and p, which may be the same or different, are either 0 or 1. Also disclosed are processes for their preparation, pharmaceutical compositions containing them and their use as medicaments particularly in treating disorders of the central nervous system (CNS).
    Type: Application
    Filed: November 10, 2005
    Publication date: May 1, 2008
    Applicant: SMITHKLINE BEECHAM CORPORATION
    Inventors: Roderick Alan Porter, Paul William Smith
  • Benzamide derivatives as antagonists of orexin receptors
    Patent number: 7078565
    Abstract: Disclosed are phenyl-alkylene benzamides useful as orexin antagonists
    Type: Grant
    Filed: October 30, 2002
    Date of Patent: July 18, 2006
    Assignee: SmithKline Beecham plc
    Inventors: Wai Ngor Chan, Amanda Johns, Roderick Alan Porter, Rachel Elizabeth Anne Stead, Mythily Vimal
  • Piperidine compounds for use as orexin receptor antagonist
    Publication number: 20040215014
    Abstract: A invention relates to N auroyl cyclic amine derivatives and their use as pharmaceuticals, specifically as orexin receptor antagonists.
    Type: Application
    Filed: December 17, 2003
    Publication date: October 28, 2004
    Inventors: Wai Ngor Chan, Amanda Johns, Christopher Norbert Johnson, Riccardo Novelli, Roderick Alan Porter
  • N-aroyl cyclic amine derivatives as orexin receptor antagonists
    Publication number: 20040192673
    Abstract: This invention relates to N-aroyl cyclic amine derivatives of formula (I): wherein: Y represents a bond, oxygen, or a group (CH2)n, wherein n represents 1, 2 or 3 m represents 1, 2 or 3; p represents 0 or 1; X is O,SC═O, SO2, or —CH═CH; Ar1 is aryl, or a mono or bicyclic heteroaryl group containing up to 4 heteroatoms selected from N, O and S; any of which may be optionally substituted; Ar2 represents phenyl or a 5- or 5-membered heterocyclyl group containing up to 3 heteroatoms selected from N, O and S, wherein the phenyl or heterocyclyl group is substituted by R1 and further optional substituents; or Ar2 represents an optionally substituted bicyclic aromatic or bicyclic heteroaromatic group containing up to 3 heteroatoms selected from N, O and S; R1 represents hydrogen, optionally substituted (C1-4)alkoxy, halo, cyano, optionally substituted (C1-16)alkyl, optionally substituted 5- or 6-membered heterocyclic ring containing up to 4 heteroatoms selected from N, O and S; or a pharmaceutical acc
    Type: Application
    Filed: April 15, 2004
    Publication date: September 30, 2004
    Inventors: Pascale Gaillard, Christopher Norbert Johnson, Riccardo Novelli, Roderick Alan Porter, Geoffrey Stemp, Kevin Michael Thewlis
  • N-aroyl cyclic amines
    Publication number: 20040143115
    Abstract: This invention relates to N-aroyl cyclic amine derivatives and their use as orexin antagonists 1
    Type: Application
    Filed: November 5, 2003
    Publication date: July 22, 2004
    Inventors: Clive Leslie Branch, Steven Coulton, Amanda Johns, Christopher Norbert Johnson, Roderick Alan Porter, Geoffrey Stemp, Kevin Thewlis
  • Phenyl urea and phenyl thiourea derivatives as orexin receptor antagonists
    Patent number: 6699879
    Abstract: The present invention provides phenyl urea and phenyl thiourea derivatives which are non-peptide antagonists of human orexin receptors, in particular orexin-1 receptors, of formula (I) in which: Z represents oxygen or sulfur; and R1 to R7 represent various substituent groups; and pharmaceutically acceptable salts thereof. In particular, these compounds are of potential use in the treatment of obesity including obesity observed in Type 2(non-insulin-dependent) diabetes patients and/or sleep disorders.
    Type: Grant
    Filed: April 29, 2002
    Date of Patent: March 2, 2004
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Steven Coulton, Amanda Johns, Roderick Alan Porter
  • Phenyl urea and phenyl thiourea derivatives
    Patent number: 6596730
    Abstract: Compounds of formula (I): in which: one of X and Y is N and the other is CH; Z represents oxygen or sulfur; and R1 to R7 represent various substituent groups; and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: December 5, 2001
    Date of Patent: July 22, 2003
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Steven Coulton, Amanda Johns, Roderick Alan Porter
  • Pyrimidinone compounds and pharmaceutical compositions containing them
    Publication number: 20020120139
    Abstract: A group of novel pyrimidone compounds are inhibitors of the enzyme LDL PLA2 and therefore of use in treating atherosclerosis.
    Type: Application
    Filed: April 2, 2002
    Publication date: August 29, 2002
    Inventors: Deirdre Mary Bernadette Hickey, Robert John Ife, Colin Andrew Leach, Ivan Leo Pinto, Roderick Alan Porter, Stephen Allan Smith