Patents by Inventor Roderick Peter Hafner
Roderick Peter Hafner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11690969Abstract: A delivery device for and a method of delivering gases to the nasal airway, in particular therapeutic gases and gases in combination with active substances, either as powders or liquids, for enhanced uptake of the active substances.Type: GrantFiled: August 6, 2020Date of Patent: July 4, 2023Assignee: OptiNose Inc.Inventors: Per Gisle Djupesland, Roderick Peter Hafner
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Publication number: 20230181849Abstract: A nasal delivery device for delivering substance to a nasal cavity of a subject, the delivery device comprising: a substance supply unit for supplying a dose of substance to be delivered to the nasal cavity of the subject, the substance supply unit including an inlet and an outlet; a nosepiece unit including a nosepiece for fitting to a nasal cavity of the subject and being in fluid communication with the outlet of the substance supply unit; and a mouthpiece unit including a mouthpiece in fluid communication with the inlet of the substance supply unit and through which the subject in use exhales such as to entrain substance from the container chamber and deliver the same through the nosepiece, and at least one temperature modifier for reducing a temperature of the exhaled air flow such as to reduce the absolute humidity thereof.Type: ApplicationFiled: February 6, 2023Publication date: June 15, 2023Applicant: OptiNose, Inc.Inventors: Per Gisle DJUPESLAND, Roderick Peter HAFNER, Colin David SHELDRAKE
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Patent number: 11571531Abstract: A nasal delivery device for delivering substance to a nasal cavity of a subject, the delivery device comprising: a substance supply unit for supplying a dose of substance to be delivered to the nasal cavity of the subject, the substance supply unit including an inlet and an outlet; a nosepiece unit including a nosepiece for fitting to a nasal cavity of the subject and being in fluid communication with the outlet of the substance supply unit; and a mouthpiece unit including a mouthpiece in fluid communication with the inlet of the substance supply unit and through which the subject in use exhales such as to entrain substance from the container chamber and deliver the same through the nosepiece, and at least one temperature modifier for reducing a temperature of the exhaled air flow such as to reduce the absolute humidity thereof.Type: GrantFiled: January 24, 2018Date of Patent: February 7, 2023Assignee: OptiNose Inc.Inventors: Per Gisle Djupesland, Roderick Peter Hafner, Colin David Sheldrake
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Publication number: 20210346621Abstract: Intranasal administration of proteins, such as insulin and insulin analogues, in particular immunogenic proteins to the upper posterior region of a nasal cavity of a subject, and in particular the olfactory bulb region.Type: ApplicationFiled: May 25, 2021Publication date: November 11, 2021Inventor: Roderick Peter HAFNER
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Publication number: 20210187216Abstract: A delivery device for and method of delivering a powdered substance, in particular a triptan, such as sumatriptan, to the posterior region of a nasal cavity of a subject, in particular for the treatment of headaches, for example, cluster headaches and migraine, and neuropathic pain, the delivery device comprising: a nosepiece for insertion into a nasal cavity of a subject through which the powdered substance is delivered to the posterior region of the nasal cavity of the subject, in particular the upper posterior two thirds of the nasal cavity; and a substance supply unit which is operable to deliver the powdered substance through the nosepiece.Type: ApplicationFiled: July 27, 2020Publication date: June 24, 2021Applicant: OptiNose ASInventors: Per Gisle Djupesland, Roderick Peter Hafner
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Publication number: 20210085907Abstract: A delivery device for and a method of delivering gases to the nasal airway, in particular therapeutic gases and gases in combination with active substances, either as powders or liquids, for enhanced uptake of the active substances.Type: ApplicationFiled: August 6, 2020Publication date: March 25, 2021Inventors: Per Gisle DJUPESLAND, Roderick Peter HAFNER
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Patent number: 10765829Abstract: A delivery device for and a method of delivering gases to the nasal airway, in particular therapeutic gases and gases in combination with active substances, either as powders or liquids, for enhanced uptake of the active substances.Type: GrantFiled: January 12, 2018Date of Patent: September 8, 2020Assignee: OptiNose ASInventors: Per Gisle Djupesland, Roderick Peter Hafner
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Publication number: 20200276401Abstract: A delivery device for and method of providing for delivery of substance to the central nervous system (CNS) of a subject, the delivery device comprising: a nosepiece unit (17) for insertion into a nasal airway (1) of a subject and comprising an outlet unit (21) which includes a nozzle (25) for delivering substance into the nasal airway of the subject; and a substance supply unit which is operable to deliver a dose of substance to the nozzle: wherein the delivery device is configured such that at least 30% of the dose as initially deposited in the nasal airway is deposited in an upper posterior region of the nasal airway, thereby providing a CNS concentration of the substance, and hence CNS effect, which is significantly greater than that which would be predicted from a counterpart blood plasma concentration of the substance.Type: ApplicationFiled: September 26, 2019Publication date: September 3, 2020Inventors: Per Gisle DJUPESLAND, Roderick Peter HAFNER
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Patent number: 10722667Abstract: A delivery device for and method of delivering a powdered substance, in particular a triptan, such as sumatriptan, to the posterior region of a nasal cavity of a subject, in particular for the treatment of headaches, for example, cluster headaches and migraine, and neuropathic pain, the delivery device comprising: a nosepiece for insertion into a nasal cavity of a subject through which the powdered substance is delivered to the posterior region of the nasal cavity of the subject, in particular the upper posterior two thirds of the nasal cavity; and a substance supply unit which is operable to deliver the powdered substance through the nosepiece.Type: GrantFiled: April 7, 2017Date of Patent: July 28, 2020Assignee: OptiNose ASInventors: Per Gisle Djupesland, Roderick Peter Hafner
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Publication number: 20200023146Abstract: A nasal delivery device for and method of delivering substance to a nasal cavity of a subject, the delivery device comprising: a container-receiving unit comprising a container chamber for receiving a substance-containing container which contains substance to be delivered to the nasal cavity of the subject, the container chamber including an inlet and an outlet; a nosepiece unit including a nosepiece for fitting to a nasal cavity of the subject and being in fluid communication with the outlet of the container chamber; a mouthpiece unit including a mouthpiece in fluid communication with the inlet of the container chamber and through which the subject in use exhales, such as to entrain substance from the container and deliver the same through the nosepiece; and moisture-mitigation means for mitigating an effect of moisture in an exhaled breath on the entrainment of substance from the container, which means are provided, for example, by providing the container in a replaceable container-containing member, by a pType: ApplicationFiled: July 30, 2019Publication date: January 23, 2020Inventors: Per Gisle DJUPESLAND, Roderick Peter HAFNER, Colin David SHELDRAKE
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Patent number: 10478574Abstract: A delivery device for and method of providing for delivery of substance to the central nervous system (CNS) of a subject, the delivery device comprising: a nosepiece unit (17) for insertion into a nasal airway (1) of a subject and comprising an outlet unit (21) which includes a nozzle (25) for delivering substance into the nasal airway of the subject; and a substance supply unit which is operable to deliver a dose of substance to the nozzle: wherein the delivery device is configured such that at least 30% of the dose as initially deposited in the nasal airway is deposited in an upper posterior region of the nasal airway, thereby providing a CNS concentration of the substance, and hence CNS effect, which is significantly greater than that which would be predicted from a counterpart blood plasma concentration of the substance.Type: GrantFiled: January 19, 2006Date of Patent: November 19, 2019Assignee: OptiNose ASInventors: Per Gisle Djupesland, Roderick Peter Hafner
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Patent number: 10398859Abstract: A nasal delivery device for and method of delivering substance to a nasal cavity of a subject, the delivery device comprising: a container-receiving unit comprising a container chamber for receiving a substance-containing container which contains substance to be delivered to the nasal cavity of the subject, the container chamber including an inlet and an outlet; a nosepiece unit including a nosepiece for fitting to a nasal cavity of the subject and being in fluid communication with the outlet of the container chamber; a mouthpiece unit including a mouthpiece in fluid communication with the inlet of the container chamber and through which the subject in use exhales, such as to entrain substance from the container and deliver the same through the nosepiece; and moisture-mitigation means for mitigating an effect of moisture in an exhaled breath on the entrainment of substance from the container, which means are provided, for example, by providing the container in a replaceable container-containing member, by a pType: GrantFiled: July 13, 2015Date of Patent: September 3, 2019Assignee: OptiNose ASInventors: Per Gisle Djupesland, Roderick Peter Hafner, Colin David Sheldrake
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Publication number: 20190125992Abstract: Intranasal administration of proteins, such as insulin and insulin analogues, in particular immunogenic proteins to the upper posterior region of a nasal cavity of a subject, and in particular the olfactory bulb region.Type: ApplicationFiled: September 26, 2018Publication date: May 2, 2019Inventor: Roderick Peter HAFNER
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Publication number: 20190015621Abstract: A delivery device for and a method of delivering gases to the nasal airway, in particular therapeutic gases and gases in combination with active substances, either as powders or liquids, for enhanced uptake of the active substances.Type: ApplicationFiled: January 12, 2018Publication date: January 17, 2019Inventors: Per Gisle DJUPESLAND, Roderick Peter HAFNER
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Patent number: 10112021Abstract: Intranasal administration of proteins, such as insulin and insulin analogues, in particular immunogenic proteins to the upper posterior region of a nasal cavity of a subject, and in particular the olfactory bulb region.Type: GrantFiled: March 2, 2015Date of Patent: October 30, 2018Assignee: OptiNose ASInventor: Roderick Peter Hafner
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Publication number: 20180272085Abstract: A nasal delivery device for delivering substance to a nasal cavity of a subject, the delivery device comprising: a substance supply unit for supplying a dose of substance to be delivered to the nasal cavity of the subject, the substance supply unit including an inlet and an outlet; a nosepiece unit including a nosepiece for fitting to a nasal cavity of the subject and being in fluid communication with the outlet of the substance supply unit; and a mouthpiece unit including a mouthpiece in fluid communication with the inlet of the substance supply unit and through which the subject in use exhales such as to entrain substance from the container chamber and deliver the same through the nosepiece, and at least one temperature modifier for reducing a temperature of the exhaled air flow such as to reduce the absolute humidity thereof.Type: ApplicationFiled: January 24, 2018Publication date: September 27, 2018Inventors: Per Gisle DJUPESLAND, Roderick Peter HAFNER, Colin David SHELDRAKE
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Patent number: 9850281Abstract: Polypeptides which may be used for preventing or treating allergy to moulds of the Cladosporium and/or Alternaria genus, have up to 30 amino acids in length and comprise: (I) the amino acid sequence: (a) GGYKAAVRPTMLE (SEQ ID NO: 35; Cla35), (b) AE V YQKLK SLTKK (SEQ ID NO: 31; Cla16), (c) VAITYASRAQGAE (SEQ ID NO: 32; Cla25), (d) GHHFKERGT-GSLVIT (SEQ ID NO: 33; Cla26), or (e) ANYTQTKTVSIRL (SEQ ID NO: 34; Cla29); or (II) a T cell epitope-containing variant sequence which is a said amino acid sequence (I) having up to six amino acid modifications, each of which is independently a deletion, substitution or insertion.Type: GrantFiled: May 30, 2013Date of Patent: December 26, 2017Assignee: Circassia LimitedInventors: Roderick Peter Hafner, Paul Laidler, Pascal Hickey, Mark Larche
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Publication number: 20170274164Abstract: A delivery device for and method of delivering a powdered substance, in particular a triptan, such as sumatriptan, to the posterior region of a nasal cavity of a subject, in particular for the treatment of headaches, for example, cluster headaches and migraine, and neuropathic pain, the delivery device comprising: a nosepiece for insertion into a nasal cavity of a subject through which the powdered substance is delivered to the posterior region of the nasal cavity of the subject, in particular the upper posterior two thirds of the nasal cavity; and a substance supply unit which is operable to deliver the powdered substance through the nosepiece.Type: ApplicationFiled: April 7, 2017Publication date: September 28, 2017Inventors: Per Gisle DJUPESLAND, Roderick Peter HAFNER
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Patent number: 9744222Abstract: The present invention relates to compositions comprising peptides for preventing or treating allergy to house dust mites, and in particular to optimal combinations of peptides for preventing or treating said allergy.Type: GrantFiled: October 17, 2016Date of Patent: August 29, 2017Assignee: Circassia LimitedInventors: Roderick Peter Hafner, Paul Laidler, Mark Larche
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Publication number: 20170157226Abstract: The present invention relates to compositions comprising peptides for preventing or treating allergy to house dust mites, and in particular to optimal combinations of peptides for preventing or treating said allergy.Type: ApplicationFiled: October 17, 2016Publication date: June 8, 2017Inventors: Roderick Peter HAFNER, Paul LAIDLER, Mark LARCHE