Patents by Inventor Roderick Peter Hafner
Roderick Peter Hafner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20150196635Abstract: The present invention relates to compositions comprising peptides for preventing or treating allergy to birch, and in particular to optimal combinations of peptides for preventing or treating said allergy.Type: ApplicationFiled: March 31, 2015Publication date: July 16, 2015Inventors: Roderick Peter HAFNER, Paul LAIDLER, Guy LAYTON, Mark LARCHE
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Publication number: 20150165139Abstract: Intranasal administration of proteins, such as insulin and insulin analogues, in particular immunogenic proteins to the upper posterior region of a nasal cavity of a subject, and in particular the olfactory bulb region.Type: ApplicationFiled: March 2, 2015Publication date: June 18, 2015Applicant: OptiNose ASInventor: Roderick Peter HAFNER
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Patent number: 9017689Abstract: The present invention relates to compositions comprising peptides for preventing or treating allergy to birch, and in particular to optimal combinations of peptides for preventing or treating said allergy.Type: GrantFiled: February 15, 2011Date of Patent: April 28, 2015Assignee: Circassia LimitedInventors: Roderick Peter Hafner, Paul Laidler, Mark Larche, Christopher Hugh Reginald Stocker
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Publication number: 20150101605Abstract: A nasal delivery device for delivering substance to a nasal cavity of a subject, the delivery device comprising: a substance supply unit for supplying a dose of substance to be delivered to the nasal cavity of the subject, the substance supply unit including an inlet and an outlet; a nosepiece unit including a nosepiece for fitting to a nasal cavity of the subject and being in fluid communication with the outlet of the substance supply unit; and a mouthpiece unit including a mouthpiece in fluid communication with the inlet of the substance supply unit and through which the subject in use exhales such as to entrain substance from the container chamber and deliver the same through the nosepiece, and at least one temperature modifier for reducing a temperature of the exhaled air flow such as to reduce the absolute humidity thereof.Type: ApplicationFiled: September 19, 2014Publication date: April 16, 2015Inventors: Per Gisle Djupesland, Roderick Peter Hafner, Colin David Sheldrake
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Publication number: 20150098969Abstract: Pharmaceutical formulations, which may be used for preventing or treating allergy to moulds of the Alternaria and/or Cladosporium genus, comprising a pharmaceutically acceptable carrier or diluent and a polypeptide or a pharmaceutically acceptable salt thereof selected from at least three of: (a) a polypeptide comprising the amino acid sequence of WSWKIGPAIATGNT (Alt28; SEQ ID NO: 101) or a T cell epitope-containing variant sequence derived from said amino acid sequence, or a said salt thereof; (b) a polypeptide comprising the amino acid sequence of KYRRVVRAGVKVAQTAR (Alt34A; SEQ ID NO: 107) or a T cell epi tope-containing variant sequence derived from said amino acid sequence, or a said salt thereof; (c) a polypeptide comprising the amino acid sequence of KYAGVFVSTGTLGGG (SEQ ID NO: 112) or a T cell epitope-containing variant sequence derived from said amino acid sequence, or a said salt thereof; (d) a polypeptide comprising the amino acid sequence of AEVYQKLKALAKKTYGQ (Alt13A; SEQ ID NO: 83) or a T cell epiType: ApplicationFiled: May 30, 2013Publication date: April 9, 2015Inventors: Roderick Peter Hafner, Paul Laidler, Pascal Hickey, Mark Larche
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Publication number: 20150090259Abstract: A delivery device for and a method of delivering gases to the nasal airway, in particular therapeutic gases and gases in combination with active substances, either as powders or liquids, for enhanced uptake of the active substances.Type: ApplicationFiled: December 4, 2014Publication date: April 2, 2015Inventors: Per Gisle DJUPESLAND, Roderick Peter Hafner
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Patent number: 8910629Abstract: A delivery device for providing therapeutic gas to the nasal airway of a subject, the delivery device comprising: a nosepiece (21) for fitting to one nostril of the subject; a mouthpiece (23) through which the subject in use exhales and which is fluidly connected to the nosepiece (21); and a scrubber (27) which is operative at least to reduce the concentration of at least one gas from an exhaled breath of the subject as delivered through the mouthpiece (23) and provide a gas flow to the nosepiece (21) which has an increased concentration of at least one other,” therapeutic gas which provides a therapeutic effect.Type: GrantFiled: July 25, 2007Date of Patent: December 16, 2014Assignee: OptiNose ASInventors: Per Gisle Djupesland, Roderick Peter Hafner
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Patent number: 8899229Abstract: A nasal delivery device for delivering substance to a nasal cavity of a subject, the delivery device comprising: a substance supply unit for supplying a dose of substance to be delivered to the nasal cavity of the subject, the substance supply unit including an inlet and an outlet; a nosepiece unit including a nosepiece for fitting to a nasal cavity of the subject and being in fluid communication with the outlet of the substance supply unit; and a mouthpiece unit including a mouthpiece in fluid communication with the inlet of the substance supply unit and through which the subject in use exhales such as to entrain substance from the container chamber and deliver the same through the nosepiece, and at least one temperature modifier for reducing a temperature of the exhaled air flow such as to reduce the absolute humidity thereof.Type: GrantFiled: February 23, 2006Date of Patent: December 2, 2014Assignee: OptiNose ASInventors: Per Gisle Djupesland, Roderick Peter Hafner, Colin David Sheldrake
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Publication number: 20140328868Abstract: A first or second polypeptide for use in a method of treating or preventing a disorder by tolerisation, wherein said method comprises administration of the first and second polypeptide; and wherein both first and second polypeptides: i) are of 7 to 30 amino acids in length; ii) comprise at least one MHC Class II-binding T cell epitope; and iii) are a fragment of a protein allergen or a homologous variant of said fragment; wherein said first polypeptide induces the release of an amount of IL-10 that is greater than the amount of IL-10 released in response to the whole protein allergen from which the first polypeptide derives; wherein said disorder is characterised by an inappropriate immune response to the protein allergen from which the second polypeptide derives.Type: ApplicationFiled: May 2, 2014Publication date: November 6, 2014Inventors: Mark LARCHE, Roderick Peter HAFNER, Paul LAIDLER
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Patent number: 8875704Abstract: A delivery device for and method of delivering a powdered substance, in particular a triptan, such as sumatriptan, to the posterior region of a nasal cavity of a subject, in particular for the treatment of headaches, for example, cluster headaches and migraine, and neuropathic pain, the delivery device comprising: a nosepiece for insertion into a nasal cavity of a subject through which the powdered substance is delivered to the posterior region of the nasal cavity of the subject, in particular the upper posterior two thirds of the nasal cavity; and a substance supply unit which is operable to deliver the powdered substance through the nosepiece.Type: GrantFiled: May 9, 2014Date of Patent: November 4, 2014Assignee: Optinose ASInventors: Per Gisle Djupesland, Roderick Peter Hafner
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Publication number: 20140302071Abstract: The present invention relates to compositions comprising peptides for preventing or treating allergy to house dust mites, and in particular to optimal combinations of peptides for preventing or treating said allergy.Type: ApplicationFiled: May 19, 2014Publication date: October 9, 2014Inventors: Roderick Peter HAFNER, Paul LAIDLER, Guy LAYTON, Mark LARCHE
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Publication number: 20140246022Abstract: A delivery device for and method of delivering a powdered substance, in particular a triptan, such as sumatriptan, to the posterior region of a nasal cavity of a subject, in particular for the treatment of headaches, for example, cluster headaches and migraine, and neuropathic pain, the delivery device comprising: a nosepiece for insertion into a nasal cavity of a subject through which the powdered substance is delivered to the posterior region of the nasal cavity of the subject, in particular the upper posterior two thirds of the nasal cavity; and a substance supply unit which is operable to deliver the powdered substance through the nosepiece.Type: ApplicationFiled: May 9, 2014Publication date: September 4, 2014Applicant: OPTINOSE ASInventors: Per Gisle DJUPESLAND, Roderick Peter HAFNER
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Patent number: 8821887Abstract: A first or second polypeptide for use in a method of treating or preventing a disorder by tolerization, wherein said method comprises administration of the first and second polypeptide; and wherein both first and second polypeptides: i) are of 7 to 30 amino acids in length; ii) comprise at least one MHC Class II-binding T cell epitope; and iii) are a fragment of a protein allergen or a homologous variant of said fragment; wherein said first polypeptide induces the release of an amount of IL-10 that is greater than the amount of IL-10 released in response to the whole protein allergen from which the first polypeptide derives; wherein said disorder is characterized by an inappropriate immune response to the protein allergen from which the second polypeptide derives.Type: GrantFiled: August 14, 2009Date of Patent: September 2, 2014Assignee: Circassia LimitedInventors: Mark Larche, Roderick Peter Hafner, Paul Laidler
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Publication number: 20140186403Abstract: The present invention relates to compositions comprising peptides for preventing or treating allergy to house dust mites, and in particular to optimal combinations of peptides for preventing or treating said allergy.Type: ApplicationFiled: January 8, 2014Publication date: July 3, 2014Applicant: CIRCASSIA LIMITEDInventors: Roderick Peter HAFNER, Paul LAIDLER, Mark LARCHE
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Patent number: 8753644Abstract: The present invention relates to compositions comprising peptides for preventing or treating allergy to house dust mites, and in particular to optimal combinations of peptides for preventing or treating said allergy.Type: GrantFiled: February 5, 2010Date of Patent: June 17, 2014Assignee: Circassia LimitedInventors: Roderick Peter Hafner, Paul Laidler, Mark Larche, Christopher Hugh Reginald Stocker
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Publication number: 20140050750Abstract: The present invention relates to compositions comprising peptides for preventing or treating allergy to cats, and in particular to optimal combinations of peptidesType: ApplicationFiled: August 22, 2013Publication date: February 20, 2014Applicant: CIRCASSIA LIMITEDInventors: RODERICK PETER HAFNER, MARK LARCHE, ANTHONY BARRINGTON KAY
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Patent number: 8652485Abstract: The present invention relates to compositions comprising peptides for preventing or treating allergy to house dust mites, and in particular to optimal combinations of peptides for preventing or treating said allergy.Type: GrantFiled: August 15, 2008Date of Patent: February 18, 2014Assignee: Circassia LimitedInventors: Roderick Peter Hafner, Paul Laidler, Mark Larche
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Publication number: 20140041660Abstract: A nasal delivery device for and method of delivering substance to a nasal cavity of a subject, the delivery device comprising: a container-receiving unit comprising a container chamber for receiving a substance-containing container which contains substance to be delivered to the nasal cavity of the subject, the container chamber including an inlet and an outlet; a nosepiece unit including a nosepiece for fitting to a nasal cavity of the subject and being in fluid communication with the outlet of the container chamber; a mouthpiece unit including a mouthpiece in fluid communication with the inlet of the container chamber and through which the subject in use exhales, such as to entrain substance from the container and deliver the same through the nosepiece; and moisture-mitigation means for mitigating an effect of moisture in an exhaled breath on the entrainment of substance from the container, which means are provided, for example, by providing the container in a replaceable container-containing member, by a pType: ApplicationFiled: October 21, 2013Publication date: February 13, 2014Applicant: OPTINOSE ASInventors: Per Gisle Djupesland, Roderick Peter Hafner, Colin David Sheldrake
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Publication number: 20130336999Abstract: The present invention relates to peptide which are formulated or engineered to prevent or reduce the formation of dimers.Type: ApplicationFiled: August 23, 2013Publication date: December 19, 2013Applicant: CIRCASSIA LIMITEDInventors: RODERICK PETER HAFNER, PAUL LAIDLER
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Patent number: 8590530Abstract: A nasal delivery device for and method of delivering substance to a nasal cavity of a subject, the delivery device comprising: a container-receiving unit comprising a container chamber for receiving a substance-containing container which contains substance to be delivered to the nasal cavity of the subject, the container chamber including an inlet and an outlet; a nosepiece unit including a nosepiece for fitting to a nasal cavity of the subject and being in fluid communication with the outlet of the container chamber; a mouthpiece unit including a mouthpiece in fluid communication with the inlet of the container chamber and through which the subject in use exhales, such as to entrain substance from the container and deliver the same through the nosepiece; and moisture-mitigation means for mitigating an effect of moisture in an exhaled breath on the entrainment of substance from the container.Type: GrantFiled: May 14, 2012Date of Patent: November 26, 2013Assignee: OptiNose ASInventors: Per Gisle Djupesland, Roderick Peter Hafner, Colin David Sheldrake