Patents by Inventor Roel Penterman

Roel Penterman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11072813
    Abstract: Methods and devices for detection of micro-organisms present or suspected to be present within a mammalian blood sample are provided. A selective lysis is obtained by incubating the sample in a non-ionic detergent under alkaline conditions.
    Type: Grant
    Filed: March 26, 2019
    Date of Patent: July 27, 2021
    Assignee: Koninklijke Philips N.V.
    Inventors: Bart Edward Gusta Jozef Van Meerbergen, Oana Mihaela Piciu, Ron Gill, Kristiane Anne Schmidt, Sieglinde Neerken, Marc Wilhelmus Gijsbert Ponjee, Zeynep Seflek Unay, Roel Penterman, Paul Arnold Van De Wiel
  • Patent number: 10416467
    Abstract: A method of producing a lenticular device for an autostereoscopic display apparatus includes providing a substrate having a surface which corresponds in shape to a desired surface profile for the array of lenticular elements, and providing an optical layer mixture of an optically birefringent material and a polymer precursor over the substrate surface. The optical layer is exposed to a stimulus for polymerizing the polymer precursor to have at least a polymer surface layer, thereby enclosing the material between the polymerized material and the surface to define lenticular elements. This method allows a simple polymerization process, forming a single layer, to complete the LC cell formation in the desired lenticular array shape.
    Type: Grant
    Filed: December 8, 2014
    Date of Patent: September 17, 2019
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Hans Zuidema, Henricus J. C. Kuijpers, Roel Penterman
  • Publication number: 20190218595
    Abstract: Methods and devices for detection of micro-organisms present or suspected to be present within a mammalian blood sample are provided. A selective lysis is obtained by incubating the sample in a non-ionic detergent under alkaline conditions.
    Type: Application
    Filed: March 26, 2019
    Publication date: July 18, 2019
    Inventors: Bart Edward Gusta Jozef Van MEERBERGEN, Oana Mihaela PICIU, Ron GILL, Kristiane Anne SCHMIDT, Sieglinde NEERKEN, Marc Wilhelmus Gijsbert PONJEE, Zeynep Seflek Unay, Roel PENTERMAN, Paul Arnold VAN DE WIEL
  • Patent number: 10308976
    Abstract: Methods and devices for the selective lysis of cells in a sample comprising micro-organisms such as bacteria are provided. The selective lysis is obtained by incubating the sample in a non-ionic detergent under alkaline conditions.
    Type: Grant
    Filed: December 7, 2010
    Date of Patent: June 4, 2019
    Assignee: Koninklijke Philips N.V.
    Inventors: Bart Edward Jozef Gusta Van Meerbergen, Oana Mihaela Piciu, Ron Gill, Kristiane Anne Schmidt, Sieglinde Neerken, Marc Wilhelmus Gijsbert Ponjee, Zeynep Seflek, Roel Penterman, Paul Arnold Van De Wiel
  • Patent number: 10254553
    Abstract: A method of producing a lenticular device for an autostereoscopic display apparatus includes providing a substrate having a surface which corresponds in shape to a desired surface profile for the array of lenticular elements, and providing an optical layer mixture of an optically birefringent material and a polymer precursor over the substrate surface. The optical layer is exposed to a stimulus for polymerizing the polymer precursor to have at least a polymer surface layer, thereby enclosing the material between the polymerized material and the surface to define lenticular elements. This method allows a simple polymerization process, forming a single layer, to complete the LC cell formation in the desired lenticular array shape.
    Type: Grant
    Filed: September 8, 2006
    Date of Patent: April 9, 2019
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Hans Zuidema, Henricus J. C. Kuijpers, Roel Penterman
  • Patent number: 9874294
    Abstract: The invention relates to a valve (2) for controlling a passage of particles from a first region (6) to a second region (7), wherein the valve (2) comprises a valve material (4) having a modifiable degree of penetrability and a valve region (16) comprising the valve material (4), wherein the valve region (16) and the valve material (4) are adapted such that the particles have to penetrate the valve material (4) if the particles pass the valve (2) for being transferred from the first region (6) to the second region (7). The degree of opening of the valve (2) can easily be controlled by modifying the degree of penetrability of the valve material (4), for example, by modifying the temperature of the valve material (4). Moreover, by penetrating the valve material (4) the particles can be separated from other elements like a fluid containing the particles.
    Type: Grant
    Filed: June 2, 2010
    Date of Patent: January 23, 2018
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Remco Christiaan Den Dulk, Roel Penterman, Menno Willem Jose Prins
  • Patent number: 9863006
    Abstract: The present invention discloses methods, kits-of-parts, and devices for the selective lysis of eukaryotic cells in a sample comprising micro-organisms such as bacteria unicellular fungi. The selective lysis is obtained by incubating the sample in an ionic surfactant under alkaline conditions.
    Type: Grant
    Filed: April 30, 2012
    Date of Patent: January 9, 2018
    Assignee: Biocartis NV
    Inventors: Irene Dobbelaer, Sieglinde Neerken, Paul Van De Wiel, Bart Van Meerbergen, Roel Penterman
  • Patent number: 9784805
    Abstract: The invention relates to a nuclear magnetic resonance imaging radio frequency-receiver (112; 216; 308; 404), the receiver (112; 216; 308; 404) being adapted to receive analog signals from at least one radio frequency receiver coil unit (106; 200; 202; 300; 400; 402), the radio frequency receiver (112; 216; 308; 404) comprising: an analog-digital converter (118; 226) to convert the analog pre-amplified magnetic resonance signal into a digital signal, means (120; 230) for digital down converting the digital signal and a first communication interface (130; 252) adapted for transmitting the down converted digital signal via a communication link (e.g. wireless, optical or wire-bound).
    Type: Grant
    Filed: June 16, 2008
    Date of Patent: October 10, 2017
    Assignee: Koninklijke Philips N.V.
    Inventors: Marc Paul Saes, Johan Samuel Van Den Brink, Filips Van Liere, Roel Penterman, Ralph Kurt, Emiel Peeters, Dirk Jan Broer, Michel Paul Barbara Van Bruggen, Hans Van Zon, Miha Fuderer
  • Patent number: 9663813
    Abstract: A method for filtering a sample comprising the steps of: (a) providing a sample with eukaryotic cells and containing or suspected to contain a micro-organism; (b) performing a selective lysis of the eukaryotic cells to obtain a lysed sample; (c) filtering the lysed sample obtained in step (b) through a filter arranged to retain the micro-organism; and (d) washing the filter with a detergent based wash buffer to selectively solubilize proteins originating from the eukaryotic cells retained by the filter, by passing the detergent based wash buffer through the filter, to remove protein clogs from the filter in order to allow an additional step (c) of filtering said lysed sample.
    Type: Grant
    Filed: June 26, 2013
    Date of Patent: May 30, 2017
    Assignee: Biocartis NV
    Inventors: Roel Penterman, Bart Van Meerbergen
  • Patent number: 9522398
    Abstract: System for performing biological analysis comprising: a cartridge having a deformable chamber suitable for containing a liquid to be analyzed; a heater having a heating face arranged to heat the liquid contained in the deformable chamber; characterized in that the heating face of the heater is moveable from a first position to at least a second position, different from the first position, to allow an increase of volume of said deformable chamber in order to compensate an increase of pressure in the deformable chamber during the heating of said liquid by said heater.
    Type: Grant
    Filed: June 27, 2013
    Date of Patent: December 20, 2016
    Assignee: BIOCARTIS NV
    Inventors: Bart Van Meerbergen, Roel Penterman, Nicolas Vergauwe
  • Patent number: 9291284
    Abstract: The invention relates to a micro valve for use in a biosensor, a micro fluidic device, use of such a device, and a micro fluidic element. Biosensors are used for detection of molecules and/or ions, such as protein, drug, DNA, RNA, hormone, glucose, insulin, enzyme, fungus, bacterium, etc., in a biological sample. The sensor can be used for diagnostic application, but for instance also drugs, either therapeutic or abuse, may be detected in for instance blood, urine and saliva.
    Type: Grant
    Filed: January 20, 2012
    Date of Patent: March 22, 2016
    Assignee: Biocartis NV
    Inventors: Roel Penterman, Johannes Van Eemeren, Reinhold Wimberger-Friedl, Hendrik Van Amerongen
  • Patent number: 9267109
    Abstract: The present invention is related to a method for the production of cell sheets comprising at least two different cell types, said method comprising the steps of providing a continuous cell sheet which is disposed on a substrate comprising shape transition properties and/or alterable surface characteristics; exposing said continuous cell sheet to a releasing agent in a patterned fashion; washing the cell sheet after exposure to the releasing agent in order to remove cells which have been affected by the releasing agent, and repopulating the gaps remaining after the cells which have been affected by the releasing agent have been removed with a second cell type.
    Type: Grant
    Filed: December 5, 2008
    Date of Patent: February 23, 2016
    Assignee: Koninklijke Philips N.V.
    Inventors: Emiel Peeters, Roel Penterman, Ralph Kurt, Dirk Jan Wilfred Broer
  • Patent number: 9108220
    Abstract: According to an aspect of the present invention, a device for fragmenting molecules in a sample by ultrasound is provided. The device comprises a planar-shaped cartridge and a fragmentation instrument that has a vessel-like shape. By means of applying under-pressure in the fragmentation instrument the cartridge is pulled towards the fragmentation instrument and therefore spatially closes a fluid compartment that is comprised by the fragmentation instrument. Afterwards, an ultrasound treatment of the sample, which is comprised in a sample compartment of the cartridge, may be processed. A sealing layer is provided in between the cartridge and the fragmentation instrument in order to hold the fixation of the cartridge tightly and in order to provide for leakage prevention out of the fluid compartment.
    Type: Grant
    Filed: June 5, 2012
    Date of Patent: August 18, 2015
    Assignee: Koninklijke Philips N.V.
    Inventors: Cristian Bogdan Craus, Jacob Marinus Jan Den Toonder, Roel Penterman, Pieter Jan Van Der Zaag
  • Publication number: 20150182965
    Abstract: System for performing biological analysis comprising: a cartridge having a deformable chamber suitable for containing a liquid to be analyzed; a heater having a heating face arranged to heat the liquid contained in the deformable chamber; characterized in that the heating face of the heater is moveable from a first position to at least a second position, different from the first position, to allow an increase of volume of said deformable chamber in order to compensate an increase of pressure in the deformable chamber during the heating of said liquid by said heater.
    Type: Application
    Filed: June 27, 2013
    Publication date: July 2, 2015
    Applicant: BIOCARTIS NV
    Inventors: Bart Van Meerbergen, Roel Penterman, Nicolas Vergauwe
  • Patent number: 9044752
    Abstract: A microfluidic cartridge for placement onto a parallel pneumatic interface plate of a pneumatic instrument is provided. The cartridge includes a three dimensional fluid channel, in which a fluid is to be transported, a flexible membrane that spans a plane and is part of an outer surface of the cartridge. The three dimensional fluid channel is spatially defined in three dimensions by internal walls of the cartridge and by the flexible membrane. The flexible membrane is in a ground state, when no pressure or vacuum is applied to the flexible membrane. However, the flexible membrane is pneumatically deflectable from the ground state perpendicular to the plane of the flexible membrane in two directions when the cartridge is placed onto the parallel pneumatic interface plate.
    Type: Grant
    Filed: October 6, 2010
    Date of Patent: June 2, 2015
    Assignee: Biocartis NV
    Inventors: Reinhold Wimberger-Friedl, Roel Penterman, Hendrik Halling Van Amerongen, Johannes Theodorus Antonius Loring, Jochem Martijn Van Uden
  • Publication number: 20150132793
    Abstract: A method for filtering a sample comprising the steps of: (a) providing a sample with eukaryotic cells and containing or suspected to contain a micro-organism; (b) performing a selective lysis of the eukaryotic cells to obtain a lysed sample; (c) filtering the lysed sample obtained in step (b) through a filter arranged to retain the micro-organism; (d) washing the filter with a detergent based wash buffer to selectively solubilize proteins originating from the eukaryotic cells retained by the filter, by passing the detergent based wash buffer through the filter, to remove protein clogs from the filter in order to allow an additional step (c) of filtering said lysed sample.
    Type: Application
    Filed: June 26, 2013
    Publication date: May 14, 2015
    Applicant: Biocartis NV
    Inventors: Roel Penterman, Bart Van Meerbergen
  • Publication number: 20150092126
    Abstract: A method of producing a lenticular device for an autostereoscopic display apparatus comprises providing a substrate having a surface which corresponds in shape to a desired surface profile for the array of lenticular elements, and providing an optical layer mixture of an optically birefringent material and a polymer precursor over the substrate surface. The optical layer is exposed to a stimulus for polymerizing the polymer precursor to have at least a polymer surface layer, thereby enclosing the material between the polymerized material and the surface to define lenticular elements. This method allows a simple polymerization process, forming a single layer, to complete the LC cell formation in the desired lenticular array shape.
    Type: Application
    Filed: December 8, 2014
    Publication date: April 2, 2015
    Inventors: HANS ZUIDEMA, HENRICUS J.C. KUIJPERS, ROEL PENTERMAN
  • Publication number: 20140193305
    Abstract: According to an aspect of the present invention, a device for fragmenting molecules in a sample by ultrasound is provided. The device comprises a planar-shaped cartridge and a fragmentation instrument that has a vessel-like shape. By means of applying under-pressure in the fragmentation instrument the cartridge is pulled towards the fragmentation instrument and therefore spatially closes a fluid compartment that is comprised by the fragmentation instrument. Afterwards, an ultrasound treatment of the sample, which is comprised in a sample compartment of the cartridge, may be processed. A sealing layer is provided in between the cartridge and the fragmentation instrument in order to hold the fixation of the cartridge tightly and in order to provide for leakage prevention out of the fluid compartment.
    Type: Application
    Filed: June 5, 2012
    Publication date: July 10, 2014
    Applicant: KONINKLIJKE PHILIPS N.V.
    Inventors: Cristian Bogdan Craus, Jacob Marinus Jan Den Toonder, Roel Penterman, Pieter Jan Van Der Zaag
  • Publication number: 20140087361
    Abstract: The present invention discloses methods, kits-of-parts, and devices for the selective lysis of eukaryotic cells in a sample comprising micro-organisms such as bacteria unicellular fungi. The selective lysis is obtained by incubating the sample in an ionic surfactant under alkaline conditions.
    Type: Application
    Filed: April 30, 2012
    Publication date: March 27, 2014
    Inventors: Irene Dobbelaer, Sieglinde Neerken, Paul Van De Wiel, Bart Van Meerbergen, Roel Penterman
  • Publication number: 20130299015
    Abstract: The invention relates to a micro valve for use in a biosensor, a micro fluidic device, use of such a device, and a micro fluidic element. Biosensors are used for detection of molecules and/or ions, such as protein, drug, DNA, RNA, hormone, glucose, insulin, enzyme, fungus, bacterium, etc., in a biological sample. The sensor can be used for diagnostic application, but for instance also drugs, either therapeutic or abuse, may be detected in for instance blood, urine and saliva.
    Type: Application
    Filed: January 20, 2012
    Publication date: November 14, 2013
    Inventors: Roel Penterman, Johannes Van Eemeren, Reinhold Wimberger-Friedl, Henrik Van Amerongen