Patents by Inventor Roelof Ary Lans Bovenberg

Roelof Ary Lans Bovenberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the production of 7-ADCA via expandase activity on penicillin G
    Patent number: 6020151
    Abstract: A process is taught for the preparation and recovery of 7-aminodesacetoxycephalosporanic acid (7-ADCA) via enzymatic ring expansion activity on penicillin G, using a Penicillium chrysogenum transformant strain expressing expandase.
    Type: Grant
    Filed: February 18, 1998
    Date of Patent: February 1, 2000
    Assignee: DSM N.V.
    Inventors: Roelof Ary Lans Bovenberg, Bertus Pieter Koekman, Dirk Schipper, Adrianus Wilhelmus Hermanus Vollebregt
  • Direct selection of transformants on acetate-containing media
    Patent number: 5925515
    Abstract: A transformant selection system has been developed, particularly for a .beta.-lactam producing strain, more particularly for P. chrysogenum, by the complementation of a mutation of said .beta.-lactam producing strain by a homologous selection marker without interfering with .beta.-lactam biosynthesis. Particularly, in applying said transformant selection system a positive selection agent, for instance fluoroacetate is used for the isolation of fac mutants of said strain, particularly of said .beta.-lactam producing strain. Furthermore, a gene entitled facA has been isolated from P. chrysogenum.
    Type: Grant
    Filed: June 11, 1992
    Date of Patent: July 20, 1999
    Assignee: Gist-brocades B.V.
    Inventors: Willem Van Hartingsveldt, Robert Franciscus Maria Van Gorcom, R. J. Gouka, Roelof Ary Lans Bovenberg
  • Process for the production of SSC's via expandase activity on penicillin G
    Patent number: 5919680
    Abstract: An overall process for the preparation and recovery of 7-aminodesacetoxycephalosporanic acid (7-ADCA) via enzymatic ring expansion activity on penicillin G, using a Penicillium chrysogenum transformant strain expressing modified expandase enzyme.
    Type: Grant
    Filed: November 27, 1996
    Date of Patent: July 6, 1999
    Assignee: Isis Innovation Limited
    Inventors: John David Sutherland, Roelof Ary Lans Bovenberg, Jan Metske van der Laan
  • Process for the efficient production of 7-ADCA via 3-(carboxyethylthio) propionyl-7-ADCA
    Patent number: 5795733
    Abstract: An overall efficient process for the preparation and recovery of 7-aminodesacetoxycephalosporanic acid (7-ADCA) via 3-(carboxyethylthio)propionyl-7-ADCA, using a Penicillium chrysogenum transformant strain expressing expandase in conjunction with acyltransferase, is provided.
    Type: Grant
    Filed: May 13, 1996
    Date of Patent: August 18, 1998
    Assignee: Gist-Brocades, B.V.
    Inventors: Roelof Ary Lans Bovenberg, Bertus Pieter Koekman, Andreas Hoekema, Jan Metske Van Der Laan, Jan Verweij, Erik De Vroom
  • DNA comprising regulatory regions from gene y of penicillium chrysogenum
    Patent number: 5747285
    Abstract: A gene expression system and a protein secretion system for eukaryotic, especially fungal, microorganisms has been provided for.
    Type: Grant
    Filed: March 8, 1994
    Date of Patent: May 5, 1998
    Assignee: Gist-Brocades, NV.
    Inventors: Roelof Ary Lans Bovenberg, Adrianus Wilhelmus Hermanus Vollebregt, Pieter Van Solingen
  • Process for the production of 7-ADCA via expandase activity on penicillin G
    Patent number: 5731165
    Abstract: An overall process for the preparation and recovery of 7-aminodesacetoxycephalosporanic acid (7-ADCA) via enzymatic ring expansion activity on penicillin G, using a Penicillium chrysogenum transformant strain expressing expandase.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: March 24, 1998
    Assignee: Gist-brocades, B.V.
    Inventors: Roelof Ary Lans Bovenberg, Bertus Pieter Koekman, Dirk Schipper, Adrianus Wilhelmus Vollebregt
  • Process for the efficient production of 7-ADCA via 2-(carboxyethylthio)acetyl-7-ADCA and 3-(carboxymethylthio)propionyl-7-ADCA
    Patent number: 5726032
    Abstract: An overall efficient process for the preparation and recovery of 7-aminodesacetoxycephalosporanic acid (7-ADCA) via 2-(carboxyethylthio)acetyl- and 3-(carboxymethylthio)propionyl-7-ADCA, using a Penicillium chrysogenum transformant strain expressing expandase in conjunction with acyltransferase, is provided.
    Type: Grant
    Filed: April 4, 1996
    Date of Patent: March 10, 1998
    Assignee: Gist-Brocades B.V.
    Inventors: Roelof Ary Lans Bovenberg, Bertus Pieter Koekman, Andreas Hoekema, Jan Metske Van Der Laan, Jan Verweij, Erik De Vroom
  • Oxido reductase enzyme system obtainable from P. chrysogenum, the set of genes encoding the same and the use of oxido reductase enzyme systems or genes encoding the same for increasing antibiotic production
    Patent number: 5652132
    Abstract: A new oxido reductase enzyme activity obtainable from P. chrysogenum, involved in the production of .beta.-lactams, the set of genes encoding said enzyme activity, and a method to enhance said production by using the above-mentioned oxido reductase system and other oxido reductase systems or genes encoding for the same have been disclosed.
    Type: Grant
    Filed: July 12, 1994
    Date of Patent: July 29, 1997
    Assignee: Gist-Brocades, B.V.
    Inventors: Yair Aharonowitz, Lucia Helena Maria Van Der Voort, Gerald Cohen, Roelof Ary Lans Bovenberg, Rachel Schreiber, Anat Argaman, Yossef Av-Gay, Helena Maria Nan, Alfred Kattevilder, Harriet Pa Lissa, Henk Van Liempt