Patents by Inventor Roger Crystal

Roger Crystal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and Methods for the Treatment of Opioid Overdose
    Publication number: 20260021038
    Abstract: Drug products adapted for nasal delivery, comprising a pre-primed device filled with a pharmaceutical composition comprising nalmefene are provided. Methods of treating opioid overdose with the drug products are also provided.
    Type: Application
    Filed: April 4, 2025
    Publication date: January 22, 2026
    Inventors: Phil SKOLNICK, Mark ELLISON, Roger CRYSTAL
  • Compositions and methods for the treatment of opioid overdose
    Patent number: 12290596
    Abstract: Drug products adapted for nasal delivery, comprising a pre-primed device filled with a pharmaceutical composition comprising nalmefene are provided. Methods of treating opioid overdose with the drug products are also provided.
    Type: Grant
    Filed: August 4, 2022
    Date of Patent: May 6, 2025
    Assignee: Indivior UK Limited
    Inventors: Phil Skolnick, Mark Ellison, Roger Crystal
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF OPIOID OVERDOSE
    Publication number: 20250127712
    Abstract: Drug products adapted for nasal delivery, comprising a pre-primed device filled with a pharmaceutical composition comprising nalmefene are provided. Methods of treating opioid overdose with the drug products are also provided.
    Type: Application
    Filed: June 25, 2024
    Publication date: April 24, 2025
    Inventor: Roger CRYSTAL
  • COMPOSITIONS, DEVICES, AND METHODS FOR THE TREATMENT OF OVERDOSE AND REWARD-BASED DISORDERS
    Publication number: 20240408004
    Abstract: Drug products adapted for nasal delivery, comprising a device filled with a pharmaceutical composition comprising naltrexone are provided. Formulations and methods of treating alcohol use disorder and related conditions with the drug products are also provided.
    Type: Application
    Filed: December 21, 2023
    Publication date: December 12, 2024
    Applicants: Aegis Therapeutics, LLC, Indivior UK Limited
    Inventors: Edward T. MAGGIO, Roger CRYSTAL, Mark ELLISON, Phil SKOLNICK, Arvind AGRAWAL
  • COMPOSITIONS, DEVICES AND METHODS FOR THE TREATMENT OF ALCOHOL USE DISORDER
    Publication number: 20240408003
    Abstract: Drug products adapted for nasal delivery, comprising a pre-primed device filled with a pharmaceutical composition comprising naltrexone are provided. Formulations and methods of treating alcohol use disorder and related conditions with the drug products are also provided.
    Type: Application
    Filed: December 21, 2023
    Publication date: December 12, 2024
    Applicants: Indivior UK Limited, Aegis Therapeutics, LLC
    Inventors: Roger CRYSTAL, Arvind AGRAWAL, Edward T. MAGGIO
  • METHODS FOR TREATING A PULMONARY DISEASE WITH AN ALK-5 (TGF BETA R1) INHIBITOR
    Publication number: 20240307363
    Abstract: The present invention concerns liquid, dry powder and metered-dose formulations for therapeutic inhaled delivery of ALK5 (TGF-?R1) inhibitor containing compositions to desired anatomical sites, for treatment or prophylaxis of a variety of pulmonary disease conditions such as Idiopathic Pulmonary Fibrosis, Idiopathic Interstitial Pneumonia, scleroderma-associated interstitial lung disease, sarcoidosis, cystic fibrosis, lung cancer, and a COVID infection.
    Type: Application
    Filed: May 3, 2022
    Publication date: September 19, 2024
    Applicant: Thirona Bio, Inc.
    Inventors: David A. BULLOUGH, John Gordon FOULKES, Nigel R.A. Beeley, Roger Crystal
  • FORMULATIONS AND METHODS FOR THE PREVENTION OF OPIOID OVERDOSE
    Publication number: 20240197719
    Abstract: Formulations and methods for the preventative treatment of incidental opioid overdose comprising the intranasal (IN) administration of a pharmaceutical formulation containing the opioid antagonist nalmefene as a prophylactic measure.
    Type: Application
    Filed: February 8, 2024
    Publication date: June 20, 2024
    Applicants: Aegis Therapeutics, LLC, Indivior Inc.
    Inventors: Roger CRYSTAL, Phil SKOLNICK, Edward T. MAGGIO
  • Methods, Parenteral Pharmaceutical Formulations, and Devices for the Prevention of Opioid Overdose
    Publication number: 20230225961
    Abstract: Methods, pharmaceutical formulations and devices for the preventative treatment of incidental opioid overdose comprising the intramuscular or subcutaneous administration using an auto-injection device of a pharmaceutical formulation containing the opioid antagonist nalmefene as a prophylactic measure.
    Type: Application
    Filed: February 27, 2023
    Publication date: July 20, 2023
    Inventors: Roger Crystal, Phil Skolnick, Edward T. Maggio
  • Compositions and Methods for the Treatment of Opioid Overdose
    Publication number: 20230055547
    Abstract: Drug products adapted for nasal delivery, comprising a pre-primed device filled with a pharmaceutical composition comprising nalmefene are provided. Methods of treating opioid overdose with the drug products are also provided.
    Type: Application
    Filed: August 4, 2022
    Publication date: February 23, 2023
    Inventors: Phil Skolnick, Mark Ellison, Roger Crystal
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF OPIOID OVERDOSE
    Publication number: 20220387306
    Abstract: Drug products adapted for nasal delivery, comprising a pre-primed device filled with a pharmaceutical composition comprising nalmefene are provided. Methods of treating opioid overdose with the drug products are also provided.
    Type: Application
    Filed: August 4, 2022
    Publication date: December 8, 2022
    Applicants: Opiant Pharmaceuticals, Inc., Aegis Therapeutics, LLC
    Inventors: Roger CRYSTAL, Edward T. MAGGIO
  • Compositions and methods for the treatment of opioid overdose
    Patent number: 11458091
    Abstract: Drug products adapted for nasal delivery, comprising a pre-primed device filled with a pharmaceutical composition comprising nalmefene are provided. Methods of treating opioid overdose with the drug products are also provided.
    Type: Grant
    Filed: November 9, 2017
    Date of Patent: October 4, 2022
    Assignees: Opiant Pharmaceuticals, Inc., Aegis Therapeutics, LLC
    Inventors: Roger Crystal, Edward T. Maggio
  • NASAL DRUG PRODUCTS AND METHODS OF THEIR USE
    Publication number: 20220071896
    Abstract: Drug products adapted for nasal delivery, comprising a pre-primed device filled with a pharmaceutical composition comprising an opioid receptor antagonist, are provided. Methods of treating opioid overdose or its symptoms with the inventive drug products are also provided.
    Type: Application
    Filed: November 17, 2021
    Publication date: March 10, 2022
    Inventors: Fintan KEEGAN, Robert Gerard BELL, Roger CRYSTAL, Michael Brenner WEISS
  • METHODS, PARENTERAL PHARMACEUTICAL FORMULATIONS, AND DEVICES FOR THE PREVENTION OF OPIOID OVERDOSE
    Publication number: 20210401827
    Abstract: Methods, pharmaceutical formulations and devices for the preventative treatment of incidental opioid overdose comprising the intramuscular or subcutaneous administration using an auto-injection device of a pharmaceutical formulation containing the opioid antagonist nalmefene as a prophylactic measure.
    Type: Application
    Filed: November 7, 2019
    Publication date: December 30, 2021
    Inventors: Roger Crystal, Phil Skolnick
  • METHODS, PARENTERAL PHARMACEUTICAL FORMULATIONS, AND DEVICES FOR THE PREVENTION OF OPIOID OVERDOSE
    Publication number: 20210275444
    Abstract: Methods, pharmaceutical formulations and devices for the preventative treatment of incidental opioid overdose comprising the intramuscular or subcutaneous administration using an auto-injection device of a pharmaceutical formulation containing the opioid antagonist nalmefene as a prophylactic measure.
    Type: Application
    Filed: May 13, 2021
    Publication date: September 9, 2021
    Inventors: Roger Crystal, Phil Skolnick
  • NASAL DRUG PRODUCTS AND METHODS OF THEIR USE
    Publication number: 20210275519
    Abstract: Drug products adapted for nasal delivery, comprising a pre-primed device filled with a pharmaceutical composition comprising an opioid receptor antagonist, are provided. Methods of treating opioid overdose or its symptoms with the inventive drug products are also provided.
    Type: Application
    Filed: December 18, 2020
    Publication date: September 9, 2021
    Inventors: Roger CRYSTAL, Michael Brenner WEISS
  • FORMULATIONS AND METHODS FOR THE PREVENTION OF OPIOID OVERDOSE
    Publication number: 20210220346
    Abstract: Formulations and methods for the preventative treatment of incidental opioid overdose comprising the intranasal (IN) administration of a pharmaceutical formulation containing the opioid antagonist nalmefene as a prophylactic measure.
    Type: Application
    Filed: May 15, 2019
    Publication date: July 22, 2021
    Inventors: Roger Crystal, Phil Skolnick, Edward T. Maggio
  • NASAL DRUG PRODUCTS AND METHODS OF THEIR USE
    Publication number: 20210093557
    Abstract: Drug products adapted for nasal delivery, comprising a pre-primed device filled with a pharmaceutical composition comprising an opioid receptor antagonist, are provided. Methods of treating opioid overdose or its symptoms with the inventive drug products are also provided.
    Type: Application
    Filed: May 7, 2020
    Publication date: April 1, 2021
    Inventors: Fintan KEEGAN, Robert Gerard BELL, Roger CRYSTAL, Michael Brenner WEISS
  • COMPOSITIONS, DEVICES, AND METHODS FOR THE TREATMENT OF OPIOID-RECEPTOR-MEDIATED CONDITIONS
    Publication number: 20210077382
    Abstract: Drug products adapted for nasal delivery comprising naltrexone, alone or in combination with excipients, are provided. Pre-primed devices for intranasal administration of the drug products are also provided.
    Type: Application
    Filed: September 17, 2020
    Publication date: March 18, 2021
    Inventors: Roger Crystal, Edward T. Maggio
  • COMPOSITIONS, DEVICES, AND METHODS FOR THE TREATMENT OF OVERDOSE AND REWARD-BASED DISORDERS
    Publication number: 20200390691
    Abstract: Drug products adapted for nasal delivery, comprising a device filled with a pharmaceutical composition comprising naltrexone are provided. Formulations and methods of treating alcohol use disorder and related conditions with the drug products are also provided.
    Type: Application
    Filed: December 19, 2019
    Publication date: December 17, 2020
    Inventors: Edward T. Maggio, Roger Crystal, Mark Ellison, Phil Skolnick
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF OPIOID OVERDOSE
    Publication number: 20200060967
    Abstract: Drug products adapted for nasal delivery, comprising a pre-primed device filled with a pharmaceutical composition comprising nalmefene are provided. Methods of treating opioid overdose with the drug products are also provided.
    Type: Application
    Filed: November 9, 2017
    Publication date: February 27, 2020
    Inventors: Roger Crystal, Edward T. Maggio