Abstract: One or more techniques and/or systems are provided for generating a bundle package, digitally signing the bundle package, selectively disturbing the bundle package, and/or indexing one or more resource packages retrieved from the bundle package. That is, a bundle package (e.g., an application or game bundle package) comprises one or more app packages comprising application code configured to execute on various computing environments (e.g., operating systems, processors, etc.). The bundle package may comprise one or more resource packages comprising supplemental data used to provide optional user experience functionality for the application (e.g., French language support, high resolution textures, a gaming pad support, etc.). In this way, a client device may selectively download portions of the bundle package that may be relevant, which may mitigate download bandwidth, storage space, or resources otherwise used to obtain unnecessary portions of the bundle package (e.g.

Abstract: A safety helmet includes damping elements for example made from expanded polystyrene added onto a shell made from an elastically deformable material. The whole of the surface, facing the shell, of the damping elements arranged along the periphery of the opening is positioned against the shell to form an inner supporting belt completely in contact with the shell. The helmet is arranged in such a way that a position of the head in the cavity of the helmet causes a deformation of the supporting belt by elastic deformation of the shell according to the morphology of the head, generating permanent tightening of the supporting belt against the head in substantially uniform manner along the supporting belt.

Abstract: A method and apparatus for providing system clock failover using a one-shot circuit are disclosed. A process, in one embodiment, is able to detect a clock failure using a one-shot circuit, wherein the clock signals are generated by a first clock circuit. Upon generating a switching signal in response to the clock failure, a system reset signal is asserted for a predefined time period in accordance with the clock failure. After switching a second clock circuit to replace the first clock circuit, the process is capable of resuming the clock signals via the second clock circuit.

Abstract: A method and apparatus for providing system clock failover using a one-shot circuit are disclosed. A process, in one embodiment, is able to detect a clock failure using a one-shot circuit, wherein the clock signals are generated by a first clock circuit. Upon generating a switching signal in response to the clock failure, a system reset signal is asserted for a predefined time period in accordance with the clock failure. After switching a second clock circuit to replace the first clock circuit, the process is capable of resuming the clock signals via the second clock circuit.

Abstract: A safety helmet includes damping elements for example made from expanded polystyrene added onto a shell made from an elastically deformable material. The whole of the surface, facing the shell, of the damping elements arranged along the periphery of the opening is positioned against the shell to form an inner supporting belt completely in contact with the shell. The helmet is arranged in such a way that a position of the head in the cavity of the helmet causes a deformation of the supporting belt by elastic deformation of the shell according to the morphology of the head, generating permanent tightening of the supporting belt against the head in substantially uniform manner along the supporting belt.

Abstract: A public address system including a wireless IR microphone for picking up a sound and converting it to an IR light signal including an audio signal representative of said sound and adapted for being transmitted to an IR sensor; an IR sensor including an IR photo detector for receiving said IR light signal and a first receiver for extracting said audio signal and a first transmitter transmitting it to a base station; a base station including a second receiver for receiving said audio signal from said IR sensor and a processor for processing said audio signal to provide a processed audio signal and a second transmitter transmitting it to a loud speaker; and a loud speaker unit for receiving said processed audio signal and converting it to a processed sound signal for being presented to an audience, wherein said IR sensor and loudspeaker unit are integrated into a sensor-speaker assembly.

Abstract: The invention provides compositions comprising a pharmaceutical compound having one or more Microsomal Triglyceride Transfer Protein (MTP) inhibitors that are covalently linked to one or more Liver Fatty Acid-Binding Protein (L-FABP) inhibitors. Also disclosed are methods for using the inventive pharmaceutical compositions in the treatment of hepatic steatosis and hyperlipidemia while avoiding the harmful side effects of steatorrhea.

Abstract: The invention provides compositions and methods for treating hyperlipidemia by administering a Microsomal Triglyceride Transfer Protein (MTP) inhibitor in combination with a Liver Fatty Acid-Binding Protein (L-FABP) inhibitor, methods of preventing the development of hepatic steatosis, methods of identifying an agent useful for treating hyperlipidemia, and methods of screening for inhibitors of MTP and L-FABP activity. Also provided are pharmaceutical compositions comprising a MTP inhibitor and a L-FABP inhibitor.

Abstract: The disclosed method includes collecting and monitoring customer preferences; performing calculations based on the collected and monitored preferences, the calculations being for determining at least a target audience of the advertisement campaign, an advertisement media presentation, an advertisement media delivery time and an expense minimizing advertisement media delivery route for advertisements to be transmitted to a portable communication device to customers based on the individual customer's preferences through a network; and receiving and outputting the advertisements on the portable communication device.

Abstract: The disclosed method includes collecting and monitoring customer preferences; performing calculations based on the collected and monitored preferences, the calculations being for determining at least a target audience of the advertisement campaign, an advertisement media presentation, an advertisement media delivery time and an expense minimizing advertisement media delivery route for advertisements to be transmitted to a portable communication device to customers based on the individual customer's preferences through a network; and receiving and outputting the advertisements on the portable communication device.

Abstract: A system for dynamically pricing media content is operatively coupled to one or more clients over a network. The system dynamically adjusts pricing of the media content and delivers the media content to the clients that order the media content at a dynamically adjusted price. The price can be dynamically adjusted based on profit optimization. Alternatively or additionally, the price can be adjusted based to time between purchases. Further, the system is capable of rewarding institutions for allowing their members to access the system.

Abstract: An isolated polypeptide (JNK) characterized by having a molecular weight of 46 kD as determined by reducing SDS-PAGE, having serine and Threonine kinase activity, phosphorylating the c-Jun N-terminal activation domain and polynucleotide sequences and method of deterction of JNK are provided herein. JNK phosphorylates c-Jun N-terminal activation domain which affects gene expression from AP-1 sites.

Abstract: JNK-interacting protein 1 (JIP-1), an inhibitor of the JNK1 protein, and methods of treating a pathological condition or of preventing the occurrence of a pathological condition in a patient by the administration of a therapeutically effective amount of JIP-1 polypeptides, peptides, peptide mimetics, or nucleic acids are described.

Abstract: The invention relates to the treatment and prevention of type I diabetes. More specifically, the invention relates to compounds that treat or prevent the body's immune system from destroying ?-cells (i.e., insulin-producing cells in the pancreatic islets of Langerhans) by inhibition of JNK2, selective inhibition of JNK2, or inhibition of the expression of the MAPK9 gene or gene product. In one embodiment, the present invention contemplates the diagnosis, identification, production, and use of compounds which modulate MAPK9 gene expression or the activity of the MAPK9 gene product including but not limited to, JNK2, the nucleic acid encoding MAPK9 and homologues, analogues, and deletions thereof, as well as antisense, ribozyme, triple helix, antibody, and polypeptide molecules as well as small inorganic molecules. The present invention contemplates a variety of pharmaceutical formulations and routes of administration for such compounds.

Abstract: A system for dynamically pricing media content is operatively coupled to one or more clients over a network. The system dynamically adjusts pricing of the media content and delivers the media content to the clients that order the media content at a dynamically adjusted price. The price can be dynamically adjusted based on profit optimization. Alternatively or additionally, the price can be adjusted based to time between purchases. Further, the system is capable of rewarding institutions for allowing their members to access the system.