Patents by Inventor Roger Frechette

Roger Frechette has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 9-aminomethyl substituted minocycline compounds
    Patent number: 9365500
    Abstract: The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and minocycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Grant
    Filed: June 27, 2014
    Date of Patent: June 14, 2016
    Assignee: PARATEK PHARMACEUTICALS, INC.
    Inventors: Mark L. Nelson, Roger Frechette, Mohamed Y. Ismail, Laura Honeyman, Todd Bowser, Beena Bhatia
  • 9-AMINOMETHYL SUBSTITUTED MINOCYCLINE COMPOUNDS
    Publication number: 20140309199
    Abstract: The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and minocycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Application
    Filed: June 27, 2014
    Publication date: October 16, 2014
    Inventors: Mark L. Nelson, Roger Frechette, Mohamed Y. Ismail, Laura Honeyman, Todd Bowser, Beena Bhatia
  • 7-substituted tetracycline compounds
    Patent number: 8492365
    Abstract: The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Grant
    Filed: June 9, 2009
    Date of Patent: July 23, 2013
    Assignees: Trustees of Tufts College, Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Roger Frechette, Peter Viski, Mohamed Ismail, Todd Bowser, Beena Bhatia, David Messersmith, Laura McIntyre, Darrell Koza, Glen Rennie, Paul Sheahan, Paul Hawkins, Atul Verma, Tadeusz Warchol, Upul Bandarage
  • 9-SUBSTITUTED MINOCYCLINE COMPOUNDS
    Publication number: 20120283201
    Abstract: The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Application
    Filed: July 12, 2012
    Publication date: November 8, 2012
    Applicants: Trustees of Tufts College, Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Roger Frechette, Peter Viski, Mohamed Y. Ismail, Todd Bowser, Jimmy Dumornay, Glen Rennie, Gui Liu, Darrell J. Koza, Paul Sheahan, Karen Stapleton, Paul Hawkins, Beena Bhalie, Atul K. Verma, Laura Honeyman, Tadeusz Warchol, David Messersmith
  • 7-pyrazolyl tetracycline compounds and methods of use thereof
    Patent number: 8304445
    Abstract: The present invention provides compounds of Formula (I) and related methods and formulations: wherein: A represents a pyrazole ring optionally substituted by one or more R groups.
    Type: Grant
    Filed: March 1, 2011
    Date of Patent: November 6, 2012
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Sophie Huss, Jose M. Bueno, Jose M. Fiandor, Roger Frechette
  • METHODS FOR IDENTIFYING AND USING MarR FAMILY POLYPEPTIDE BINDING COMPOUNDS
    Publication number: 20120209003
    Abstract: Methods for identifying MarR family inhibiting compounds are described. The methods include the use of computer aided rational based drug design programs and three dimensional structures of MarR family polypeptides.
    Type: Application
    Filed: September 9, 2011
    Publication date: August 16, 2012
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Michael N. Alekshun, Stuart B. Levy, Brent L. Podlogar, Roger Frechette
  • 7-pyrollyl 9-aminoacyl tetracycline compounds and methods of use thereof
    Patent number: 8211937
    Abstract: A compound of formula (I): wherein: A represents an aromatic 5 membered heterocycle, optionally containing, in addition to the nitrogen atom indicated in formula (I), one to three additional nitrogen atoms.
    Type: Grant
    Filed: December 3, 2007
    Date of Patent: July 3, 2012
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Sophie Huss, Jose M. Fiandor, Roger Frechette
  • Bicyclic PPAT inhibitors as antibacterial agents
    Patent number: 8124616
    Abstract: Disclosed are compounds of Formula I, pharmaceutical compositions comprising Formula I and methods of treating bacterial infections. The disclosed compounds are inhibitors of PPAT (phosphopantetheine adenyl transferase), and are useful in the treatment and prevention of diseases caused by bacteria, particularly bacteria dependent on PPAT, for example, species such Escherichia coli, Helicobacter pylori, Staphyloccocus aureus, and the like.
    Type: Grant
    Filed: November 26, 2008
    Date of Patent: February 28, 2012
    Assignee: Biota Scientific Management Pty Ltd
    Inventor: Roger Frechette
  • 9-aminoacyl tetracycline compounds and methods of use thereof
    Patent number: 8101591
    Abstract: A compound of formula (I):
    Type: Grant
    Filed: November 24, 2009
    Date of Patent: January 24, 2012
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Carmen Garcia-Luzon, Juan Carlos Cuevas, Jose M. Fiandor, Araceli Mallo, Mark L. Nelson, Roger Frechette
  • 9-substituted minocycline compounds
    Patent number: 8048867
    Abstract: The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Grant
    Filed: May 4, 2004
    Date of Patent: November 1, 2011
    Assignees: Trustees of Tufts College, Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Roger Frechette, Peter Viski, Mohamed Y. Ismail, Todd Bowser, Jimmy Dumornay, Glen Rennie, Gui Liu, Darrell J. Koza, Paul Sheahan, Karen Stapleton, Paul Hawkins, Beena Bhatia, Atul K. Verma, Laura McIntyre, Tadeusz Warchol, David Messersmith
  • Methods for identifying and using MarR family polypeptide binding compounds
    Patent number: 8039221
    Abstract: Methods for identifying MarR family inhibiting compounds are described. The methods include the use of computer aided rational based drug design programs and three dimensional structures of MarR family polypeptides.
    Type: Grant
    Filed: June 18, 2009
    Date of Patent: October 18, 2011
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Michael N. Alekshun, Stuart B. Levy, Brent L. Podlogar, Roger Frechette
  • 7-Pyrazolyl Tetracycline Compounds and Methods of Use Thereof
    Publication number: 20110160165
    Abstract: The present invention provides compounds of Formula (I) and related methods and formulations: wherein: A represents a pyrazole ring optionally substituted by one or more R groups.
    Type: Application
    Filed: March 1, 2011
    Publication date: June 30, 2011
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Sophie Huss, Jose M. Bueno, Jose M. Fiandor, Roger Frechette
  • 7-And 9-Carbamate, Urea, Thiourea, Thiocarbamate, And Heteroaryl-Amino Substituted Tetracycline Compounds
    Publication number: 20110092467
    Abstract: Substituted tetracycline compounds, methods of synthesis, and methods of use are discussed. Tetracyclines useful for treating tetracycline related disorders are also discussed. Intermediates useful for synthesizing other tetracycline compounds are also included.
    Type: Application
    Filed: December 22, 2010
    Publication date: April 21, 2011
    Applicants: Paratek Pharmaceuticals, Inc., Trustees of Tufts College
    Inventors: Mark L. Nelson, Stuart B. Levy, Roger Frechette, Todd Bowser, Mohamed Y. Ismail
  • Substituted Tetracycline Compounds
    Publication number: 20110086822
    Abstract: The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Application
    Filed: October 8, 2010
    Publication date: April 14, 2011
    Inventors: Mark L. Nelson, Kwasi Ohemeng, Roger Frechette, Paul Abato, Victor Amoo, Upul Bandarage, Joel Berniac, Beena Bhatia, Jackson Chen, Mohamed Y. Ismail, Oak Kim, Laura Honeyman, Rachid Mechiche, Andre Pearson, Laxma Reddy Nagavelli, Paul Sheahan, Atul K. Verma, Peter Viski, Tadeusz Warchol
  • Process for preparing five-membered heterocyclyl tetracycline compounds and methods of use thereof
    Patent number: 7897784
    Abstract: The present invention provides processes for preparing a compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein A is a pyrrole, tetrazole or triazole ring.
    Type: Grant
    Filed: November 24, 2009
    Date of Patent: March 1, 2011
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Sophie Huss, Jose M. Bueno, Jose M. Fiandor, Roger Frechette
  • Methods for Identifying and Using MarR Family Polypeptide Binding Compounds
    Publication number: 20110015375
    Abstract: Methods for identifying MarR family inhibiting compounds are described. The methods include the use of computer aided rational based drug design programs and three dimensional structures of MarR family polypeptides.
    Type: Application
    Filed: June 18, 2009
    Publication date: January 20, 2011
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Michael N. Alekshun, Stuart B. Levy, Brent L. Podlogar, Roger Frechette
  • 7- and 9- carbamate, urea, thiourea, thiocarbamate, and heteroaryl-amino substituted tetracycline compounds
    Patent number: 7858600
    Abstract: Substituted tetracycline compounds, methods of synthesis, and methods of use are discussed. Tetracyclines useful for treating tetracycline related disorders are also discussed. Intermediates useful for synthesizing other tetracycline compounds are also included.
    Type: Grant
    Filed: February 24, 2004
    Date of Patent: December 28, 2010
    Assignees: Paratek Pharmaceuticals, Inc., Trustees of Tufts College
    Inventors: Mark L. Nelson, Stuart B. Levy, Roger Frechette, Todd Bowser, Mohamed Y. Ismail
  • 7,9-SUBSTITUTED TETRACYCLINE COMPOUNDS
    Publication number: 20100160263
    Abstract: The present invention pertains to novel 7,9-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Application
    Filed: November 12, 2009
    Publication date: June 24, 2010
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Roger Frechette, Peter Viski, Mohamed Ismail, Todd Bowser, Laura McIntyre, Beena Bhatia, Paul Hawkins, Laxma Reddy Nagavelli, Karen Stepleton, Tad Warchol, Paul Sheahan
  • 9-Aminomethyl Substituted Minocycline Compounds
    Publication number: 20100113400
    Abstract: The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and minocycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Application
    Filed: May 28, 2009
    Publication date: May 6, 2010
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Roger Frechette, Mohamed Y. Ismail, Laura Honeyman, Todd Bowser, Beena Bhatia
  • Five-membered heterocyclyl tetracycline compounds and methods of use thereof
    Patent number: 7696358
    Abstract: The present invention describes methods of treating bacterial infections with 7-pyrrolyl tetracycline compounds of formula (I):
    Type: Grant
    Filed: December 2, 2005
    Date of Patent: April 13, 2010
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Sophie Huss, Jose M. Bueno, Jose M. Fiandor, Roger Frechette