Patents by Inventor Roger Frechette

Roger Frechette has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 7,9-substituted tetracycline compounds
    Patent number: 7696186
    Abstract: The present invention pertains to novel 7,9-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Grant
    Filed: December 16, 2003
    Date of Patent: April 13, 2010
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Roger Frechette, Peter Viski, Mohamed Y. Ismail, Todd Bowser, Laura McIntyre, Beena Bhatia, Paul Hawkins, Laxma Reddy, Karen Stapleton, Tadeusz Warchol, Paul Sheahan
  • 7-PYRROLYL TETRACYCLINE COMPOUNDS AND METHODS OF USE THEREOF
    Publication number: 20100081826
    Abstract: A compound of Formula (I):
    Type: Application
    Filed: November 24, 2009
    Publication date: April 1, 2010
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Sophie Huss, Jose M. Bueno, Jose M. Fiandor, Roger Frechette
  • 9-AMINOACYL TETRACYCLINE COMPOUNDS AND METHODS OF USE THEREOF
    Publication number: 20100075929
    Abstract: A compound of formula (I):
    Type: Application
    Filed: November 24, 2009
    Publication date: March 25, 2010
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Carmen García-Luzón, Juan Carlos Cuevas, Jose M. Fiandor, Araceli Mallo, Mark L. Nelson, Roger Frechette
  • 9-aminoacyl tetracycline compounds and methods of use thereof
    Patent number: 7652002
    Abstract: A compound of formula (I):
    Type: Grant
    Filed: December 20, 2006
    Date of Patent: January 26, 2010
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Carmen García-Luzón, Juan Carlos Cuevas, Jose M. Fiandor, Araceli Mallo, Mark L. Nelson, Roger Frechette
  • 9-SUBSTITUTED MINOCYCLINE COMPOUNDS
    Publication number: 20090325908
    Abstract: The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Application
    Filed: January 9, 2009
    Publication date: December 31, 2009
    Inventors: Mark L. Nelson, Roger Frechette, Peter Viski, Mohamed Y. Ismail, Todd Bowser, Jimmy Dumornay, Glen Rennie, Gui Liu, Darrell J. Koza, Paul Sheahan, Karen Stapleton, Paul Hawkins, Beena Bhatia, Atul K. Verma, Laura Honeyman, Tadeusz Warchol, David Messersmith
  • 7-SUBSTITUTED TETRACYCLINE COMPOUNDS
    Publication number: 20090306022
    Abstract: The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Application
    Filed: June 9, 2009
    Publication date: December 10, 2009
    Applicants: Trustees of Tufts College, Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Roger Frechette, Peter Viski, Mohamed Ismail, Todd Bowser, Beena Bhatia, David Messersmith, Laura McIntyre, Darrell Koza, Glen Rennie, Paul Sheahan, Paul Hawkins, Atul Verma, Tadeusz Warchol, Upul Bandarage
  • 7-substituted tetracycline compounds
    Patent number: 7595309
    Abstract: The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Grant
    Filed: May 24, 2004
    Date of Patent: September 29, 2009
    Assignees: Trustees of Tufts College, Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Roger Frechette, Peter Viski, Beena Bhatia, David Messersmith, Mohamed Y. Ismail, Todd Bowser, Laura McIntyre, Darrell J. Koza, Glen Rennie, Paul Sheahan, Paul Hawkins, Atul K. Verma, Tadeusz Warchol, Upul Bandarage
  • SUBSTITUTED TETRAHYDROQUINOLINES AS ANTIBACTERIAL AGENTS
    Publication number: 20090203726
    Abstract: A method of treating a subject for a bacterial infection includes administering to a subject in need of treatment for a bacterial infection an effective amount of a compound represented by structural formula (I-a), or a pharmaceutically acceptable salt, solvate, or hydrate thereof. The variables in structural formula (I-a) are described herein.
    Type: Application
    Filed: November 26, 2008
    Publication date: August 13, 2009
    Applicant: MAXTHERA INC.
    Inventor: Roger FRECHETTE
  • BICYCLIC PPAT INHIBITORS AS ANTIBACTERIAL AGENTS
    Publication number: 20090203730
    Abstract: Disclosed are compounds of Formula I, pharmaceutical compositions comprising Formula I and methods of treating bacterial infections. The disclosed compounds are inhibitors of PPAT (phosphopantetheine adenyl transferase), and are useful in the treatment and prevention of diseases caused by bacteria, particularly bacteria dependent on PPAT, for example, species such Escherichia coli, Helicobacter pylori, Staphyloccocus aureus, and the like.
    Type: Application
    Filed: November 26, 2008
    Publication date: August 13, 2009
    Applicant: MAXTHERA INC.
    Inventor: Roger FRECHETTE
  • 9-aminomethyl substituted minocycline compounds
    Patent number: 7553828
    Abstract: The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and minocycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Grant
    Filed: February 24, 2004
    Date of Patent: June 30, 2009
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Roger Frechette, Mohamed Y. Ismail, Laura Honeyman, Todd Bowser, Beena Bhatia
  • 7-Pyrollyl 9-Aminoacyl Tetracycline Compounds and Methods of Use Thereof
    Publication number: 20090054379
    Abstract: A compound of formula (I): wherein: A represents an aromatic 5 membered heterocycle, optionally containing, in addition to the nitrogen atom indicated in formula (I), one to three additional nitrogen atoms and optionally substituted by one or more groups “R” selected from halogen, —NRaRb, C1-6 alkyl, C2-6 alkenyl, C3-6 alkynyl, aryl, heteroaryl, hydroxy, —OC1-6 alkyl, formyl, cyano, trifluoromethyl, —CHNORa, —CO2Ra, —CONRaRb, —NRaC(O)Ra, —NRaC(O)ORa, —OC(O)NRaRb, —OC(O)Ra, —OC(O)ORa, or a C1-6 alkyl group substituted by one or more groups selected from hydroxy, —NRaRb, —OC1-6 alkyl, —SRa, —CHNORa, —CO2Ra, —CONRaRb, —NRaC(O)Ra, —NRaC(O)ORa, —OC(O)NRaRb, —OC(O)Ra, —OC(O)ORa X represents —NRxRy or —OC1-6 alkyl optionally substituted by one or more groups selected from hydroxy, methoxy, halogen, amino and trifluoromethyl.
    Type: Application
    Filed: December 3, 2007
    Publication date: February 26, 2009
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Sophie Huss, Jose M. Fiandor, Roger Frechette
  • Amino-methyl substituted tetracycline compounds
    Patent number: 7326696
    Abstract: Aminomethyl substituted tetracycline compounds, pharmaceutical compositions, and methods of use thereof are discussed.
    Type: Grant
    Filed: December 15, 2003
    Date of Patent: February 5, 2008
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Kwasi Ohemeng, Roger Frechette, Paul Abato, Victor Amoo, Haregewein Assefa, Joel Berniac, Beena Bhatia, Todd Bowser, Jackson Chen, Laura Honeyman, Mohamed Y. Ismail, Oak Kim, Rachid Mechiche, N. Laxma Reddy, Atul K. Verma, Peter Viski, Tadeusz Warchol, Ivan Yanachkov
  • 7-pyrollyl 9-aminoacyl tetracycline compounds and methods of use thereof
    Patent number: 7323492
    Abstract: A compound of formula (I): wherein: A represents an aromatic 5 membered heterocycle, optionally containing, in addition to the nitrogen atom indicated in formula (I), one to three additional nitrogen atoms.
    Type: Grant
    Filed: January 5, 2004
    Date of Patent: January 29, 2008
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Sophie Huss, Jose M. Fiandor, Roger Frechette
  • Amino-methyl substituted tetracycline compounds
    Publication number: 20080015169
    Abstract: Aminomethyl substituted tetracycline compounds, pharmaceutical compositions, and methods of use thereof are discussed.
    Type: Application
    Filed: June 5, 2007
    Publication date: January 17, 2008
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Mark Nelson, Kwasi Ohemeng, Roger Frechette, Paul Abato, Victor Amoo, Haregewein Assefa, Joel Berniac, Beena Bhatia, Todd Bowser, Jackson Chen, Laura Honeyman, Mohamed Ismail, Oak Kim, Rachid Mechiche, N. Reddy, Atul Verma, Peter Viski, Tadeusz Warchol, Ivan Yanachkov
  • 9-Aminoacyl tetracycline compounds and methods of use thereof
    Publication number: 20070270389
    Abstract: A compound of formula (I):
    Type: Application
    Filed: December 20, 2006
    Publication date: November 22, 2007
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Carmen Garcia-Luzon, Juan Cuevas, Jose Fiandor, Araceli Mallo, Mark Nelson, Roger Frechette
  • 9-aminoacyl tetracycline compounds and methods of use thereof
    Patent number: 7208482
    Abstract: A compound of formula (I):
    Type: Grant
    Filed: August 6, 2003
    Date of Patent: April 24, 2007
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Carmen García-Luzón, Juan Carlos Cuevas, Jose M. Fiandor, Araceli Mallo, Mark L. Nelson, Roger Frechette
  • Methods for identifying and using MarR family polypeptide binding compounds
    Patent number: 7075582
    Abstract: Methods for identifying MarR family inhibiting compounds are described. The methods include the use of computer aided rational based drug design programs and three dimensional structures of MarR family polypeptides.
    Type: Grant
    Filed: July 15, 2002
    Date of Patent: July 11, 2006
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Michael N. Alekshun, Stuart B. Levy, Brent L. Podlogar, Roger Frechette
  • Methods for identifying and using MarR family polypeptide binding compounds
    Publication number: 20060084678
    Abstract: Methods for identifying MarR family inhibiting compounds are described. The methods include the use of computer aided rational based drug design programs and three dimensional structures of MarR family polypeptides.
    Type: Application
    Filed: December 7, 2005
    Publication date: April 20, 2006
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Michael Alekshun, Stuart Levy, Brent Podlogar, Roger Frechette
  • 7-Pyrollyl tetracycline compounds and methods of use thereof
    Publication number: 20060084634
    Abstract: A compound of Formula (I):
    Type: Application
    Filed: December 2, 2005
    Publication date: April 20, 2006
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Sophie Huss, Jose Bueno, Jose Fiandor, Roger Frechette
  • 7-pyrrolyl tetracycline compounds and methods of use thereof
    Patent number: 7001918
    Abstract: A compound of Formula (I): wherein variables R, R1, R2, R3 and A are as defined in the
    Type: Grant
    Filed: June 1, 2004
    Date of Patent: February 21, 2006
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Sophie Huss, Jose M. Bueno, Jose M. Fiandor, Roger Frechette