Abstract: A probe for a closed transfer system, the probe including a probe body and a probe tip. The probe body defines an inlet, an outlet, and a plurality of channels. The outlet is in fluid communication with the inlet via at least one of the plurality of channels. The probe tip is located at a top end of the probe body and defines a first passageway. The first passageway is in fluid communication with at least one of the plurality of channels. The probe body is configured to be slidably moveable within a coupler body between a first position where the probe tip is received within the coupler body and a second position where the probe tip extends at least partially away from the coupler body to open a fluid flow path through the coupler body.

Abstract: A coupler for use in a closed transfer system is provided. The coupler includes a body with an axial slot, an outlet, and a probe that extends from a first end portion to a second end portion and at least partially received within the body, the probe configured to be movable relative to the body between a first position and a second position to selectively control the flow of fluid through the outlet. A handle is coupled to the probe and configured to interface with the axial slot, wherein the handle is configured to move axially along the axial slot to move the probe between the first position and the second position.

Abstract: A probe for a closed transfer system, the probe including a probe body and a probe tip. The probe body defines an inlet, an outlet, and a plurality of channels. The outlet is in fluid communication with the inlet via at least one of the plurality of channels. The probe tip is located at a top end of the probe body and defines a first passageway. The first passageway is in fluid communication with at least one of the plurality of channels. The probe body is configured to be slidably moveable within a coupler body between a first position where the probe tip is received within the coupler body and a second position where the probe tip extends at least partially away from the coupler body to open a fluid flow path through the coupler body.

Abstract: A probe assembly configured to selectively restrict fluid flow through an outlet of a closed transfer system. The probe assembly has an elongate probe body with a top end portion, a bottom end portion, an outer wall, and an internal structure defining a fluid chamber extending from the bottom end portion to the top end portion. The fluid chamber has a fluid chamber inlet at the bottom end portion extending through the outer wall into the fluid chamber and a fluid chamber outlet at the top end portion extending from the fluid chamber through the outer wall. A probe tip with a cylindrical bore is configured to engage the top end portion of the elongate probe body and a probe tip outlet is configured to be in fluid communication with the fluid chamber outlet. A rotating head located circumjacent to the probe tip and adjacent to the probe tip outlet is configured to rotate about the probe tip.

Abstract: A probe assembly configured to selectively restrict fluid flow through an outlet of a closed transfer system. The probe assembly has an elongate probe body with a top end portion, a bottom end portion, an outer wall, and an internal structure defining a fluid chamber extending from the bottom end portion to the top end portion. The fluid chamber has a fluid chamber inlet at the bottom end portion extending through the outer wall into the fluid chamber and a fluid chamber outlet at the top end portion extending from the fluid chamber through the outer wall. A probe tip with a cylindrical bore is configured to engage the top end portion of the elongate probe body and a probe tip outlet is configured to be in fluid communication with the fluid chamber outlet. A rotating head located circumjacent to the probe tip and adjacent to the probe tip outlet is configured to rotate about the probe tip.

Abstract: Embodiments of the invention provide a probe assembly configured to selectively restrict fluid flow through an outlet of a closed transfer system. The probe assembly has an elongate probe body with a top end portion, a bottom end portion, an outer wall, and an internal structure defining a fluid chamber extending from the bottom end portion to the top end portion. The fluid chamber has a fluid chamber inlet at the bottom end portion extending through the outer wall into the fluid chamber and a fluid chamber outlet at the top end portion extending from the fluid chamber through the outer wall. A probe tip with a cylindrical bore is configured to engage the top end portion of the elongate probe body and a probe tip outlet is configured to be in fluid communication with the fluid chamber outlet. A rotating head located circumjacent to the probe tip and adjacent to the probe tip outlet is configured to rotate about the probe tip.

Abstract: A coupler for use in a closed transfer system is provided. The coupler includes a body with an axial slot, an outlet, and a probe that extends from a first end portion to a second end portion and at least partially received within the body, the probe configured to be movable relative to the body between a first position and a second position to selectively control the flow of fluid through the outlet. A handle is coupled to the probe and configured to interface with the axial slot, wherein the handle is configured to move axially along the axial slot to move the probe between the first position and the second position.

Abstract: Embodiments of the invention provide a coupler for use in a closed transfer system configured to selectively engage a container seated in fluid communication with the coupler. The coupler has a body with a slot having an axial component, and an outlet. A probe extends from a first end portion to a second end portion and is at least partially received within the body, the probe is configured to be movable relative to the body between a first position and a second position to selectively control a flow of fluid through the outlet. A probe tip with a cylindrical bore is configured to engage the second end portion of the probe, and a handle is coupled to the probe and configured to interface with the slot. Axial movement of the handle along the slot moves the probe between the first position and the second position.

Abstract: Embodiments of the invention provide a coupler for use in a closed transfer system configured to selectively engage a container seated in fluid communication with the coupler. The coupler has a body with a slot having an axial component, and an outlet. A probe extends from a first end portion to a second end portion and is at least partially received within the body, the probe is configured to be movable relative to the body between a first position and a second position to selectively control a flow of fluid through the outlet. A probe tip with a cylindrical bore is configured to engage the second end portion of the probe, and a handle is coupled to the probe and configured to interface with the slot. Axial movement of the handle along the slot moves the probe between the first position and the second position.

Abstract: Embodiments of the invention provide a probe assembly configured to selectively restrict fluid flow through an outlet of a closed transfer system. The probe assembly has an elongate probe body with a top end portion, a bottom end portion, an outer wall, and an internal structure defining a fluid chamber extending from the bottom end portion to the top end portion. The fluid chamber has a fluid chamber inlet at the bottom end portion extending through the outer wall into the fluid chamber and a fluid chamber outlet at the top end portion extending from the fluid chamber through the outer wall. A probe tip with a cylindrical bore is configured to engage the top end portion of the elongate probe body and a probe tip outlet is configured to be in fluid communication with the fluid chamber outlet. A rotating head located circumjacent to the probe tip and adjacent to the probe tip outlet is configured to rotate about the probe tip.

Abstract: The invention relates to the use of a compound of Formula (I) or a salt, solvate or prodrug thereof, wherein R1, R2, R3, n and m are as described in the specification, in the preparation of a medicament for the treatment or prevention of a disease condition mediated through glucokinase (GLK), such as type 2 diabetes. The invention also relates to a novel group of compounds of Formula (I) and to methods for preparing compounds of Formula (I).

Abstract: The invention relates to the use of a compound of Formula (I) or a salt, solvate or prodrug thereof, wherein R1, R2, R3, n and m are as described in the specification, in the preparation of a medicament for the treatment or prevention of a disease condition mediated through glucokinase (GLK), such as type 2 diabetes. The invention also relates to a novel group of compounds of Formula (I) and to methods for preparing compounds of Formula (I).

Abstract: The invention relates to the use of a compound of Formula (I) or a salt, solvate or prodrug thereof, wherein R1, R2, R3, n and m are as described in the specification, in the preparation of a medicament for the treatment or prevention of a disease condition mediated through glucokinase (GLK), such as type 2 diabetes. The invention also relates to a novel group of compounds of Formula (I) and to methods for preparing compounds of Formula (I).

Abstract: The invention relates to the use of a compound of Formula (I) or a salt, solvate or prodrug thereof, wherein R1, R2, R3, n and m are as described in the specification, in the preparation of a medicament for the treatment or prevention of a disease condition mediated through glucokinase (GLK), such as type 2 diabetes. The invention also relates to a novel group of compounds of Formula (I) and to methods for preparing compounds of Formula (I).

Abstract: The invention relates to the use of a compound of Formula (I) or a salt, solvate or prodrug thereof, wherein R1, R2, R3, n and m are as described in the specification, in the preparation of a medicament for the treatment or prevention of a disease condition mediated through glucokinase (GLK), such as type 2 diabetes. The invention also relates to a novel group of compounds of Formula (I) and to methods for preparing compounds of Formula (I).

Abstract: The invention is related to novel compounds of Formula (I) or a salt, solvate or prodrug thereof, wherein R1, R2, R3, n and m are as described in the specification, useful in the treatment of a disease or condition mediated through glucokinase (GLK), such as type 2 diabetes. The invention also relates to methods for preparing compounds of Formula (I) and their use as medicaments in the treatment of diseases mediated by glucokinase.

Abstract: The invention related to novel compounds of Formula (I) or a salt, solvate or prodrug thereof, wherein A, R1, R2, R3, n and m are as described in the specification, useful in the treatment of a disease or condition mediated through glucokinase (GLK), such as type 2 diabetes. The invention also relates to methods for preparing compounds of Formula (I) and their use as medicaments in the treatment of diseases mediated by glucokinase.

Abstract: The invention relates to novel compounds of Formula (I) or a salt, solvate or prodrug thereof, wherein A, R1, R2, R3, n and m are described in the specification, useful in the treatment of a disease or condition mediated through glucokinase (GLK), such as type 2 diabetes. The invention also relates to methods for preparing compounds of Formula (I) and their use as medicaments in the treatment of diseases mediated by glucokinase.

Abstract: The invention related to novel compounds of Formula (I) or a salt, solvate or prodrug thereof, wherein R1, R2, R3, n and m are as described in the specification, useful in the treatment of a disease or condition mediated through glucokinase (GLK), such as type 2 diabetes. The invention also relates to methods for preparing compounds of Formula (I) and their use as medicaments in the treatment of diseases mediated by glucokinase.

Abstract: A system of providing medical after sales support to a patient or other user associated with a patient having a packaged medical product with a product code identifying the product is disclosed, wherein the user remains anonymous. A product code and a user identifier or contact address are received at a medical information computer (3) over a communications link (2,5) from a user (1,4). The received code is verified to determine if it corresponds to a valid code stored in a product code database (3e). The received user identifier/contact address is verified to determine if it corresponds to a valid user identifier/contact address stored in a user identifier/contact address database (3f). Information related to the packaged medical product identified by the product code is retrieved from a user medication record database (3h) or product information database (3g), upon positive verification.