Abstract: A virtual disc enabled media player is disclosed. The media player includes a storage medium having instructions stored thereon which when executed by a processor in the media player cause certain actions to be performed. The actions include the media player executing a virtual disc software image as if it were a physical medium. This allows the player to access content and information when no physical media is present in the media player. The content and information may be obtained over a network such as the Internet. The media player may be a BLU-RAY DISC player.

Abstract: Updating a file system in a media player is disclosed. The media player or a portable medium in the media player may have instructions which cause the media player to request an update to a portable medium. The update is composed of multiple update components from an update server. In response to the request, the update server queries content servers for information about the update request. Based on available update information from the content servers, the update server creates a composite manifest file, the composite manifest including a plurality of content updates. The update server digitally signs the composite manifest and sends the composite manifest file, the signature file, and location information for the updates included in the manifest file to the media player. The media player downloads the content updates. The media player and the portable medium may conform to the Blu-ray Disc specifications.

Abstract: An optical article comprising a first file encoded on the optical article comprising data structure information; a second file encoded on the optical article comprising a backup of the first file; wherein at least one of the first file or the second file must be fully readable for the player to read the data on the optical article; and a mark disposed on at least a portion of the optical article where the first file is encoded and at least a portion of the optical article where the second file is encoded; wherein the mark comprises an optical state change material; wherein the optical state change material undergoes a change in its optical state when exposed to an activation signal selected from one or more of a laser, thermal energy, infrared rays, X-rays, gamma rays, microwaves, visible light, ultraviolet light, ultrasound waves, radio frequency waves, electrical energy, chemical energy, magnetic energy, and mechanical energy; wherein the optical article is transformed from a pre-activated state to an activ

Abstract: A controlled release pharmaceutical dosage form for bacteriophage is presented. The dosage form is prepared by drying the active ingredient together with a dispersion or solution of polymethacrylate copolymer and a lyprotectant using mild, entirely aqueous conditions.

Abstract: An optical article for playback in a player includes a plurality of optically detectable marks disposed on a surface of the optical article; wherein the plurality of optically detectable marks are in a pre-determined combination of a first state and a second state; and at least one first control logic comprising at least one sector; wherein each optically detectable mark is associated with a particular first control logic; wherein each first control logic is executed only when its associated optically detectable mark is in a pre-determined state; and wherein a customized player-readable code is determined using a combination of the plurality of optically detectable marks and their associated first control logic. A method of making the optical article, a method of customizing the optical article, a method and a system for the playback of the optical article are also included.

Abstract: An optical article for playback in a player includes a permanent player-readable code comprising a first set of a plurality of optically-detectable marks disposed on the optical article; a second set of plurality of optically-detectable marks disposed on a surface of the optical article; wherein the plurality of optically-detectable marks are in a pre-determined combination of a first state and a second state; and at least one first control logic comprising at least one sector; wherein each optically detectable mark is associated with a particular first control logic; wherein each first control logic is executed only when its associated optically-detectable mark is in a pre-determined state; wherein a customized player-readable code is determined using a combination of the plurality of optically-detectable marks and their associated first control logic; and wherein the optical article is activated when the customized player-readable code is in a pre-determined relationship with the permanent code.

Abstract: An optical article for playback in a player includes a first file comprising a first control logic; and a second file comprising a second control logic. The first file is configured to direct the player to play a first content data stored on the optical article, when the first control logic is read by the player. The player is directed to read the second file if the player cannot read the first file. The second file is configured to direct the player to play a second content data stored on the article when the second control logic is read by the player. The optical article includes a mark containing an optical state change material disposed on at least a portion of the first file, wherein the mark is in one of a first optical state or a second optical state, and wherein the first control logic can be read only when the mark is in the second optical state.

Abstract: An optical article for playback in a player includes at least one sector comprising a first control logic configured to set the value of a first register, the first register having a default value before it is set, and a non-default value after it is set, and a first command to be read sequentially after the sector. The first command is configured to direct the player to play a first content on the article if the first register is set to the default value and to direct the player to play a second content on the article if the first register is set to the non-default value. The optical article includes a mark containing an optical state change material disposed on the sector, wherein the mark is in one of a first optical state or a second optical state, and wherein the first control logic can be read only when the mark is in the second optical state.

Abstract: There are provided methods and apparatus for synchronized stream packing of packets that differ contextually between A/V streams in a parallel presentation. A method includes the step of identifying sub-picture/subtitle packets and/or audio packets having arrival timestamps and/or presentation timestamps that match an arrival timestamp and/or a presentation timestamp, respectively, of video packets. The method also includes the step of packing a Video Object Unit (VOBU) and/or a Transport Stream (TS) with the identified sub-picture/subtitle and audio packets and the video packets having the matching timestamps.

Abstract: The present invention provides a computational model and methods of use thereof for predicting whether a compound is likely to inhibit K+ flow through the hERG ion channel. Methods for in silico screening of compounds that have a lower likelihood of inhibiting hERG are also provided.

Abstract: The systems and methods of extending the capabilities of media players included in or with a computing device are disclosed. The systems and methods provide a way for content that fully complies with a given media format specification to utilize network capabilities defined by that specification to create a bridge to an application and resources on the same platform that extend beyond those defined within the media format specification.

Abstract: This document discusses, among other things, systems, devices, and methods for using surface energy to assist in fluid transport or separation. One example includes removing mucus from a subject's lungs during mechanical ventilation of the subject using a tracheal tube. At least one wicking fluid pickup port is located more distal than a sealing device between the tracheal tube and the trachea. Surface energy assists in introducing mucus into the port. Ventilation of the subject is not impaired by the mucus removal. Safety venting reduces or avoids damage to tissue occluding the port. Other structures may assist in directing the mucus toward the port. Various illustrative examples include single lumen tracheal tubes, double lumen tracheal tubes, two-piece tracheal tubes (having outer and inner cannulas) and bronchial blockers.

Abstract: A multi-barrier filter comprising a halogenated resin capable of removing contaminants from a fluid, and at least one contaminant sorbent medium downstream of the halogenated resin capable of adsorbing or absorbing contaminants. The at least one contaminant sorbent medium is preferably “halogen-neutral” to maximize the antimicrobial effectiveness of the halogen in the fluid. The filter may comprise at least one “halogen-scavenger” barrier downstream of the halogen-neutral barrier. Because of the efficiency of the filter, a low-residual halogenated resin, such as, for example, low residual iodinated resin, may be used.

Abstract: An improved light-emitting panel having a plurality of micro-components sandwiched between two substrates is disclosed. Each micro-component contains a gas or gas-mixture capable of ionization when a sufficiently large voltage is supplied across the micro-component via at least two electrodes. An improved method of manufacturing a light-emitting panel is also disclosed, which uses a web fabrication process to manufacturing light-emitting displays as part of a high-speed, continuous inline process.

Abstract: An aqueous dispersion of a polymerized (e.g., oxidized) oil, preferably an oxidized vegetable oil, suitable for reducing dusting in industrial processes, prepared by using, as the primary dispersing (emulsification) agent, a sulfated or sulfonated oil (also preferably a sulfated or sulfonated vegetable oil) to disperse the polymerized oil.

Abstract: A system comprising an elongated member, sized and shaped to be inserted within a subject's trachea, the elongated member comprising proximal and distal ends; a seal, extending around the elongated member at or near the distal end of the elongated member; at least one wicking fluid pickup port, positioned near the distal end of the elongated member, the at least one wicking fluid pickup port located more proximal than at least a portion of the seal; and at least one lumen, coupled in fluid communication with the at least one wicking fluid pickup port and extending toward the proximal end of the elongated member, the seal comprising an inflatable cuff having a proximal surface, wherein the at least one wicking fluid pickup port is disposed near an inner tracheal wall when the distal end of the elongated member is positioned within a trachea of a person and the inflatable cuff is inflated.

Abstract: A method and apparatus for affecting the properties of a material comprise vibrating the material during its formation (i.e., “surface sifting”). The method comprises the steps of providing a material formation device and applying a plurality of vibrations to the material during formation, which vibrations comprise oscillations having dissimilar, non-harmonic frequencies and at least two different directions. The apparatus comprises a plurality of vibration sources that impart vibrations to the material.

Abstract: This document discusses, among other things, systems, devices, and methods for using surface energy to assist in fluid transport or separation. One example includes removing mucus from a subject's lungs during mechanical ventilation of the subject using a tracheal tube. At least one wicking fluid pickup port is located more distal than a sealing device between the tracheal tube and the trachea. Surface energy assists in introducing mucus into the port. A peristalsis or other pump is used to remove from the subject a substantially contiguous column of the wicked-in liquid. Ventilation of the subject is not impaired by the mucus removal. Safety venting reduces or avoids damage to tissue occluding the port. Other structures may assist in directing the mucus toward the port. Various illustrative examples include single lumen tracheal tubes, double lumen tracheal tubes, two-piece tracheal tubes (having outer and inner cannulas) and bronchial blockers.

Abstract: The present invention relates to 9-substituted adenine derivatives represented by formula (I) wherein W is selected from the group consisting of H, halogen, azido and amino group; X is selected from the group consisting of O, S, N(H), CH2, CH and C; Y is selected from the group consisting of H, hydroxy, C1-4 alkyl, C1-4 alkoxy and halogen; R is selected from the group consisting of H, hydroxymethyl, C1-4 alkyl, and C1-4 alkoxy; R1is selected from the group consisting of O, NH and CH2; R2represents a radical selected from the group consisting of —(CH2)n—S—C(O)—R4 and —(CH2)n—S—S—R4, where n=1-4 and R4is a C1-4-alkyl or aryl group and R4 is optionally substituted with a halogen, amino, N-alkylamino, N, N-dialkylamino or C1-4 alkoxy group and wherein each of the R2radicals may be the same or different; and R3is O or S. The derivatives are useful as prodrugs for inhibiting adenylyl cyclase and lowering 3?:5?-cAMP in cells, thereby inhibiting adenylyl cyclase dependent effects within cells.

Abstract: An improved light-emitting panel having a plurality of micro-components at least partially disposed in a socket and sandwiched between two substrates is disclosed. Each micro-component contains a gas or gas-mixture capable of ionization when a sufficiently large voltage is supplied across the micro-component via at least two electrodes.