Abstract: Described herein are systems and methods of receiving first and second input signals at a first two-input comparator, responsively generating a first subchannel output, receiving third and fourth input signals at a second two-input comparator, responsively generating a second subchannel output, receiving the first, second, third, and fourth input signals at a third multi-input comparator, responsively generating a third subchannel output representing a comparison of an average of the first and second input signals to an average of the third and fourth input signals, configuring a first data detector connected to the second subchannel output and a second data detector connected to the third subchannel output according to a legacy mode of operation and a P4 mode of operation.

Abstract: Methods and systems are described for receiving, over a plurality of consecutive signaling intervals, a plurality of codewords, each codeword received as a plurality of symbols via wires of a multi-wire bus, the plurality of symbols received at a plurality of multi-input comparators (MICs), wherein each symbol is received by at least two MICs, generating, for each codeword, a corresponding linear combination of the received symbols, generating a plurality of composite skew measurement signals over the plurality of consecutive signaling intervals, each composite skew measurement signal based on samples of one or more linear combinations, and updating wire-specific skew values of the wires of the multi-wire bus, wherein one or more wire-specific skew values are updated according to composite skew measurement signals associated with linear combinations formed by at least two different MICs.

Abstract: A pair of ground planes arranged in parallel, a dielectric medium disposed in between the pair of ground planes, and a set of at least four signal conductors disposed in the dielectric medium, the set of at least four signal conductors having (i) a first pair of signal conductors arranged proximate to a first ground plane of the pair of ground planes and (ii) a second pair of signal conductors arranged proximate to a second ground plane of the pair of ground planes, each signal conductor of the set of at least four signal conductors configured to carry a respective signal corresponding to a symbol of a codeword of a vector signaling code.

Abstract: A plurality of driver slice circuits arranged in parallel having a plurality of driver slice outputs, each driver slice circuit having a digital driver input and a driver slice output, each driver slice circuit configured to generate a signal level determined by the digital driver input, and a common output node connected to the plurality of driver slice outputs and a wire of a multi-wire bus, the multi-wire bus having a characteristic transmission impedance matched to an output impedance of the plurality of driver slice circuits arranged in parallel, each driver slice circuit of the plurality of driver slice circuits having an individual output impedance that is greater than the characteristic transmission impedance of the wire of the multi-wire bus.

Abstract: Generating, during a first and second signaling interval, an aggregated data signal by forming a linear combination of wire signals received in parallel from wires of a multi-wire bus, wherein at least some of the wire signals undergo a signal level transition during the first and second signaling interval; measuring a signal skew characteristic of the aggregated data signal; and, generating wire-specific skew offset metrics, each wire-specific skew offset metric based on the signal skew characteristic.

Abstract: In certain embodiments, the invention includes therapeutic methods of using a BTK inhibitor to treat solid tumor cancers by modulation of the tumor microenvironment, including macrophages, monocytes, mast cells, helper T cells, cytotoxic T cells, regulatory T cells, natural killer cells, myeloid-derived suppressor cells, regulatory B cells, neutrophils, dendritic cells, and fibroblasts.

Abstract: In a detection circuit, inputs correspond to received indications of vector signaling code words received by a first integrated circuit from a second integrated circuit. With four inputs, the circuit compares a first pair to obtain a first difference result and compares a second pair, disjoint from the first pair, to obtain a second difference result. The first and second difference results are then summed to form an output function. A system might use a plurality of such detection circuits to arrive at an input word. The circuit can include amplification, equalization, and input selection with efficient code word detection. The vector signaling code can be a Hadamard matrix code encoding for three input bits. The circuit might also have frequency-dependent gain, a selection function that directs one of the summation function result or the first difference result to the output function, variable gain, and/or a slicer.

Abstract: Properties and the construction method of Orthogonal Differential Vector Signaling Codes are disclosed which are tolerant of order-reversal, as may occur when physical routing of communications channel wires causes the bus signal order to be reversed. Operation using the described codes with such bus-reversed signals can avoid complete logical or physical re-ordering of received signals or other significant duplication of receiver resources.

Abstract: Transmission line driver systems are described which are comprised of multiple paralleled driver elements. The paralleled structure allows efficient generation of multiple output signal levels with adjustable output amplitude, optionally including Finite Impulse Response signal shaping and skew pre-compensation.

Abstract: Systems and methods are described for transmitting data over physical channels to provide a high bandwidth, low latency interface between a transmitting device and a receiving device operating at high speed with low power utilization. Communication is performed using group signaling over sets of four wires using a vector signaling code, where each wire of a set carries a low-swing signal that may take on one of four signal values. Topologies and designs of wire sets are disclosed with preferred characteristics for group signaling communications.

Abstract: Therapeutic combinations of a phosphoinositide 3-kinase (PI3K) inhibitor, including PI3K inhibitors selective for the ?- and ?-isoforms and selective for both ?- and ?-isoforms (PI3K-?,?, PI3K-?, and PI3K-?), a Janus kinase-2 (JAK-2) inhibitor, a Bruton's tyrosine kinase (BTK) inhibitor, and/or a B-cell lymphoma-2 (BCL-2) inhibitor are described. In some embodiments, the invention provides therapeutic combinations of a PI3K-? inhibitor and a BTK inhibitor, a JAK-2 and a BTK inhibitor, and a BCL-2 and BTK inhibitor.

Abstract: Therapeutic combinations of a phosphoinositide 3-kinase (PI3K) inhibitor, including PI3K inhibitors selective for the ?- and ?-isoforms and selective for both ?- and ?-isoforms (PI3K-?,?, PI3K-?, and PI3K-?, a Janus kinase-2 (JAK-2) inhibitor, a cyclin-dependent kinase-4/6 (CDK4/6) inhibitor, and/or a Bruton's tyrosine kinase (BTK) inhibitor are described. In certain embodiments, the invention includes therapeutic combinations of a cyclin-dependent kinase-4/6 (CDK4/6) inhibitor and a BTK inhibitor, a PI3K-? inhibitor and a BTK inhibitor, a JAK-2 and a BTK inhibitor, and a JAK-2, PI3K-?, and BTK inhibitor.

Abstract: Therapeutic combinations of a Janus kinase-2 (JAK-2) inhibitor, a Bruton's tyrosine kinase (BTK) inhibitor, and/or a phosphoinositide 3-kinase (PI3K) inhibitor, including PI3K inhibitors selective for the ?- and ?-isoforms and selective for both ?- and ?-isoforms, are described. In some embodiments, the invention provides pharmaceutical compositions comprising combinations of (1) a PI3K-?inhibitor and a BTK inhibitor, (2) a JAK-2 inhibitor and a BTK inhibitor, or (3) a JAK-2 inhibitor, PI3K-? inhibitor, and BTK inhibitor, and methods of using the pharmaceutical compositions for treating a disease, in particular a cancer.

Abstract: Transmission line driver systems are described which are comprised of multiple paralleled driver elements. The paralleled structure allows efficient generation of multiple output signal levels with adjustable output amplitude, optionally including Finite Impulse Response signal shaping and skew pre-compensation.

Abstract: Vector signaling codes are synergistically combined with multi-level signaling, the increased alphabet size provided by the multi-level signaling enabling a larger codeword space for a given number of symbols, at the cost of reduced receiver detection margin for each of the multiple signal levels. Vector signaling code construction methods are disclosed in which code construction and selection of multi-level signal levels are coordinated with the design of an associated receive comparator network, wherein modified signal levels encoded and emitted by the transmitter result in increased detection margin at the receive comparators.

Abstract: Properties and the construction method of Orthogonal Differential Vector Signaling Codes are disclosed which are tolerant of order-reversal, as may occur when physical routing of communications channel wires causes the bus signal order to be reversed. Operation using the described codes with such bus-reversed signals can avoid complete logical or physical reordering of received signals or other significant duplication of receiver resources.

Abstract: An efficient regulated power supply for a communications interface is disclosed using a data-dependent charge pump design. Data patterns known to produce increased power supply load concurrently raise power supply source current, leading to significant overall power savings for the combined communications driver and regulator over known switched and linear regulator solutions.

Abstract: Therapeutic combinations of a Janus kinase-2 (JAK-2) inhibitor, a Bruton's tyrosine kinase (BTK) inhibitor, and/or a phosphoinositide 3-kinase (PI3K) inhibitor, including PI3K inhibitors selective for the ?- and ?-isoforms and selective for both ?- and ?-isoforms, are described. In some embodiments, the invention provides pharmaceutical compositions comprising combinations of (1) a PI3K-? inhibitor and a BTK inhibitor, (2) a JAK-2 inhibitor and a BTK inhibitor, or (3) a JAK-2 inhibitor, PI3K-? inhibitor, and BTK inhibitor, and methods of using the pharmaceutical compositions for treating a disease, in particular a cancer.

Abstract: Transmission line driver systems are described which are comprised of multiple paralleled driver elements. The paralleled structure allows efficient generation of multiple output signal levels with adjustable output amplitude, optionally including Finite Impulse Response signal shaping and skew pre-compensation.

Abstract: In a detection circuit, inputs correspond to received indications of vector signaling code words received by a first integrated circuit from a second integrated circuit. With four inputs, the circuit compares a first pair to obtain a first difference result and compares a second pair, disjoint from the first pair, to obtain a second difference result. The first and second difference results are then summed to form an output function. A system might use a plurality of such detection circuits to arrive at an input word. The circuit can include amplification, equalization, and input selection with efficient code word detection. The vector signaling code can be a Hadamard matrix code encoding for three input bits. The circuit might also have frequency-dependent gain, a selection function that directs one of the summation function result or the first difference result to the output function, variable gain, and/or a slicer.