Abstract: Vector signaling codes are synergistically combined with multi-level signaling, the increased alphabet size provided by the multi-level signaling enabling a larger codeword space for a given number of symbols, at the cost of reduced receiver detection margin for each of the multiple signal levels. Vector signaling code construction methods are disclosed in which code construction and selection of multi-level signal levels are coordinated with the design of an associated receive comparator network, wherein modified signal levels encoded and emitted by the transmitter result in increased detection margin at the receive comparators.

Abstract: Systems and methods are described for transmitting data over physical channels to provide a high bandwidth, low latency interface between integrated circuit chips with low power utilization. Communication is performed using group signaling over multiple wires using a vector signaling code, where each wire carries a low-swing signal that may take on more than two signal values.

Abstract: In a detection circuit, inputs correspond to received indications of vector signaling code words received by a first integrated circuit from a second integrated circuit. With four inputs, the circuit compares a first pair to obtain a first difference result and compares a second pair, disjoint from the first pair, to obtain a second difference result. The first and second difference results are then summed to form an output function. A system might use a plurality of such detection circuits to arrive at an input word. The circuit can include amplification, equalization, and input selection with efficient code word detection. The vector signaling code can be a Hadamard matrix code encoding for three input bits. The circuit might also have frequency-dependent gain, a selection function that directs one of the summation function result or the first difference result to the output function, variable gain, and/or a slicer.

Abstract: Systems and methods are described for transmitting data over physical channels to provide a high bandwidth, low latency interface between a transmitting device and a receiving device operating at high speed with low power utilization. Communication is performed using group signaling over sets of four wires using a vector signaling code, where each wire of a set carries a low-swing signal that may take on one of four signal values. Topologies and designs of wire sets are disclosed with preferred characteristics for group signaling communications.

Abstract: In some embodiments, the invention includes a therapeutic combination of a phosphoinositide 3-kinase (PI3K) inhibitor, including PI3K inhibitors selective for the ?- and ?-isoforms and selective for both ?- and ?-isoforms, and a Bruton's tyrosine kinase (BTK) inhibitor. In some embodiments, the invention includes therapeutic methods of using a BTK inhibitor and a PI3K-? inhibitor to treat solid tumor cancers by modulation of the tumor microenvironment, including macrophages, monocytes, mast cells, helper T cells, cytotoxic T cells, regulatory T cells, natural killer cells, myeloid-derived suppressor cells, regulatory B cells, neutrophils, dendritic cells, and fibroblasts.

Abstract: Described herein are systems and methods of receiving first and second input signals at a first two-input comparator, responsively generating a first subchannel output, receiving third and fourth input signals at a second two-input comparator, responsively generating a second subchannel output, receiving the first, second, third, and fourth input signals at a third multi-input comparator, responsively generating a third subchannel output representing a comparison of an average of the first and second input signals to an average of the third and fourth input signals, configuring a first data detector connected to the second subchannel output and a second data detector connected to the third subchannel output according to a legacy mode of operation and a P4 mode of operation.

Abstract: Therapeutic compositions and methods of using the compositions, including combinations of a Bruton's tyrosine kinase (BTK) inhibitor, a phosphomositide 3-kinase (PI3K) inhibitor, including PI3K inhibitors selective for the ?- and ?-isoforms and selective for both y- and ?-isoforms (PI3K-?,?, PI3K-?, and PI3K-?, a programmed death 1 (PD-1) or programmed death ligand 1 (PD-L1) inhibitor, and/or a Janus kinase-2 (JAK-2) inhibitor are described. In certain embodiments, the invention includes therapeutic methods of using a PD-1 monoclonal antibody and a BTK inhibitor. In other embodiments, the invention includes therapeutic methods of using a PD-L1 monoclonal antibody and a BTK inhibitor. In other embodiments, the invention includes therapeutic methods of using a PD-1 inhibitor, a BTK inhibitor, and a PI3K˜? inhibitor. In other embodiments, the invention includes therapeutic methods of using a PD-L1 inhibitor, a BTK inhibitor, and a PI3K˜? inhibitor.

Abstract: Therapeutic combinations of a phosphoinositide 3-kinase (PI3K) inhibitor, including PI3K inhibitors selective for the ?- and ?-isoforms and selective for both ?- and ?-isoforms (PI3K-?,?, PI3K-?, and PI3K-?), a Janus kinase-2 (JAK-2) inhibitor, a Bruton's tyrosine kinase (BTK) inhibitor, and/or a B-cell lymphoma-2 (BCL-2) inhibitor are described. In some embodiments, the invention provides therapeutic combinations of a PI3K-? inhibitor and a BTK inhibitor, a JAK-2 and a BTK inhibitor, and a BCL-2 and BTK inhibitor.

Abstract: In certain embodiments, the invention includes therapeutic methods of using a BTK inhibitor to treat solid tumor cancers by modulation of the tumor microenvironment, including macrophages, monocytes, mast cells, helper T cells, cytotoxic T cells, regulatory T cells, natural killer cells, myeloid-derived suppressor cells, regulatory B cells, neutrophils, dendritic cells, and fibroblasts.

Abstract: Therapeutic combinations of a phosphoinositide 3-kinase (PI3K) inhibitor, including PI3K inhibitors selective for the ?- and ?-isoforms and selective for both ?- and ?-isoforms (PI3K-?,?, PI3K-?, and PI3K-?, a Janus kinase-2 (JAK-2) inhibitor, a cyclin-dependent kinase-4/6 (CDK4/6) inhibitor, and/or a Bruton's tyrosine kinase (BTK) inhibitor are described. In certain embodiments, the invention includes therapeutic combinations of a cyclin-dependent kinase-4/6 (CDK4/6) inhibitor and a BTK inhibitor, a PI3K-? inhibitor and a BTK inhibitor, a JAK-2 and a BTK inhibitor, and a JAK-2, PI3K-?, and BTK inhibitor.

Abstract: Described herein are systems and methods of receiving first and second input signals at a first two-input comparator, responsively generating a first subchannel output, receiving third and fourth input signals at a second two-input comparator, responsively generating a second subchannel output, receiving the first, second, third, and fourth input signals at a third multi-input comparator, responsively generating a third subchannel output representing a comparison of an average of the first and second input signals to an average of the third and fourth input signals, configuring a first data detector connected to the second subchannel output and a second data detector connected to the third subchannel output according to a legacy mode of operation and a P4 mode of operation.

Abstract: Therapeutic combinations of a Janus kinase-2 (JAK-2) inhibitor, a Bruton's tyrosine kinase (BTK) inhibitor, and/or a phosphoinositide 3-kinase (PI3K) inhibitor, including PI3K inhibitors selective for the ?- and ?-isoforms and selective for both ?- and ?-isoforms, are described. In some embodiments, the invention provides pharmaceutical compositions comprising combinations of (1) a PI3K-? inhibitor and a BTK inhibitor, (2) a JAK-2 inhibitor and a BTK inhibitor, or (3) a JAK-2 inhibitor, PI3K-? inhibitor, and BTK inhibitor, and methods of using the pharmaceutical compositions for treating a disease, in particular a cancer.

Abstract: Transmission line driver systems are described which are comprised of multiple paralleled driver elements. The paralleled structure allows efficient generation of multiple output signal levels with adjustable output amplitude, optionally including Finite Impulse Response signal shaping and skew pre-compensation.

Abstract: Therapeutic methods of treating chronic lymphocytic leukemia (CLL) and small lymphocytic leukemia (SLL) are described. In certain embodiments, the invention includes therapeutic methods of treating CLL and SLL using a BTK inhibitor. In certain embodiments, the invention includes therapeutic methods of treating subtypes of CLL and SLL using a BTK inhibitor, including subtypes of CLL in patients sensitive to thrombosis and subtypes of CLL that increase monocytes and NK cells in peripheral blood after treatment with a BTK inhibitor. In certain embodiments, the invention includes therapeutic methods of treating CLL and SLL using a combination of a BTK inhibitor and an anti-CD20 antibody.

Abstract: Systems and methods are described for transmitting data over physical channels to provide a high bandwidth, low latency interface between a transmitting device and a receiving device operating at high speed with low power utilization. Communication is performed using group signaling over sets of four wires using a vector signaling code, where each wire of a set carries a low-swing signal that may take on one of four signal values. Topologies and designs of wire sets are disclosed with preferred characteristics for group signaling communications.

Abstract: Systems and circuits are described for transmitting data over physical channels to provide a fault tolerant, high speed, low latency interface such as between a memory controller and memory devices. Communications signals are communicated over interconnection groups comprised of multiple wires, with the described encoding and decoding permitting continued communication in the presence of a wire failure within an interconnection group. An efficient distributable voltage regulator to provide communications driver power is also disclosed.

Abstract: In a detection circuit, inputs correspond to received indications of vector signaling code words received by a first integrated circuit from a second integrated circuit. With four inputs, the circuit compares a first pair to obtain a first difference result and compares a second pair, disjoint from the first pair, to obtain a second difference result. The first and second difference results are then summed to form an output function. A system might use a plurality of such detection circuits to arrive at an input word. The circuit can include amplification, equalization, and input selection with efficient code word detection. The vector signaling code can be a Hadamard matrix code encoding for three input bits. The circuit might also have frequency-dependent gain, a selection function that directs one of the summation function result or the first difference result to the output function, variable gain, and/or a slicer.

Abstract: Transmission line driver systems are described which are comprised of multiple paralleled driver elements. The paralleled structure allows efficient generation of multiple output signal levels with adjustable output amplitude, optionally including Finite Impulse Response signal shaping and skew pre-compensation.

Abstract: Properties and the construction method of Orthogonal Differential Vector Signaling Codes are disclosed which are tolerant of order-reversal, as may occur when physical routing of communications channel wires causes the bus signal order to be reversed. Operation using the described codes with such bus-reversed signals can avoid complete logical or physical re-ordering of received signals or other significant duplication of receiver resources.

Abstract: Systems and methods are described for transmitting data over physical channels to provide a high bandwidth, low latency interface between integrated circuit chips with low power utilization. Communication is performed using group signaling over multiple wires using a vector signaling code, where each wire carries a low-swing signal that may take on more than two signal values.