Abstract: The present invention relates to compounds comprising a quaternary ammonium group, their use in skin diseases, and their preparation.

Abstract: The present invention relates to compounds comprising a quaternary ammonium group, their use in skin diseases, and their preparation.

Abstract: The present invention relates to compounds comprising a quaternary ammonium group, their use in skin diseases, and their preparation.

Abstract: Process for the separation of a biomolecule containing at least one cationic group from a liquid medium containing the biomolecule, which includes the use of a tetraphenylborate (TPB) salt.

Abstract: The present invention relates to compounds comprising a quaternary ammonium group, their use in skin diseases, and their preparation.

Abstract: The present invention relates to an alpha-MSH analogue compound, the use in skin diseases, and the preparation.

Abstract: Process for the separation of a biomolecule containing at least one cationic group from a liquid medium containing said biomolecule, which comprises the use of a tetraphenylborate (TPB) salt.

Abstract: Process for the separation of a biomolecule containing at least one cationic group from a liquid medium containing said biomolecule, which comprises the use of a tetraphenylborate (TPB) salt.

Abstract: A process for the manufacture of peptide Omiganan in solution phase. Novel intermediates in the process for the manufacture of Omiganan and processes for the manufacture of these intermediates.

Abstract: The present invention relates to a process for producing N-alkyl-N-trialkylsilylamides from trialkylsilylhalides and N-alkylamides in the presence of a base and in the absence of a solvent.

Abstract: The invention provides crystalline forms of the peptide Gly-Gly-Val-Leu-Val-Gln-Pro-Gly (SEQ ID NO 1), and salts of the peptide, which may further have associated water molecules. These salts and hydrated salts of the peptide and compositions comprising these materials have advantageous pharmaceutical properties.

Abstract: The present invention relates to a process for producing N-alkyl-N-trialkylsilylamides from trialkylsilylhalides and N-alkylamides in the presence of a base and in the absence of a solvent.

Abstract: A thermo-responsive polymer covalently bound with a peptide, wherein the peptide comprises a peptide moiety that is able to self-assemble and a functional peptide moiety comprising a bioactive sequence, and compositions comprising such thermo-responsive polymer covalently bound with a peptide. Methods for the preparation of such thermo-responsive polymers covalently bound with a peptide and the use thereof for the preparation of hydrogels.

Abstract: Process for the manufacture of a peptide or peptide analog, which comprises (a) producing a persilylated peptide or persilylated peptide analogue by silylating a corresponding peptide by reaction with a silylating agent other than trimethylsilylcyanide, and (b) reacting a compound of formula (I) X-A-COOH wherein X is an amino protecting group, A is an amino acid, peptide or peptide analogue residue, and —COOH designates an optionally activated carboxylic group, with a persilylated peptide or a persilylated peptide analogue containing from 4 to 15 amino acids.

Abstract: Use of the amino acid sequence Har-Gly-Asp (hRGD) as a bioactive sequence in functional peptides to promote cell adhesion, cell growth, and/or cell differentiation, and in the preparation of hydrogels, preferably hydrogels for cell culture. A hydrogel comprising the hRGD sequence, especially a hydrogel wherein the hRGD sequence is part of the hydrogel scaffold.

Abstract: A process for manufacturing a cyclic peptide which comprises providing a cyclic peptide bonded to a Merrifield-type resin and cleaving the cyclic peptide from the Merrifield type resin by transesterification.

Abstract: Method for preparing a peptide or a peptide derivative which comprises it least one step in which a free amino acid or a free peptide is reacted with a urethane-protected amino acid N-carboxyanhydride (UNCA) solution.

Abstract: Process for the separation of a biomolecule containing at least one cationic group from a liquid medium containing said biomolecule, which comprises the use of a tetraphenylborate (TPB) salt.

Abstract: A process for the manufacture of peptide Omiganan in solution phase. Novel intermediates in the process for the manufacture of Omiganan and processes for the manufacture of these intermediates.

Abstract: Process for the manufacture of a peptide or peptide analog, which comprises (a) producing a persilylated peptide or persilylated peptide analogue by silylating a corresponding peptide by reaction with a silylating agent other than trimethylsilylcyanide, and (b) reacting a compound of formula (I) X-A-COOH wherein X is an amino protecting group, A is an amino acid, peptide or peptide analogue residue, and —COOH designates an optionally activated carboxylic group, with a persilylated peptide or a persilylated peptide analogue containing from 4 to 15 amino acids.