Abstract: The disclosure concerns a method and a device for enriching cells, cell fragments and molecules from whole blood for a specific detection of at least one population of cells, cell fragments or molecules contained therein. The task was to detect a broad spectrum of target objects including their molecules simply, quickly and yet sensitively and specifically from whole blood. According to the disclosure, not the target objects themselves, but matrix objects are specifically enriched, but target objects are specifically analyzed and thus a specific and sensitive detection of target objects is achieved.

Abstract: The disclosure concerns a method and a device for enriching cells, cell fragments and molecules from whole blood for a specific detection of at least one population of cells, cell fragments or molecules contained therein. The task was to detect a broad spectrum of target objects including their molecules simply, quickly and yet sensitively and specifically from whole blood. According to the disclosure, not the target objects themselves, but matrix objects are specifically enriched, but target objects are specifically analyzed and thus a specific and sensitive detection of target objects is achieved.

Abstract: The disclosure concerns a method and a device for enriching cells, cell fragments and molecules from whole blood for a specific detection of at least one population of cells, cell fragments or molecules contained therein. The task was to detect a broad spectrum of target objects including their molecules simply, quickly and yet sensitively and specifically from whole blood. According to the disclosure, not the target objects themselves, but matrix objects are specifically enriched, but target objects are specifically analyzed and thus a specific and sensitive detection of target objects is achieved.

Abstract: The present invention provides a method of capturing thrombi in a blood vessel, which includes delivering a removable filter in a collapsed state within the blood vessel and deploying the filter to an expanded state within the blood vessel. The filter includes a plurality of primary struts and a plurality of secondary struts emanating from a hub and extending arcuately along a longitudinal axis and linearly radially. Each primary strut has an arcuate segment including first and second curved portions. Each secondary strut includes first and second arcs. The primary struts terminate with an anchoring hook. Each primary strut crosses another primary strut along the longitudinal axis in the collapsed state such that the arcuate segments occupy a first diameter and the anchoring hooks occupy a second diameter, the first diameter being greater than the second diameter for filter retrieval or delivery.

Abstract: A removable filter having a collapsed state and an expanded state for capturing thrombi in a blood vessel is disclosed. The filter comprises a plurality of primary struts and a plurality of secondary struts. Each primary strut in the expanded state extends from a primary strut first end to an anchoring hook. Each primary strut extends arcuately along a longitudinal axis and linearly radially. The plurality of primary strut first ends are attached together along the longitudinal axis. Each secondary strut in the expanded state extends from a secondary strut first end to a free end. Each secondary strut extends arcuately along the longitudinal axis and linearly radially. The plurality of secondary struts are attached together along the longitudinal axis. The plurality of secondary struts centralize the filter in the expanded state in the blood vessel.

Abstract: Modified endogenous human interferon-gamma (hIFN-?), biologically inactive but preserving binding affinity to the hIFN-? receptor, has applicability in the treatment of autoimmune diseases, especially multiple sclerosis.

Abstract: Inactivated protein derivatives of the hIFN-? that preserve affinity to the hIFN-? receptor are useful in the treatment of autoimmune diseases, especially multiple sclerosis.

Abstract: The invention relates to an inhibitor of endogenous human interferon-gamma (hIFN-ϝ) in autoimmune diseases, especially in multiple sclerosis. More precisely, the invention relates to inactivated protein derivatives of the hIFN-ϝ with preserved affinity to the hIFN-ϝ receptor. The derivatives represent genetically modified variants of hIFN-ϝ where the C-terminal part of the molecule is either deleted or replaced with a polypeptide sequence of another human protein and a recombinant hIFN-ϝ inactivated by physical or chemical methods.

Abstract: The present invention provides a method of capturing thrombi in a blood vessel, which includes delivering a removable filter in a collapsed state within the blood vessel and deploying the filter to an expanded state within the blood vessel. The filter includes a plurality of primary struts and a plurality of secondary struts emanating from a hub and extending arcuately along a longitudinal axis and linearly radially. Each primary strut has an arcuate segment including first and second curved portions. Each secondary strut includes first and second arcs. The primary struts terminate with an anchoring hook. Each primary strut crosses another primary strut along the longitudinal axis in the collapsed state such that the arcuate segments occupy a first diameter and the anchoring hooks occupy a second diameter, the first diameter being greater than the second diameter for filter retrieval or delivery.

Abstract: The invention relates to an inhibitor of endogenous human interferon-gamma (hIFN-ϝ) in autoimmune diseases, especially in multiple sclerosis. More precisely, the invention relates to inactivated protein derivatives of the hIFN-ϝ with preserved affinity to the hIFN-ϝ receptor. The derivatives represent genetically modified variants of hIFN-ϝ, where the C-terminal part of the molecule is either deleted or replaced with a polypeptide sequence of another human protein and a recombinant hIFN-ϝ, inactivated by physical or chemical methods.

Abstract: The present invention provides a removable vena cava filter for capturing thrombi in a blood vessel. The filter comprises a plurality of primary struts having first ends attached together along a longitudinal axis. Each primary strut has an arcuate segment extending from the first end to an anchoring hook. The primary struts are configured to move between an expanded state for engaging the anchoring hooks with the blood vessel and a collapsed state for filter retrieval or delivery. Each primary strut are configured to cross another primary strut along the longitudinal axis in the collapsed state such that the arcuate segments occupy a first diameter greater than a second diameter occupied by the anchoring hooks in the collapsed state for filter retrieval or delivery.

Abstract: The present invention provides a removable vena cava filter for capturing thrombi in a blood vessel. The filter comprises a plurality of primary struts having first ends attached together along a longitudinal axis. Each primary strut includes an arcuate segment having a first tensile strength. The arcuate segment extends from the first end to an anchoring hook. The anchoring hook is integral with the arcuate segment and having the first thickness and first tensile strength. The filter further comprises a plurality of secondary struts freely spaced between the primary struts and having connected ends attached together along the longitudinal axis. Each secondary strut freely extends from the connected end to a free end avoiding contact with other secondary struts and primary struts. Each secondary strut has a second tensile strength.

Abstract: The invention relates to an inhibitor of endogenous human interferon-gamma (hIFN-ϝ) in autoimmune diseases, especially in multiple sclerosis. More precisely, the invention relates to inactivated protein derivatives of the hIFN-ϝ with preserved affinity to the hIFN-ϝ receptor. The derivatives represent genetically modified variants of hIFN-ϝ where the C-terminal part of the molecule is either deleted or replaced with a polypeptide sequence of another human protein and a recombinant hIFN-ϝ inactivated by physical or chemical methods.

Abstract: In an extraction device (1) for extracting objects (2), in particular clots, foreign bodies, etc., from cavities (3) in a human or animal body, with first and second compressible and expandable collecting baskets (10, 20, 102, 110) between which the object (2) can be captured, said collecting baskets being mutually displaceable and being able to be drawn one into the other, at least one collecting basket (10) is umbrella-like in the expanded state and is designed with flexible wire-like adjustment elements for deliberately changing the shape and/or position of the collecting basket so that the object can be captured in the latter and can be drawn into the other collecting basket (20).

Abstract: The present invention provides a removable vena cava filter for capturing thrombi in a blood vessel. The filter comprises a plurality of primary struts having first ends attached together along a longitudinal axis. Each primary strut includes an arcuate segment having a first tensile strength. The arcuate segment extends from the first end to an anchoring hook. The anchoring hook is integral with the arcuate segment and having the first thickness and first tensile strength. The filter further comprises a plurality of secondary struts freely spaced between the primary struts and having connected ends attached together along the longitudinal axis. Each secondary strut freely extends from the connected end to a free end avoiding contact with other secondary struts and primary struts. Each secondary strut has a second tensile strength.

Abstract: A removable filter having a collapsed state and an expanded state for capturing thrombi in a blood vessel is disclosed. The filter comprises a plurality of primary struts and a plurality of secondary struts. Each primary strut in the expanded state extends from a primary strut first end to an anchoring hook. Each primary strut extends arcuately along a longitudinal axis and linearly radially. The plurality of primary strut first ends are attached together along the longitudinal axis. Each secondary strut in the expanded state extends from a secondary strut first end to a free end. Each secondary strut extends arcuately along the longitudinal axis and linearly radially. The plurality of secondary struts are attached together along the longitudinal axis. The plurality of secondary struts centralize the filter in the expanded state in the blood vessel.

Abstract: The present invention provides a removable vena cava filter for capturing thrombi in a blood vessel. The filter comprises a plurality of primary struts having first ends attached together along a longitudinal axis. Each primary strut has an arcuate segment extending from the first end to an anchoring hook. The primary struts are configured to move between an expanded state for engaging the anchoring hooks with the blood vessel and a collapsed state for filter retrieval or delivery. Each primary strut are configured to cross another primary strut along the longitudinal axis in the collapsed state such that the arcuate segments occupy a first diameter greater than a second diameter occupied by the anchoring hooks in the collapsed state for filter retrieval or delivery.

Abstract: The invention relates to advantageous processes for preparing heterologous proteins in prokaryotic host cells by improved codon use and/or expression of tRNAs which code for codons occurring rarely in said host cell.

Abstract: In a method for the operation of a four-stroke reciprocating piston internal combustion engine with alternating compression. ignition and spark ignition, fuel is injected directly, fresh charge is delivered and combustion exhaust gas is led off. At low and medium partial load a partially homogenized, lean basic mixture of air, fuel and retained exhaust gas is formed for the compression ignition, and at higher partial load and at full load a homogeneous, stoichiometric mixture is formed for the spark ignition. Further features include exhaust gas retention, a build-up of exhaust gas and activation injection into the retained exhaust gas. For a smooth transition between the two operating modes, in addition to the co-ordinated interaction of exhaust gas retention, build up of exhaust gas, restriction of the fresh charge, and of the ignition advance angle in spark ignition, together with the quantity and the timing of the fuel injection, use is also made of exhaust gas recirculation.

Abstract: The invention relates to advantageous processes for preparing heterologous proteins in prokaryotic host cells by improved codon use and/or expression of tRNAs which code for codons occurring rarely in said host cell.