Abstract: A system for monitoring a traffic situation includes at least one radar sensor unit for recording environmental data in a monitoring region of the radar sensor unit. A central processor evaluates the environmental data from the radar sensor unit and determines the traffic situation within the monitoring region based on the environmental data. A reference signal unit for outputting a reference signal to the radar sensor unit is configured to modulate a radar signal emitted by the radar sensor unit and to reflect a modulated radar signal back to the radar sensor unit as a reference signal. The processor identifies the modulated radar signal as a reference signal from the reference signal unit and recognizes a malfunction of the radar sensor unit if a reference signal is not received by the radar sensor unit.

Abstract: This invention relates to a novel process for making alkyl 7-amino-5-methyl-[1,2,5]-oxadiazolo[3,4-b]pyridine-carboxylate.

Abstract: An apparatus is configured to pull a single crystal of semiconductor material from a melt contained in a crucible. The apparatus includes: a rotatable pulling shaft; a rotatable crucible shaft; a double worm gear between a drive and the pulling shaft; and a further double worm gear between a further drive and the crucible shaft.

Abstract: This invention relates to a novel process for making alkyl 7-amino-5-methyl-[1,2,5]-oxadiazolo[3,4-b]pyridine-carboxylate.

Abstract: The invention relates to novel 7?-hydroxysteroid dehydrogenases which are obtainable from bacteria of the genus Collinsella, especially of the strain Collinsella aerofaciens, to the sequences encoding said enzymes, to methods for producing said enzymes and to their use in the enzymatic conversion of cholic acid compounds, and especially in the production of ursodeoxycholic acid (UDCS). The invention also relates to novel methods for the synthesis UDCS.

Abstract: The invention relates to novel 7ß-hydroxysteroid dehydrogenases which are obtainable from bacteria of the genus Collinsella, especially of the strain Collinsella aerofaciens, to the sequences encoding said enzymes, to methods for producing said enzymes and to their use in the enzymatic conversion of cholic acid compounds, and especially in the production of ursodeoxycholic acid (UDCS). The invention also relates to novel methods for the synthesis UDCS.

Abstract: The invention relates to novel 7?-hydroxysteroid dehydrogenases which are obtainable from bacteria of the genus Collinsella, especially of the strain Collinsella aerofaciens, to the sequences encoding said enzymes, to methods for producing said enzymes and to their use in the enzymatic conversion of cholic acid compounds, and especially in the production of ursodeoxycholic acid (UDCS). The invention also relates to novel methods for the synthesis UDCS.

Abstract: For signal luminaires which indicate the term STOP or DANGER upon activation, a circuit containing a first operating case feed unit and a second auxiliary source is provided for the purpose of supplying a reliable power supply. In this case, the second auxiliary source is inductively coupled to the signal luminaire electric circuit; while the signal luminaires are capacitively coupled to ground. The use of switches during operation in a fall-back level is obviated in this way.

Abstract: This Stirling machine comprises a transfer piston (6, 6a) and a moving part (14) of a generator or of an electric motor, the transfer piston (6, 6a) periodically displacing a working gas between an expansion chamber (VE) and a compression chamber (Vc) which chambers are respectively associated with two working faces of the transfer piston (6, 6a) of which the cross-sectional area ratio ac/aE is >0.35 so that its displacement along an axis X oriented towards the expansion volume (VE) generates an in-phase working gas pressure component Px that opposes the displacement of the piston (6, 6a), so that all of the mechanical energy produced is transmitted to the moving part (14). This machine comprises a resonant second piston (10) coupled to the transfer piston (6, 6a) by a quantity of energy that is proportional to the pressure component Px.

Abstract: The invention relates to 12 ?-hydroxysteroid dehydrogenases, nucleic acid sequences coding for the same, expression cassettes and vectors, recombinant microorganisms containing the corresponding coding nucleic acid sequences, a method for producing said 12 ?-hydroxysteroid dehydrogenases, a method for enzymatic oxidation of 12 ?-hydroxysteroids using said enzyme, a method for enzymatic reduction of 12-ketosteroids using said enzyme, a method for qualitative or quantitative determination of 12-ketosteroids and/or 12?-hydroxysteroids using said 12?-hydroxysteroid dehydrogenases and a method for production of ursodesoxycholic acid, comprising the enzyme-catalyzed cholic acid oxidation using said 12 ?-hydroxysteroid dehydrogenases.

Abstract: The invention provides 12?-hydroxysteroid dehydrogenases, nucleic acid sequences coding for the same, expression cassettes and vectors, recombinant microorganisms containing the corresponding coding nucleic acid sequences, methods for producing said 12?-hydroxysteroid dehydrogenases, methods for enzymatic oxidation of 12?-hydroxysteroids using said enzyme, methods for enzymatic reduction of 12-ketosteroids using said enzyme, methods for qualitative or quantitative determination of 12-ketosteroids and/or 12?-hydroxysteroids using said 12?-hydroxysteroid dehydrogenases and methods for production of ursodesoxycholic acid, comprising the enzyme-catalysed cholic acid oxidation using said 12?-hydroxysteroid dehydrogenases.

Abstract: The present invention relates to a process for preparing CCR3 inhibitors of formula 1, wherein R1 is H, C1-6-alkyl, C0-4-alkyl-C3-6-cycloalkyl, C1-6-haloalkyl; R2 is H, C1-6-alkyl; X is an anion selected from the group consisting of chloride or ½ dibenzoyltartrate j is 1 or 2.

Abstract: The present invention relates to a specific salt of a dihydropteridione derivative, namely the trihydrochloride salt of the compound N-[trans-4-[4-(cyclopropylmethyl)-1-piperazinyl]cyclohexyl]-4-[[(7R)-7-ethyl-5,6,7,8-tetrahydro-5-methyl-8-(1-methylethyl)-6-oxo-2-pteridinyl]amino]-3-methoxy-benzamide, to its crystallization in the form of an hydrate with water, to a process for the manufacture thereof, and to the use thereof in a pharmaceutical composition.

Abstract: The present invention relates to a process for preparing CCR3 inhibitors of formula 1, wherein R1 is H, C1-6-alkyl, C0-4-alkyl-C3-6-cycloalkyl, C1-6-haloalkyl; R2 is H, C1-6-alkyl; X is an anion selected from the group consisting of chloride or ½ dibenzoyltartrate j is 1 or 2.

Abstract: The invention relates to novel microbial 7?-hydroxysteroid dehydrogenase (7?-HSDH) knockout mutants and to the use thereof for producing other HSDHs having various functionalities, such as 3?-, 7?- or 12?-HSDH, and to the use of thus-produced HSDH enzymes in enzymatic reactions of cholic acid compounds, and in particular for producing ursodeoxycholic acid (UDCS). The invention relates in particular to novel methods for synthesizing UDCS.

Abstract: The present invention encompasses a process for preparing compounds of formula (1), wherein a compound of formula (2) is reacted in the presence of a catalyst and a solvent under hydrogen pressure to form a compound of formula (1) and wherein A and R1—R4 are defined herein.

Abstract: For signal luminaires which indicate the term STOP or DANGER upon activation, a circuit containing a first operating case feed unit and a second auxiliary source is provided for the purpose of supplying a reliable power supply. In this case, the second auxiliary source is inductively coupled to the signal luminaire electric circuit; while the signal luminaires are capacitively coupled to ground. The use of switches during operation in a fall-back level is obviated in this way.

Abstract: The invention relates to novel 7?-hydroxysteroid dehydrogenases which are obtainable from bacteria of the genus Collinsella, especially of the strain Collinsella aerofaciens, to the sequences encoding said enzymes, to methods for producing said enzymes and to their use in the enzymatic conversion of cholic acid compounds, and especially in the production of ursodeoxycholic acid (UDCS). The invention also relates to novel methods for the synthesis UDCS.

Abstract: This Stirling machine comprises a transfer piston (6, 6a) and a moving part (14) of a generator or of an electric motor, the transfer piston (6, 6a) periodically displacing a working gas between an expansion chamber (VE) and a compression chamber (Vc) which chambers are respectively associated with two working faces of the transfer piston (6, 6a) of which the cross-sectional area ratio ac/aE is >0.35 so that its displacement along an axis X oriented towards the expansion volume (VE) generates an in-phase working gas pressure component Px that opposes the displacement of the piston (6, 6a), so that all of the mechanical energy produced is transmitted to the moving part (14). This machine comprises a resonant second piston (10) coupled to the transfer piston (6, 6a) by a quantity of energy that is proportional to the pressure component Px.

Abstract: The present invention relates to a crystalline form a dihydropteridione derivative, namely a crystalline form of the free base N-[trans-4-[4-(cyclopropylmethyl)-1-piperazinyl]cyclohexyl]-4-[[(7R)-7-ethyl-5,6,7,8-tetrahydro-5-methyl-8-(1-methylethyl)-6-oxo-2-pteridinyl]amino]-3-methoxy-benzamide, to a process for the manufacture thereof, and to the use thereof in a pharmaceutical composition.