Patents by Inventor Rolf Schmid

Rolf Schmid has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modified cytochrome p450 monooxygenases
    Patent number: 7531335
    Abstract: The present invention relates to modified cytochrome P450 monooxygenases with an altered substrate profile, to nucleic acid sequences coding therefor, to expression constructs and vectors, to recombinant microorganisms which comprise these vectors, and to processes for the microbiological production of terminally or subterminally hydroxylated aliphatic carboxylic acids.
    Type: Grant
    Filed: July 27, 2000
    Date of Patent: May 12, 2009
    Assignee: BASF Aktiengesellschaft
    Inventors: Bernhard Hauer, Juergen Pleiss, Ulrich Schwaneberg, Jutta Schmitt, Markus Fischer, Rolf Schmid, Qing-shan Li
  • Physiologically acceptable salts of 3--1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionic acid ethyl ester
    Publication number: 20090042948
    Abstract: The invention relates to new, physiologically acceptable salts of the active substance ethyl 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazole-5-carbonyl)-pyridin-2-yl-amino]-propionate.
    Type: Application
    Filed: October 8, 2008
    Publication date: February 12, 2009
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Peter Sieger, Norbert Hauel, Rolf Schmid
  • SPECIFIC SALT, ANHYDROUS AND CRYSTALLINE FORM OF A DIHYDROPTERIDIONE DERIVATIVE
    Publication number: 20090030004
    Abstract: The present invention relates to a specific salt of a dihydropteridione derivative, namely the trihydrochloride salt of the compound N-[trans-4-[4-(cyclopropylmethyl)-1-piperazinyl]cyclohexyl]-4-[[(7R)-7-ethyl-5,6,7,8-tetrahydro-5-methyl-8-(1-methylethyl)-6-oxo-2-pteridinyl]amino]-3-methoxy-benzamide, to its crystallisation in the form of an hydrate with water, to a process for the manufacture thereof, and to the use thereof in a pharmaceutical composition.
    Type: Application
    Filed: September 17, 2008
    Publication date: January 29, 2009
    Inventors: Guenter Linz, Peter Sieger, Matthias Grauert, Rolf Schmid
  • Specific salt, anhydrous and crystalline form of a dihydropteridione derivative
    Patent number: 7439358
    Abstract: The present invention relates to a specific salt of a dihydropteridione derivative, namely the trihydrochloride salt of the compound N-[trans-4-[4-(cyclopropylmethyl)-1-piperazinyl]cyclohexyl]-4-[[(7R)-7-ethyl-5,6,7,8-tetrahydro-5-methyl-8-(1-methylethyl)-6-oxo-2-pteridinyl]amino]-3-methoxy-benzamide, to its crystallisation in the form of an hydrate with water, to a process for the manufacture thereof, and to the use thereof in a pharmaceutical composition.
    Type: Grant
    Filed: January 30, 2007
    Date of Patent: October 21, 2008
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Guenter Linz, Peter Sieger, Matthias Grauert, Rolf Schmid
  • 3-[(2-{[4-(HEXYLOXYCARBONYLAMINOIMINOMETHYL) PHENYLAMINO]METHYL}-1-METHYL-1H-BENZIMIDAZOL-5- CARBONYL)PYRIDIN-2-YLAMINO]PROPIONIC ACID ETHYLESTER METHANSULFONATE AND ITS USE AS A MEDICAMENT
    Publication number: 20080119523
    Abstract: Ethyl 3-[(2-{[4-(hexyloxycarbonylaminoiminomethyl)phenylamino]methyl}-1-methyl-1H-benzimidazole-5-carbonyl)pyridin-2-ylamino]propionate methanesulfonate in the crystalline modifications I and II and as the hemihydrate and the use thereof as a pharmaceutical composition.
    Type: Application
    Filed: January 30, 2008
    Publication date: May 22, 2008
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Rolf Schmid, Peter Sieger, Rainer Sobotta
  • Method for producing a hydroxylation catalyst and the use thereof
    Patent number: 7364884
    Abstract: A process for preparing a hydroxylation catalyst by i) embedding a cystochrome P450 monooxygenase in a sol-gel matrix, ii) embedding an enzymatic NADPH-regenerating system in a sol-gel matrix, and combining the two components i) and ii) unless they were already mixed together before the embedding.
    Type: Grant
    Filed: May 5, 2004
    Date of Patent: April 29, 2008
    Assignee: BASF Aktiengesellschaft
    Inventors: Bernhard Hauer, Tilo Habicher, Rolf Schmid, Steffen Christian Maurer, Vlada Beniaminovna Urlacher, Holger Schulze, Norbert Huber, Till T. Bachmann
  • METHOD AND DEVICE FOR DETECTING QUINOLONE-RESISTANT ESCHERICHIA COLI
    Publication number: 20080096203
    Abstract: The present invention pertains to a method for detecting quinolone-resistant Escherichia coli strains in a biological sample. The present invention also relates to a kit adapted to perform the inventive method.
    Type: Application
    Filed: June 22, 2007
    Publication date: April 24, 2008
    Inventors: Xiaolei Yu, Milorad Susa, Cornelius Knabbe, Rolf Schmid, Till Bachmann
  • (R)-2-(4-amidinophenylaminomethyl)-1-methyl-5-[1-(carboxymethylamino)-1- (pyrrolidinocarbonyl)-ethyl]-benzimidazole, the monohydrochloride thereof, preparation thereof and the use as pharmaceutical composition
    Publication number: 20080076934
    Abstract: Crystalline forms of the compounds (R)-2-(4-amidinophenylaminomethyl)-1-methyl-5-[1-(carboxymethylamino)-1-(pyrrolidinocarbonyl)-ethyl]-benzimidazole and the monohydrochloride thereof, processes for the preparation thereof and the use thereof as pharmaceutical compositions.
    Type: Application
    Filed: October 2, 2007
    Publication date: March 27, 2008
    Inventors: Guenter Linz, Peter Sieger, Gunnar Schreiner, Werner Rall, Rolf Schmid
  • (R)-2-(4-amidinophenylaminomethyl)-1-methyl-5-[1-(carboxymethylamino)-1(pyrrolidinocarbonyl)-ethyl]-benzimidazole, the monohydrochloride thereof, preparation thereof and the use as pharmaceutical composition
    Patent number: 7294721
    Abstract: Crystalline forms of the compounds (R)-2-(4-amidinophenylaminomethyl)-1-methyl-5-[1-(carboxymethylamino)-1-(pyrrolidinocarbonyl)-ethyl]-benzimidazole and the monohydrochloride thereof, processes for the preparation thereof and the use thereof as pharmaceutical compositions.
    Type: Grant
    Filed: December 13, 2006
    Date of Patent: November 13, 2007
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Guenter Linz, Peter Sieger, Gunnar Schreiner, Werner Rall, Rolf Schmid
  • SPECIFIC SALT, ANHYDROUS AND CRYSTALLINE FORM OF A DIHYDROPTERIDIONE DERIVATIVE
    Publication number: 20070203146
    Abstract: The present invention relates to a specific salt of a dihydropteridione derivative, namely the trihydrochloride salt of the compound N-[trans-4-[4-(cyclopropylmethyl)-1-piperazinyl]cyclohexyl]-4-[[(7R)-7-ethyl-5,6,7,8-tetrahydro-5-methyl-8-(1-methylethyl)-6-oxo-2-pteridinyl]amino]-3-methoxy-benzamide, to its crystallisation in the form of an hydrate with water, to a process for the manufacture thereof, and to the use thereof in a pharmaceutical composition.
    Type: Application
    Filed: January 30, 2007
    Publication date: August 30, 2007
    Inventors: Guenter Linz, Peter Sieger, Matthias Grauert, Rolf Schmid
  • (R)-2-(4-amidinophenylaminomethyl)-1-methyl-5-[1-(carboxymethylamino)-1(pyrrolidinocarbonyl)-ethyl]-benzimidazole, the monohydrochloride thereof, preparation thereof and the use as pharmaceutical composition
    Publication number: 20070099974
    Abstract: Crystalline forms of the compounds (R)-2-(4-amidinophenylaminomethyl)-1-methyl-5-[1 -(carboxymethylamino)-1-(pyrrolidinocarbonyl)-ethyl]-benzimidazole and the monohydrochloride thereof, processes for the preparation thereof and the use thereof as pharmaceutical compositions.
    Type: Application
    Filed: December 13, 2006
    Publication date: May 3, 2007
    Inventors: Guenter Linz, Peter Sieger, Gunnar Schreiner, Werner Rall, Rolf Schmid
  • (R) 2-(4-amidinophenylaminomethyl)-1-methyl-5-[1-(carboxymethylamino)-1 (pyrrolidinocarbonyl)-ethyl]-benzimidazole, the monohydrochloride thereof, preparation thereof and the use as pharmaceutical composition
    Patent number: 7169934
    Abstract: Crystalline forms of the compounds (R)-2-(4-amidinophenylaminomethyl)-1-methyl-5-[1-(carboxymethylamino)-1-(pyrrolidinocarbonyl)-ethyl]-benzimidazole and the monohydrochloride thereof, processes for the preparation thereof and the use thereof as pharmaceutical compositions.
    Type: Grant
    Filed: June 17, 2003
    Date of Patent: January 30, 2007
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Guenter Linz, Peter Sieger, Gunnar Schreiner, Werner Rall, Rolf Schmid
  • Polymorphs of 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H- benzimidazole-5-carbonyl)-pyridin-2-yl-amino]-propionic acid ethyl ester
    Publication number: 20060276513
    Abstract: Disclosed are polymorphs of the active substance 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazole-5-carbonyl)-pyridin-2 -yl-amino]-propionic acid ethyl ester, the preparation thereof and the use thereof as pharmaceutical compositions.
    Type: Application
    Filed: May 31, 2006
    Publication date: December 7, 2006
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Norbert HAUEL, Rolf SCHMID, Peter SIEGER, Rainer SOBOTTA
  • Physiologically acceptable salts of 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionic acid ethyl ester
    Publication number: 20060247278
    Abstract: The invention relates to new, physiologically acceptable salts of the active substance ethyl 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazole-5-carbonyl)-pyridin-2-yl-amino]-propionate.
    Type: Application
    Filed: April 26, 2006
    Publication date: November 2, 2006
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Peter Sieger, Norbert Hauel, Rolf Schmid
  • Method for producing a hydroxylation catalyst and the use thereof
    Publication number: 20060216802
    Abstract: A process for preparing a hydroxylation catalyst by i) embedding a cystochrome P450 monooxygenase in a sol-gel matrix, ii) embedding an enzymatic NADPH-regenerating system in a sol-gel matrix, and combining the two components i) and ii) unless they were already mixed together before the embedding.
    Type: Application
    Filed: May 5, 2004
    Publication date: September 28, 2006
    Applicant: BASF AKTIENGESSELLSCHAFT
    Inventors: Bernhard Hauer, Tilo Habicher, Rolf Schmid, Steffen Maurer, Vlada Urlacher, Holger Schulze, Norbert Huber, Till Bachmann
  • Microarray and method for genotyping SHV beta lactamases
    Publication number: 20060210999
    Abstract: The present invention relates to a method for genotyping SHV beta lactamase and a method for determining antibiotic resistance conferred by a SHV-type Extended Spectrum Beta Lactamase of a bacterium. Moreover, the present invention pertains to an oligonucleotide array and a kit for a genotyping based detection of SHV beta lactamases, as well as to a method for designing improved oligonucleotide capture probes.
    Type: Application
    Filed: March 18, 2005
    Publication date: September 21, 2006
    Inventors: Verena Grimm, Milorad Susa, Cornelius Knabbe, Rolf Schmid, Till Bachmann
  • Antibiotic susceptibility and virulence factor detection in Pseudomonas aeruginosa
    Publication number: 20060211002
    Abstract: The present invention relates in general to the detection of antibiotic resistance determinants in Pseudomonas aeruginosa (P. aeruginosa). The present invention discloses a micro-array for the detection of antibiotic resistance determinants and mutations in said organism, a method for the detection of said determinants and a kit. This micro-array concept offers the rapid sensitive and specific identification of antibiotic resistance profiles.
    Type: Application
    Filed: March 18, 2005
    Publication date: September 21, 2006
    Inventors: Jan Weile, Milorad Susa, Rolf Schmid, Till Bachmann, Cornelius Knabbe
  • Method for the biotransformation of carotenoids by means of a cytochrome p450 monooxygnase
    Publication number: 20060063226
    Abstract: The invention relates to a process for the biotransformation of carotenoids using enzymes having cytochrome P450 monooxygenase activity; in particular monooxygenases from thermophilic bacteria, in particular of the genus Thermus sp.
    Type: Application
    Filed: July 25, 2003
    Publication date: March 23, 2006
    Applicant: BASF AKTIENGESELLSCHAFT
    Inventors: Markus Matuschek, Bernhard Hauer, Rolf Schmid, Isabelle Kauffmann, Francesca Blasco, Claudia Schmidt-Dannert
  • Hydrates and polymorphs of 4-[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament
    Publication number: 20060035902
    Abstract: Disclosed are hydrates and polymorphs of 4-[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, processes for preparing them and their use as pharmaceutical compositions.
    Type: Application
    Filed: August 4, 2005
    Publication date: February 16, 2006
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Guenter Linz, Peter Sieger, Gerd Kraemer, Rolf Herter, Matthias Hoffmann, Werner Rall, Rolf Schmid
  • 3-[(2-{[4-(hexyloxycarbonylaminoiminomethyl)phenylamino]methyl}-1-methyl-1H-benzimidazol-5-carbonyl)pyridin-2-ylamino]propionic acid ethylester methansulfonate and its use as medicament
    Publication number: 20050234104
    Abstract: Ethyl 3-[(2-{[4-(hexyloxycarbonylaminoiminomethyl)phenylamino]methyl}-1-methyl-1H-benzimidazole-5-carbonyl)pyridin-2-ylamino]propionate methanesulfonate in the crystalline modifications I and II and as the hemihydrate and the use thereof as a pharmaceutical composition.
    Type: Application
    Filed: August 13, 2004
    Publication date: October 20, 2005
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Rolf Schmid, Peter Sieger, Rainer Sobotta