Patents by Inventor Roman Yelensky

Roman Yelensky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9792403
    Abstract: Methods and systems for analyzing genetic variants are disclosed.
    Type: Grant
    Filed: May 9, 2014
    Date of Patent: October 17, 2017
    Assignee: FOUNDATION MEDICINE, INC.
    Inventors: James Xin Sun, Roman Yelensky
  • Publication number: 20170212984
    Abstract: Disclosed herein is a system and methods for determining the alleles, neoantigens, and vaccine composition as determined on the basis of an individual's tumor mutations. Also disclosed are systems and methods for obtaining high quality sequencing data from a tumor. Further, described herein are systems and methods for identifying somatic changes in polymorphic genome data. Finally, described herein are unique cancer vaccines.
    Type: Application
    Filed: March 22, 2017
    Publication date: July 27, 2017
    Inventors: Roman Yelensky, Adnan Derti, Brendan Bulik-Sullivan, Jennifer Busby
  • Publication number: 20170199961
    Abstract: Disclosed herein is a system and methods for determining the alleles, neoantigens, and vaccine composition as determined on the basis of an individual's tumor mutations. Also disclosed are systems and methods for obtaining high quality sequencing data from a tumor. Further, described herein are systems and methods for identifying somatic changes in polymorphic genome data. Finally, described herein are unique cancer vaccines.
    Type: Application
    Filed: December 16, 2016
    Publication date: July 13, 2017
    Inventors: Roman Yelensky, Adnan Derti, Brendan Bulik-Sullivan, Jennifer Busby
  • Publication number: 20170016073
    Abstract: Novel mutant ESR1 molecules and uses are disclosed.
    Type: Application
    Filed: February 8, 2016
    Publication date: January 19, 2017
    Inventors: Maureen T. Cronin, Garrett Michael Frampton, Doron Lipson, Vincent A. Miller, Gary Palmer, Jeffrey S. Ross, Philip James Stephens, Roman Yelensky
  • Publication number: 20160375025
    Abstract: Methods of treating a head and neck cancer are disclosed.
    Type: Application
    Filed: July 1, 2016
    Publication date: December 29, 2016
    Applicants: FOUNDATION MEDICINE, INC., UCL Business PLC
    Inventors: Chris Hendrik Boshoff, Timothy Robert Fenton, Matthias Alexander Lechner, Philip James Stephens, Matthew J. Hawryluk, Garrett Michael Frampton, Roman Yelensky
  • Patent number: 9410954
    Abstract: Methods of treating a head and neck cancer are disclosed.
    Type: Grant
    Filed: February 11, 2014
    Date of Patent: August 9, 2016
    Assignees: FOUNDATION MEDICINE, INC., UCL Business PLC
    Inventors: Chris Hendrik Boshoff, Timothy Robert Fenton, Matthias Alexander Lechner, Philip James Stephens, Matthew J. Hawryluk, Garrett Michael Frampton, Roman Yelensky
  • Publication number: 20160201135
    Abstract: Novel mutant ESR1 molecules and uses are disclosed.
    Type: Application
    Filed: August 6, 2015
    Publication date: July 14, 2016
    Inventors: Maureen T. Cronin, Garrett Michael Frampton, Doron Lipson, Vincent A. Miller, Gary Palmer, Jeffrey S. Ross, Philip James Stephens, Roman Yelensky, Lior Soussan-Gutman, Addie Dvir, Ido Wolf
  • Publication number: 20160145691
    Abstract: Novel mutant ESR1 molecules and uses are disclosed.
    Type: Application
    Filed: June 29, 2015
    Publication date: May 26, 2016
    Inventors: Maureen T. Cronin, Garrett Michael Frampton, Doron Lipson, Vincent A. Miller, Gary Palmer, Jeffrey S. Ross, Philip James Stephens, Roman Yelensky
  • Patent number: 9340830
    Abstract: A method of analyzing a tumor sample comprising: (a) acquiring a library comprising a plurality of tumor members from a tumor sample; (b) contacting the library with a bait set to provide selected members; (c) acquiring a read for a subgenomic interval from a tumor member from said library; (d) aligning said read; and (e) assigning a nucleotide value (e.g., calling a mutation) from said read for the preselected nucleotide position, thereby analyzing said tumor sample.
    Type: Grant
    Filed: December 29, 2011
    Date of Patent: May 17, 2016
    Assignee: FOUNDATION MEDICINE, INC.
    Inventors: Doron Lipson, Geoffrey Alan Otto, Alexander N. Parker, Philip James Stephens, Sean R. Downing, Mima Jarosz, Mikhail G. Shapiro, Roman Yelensky
  • Publication number: 20160009785
    Abstract: Novel fusion molecules and uses are disclosed.
    Type: Application
    Filed: November 5, 2013
    Publication date: January 14, 2016
    Inventors: Doron Lipson, Roman Yelensky, Joel Robert Greenbowe, Jie He
  • Publication number: 20150125462
    Abstract: The disclosure is directed to novel personalized therapies and methods for treating ankylosing spondylitis (AS). Specifically, this disclosure relates to methods of treating a patient having AS by selectively administering an IL-17 antagonist, e.g., an IL-17 antibody, such as secukinumab, to the AS patient on the basis of that patient being predisposed to have a favorable response to treatment with the IL-17 antagonist. Also disclosed herein are diagnostic methods and transmittable forms of information useful in predicting the likelihood that a patient having AS will respond to treatment with an IL-17 antagonist, e.g., an IL-17 antibody, such as secukinumab.
    Type: Application
    Filed: April 18, 2013
    Publication date: May 7, 2015
    Inventors: Stephan Bek, Arndt Brachat, Wolfgang Hueber, Yali Li, Ying Wang, Roman Yelensky
  • Publication number: 20150030587
    Abstract: Methods of treating a head and neck cancer are disclosed.
    Type: Application
    Filed: February 11, 2014
    Publication date: January 29, 2015
    Applicant: FOUNDATION MEDICINE, INC.
    Inventors: Chris Hendrik Boshoff, Timothy Robert Fenton, Matthias Alexander Lechner, Philip James Stephens, Matthew J. Hawryluk, Garrett Michael Frampton, Roman Yelensky
  • Publication number: 20140336996
    Abstract: Methods and systems for analyzing genetic variants are disclosed.
    Type: Application
    Filed: May 9, 2014
    Publication date: November 13, 2014
    Inventors: James Xin Sun, Roman Yelensky
  • Publication number: 20140336236
    Abstract: Novel ALK and NTRK1 fusion molecules and uses are disclosed.
    Type: Application
    Filed: April 21, 2014
    Publication date: November 13, 2014
    Applicant: FOUNDATION MEDICINE, INC.
    Inventors: Maureen T. Cronin, Doron Lipson, Roman Yelensky
  • Publication number: 20140221329
    Abstract: Novel mutant ESR1 molecules and uses are disclosed.
    Type: Application
    Filed: April 14, 2014
    Publication date: August 7, 2014
    Applicant: FOUNDATION MEDICINE, INC.
    Inventors: Maureen T. Cronin, Garrett Michael Frampton, Doron Lipson, Vincent A. Miller, Gary Palmer, Jeffrey S. Ross, Philip James Stephens, Roman Yelensky
  • Patent number: 8673972
    Abstract: Methods of treating a head and neck cancer are disclosed.
    Type: Grant
    Filed: August 2, 2013
    Date of Patent: March 18, 2014
    Assignees: Foundation Medicine, Inc., UCL Business PLC
    Inventors: Chris Hendrik Boshoff, Timothy Robert Fenton, Matthias Alexander Lechner, Philip James Stephens, Matthew J. Hawryluk, Roman Yelensky, Garrett Michael Frampton
  • Publication number: 20140037622
    Abstract: Methods of treating a head and neck cancer are disclosed.
    Type: Application
    Filed: August 2, 2013
    Publication date: February 6, 2014
    Applicants: UCL BUSINESS PLC, FOUNDATION MEDICINE, INC.
    Inventors: Chris Hendrik Boshoff, Timothy Robert Fenton, Matthias Alexander Lechner, Philip James Stephens, Matthew J. Hawryluk, Roman Yelensky, Garrett Michael Frampton
  • Publication number: 20120208706
    Abstract: A method of analyzing a tumor sample comprising: (a) acquiring a library comprising a plurality of tumor members from a tumor sample; (b) contacting the library with a bait set to provide selected members; (c) acquiring a read for a subgenomic interval from a tumor member from said library; (d) aligning said read; and (e) assigning a nucleotide value (e.g., calling a mutation) from said read for the preselected nucleotide position, thereby analyzing said tumor sample.
    Type: Application
    Filed: December 29, 2011
    Publication date: August 16, 2012
    Applicant: FOUNDATION MEDICINE, INC.
    Inventors: Sean R. Downing, Mirna Jarosz, Doron Lipson, Geoffrey Alan Otto, Alexander N. Parker, Mikhail G. Shapiro, Philip James Stephens, Roman Yelensky