Patents by Inventor Roman Yelensky

Roman Yelensky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • OPTIMIZATION OF MULTIGENE ANALYSIS OF TUMOR SAMPLES
    Publication number: 20190032118
    Abstract: A method of analyzing a tumor sample comprising: (a) acquiring a library comprising a plurality of tumor members from a tumor sample; (b) contacting the library with a bait set to provide selected members; (c) acquiring a read for a subgenomic interval from a tumor member from said library; (d) aligning said read; and (e) assigning a nucleotide value (e.g., calling a mutation) from said read for the preselected nucleotide position, thereby analyzing said tumor sample.
    Type: Application
    Filed: February 15, 2018
    Publication date: January 31, 2019
    Inventors: Doron Lipson, Geoffrey Alan Otto, Alexander N. Parker, Philip James Stephens, Sean R. Downing, Mirna Jarosz, Mikhail G. Shapiro, Roman Yelensky
  • NEOANTIGEN IDENTIFICATION, MANUFACTURE, AND USE
    Publication number: 20190034585
    Abstract: Disclosed herein is a system and methods for determining the alleles, neoantigens, and vaccine composition as determined on the basis of an individual's tumor mutations. Also disclosed are systems and methods for obtaining high quality sequencing data from a tumor. Further, described herein are systems and methods for identifying somatic changes in polymorphic genome data. Finally, described herein are unique cancer vaccines.
    Type: Application
    Filed: September 11, 2018
    Publication date: January 31, 2019
    Inventors: Roman Yelensky, Adnan Derti, Brendan Bulik-Sullivan, Jennifer Busby
  • THERAPEUTIC AND DIAGNOSTIC METHODS FOR CANCER
    Publication number: 20180371099
    Abstract: The present invention provides therapeutic and diagnostic methods and compositions for cancer, for example, bladder cancer. The invention provides methods of treating bladder cancer, methods of determining whether a patient suffering from bladder cancer is likely to respond to treatment comprising a PD-L1 axis binding antagonist, methods of predicting responsiveness of a patient suffering from bladder cancer to treatment comprising a PD-L1 axis binding antagonist, and methods of selecting a therapy for a patient suffering from bladder cancer, based on somatic mutation levels of genes of the invention (e.g., somatic mutation levels in a tumor sample obtained from the patient).
    Type: Application
    Filed: August 28, 2018
    Publication date: December 27, 2018
    Inventors: Richard BOURGON, David FABRIZIO, Gregg FINE, Garrett M. FRAMPTON, Priti HEGDE, Sanjeev MARIATHASAN, Philip J. STEPHENS, James Xin SUN, Roman YELENSKY
  • METHODS AND SYSTEMS FOR EVALUATING TUMOR MUTATIONAL BURDEN
    Publication number: 20180363066
    Abstract: Methods of evaluating tumor mutational burden in a sample, e.g., a tumor sample or a sample derived from a tumor, from a subject, are disclosed.
    Type: Application
    Filed: August 28, 2018
    Publication date: December 20, 2018
    Inventors: Zachary R. Chalmers, Caitlin F. Connelly, David Fabrizio, Garrett Michael Frampton, Priti Hegde, Marcin Kowanetz, Philip J. Stephens, James Xin Sun, Roman Yelensky
  • NOVEL ALK AND NTRK1 FUSION MOLECULES AND USES THEREOF
    Publication number: 20180346992
    Abstract: Novel ALK and NTRK1 fusion molecules and uses are disclosed.
    Type: Application
    Filed: May 14, 2018
    Publication date: December 6, 2018
    Inventors: Maureen T. Cronin, Doron Lipson, Roman Yelensky
  • HUMAN PAPILLOMA VIRUS AS PREDICTOR OF CANCER PROGNOSIS
    Publication number: 20180338977
    Abstract: Methods of treating a head and neck cancer are disclosed.
    Type: Application
    Filed: January 17, 2018
    Publication date: November 29, 2018
    Inventors: Chris Hendrik Boshoff, Timothy Robert Fenton, Matthias Alexander Lechner, Philip James Stephens, Matthew J. Hawryluk, Garrett Michael Frampton, Roman Yelensky
  • Neoantigen identification, manufacture, and use
    Publication number: 20180330055
    Abstract: Disclosed herein is a system and methods for determining the alleles, neoantigens, and vaccine composition as determined on the basis of an individual's tumor mutations. Also disclosed are systems and methods for obtaining high quality sequencing data from a tumor. Further, described herein are systems and methods for identifying somatic changes in polymorphic genome data. Finally, described herein are unique cancer vaccines.
    Type: Application
    Filed: July 19, 2018
    Publication date: November 15, 2018
    Inventors: Roman Yelensky, Adnan Derti, Brendan Bulik-Sullivan, Jennifer Busby
  • NOVEL ESTROGEN RECEPTOR MUTATIONS AND USES THEREOF
    Publication number: 20180320238
    Abstract: Novel mutant ESR1 molecules and uses are disclosed.
    Type: Application
    Filed: January 22, 2018
    Publication date: November 8, 2018
    Inventors: Maureen T. Cronin, Garrett Michael Frampton, Doron Lipson, Vincent A. Miller, Gary Palmer, Jeffrey S. Ross, Philip James Stephens, Roman Yelensky
  • Estrogen receptor mutations and uses thereof
    Patent number: 10093983
    Abstract: Novel mutant ESR1 molecules and uses are disclosed.
    Type: Grant
    Filed: June 29, 2015
    Date of Patent: October 9, 2018
    Assignee: FOUNDATION MEDICINE, INC.
    Inventors: Maureen T. Cronin, Garrett Michael Frampton, Doron Lipson, Vincent A. Miller, Gary Palmer, Jeffrey S. Ross, Philip James Stephens, Roman Yelensky
  • Neoantigen identification, manufacture, and use
    Patent number: 10055540
    Abstract: Disclosed herein is a system and methods for determining the alleles, neoantigens, and vaccine composition as determined on the basis of an individual's tumor mutations. Also disclosed are systems and methods for obtaining high quality sequencing data from a tumor. Further, described herein are systems and methods for identifying somatic changes in polymorphic genome data. Finally, described herein are unique cancer vaccines.
    Type: Grant
    Filed: March 22, 2017
    Date of Patent: August 21, 2018
    Assignee: Gritstone Oncology, Inc.
    Inventors: Roman Yelensky, Adnan Derti, Brendan Bulik-Sullivan, Jennifer Busby
  • ANALYSIS OF GENETIC VARIANTS
    Publication number: 20180218113
    Abstract: Methods and systems for analyzing genetic variants are disclosed.
    Type: Application
    Filed: September 19, 2017
    Publication date: August 2, 2018
    Inventors: James Xin Sun, Roman Yelensky
  • ALK and NTRK1 fusion molecules and uses thereof
    Patent number: 10000814
    Abstract: Novel ALK and NTRK1 fusion molecules and uses are disclosed.
    Type: Grant
    Filed: April 21, 2014
    Date of Patent: June 19, 2018
    Assignee: FOUNDATION MEDICINE, INC.
    Inventors: Maureen T. Cronin, Doron Lipson, Roman Yelensky
  • Methods of treating head and neck cancer
    Patent number: 9907798
    Abstract: Methods of treating a head and neck cancer are disclosed.
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: March 6, 2018
    Assignees: FOUNDATION MEDICINE, INC., UCL Business PLC
    Inventors: Chris Hendrik Boshoff, Timothy Robert Fenton, Matthias Alexander Lechner, Philip James Stephens, Matthew J. Hawryluk, Garrett Michael Frampton, Roman Yelensky
  • Analysis of genetic variants
    Patent number: 9792403
    Abstract: Methods and systems for analyzing genetic variants are disclosed.
    Type: Grant
    Filed: May 9, 2014
    Date of Patent: October 17, 2017
    Assignee: FOUNDATION MEDICINE, INC.
    Inventors: James Xin Sun, Roman Yelensky
  • Neoantigen Identification, Manufacture, and Use
    Publication number: 20170212984
    Abstract: Disclosed herein is a system and methods for determining the alleles, neoantigens, and vaccine composition as determined on the basis of an individual's tumor mutations. Also disclosed are systems and methods for obtaining high quality sequencing data from a tumor. Further, described herein are systems and methods for identifying somatic changes in polymorphic genome data. Finally, described herein are unique cancer vaccines.
    Type: Application
    Filed: March 22, 2017
    Publication date: July 27, 2017
    Inventors: Roman Yelensky, Adnan Derti, Brendan Bulik-Sullivan, Jennifer Busby
  • Neoantigen Identification, Manufacture, and Use
    Publication number: 20170199961
    Abstract: Disclosed herein is a system and methods for determining the alleles, neoantigens, and vaccine composition as determined on the basis of an individual's tumor mutations. Also disclosed are systems and methods for obtaining high quality sequencing data from a tumor. Further, described herein are systems and methods for identifying somatic changes in polymorphic genome data. Finally, described herein are unique cancer vaccines.
    Type: Application
    Filed: December 16, 2016
    Publication date: July 13, 2017
    Inventors: Roman Yelensky, Adnan Derti, Brendan Bulik-Sullivan, Jennifer Busby
  • NOVEL ESTROGEN RECEPTOR MUTATIONS AND USES THEREOF
    Publication number: 20170016073
    Abstract: Novel mutant ESR1 molecules and uses are disclosed.
    Type: Application
    Filed: February 8, 2016
    Publication date: January 19, 2017
    Inventors: Maureen T. Cronin, Garrett Michael Frampton, Doron Lipson, Vincent A. Miller, Gary Palmer, Jeffrey S. Ross, Philip James Stephens, Roman Yelensky
  • HUMAN PAPILLOMA VIRUS AS PREDICTOR OF CANCER PROGNOSIS
    Publication number: 20160375025
    Abstract: Methods of treating a head and neck cancer are disclosed.
    Type: Application
    Filed: July 1, 2016
    Publication date: December 29, 2016
    Applicants: FOUNDATION MEDICINE, INC., UCL Business PLC
    Inventors: Chris Hendrik Boshoff, Timothy Robert Fenton, Matthias Alexander Lechner, Philip James Stephens, Matthew J. Hawryluk, Garrett Michael Frampton, Roman Yelensky
  • Human papilloma virus as predictor of cancer prognosis
    Patent number: 9410954
    Abstract: Methods of treating a head and neck cancer are disclosed.
    Type: Grant
    Filed: February 11, 2014
    Date of Patent: August 9, 2016
    Assignees: FOUNDATION MEDICINE, INC., UCL Business PLC
    Inventors: Chris Hendrik Boshoff, Timothy Robert Fenton, Matthias Alexander Lechner, Philip James Stephens, Matthew J. Hawryluk, Garrett Michael Frampton, Roman Yelensky
  • NOVEL ESTROGEN RECEPTOR MUTATIONS AND USES THEREOF
    Publication number: 20160201135
    Abstract: Novel mutant ESR1 molecules and uses are disclosed.
    Type: Application
    Filed: August 6, 2015
    Publication date: July 14, 2016
    Inventors: Maureen T. Cronin, Garrett Michael Frampton, Doron Lipson, Vincent A. Miller, Gary Palmer, Jeffrey S. Ross, Philip James Stephens, Roman Yelensky, Lior Soussan-Gutman, Addie Dvir, Ido Wolf