Abstract: A process for the manufacture of particles comprises mechanically working a mixture of a drug and a hydrophobic and/or hydrophilic fusible carrier in a high speed mixture so as to form agglomerates, breaking the agglomerates to give controlled release particles and optionally continuing the mechanical working with the optional addition of a low percentage of the carrier or diluent.

Abstract: A controlled-release pharmaceutical preparation comprising diamorphine, or a pharmaceutically acceptable salt thereof.

Abstract: The invention relates to the use of a non-steroidal anti-inflammatory drug together with an opioid analgesic in the manufacture of a medicament for the treatment of arthritis.

Abstract: A stable pharmaceutical composition with reduced irritancy is provided, the composition comprising an aqueous solution of elemental iodine and at least one organic substance which reacts with iodine, whereby iodine loss is controlled by providing a source of iodate ions in an amount sufficient to provide from 0.01% to 0.04% by weight iodate ions, preferably from 0.02% to 0.03% by weight iodate ions.

Abstract: A process for preparing a structured composite pigmentary material comprises forming a dispersion of uncoated particles of titanium dioxide at a pH value at which the particles have a surface charge and subjecting the dispersion to cross-flow filtration until the dispersion contains more than 50% by weight titanium dioxide. The concentrated dispersion is mixed with a dispersion of chemically distinct particles having a surface charge of opposite sign under conditions which ensure that the sign of the surface charge on either of the particulate materials is not reversed. In the resultant composite pigmentary material the titanium dioxide particles are held in association with the chemically distinct particles as a result of said surface charges.

Abstract: A controlled release composition including spheroid cores of diltiazem or a pharmaceutically acceptable salt thereof and optionally a spheronizing agent, the cores being coated with a controlled release layer, and a method of manufacturing the same, is disclosed. The spheronizing agent when present is preferably microcrystalline cellulose. Ethylcellulose is a preferred release coating. The controlled release coating preferably contains a plasticizer, a surfactant and a tack-modifier.

Abstract: The integrated GPS/inertial navigation apparatus utilizes satellite signals received with two spatially-separated antennas to achieve improved heading estimates for a mobile platform. Each satellite signal comprises one or more component signals with each component signal having a different carrier frequency. The integrated GPS/inertial navigation apparatus consists of a receiver and an inertial navigation system. The receiver measures the carrier phase of each of one or more component signals of one or more satellite signals received by each of the two antennas during successive time periods of duration T.sub.p. Phase measured during a T.sub.p time period is called T.sub.p -phase. Only one component signal of one satellite signal received by one antenna is measured during any T.sub.p time period. The receiver utilizes the T.sub.p -phases of each component signal obtained during a T.sub.k time period to estimate the phase of the component signal at the end of the T.sub.

Abstract: The invention relates to a method for the high yield production of dicarboxylic acids such as azelaic acid by the controlled two step oxidation of an unsaturated hydrocarbon substrate. The method consists of two steps and involves the derivatization of the unsaturated substrate which locks and directs oxidative cleavage at the site of unsaturation to yield the desired acids.

Abstract: Apparatus is described for mounting an auxiliary motor such as a trolling motor to the transom of a boat. The apparatus includes a frame, a motor mount, a pivot connection between the frame and the motor mount, a control motor supported by the frame, a gear carried by the frame and driven by the control motor, and a linking arm connected between the gear and the motor mount.

Abstract: An improved combined ear and eye protector is disclosed which provides optimum flexibility by permitting the use of both eye and ear protection, or alternatively eye protection only or ear protection only. Maximum flexibility is achieved by providing an ear protection system which includes a head support independent of the eye protector.

Abstract: A welding ground clamp includes a pair of frame legs that are connected together by a pivot pin assembly that also establishes electrical contact between the clamp and a ground cable. The electrical contact is such that the electrical path between the workpiece engaging elements of the clamp and the ground cable are all essentially identical, and the connection to the ground cable is spaced from the workpiece engaging elements. A handle locking assembly combines the advantages of both a spring assembly and a screw lock assembly and is located away from the workpiece engaging elements.

Abstract: The invention is concerned with a novel polymer addition product comprising hydrophilic polymer backbone having a molecular weight of at least about 5,000 and to which are attached amino acid containing pendants, the pendants containing at least one arginine or lysine amino acid. The polymeric compounds of the invention are highly efficient adsorbents for bilirubin and other bile pigments, as well as for bile acids such as cholic acid.

Abstract: A method for forming a reducing gas in a molten metal bath gasifier and simultaneously directly reducing iron oxide in a shaft furnace with the gas thus produced, wherein the bath coolant is preferably provided by cleaned recycle gas from the direct reduction shaft furnace.

Abstract: Apparatus for generating a reducing gas in a molten iron bath gasifier while simultaneously producing direct reduced iron oxide in an associated shaft furnace with the gas from the gasifier. The apparatus includes means for controlling the temperature of the reducing gas to the shaft furnace, means for cleaning, upgrading, and introducing spent top gas from the direct reduction furnace to the molten bath gasifier as a gaseous coolant to cool the reaction with the bath and reduce refractory wear within the gasifier.

Abstract: An interchangeable keyboard application module is connected to a video monitor module in a computer terminal to provide sequences of processor instructions and a keyboard for performing a plurality of selectable applications. The video monitor module includes a CRT display, a serial I/O interface and a processor that processes characters received through the serial I/O interface for display on the CRT screen whether or not the application module is attached. The processor in the video monitor module detects the connection of the application module, and then selects its instructions from a memory in the application module first, to prompt the selection of a mode of operation for the terminal, and second to execute the selected mode of operation. The application module uses a plurality of keyboard overlays, each corresponding to a respective mode of operation. In a specific embodiment two of the modes of operation are programming applications related to programmable controllers.

Abstract: A preferred embodiment of an input module is connected through six address terminals and four data terminals to six banks of contacts. A single bank address is coupled to two latches in the module and then to two banks of contacts. A nibble of data is coupled from each of two banks of contacts to each of two corresponding data latches on the module. The sequential addressing of a low nibble bank and a high nibble bank and the latching of data therefrom is controlled by sequencing circuitry which is enabled each time a bank address is written to the module. In a second embodiment coded information is output through the six address terminals and decoded by two external decoders to multiplex 256 inputs to the processor. Such modules are particularly useful in multiplexing a large number of inputs to the processor of a programmable controller.

Abstract: A programmable controller has a high density I/O module for interfacing eight analog input devices to a main processor module. The high density I/O module has a microcomputer for reading, storing and updating eight words of input data. The microcomputer also communicates with the main processor of the main processor module to transfer the eight words of input status data to a main memory. The main processor is programmed to communicate with the microcomputer in two alternate modes. In one mode the main processor is directed by an applications control program to individually couple words of the status data; in the other mode the main processor is directed by firmware instructions to alter the input/output scan and couple a block of input data.

Abstract: A small, low-cost programmable controller is programmed with both bit-oriented and word oriented program instructions that are stored in a main memory. A microprocessor couples each program instruction to a respective interpreter routine of machine instructions stored in an interpreter memory. Bit-oriented program instructions with a common operation code but different bit-pointer codes are coupled to their own respective interpreter routines. The program instructions have operation codes and bit pointer codes that are assigned by a program panel, and are then translated by a translator PROM as they are coupled to an interpreter routine. Operand addresses are read through the translator PROM unchanged. Error-locating circuitry assists in detecting faulty chips in the main memory as the control program is executed. The hardware required to execute the control program is minimized, while the translator PROM allows the processor unit to be used with prior program panels.