Abstract: The present disclosure provides vector stuffer polynucleotides and compositions thereof, including expression constructs and vectors, such as viral vectors and methods of delivering a therapeutic agent (e.g., inhibitory nucleic acid) to a mammal or treating a disease.

Abstract: An ablation instrument (e.g., an ablation balloon catheter system) includes an elongate catheter having a housing with a window formed therein. An energy emitter is coupled to the elongate catheter and is configured to deliver ablative energy. A controller is received within the window and is coupled to the energy emitter such that axial movement of the controller within the window is translated to axial movement of the energy emitter and rotation of the controller within the window is translated into rotation of the energy emitter. The instrument includes a motor that is at least partially disposed within the housing of the catheter; a first gear that is operatively connected to and driven by the motor; and a second gear that is coupled to the energy emitter and is driven by the first gear to cause rotation of the energy emitter, while allowing the energy emitter to move axially.

Abstract: An antimicrobial light dressing device, system and method for a percutaneous treatment that bathes a treatment region around the percutaneous insertion with an antibacterial illumination source for preventing pathogens around the insertion from entering via the dermal puncture created by the insertion. The antimicrobial light dressing device combines a circumferential body centered around the insertion, and an arrangement of LEDs around the body that focus the light around the insertion and onto a therapeutic region of the insertion. An opening in the circumferential body has an articulated protrusion for offsetting a medicinal vessel such as an IV tube off the skin surface to avoid blocking light to an area under the vessel.

Abstract: An antimicrobial light dressing device, system and method for a percutaneous treatment that bathes a treatment region around the percutaneous insertion with an antibacterial illumination source for preventing pathogens around the insertion from entering via the dermal puncture created by the insertion. The antimicrobial light dressing device combines a circumferential body centered around the insertion, and an arrangement of LEDs around the body that focus the light around the insertion and onto a therapeutic region of the insertion. An opening in the circumferential body has an articulated protrusion for offsetting a medicinal vessel such as an IV tube off the skin surface to avoid blocking light to an area under the vessel.

Abstract: An ablation instrument (e.g., an ablation balloon catheter system) includes an elongate catheter having a housing with a window formed therein. An energy emitter is coupled to the elongate catheter and is configured to deliver ablative energy. A controller is received within the window and is coupled to the energy emitter such that axial movement of the controller within the window is translated to axial movement of the energy emitter and rotation of the controller within the window is translated into rotation of the energy emitter. The instrument includes a motor that is at least partially disposed within the housing of the catheter; a first gear that is operatively connected to and driven by the motor; and a second gear that is coupled to the energy emitter and is driven by the first gear to cause rotation of the energy emitter, while allowing the energy emitter to move axially.

Abstract: An antimicrobial light dressing device, system and method for a percutaneous treatment that bathes a treatment region around the percutaneous insertion with an antibacterial illumination source for preventing pathogens around the insertion from entering via the dermal puncture created by the insertion. The antimicrobial light dressing device combines a circumferential body centered around the insertion, and an arrangement of LEDs around the body that focus the light around the insertion and onto a therapeutic region of the insertion. An opening in the circumferential body has an articulated protrusion for offsetting a medicinal vessel such as an IV tube off the skin surface to avoid blocking light to an area under the vessel.

Abstract: An ablation instrument (e.g., an ablation balloon catheter system) includes an elongate catheter having a housing with a window formed therein. An energy emitter is coupled to the elongate catheter and is configured to deliver ablative energy. A controller is received within the window and is coupled to the energy emitter such that axial movement of the controller within the window is translated to axial movement of the energy emitter and rotation of the controller within the window is translated into rotation of the energy emitter. The instrument includes a motor that is at least partially disposed within the housing of the catheter; a first gear that is operatively connected to and driven by the motor; and a second gear that is coupled to the energy emitter and is driven by the first gear to cause rotation of the energy emitter, while allowing the energy emitter to move axially.

Abstract: Systems and methods for controlling fill media in a balloon catheter are disclosed. The system comprises a catheter having an inflatable balloon, a reservoir for fill media, and a first conduit for delivering fill media from the reservoir to the balloon. The system includes a second conduit for returning fill media from the balloon to the reservoir and a pump configured to circulate fill media through the conduits. The system also includes a valve assembly configured for placement in at least three positions. In the first position, fill media is delivered from the reservoir to the balloon to inflate the balloon. In the second position, fill media is drawn out of the balloon and returned to the reservoir. In the third position, fill media circulates through the conduits between the pump and the balloon and is prevented from flowing back to the reservoir.

Abstract: Systems and methods for controlling fill media in a balloon catheter are disclosed. The system comprises a catheter having an inflatable balloon, a reservoir for fill media, and a first conduit for delivering fill media from the reservoir to the balloon. The system includes a second conduit for returning fill media from the balloon to the reservoir and a pump configured to circulate fill media through the conduits. The system also includes a valve assembly configured for placement in at least three positions. In the first position, fill media is delivered from the reservoir to the balloon to inflate the balloon. In the second position, fill media is drawn out of the balloon and returned to the reservoir. In the third position, fill media circulates through the conduits between the pump and the balloon and is prevented from flowing back to the reservoir.

Abstract: Systems and methods are provided herein for use in identifying and/or detecting electronic message containing malicious content. One exemplary method includes receiving multiple electronic tags. Each of the multiple electronic tags corresponds to an electronic message and a use, and the user caused the electronic tag to be associated with the electronic message based on a perception that the electronic message included malicious content. The exemplary method further includes assigning, for each electronic tag, point(s) to the corresponding user when the corresponding electronic message includes malicious content, totaling, for each user, the point(s) assigned during a predefined interval, and identifying one of the user(s) with a highest total point(s), for the defined interval, as a winner, thereby incentivizing users to associate electronic tags with electronic message perceived to include malicious content.

Abstract: An ablation instrument (e.g., an ablation balloon catheter system) includes an elongate catheter having a housing with a window formed therein. An energy emitter is coupled to the elongate catheter and is configured to deliver ablative energy. A controller is received within the window and is coupled to the energy emitter such that axial movement of the controller within the window is translated to axial movement of the energy emitter and rotation of the controller within the window is translated into rotation of the energy emitter. The instrument includes a motor that is at least partially disposed within the housing of the catheter; a first gear that is operatively connected to and driven by the motor; and a second gear that is coupled to the energy emitter and is driven by the first gear to cause rotation of the energy emitter, while allowing the energy emitter to move axially.

Abstract: Systems and methods for controlling fill media in a balloon catheter are disclosed. The system comprises a catheter having an inflatable balloon, a reservoir for fill media, and a first conduit for delivering fill media from the reservoir to the balloon. The system includes a second conduit for returning fill media from the balloon to the reservoir and a pump configured to circulate fill media through the conduits. The system also includes a valve assembly configured for placement in at least three positions. In the first position, fill media is delivered from the reservoir to the balloon to inflate the balloon. In the second position, fill media is drawn out of the balloon and returned to the reservoir. In the third position, fill media circulates through the conduits between the pump and the balloon and is prevented from flowing back to the reservoir.

Abstract: Mediation sitting cushions and mats allow the user to meditate in comfort for great lengths of time, avoiding stress and pain often caused by traditional meditation cushions and mats. The layered mediation sitting cushions and mats combine a slow recovery visco-elastic foam (“VEF”), having load deformation properties and densities, with one or more base layers of a batting support. The sitting cushions and mats enable a person seated in traditional meditative positions to achieve a comfortable posture, regardless of the meditator's size or weight. The sitting cushions and mats also allow people to meditate in traditional cross-legged or kneeling postures comfortably, without irritation or pain. The mediation sitting cushions and mats also maintain of the pelvis in a neutral or slightly anterior position, resulting in proper alignment of the pelvis and spine, which minimizes the muscular and ligamentous strain caused by sitting in stillness for long periods of time.

Abstract: Systems and methods are provided herein for use in identifying and/or detecting electronic message containing malicious content. One exemplary method includes receiving multiple electronic tags. Each of the multiple electronic tags corresponds to an electronic message and a use, and the user caused the electronic tag to be associated with the electronic message based on a perception that the electronic message included malicious content. The exemplary method further includes assigning, for each electronic tag, point(s) to the corresponding user when the corresponding electronic message includes malicious content, totaling, for each user, the point(s) assigned during a predefined interval, and identifying one of the user(s) with a highest total point(s), for the defined interval, as a winner, thereby incentivizing users to associate electronic tags with electronic message perceived to include malicious content.

Abstract: A transmission structure having high propagation velocity and a low effective dielectric loss. The structure comprises a dielectric, a first reference conductor disposed below the dielectric, a signal conductor disposed above the dielectric, and a second reference conductor disposed over the signal conductor. The second reference conductor has a recess portion facing the signal conductor, the recess portion defining a gap between the second reference conductor and the signal conductor. The gap may be filled with air which has a relative dielectric constant approximately equal to one (1). Because of the physical and dielectric constant characteristics of the gap, the structure concentrates an electric field in the gap resulting in an effective dielectric constant approximately (approaching) one (1) and an effective dielectric loss approximately equal to zero (0). Thus, the structure exhibits a propagation velocity approximately equal to the speed of light.

Abstract: A cavity resonator is provided which includes a shielded enclosure enclosing a volume and a unitary conductor disposed within the volume, the unitary conductor having a first inductor portion and a transmission line portion. The transmission line portion is included in a transmission line having a reference conductor separated from the transmission line portion by a dielectric element. An active semiconductor device is coupled to the unitary conductor, and is operable to conduct a current to the unitary conductor at a resonant frequency of the unitary conductor.

Abstract: Systems and methods for improving HDCP (High-Bandwidth Digital Content Protection) authentication with DVI or HDMI receiver devices are provided. An HDCP transmitting apparatus according to the invention may include a computer and a look-up table accessible by the computer. The look-up table may include a database for storing an interoperability characteristic for an HDCP receiving device. The computer can communicate with the HDCP receiving device. The computer may also insert a delay in an initiation of the authentication and/or communication of content between the HDCP transmitting apparatus and the HDCP receiving device. The magnitude of the delay may be based on an interoperability characteristic retrieved from the look-up table that corresponds to the HDCP receiving device. The inserting may occur prior to the implementation of authentication initiation and ongoing link integrity checking between the transmitting apparatus and the HDCP receiving device.

Abstract: A microelectronic assembly includes a microelectronic package having a microelectronic element with faces and contacts, a flexible substrate spaced from and overlying a first face of the microelectronic element, and a plurality of conductive posts extending from the flexible substrate and projecting away from the first face of the microelectronic element, at least some of the conductive posts being electrically interconnected with the microelectronic element. The package includes a plurality of support elements disposed between the microelectronic element and the substrate and supporting the flexible substrate over the microelectronic element. At least some of the conductive posts are offset from the support elements. The assembly includes a circuitized substrate having conductive pads confronting the conductive posts of the microelectronic package, whereby the conductive posts are electrically interconnected with the conductive pads.

Abstract: A stacked microelectronic assembly includes a base substrate having conductive elements projecting from a bottom surface thereof and a first microelectronic subassembly underlying a bottom surface of the base substrate. The first microelectronic subassembly includes a first dielectric substrate, a first microelectronic element connected with the first dielectric substrate and first conductive posts projecting from the first dielectric substrate toward the bottom surface of the base substrate for electrically interconnecting the first microelectronic element and the base substrate. The assembly also has a second microelectronic subassembly overlying the base substrate. The second microelectronic subassembly includes a second dielectric substrate, a second microelectronic element connected with the second dielectric substrate and second conductive posts projecting toward the top surface of the base substrate for electrically interconnecting the second microelectronic element and the base substrate.

Abstract: An assembly is provided which includes a first circuit panel having a top surface, a first dielectric element and first conductive traces disposed on the first dielectric element. In addition, a second circuit panel has a bottom surface, a second dielectric element and second conductive traces disposed on the second dielectric element, where at least a portion of the second circuit panel overlies at least a portion of the first circuit panel. The assembly further includes an interconnect circuit panel having a third dielectric element which has a front surface, a rear surface opposite the front surface, a top end extending between the front and rear surfaces, a bottom end extending between the front and rear surfaces, and a plurality of interconnect traces disposed on the dielectric element.