Abstract: A composite intraluminal prosthesis which is preferably used as a vascular prothesis includes a layer of ePTFE and a layer of textile material which are secured together by an elastomeric bonding agent. The ePTFE layer includes a porous microstructure defined by nodes interconnected by fibrils. The adhesive bonding agent is preferably applied in solution so that the bonding agent enters the pores of the microstructure of the ePTFE. This helps secure the textile layer to the ePTFE layer.

Abstract: The present disclosure pertains to stents having a coating applied thereto, wherein the coating comprises a biocompatible polymer/drug mixture, as well as devices comprising a metallic stent, a biocompatible polymeric carrier and a drug.

Abstract: The present disclosure pertains to stents having a coating applied thereto, wherein the coating comprises a biocompatible polymer/drug mixture, as well as devices comprising a metallic stent, a biocompatible polymeric carrier and a drug.

Abstract: An implantable composite medical device having a longitudinal length a woven textile portion having yarns interlaced in a woven pattern, a knitted textile portion having yarns interlooped in a knitted pattern. The woven and knitted portions are securably attached to one and the other to provide a composite woven and knitted textile surface along the longitudinal length of the device. The woven portion may have a permeability from about 30 to about 500 ml/min/cm2, and the knitted portion may have a permeability from about 30 to about 15,000 ml/min/cm2. Further, a crimped woven portion with a resiliently longitudinal stretchability from about 10 to about 100 linear percent over its quiescent longitudinal dimension or an uncrimped woven portion with a resiliently longitudinal stretchability of less than about 10 linear percent over its quiescent longitudinal dimension are useful.

Abstract: An implantable composite medical device having a longitudinal length a woven textile portion having yarns interlaced in a woven pattern, a knitted textile portion having yarns interlooped in a knitted pattern. The woven and knitted portions are securably attached to one and the other to provide a composite woven and knitted textile surface along the longitudinal length of the device. The woven portion may have a permeability from about 30 to about 500 ml/min/cm2, and the knitted portion may have a permeability from about 30 to about 15,000 ml/min/cm2. Further, a crimped woven portion with a resiliently longitudinal stretchability from about 10 to about 100 linear percent over its quiescent longitudinal dimension or an uncrimped woven portion with a resiliently longitudinal stretchability of less than about 10 linear percent over its quiescent longitudinal dimension are useful.

Abstract: Methods of making multi-furcated grafts and, more particularly, a bifurcated graft from at least one ePTFE member are provided. Also provided are grafts made according to such methods.

Abstract: The present disclosure pertains to stents having a coating applied thereto, wherein the coating comprises a biocompatible polymer/drug mixture, as well as devices comprising a metallic stent, a biocompatible polymeric carrier and a drug.

Abstract: The present invention provides an implantable graft that includes an elongate graft tube having opposing ends defining an attachment site for attaching the graft to a stent. The graft further includes a reinforcement member attached adjacent to at least one of the ends of the graft for establishing a reinforced attachment site for the graft, thereby preventing elongation of a suture hole in the material. Furthermore, the present invention provides a graft wherein at least one end of the graft is folded over itself and glued or sutured to itself and/or the stent, thereby forming a reinforcement thereto.

Abstract: The invention provides expandable tubular endoluminal prostheses for the treatment of atherosclerotic lesions of blood vessels, including vulnerable plaque lesions, and methods of treatment using the prostheses. Various prostheses of the invention are characterized by hoop strength suitable for treating vulnerable plaque lesions, good conformability and good apposition to vessel walls, as well as minimal coverage areas in order to minimize the inflammatory response to the implanted prostheses.

Abstract: A stent-graft is provided for defining a prosthetic fluid passage within a body lumen. The stent-graft includes a graft having a forward section, and a pilot stent located within the forward section of the graft. The pilot stent has an expanded diameter less than that of a lumen in which it is to be deployed to permit fluid flow within the lumen during deployment of the stent-graft. Means are provided for subsequently expanding the pilot stent and the graft to the full diameter of the lumen.

Abstract: The present invention provides an implantable graft that includes an elongate graft tube having opposing ends defining an attachment site for attaching the graft to a stent. The graft further includes a reinforcement member attached adjacent to at least one of the ends of the graft for establishing a reinforced attachment site for the graft, thereby preventing elongation of a suture hole in the material. Furthermore, the present invention provides a graft wherein at least one end of the graft is folded over itself and glued or sutured to itself and/or the stent, thereby forming a reinforcement thereto.

Abstract: A composite intraluminal prosthesis which is preferably used as a vascular prosthesis includes a layer of ePTFE and a layer of textile material which are secured together by an elastomeric bonding agent. The ePTFE layer includes a porous microstructure defined by nodes interconnected by fibrils. The adhesive bonding agent is preferably applied in solution so that the bonding agent enters the pores of the microstructure of the ePTFE. This helps secure the textile layer to the ePTFE layer.

Abstract: A graft, for example, an arterio-venous shunt graft, is provided, which in a first aspect of the subject invention, is formed with longitudinal ribs. With fibrotic tissue ingrowth between the ribs, a composite rib/tissue layer is formed about the graft. The ribs provide counteracting lateral force against the embedded tissue to seal punctures formed therethrough during hemodialysis procedures. To provide additional surface area for puncturing, the graft may be formed with a truncated cross-section. With a second aspect of the invention, the graft is mounted onto a strip to prevent kinking, twisting or bending during an implantation procedure.

Abstract: Methods of preparing devices for delivering at least one therapeutic agent to a target vessel in a mammal, the devices prepared by such methods, and uses of such devices for delivering a therapeutic agent, such as an antiproliferative agent, to a target vessel.

Abstract: An elastomerically recoverable PTFE material is provided including a longitudinally compressed fibrils of ePTFE material penetrated by elastomeric material within the pores defining the elastomeric matrix. The elastomeric matrix and the compressed fibrils cooperatively expand and recover without plastic deformation of the ePTFE material. The material may be used for various prosthesis, such as a vascular a prosthesis like a patch, a graft and an implantable tubular stent. Further, a method of producing the elastomerically recoverable PTFE material is provided herein.

Abstract: An implantable composite medical device having a longitudinal length a woven textile portion having yarns interlaced in a woven pattern, a knitted textile portion having yarns interlooped in a knitted pattern. The woven and knitted portions are securably attached to one and the other to provide a composite woven and knitted textile surface along the longitudinal length of the device. The woven portion may have a permeability from about 30 to about 500 ml/min/cm2, and the knitted portion may have a permeability from about 30 to about 15,000 ml/min/cm2. Further, a crimped woven portion with a resiliently longitudinal stretchability from about 10 to about 100 linear percent over its quiescent longitudinal dimension or an uncrimped woven portion with a resiliently longitudinal stretchability of less than about 10 linear percent over its quiescent longitudinal dimension are useful.

Abstract: The present invention provides an implantable graft that includes an elongate graft tube having opposing ends defining an attachment site for attaching the graft to a stent. The graft further includes a reinforcement member attached adjacent to at least one of the ends of the graft for establishing a reinforced attachment site for the graft, thereby preventing elongation of a suture hole in the material. Furthermore, the present invention provides a graft wherein at least one end of the graft is folded over itself and glued or sutured to itself and/or the stent, thereby forming a reinforcement thereto.

Abstract: An implantable composite medical device having a longitudinal length a woven textile portion having yarns interlaced in a woven pattern, a knitted textile portion having yarns interlooped in a knitted pattern. The woven and knitted portions are securably attached to one and the other to provide a composite woven and knitted textile surface along the longitudinal length of the device. The woven portion may have a permeability from about 30 to about 500 ml/min/cm2, and the knitted portion may have a permeability from about 30 to about 15,000 ml/min/cm2. Further, a crimped woven portion with a resiliently longitudinal stretchability from about 10 to about 100 linear percent over its quiescent longitudinal dimension or an uncrimped woven portion with a resiliently longitudinal stretchability of less than about 10 linear percent over its quiescent longitudinal dimension are useful.

Abstract: Methods of preparing intravascular stents with a polymeric coating containing macrocyclic lactone (such as rapamycin or its analogs), stents and stent graphs with such coatings, and methods of treating a coronary artery with such devices. The macrocyclic lactone-based polymeric coating facilitates the performance of such devices in inhibiting restenosis.

Abstract: A method of forming a composite textile and ePTFE implantable device includes the steps of (a) providing an ePTFE layer having opposed surfaces comprising a microporous structure of nodes interconnected by fibrils; (b) providing a textile layer having opposed surfaces; (c) applying a coating of an elastomeric bonding agent to one of the opposed surfaces of the ePTFE layer or the textile layer; (d) providing a hollow member having an open end and an opposed closed end defining a fluid passageway therebetween and having a wall portion with at least one hole extending therethrough, the hole being in fluid communication with the fluid passageway; (e) concentrically placing the ePTFE layer and the textile layer onto the hollow member and over the at least one hole of the hollow member to provide an interior composite layer and an exterior composite layer, thereby defining a composite assembly, wherein the interior composite layer is one of the ePTFE layer or the textile layer and the exterior composite layer is th