Abstract: Methods of preparing intravascular stents with a polymeric coating containing macrocyclic lactone (such as rapamycin or its analogs), stents and stent graphs with such coatings, and methods of treating a coronary artery with such devices. The macrocyclic lactone-based polymeric coating facilitates the performance of such devices in inhibiting restenosis.

Abstract: Delivery of rapamycin locally, particularly from an intravascular stent, directly from micropores in the stent body or mixed or bound to a polymer coating applied on stent, to inhibit neointimal tissue proliferation and thereby prevent restenosis. This invention also facilitates the performance of the stent in inhibiting restenosis.

Abstract: An implantable microporous ePTFE tubular vascular graft exhibits long term patency, superior radial tensile strength and suture hole elongation resistance. The graft includes a first ePTFE tube and a second ePTFE tube circumferentially disposed over the first tube. The first ePTFE tube exhibits a porosity sufficient to promote cell endothelization, tissue ingrowth and healing. The second ePTFE tube exhibits enhanced radial strength in excess of the radial tensile strength of the first tube.

Abstract: A method of forming a composite textile and ePTFE implantable device includes the steps of (a) providing an ePTFE layer having opposed surfaces comprising a microporous structure of nodes interconnected by fibrils; (b) providing a textile layer having opposed surfaces; (c) applying a coating of an elastomeric bonding agent to one of the opposed surfaces of the ePTFE layer or the textile layer; (d) providing a hollow member having an open end and an opposed closed end defining a fluid passageway therebetween and having a wall portion with at least one hole extending therethrough, the hole being in fluid communication with the fluid passageway; (e) concentrically placing the ePTFE layer and the textile layer onto the hollow member and over the at least one hole of the hollow member to provide an interior composite layer and an exterior composite layer, thereby defining a composite assembly, wherein the interior composite layer is one of the ePTFE layer or the textile layer and the exterior composite layer is th

Abstract: An implantable microporous ePTFE tubular vascular graft exhibits long term patency, superior radial tensile strength and suture hole elongation resistance. The graft includes a first ePTFE tube and a second ePTFE tube circumferentially disposed over the first tube. The first ePTFE tube exhibits a porosity sufficient to promote cell endothelization, tissue ingrowth and healing. The second ePTFE tube exhibits enhanced radial strength in excess of the radial tensile strength of the first tube.

Abstract: This invention relates to an elastomerically recoverable PTFE material that includes a longitudinally compressed fibrils of ePTFE material penetrated by elastomeric material within the pores defining the elastomeric matrix. The elastomeric matrix and the compressed fibrils cooperatively expand and recover without plastic deformation of the ePTFE material. This invention was used for various prosthesis, such as a vascular prosthesis like a patch, a graft and an implantable tubular stents. Furthermore, this invention discloses a method of producing the elastomerically recoverable PTFE material which include the steps of: providing the specified ePTFE, defined by the nodes and fibrils, to meet the desired end use; longitudinally compressing the fibrils of the ePTFE, the pore size sufficiently enough to permit penetration of the elastomeric material; applying the elastomeric material within the pores to provide a structurally integral elastomerically recoverable PTFE material defining an elastomeric matrix.

Abstract: Delivery of rapamycin locally, particularly from an intravascular stent, directly from micropores in the stent body or mixed or bound to a polymer coating applied on stent, to inhibit neointimal tissue proliferation and thereby prevent restenosis. This invention also facilitates the performance of the stent in inhibiting restenosis.

Abstract: A composite intraluminal prosthesis which is preferably used as a vascular prothesis includes a layer of ePTFE and a layer of textile material which are secured together by an elastomeric bonding agent. The ePTFE layer includes a porous microstructure defined by nodes interconnected by fibrils. The adhesive bonding agent is preferably applied in solution so that the bonding agent enters the pores of the microstructure of the ePTFE. This helps secure the textile layer to the ePTFE layer.

Abstract: Delivery of rapamycin locally, particularly from intravascular stent, directly from micropores in the stent body or mixed or bound to a polymer coating applied on stent, to inhibit neointimal tissue proliferation and thereby prevent restenosis. This invention also facilitates the performance of the stent in inhibiting restenosis.

Abstract: A graft, for example, an arterio-venous shunt graft, is provided, which in a first aspect of the subject invention, is formed with longitudinal ribs. With fibrotic tissue ingrowth between the ribs, a composite rib/tissue layer is formed about the graft. The ribs provide counteracting lateral force against the embedded tissue to seal punctures formed therethrough during hemodialysis procedures. To provide additional surface area for puncturing, the graft may be formed with a truncated cross-section. With a second aspect of the invention, the graft is mounted onto a strip to prevent kinking, twisting or bending during an implantation procedure.

Abstract: An endoluminal device comprises at least a first member and a second member, which may be modular. The first member comprises a first trunk portion, a first midsection comprising a first opening, and a first leg portion. The second member comprises a second trunk portion, a second midsection comprising a second opening, and a second leg portion. The device has an assembled configuration in which the first member and second member are interlocked with one another with the second trunk portion coaxially contained within the first trunk portion, the second leg portion protruding through the first opening, and the second opening facing the first leg portion. The second midsection may have a leg stump portion that protrudes into the first leg portion of the first member in the assembled configuration. A system and method for deploying the device may use identical catheters for deploying the two members.

Abstract: A composite intraluminal prosthesis which is preferably used as a vascular prothesis includes a layer of ePTFE and a layer of textile material which are secured together by an elastomeric bonding agent. The ePTFE layer includes a porous microstructure defined by nodes interconnected by fibrils. The adhesive bonding agent is preferably applied in solution so that the bonding agent enters the pores of the microstructure of the ePTFE. This helps secure the textile layer to the ePTFE layer.

Abstract: An implantable microporous ePTFE tubular vascular graft exhibits long term patency, superior radial tensile strength and suture hole elongation resistance. The graft includes a first ePTFE tube and a second ePTFE tube circumferentially disposed over the first tube. The first ePTFE tube exhibits a porosity sufficient to promote cell endothelization, tissue ingrowth and healing. The second ePTFE tube exhibits enhanced radial strength in excess of the radial tensile strength of the first tube.

Abstract: An implantable microporous ePTFE tubular vascular graft exhibits long term patency, superior radial tensile strength and suture hole elongation resistance. The graft includes a first ePTFE tube and a second ePTFE tube circumferentially disposed over the first tube. The first ePTFE tube exhibits a porosity sufficient to promote cell endothelization, tissue ingrowth and healing. The second ePTFE tube exhibits enhanced radial strength in excess of the radial tensile strength of the first tube.

Abstract: Delivery of rapamycin locally, particularly from an intravascular stent, directly from micropores in the stent body or mixed or bound to a polymer coating applied on stent, to inhibit neointimal tissue proliferation and thereby prevent restenosis. This invention also facilitates the performance of the stent in inhibiting restenosis.

Abstract: Delivery of rapamycin locally, particularly from an intravascular stent, directly from micropores in the stent body or mixed or bound to a polymer coating applied on stent, to inhibit neointimal tissue proliferation and thereby prevent restenosis. This invention also facilitates the performance of the stent in inhibiting restenosis.

Abstract: What is described herein is a endovascular tube or bifurcated prosthesis used for the repair of aneurysms or other vessel disease. This can be soft or hard occlusive disease. This prosthesis is constructed by fabricating a structure that consists of a textile or other polymeric material and through which is threaded a superelastic metal wire such as a nitinol, a ductile wire or other filament material. The textile can be a polymeric material. The wire provides the self-expandability of the current device. Ideally, the thickness of the device should be minimized, so that it can be delivered to the diseased site using a percutaneous procedure.