Abstract: The invention provides low-dose formulations of guanylate cyclase-C (“GCC”) agonist peptides and methods for their use. The formulations of the invention can be administered either alone or in combination with one or more additional therapeutic agents, preferably an inhibitor of cGMP-dependent phosphodiesterase or a laxative.

Abstract: The invention provides processes of purifying a peptide including a GCC agonist sequence selected from the group consisting of SEQ ID NOs: 1-251 described herein. The processes include a solvent exchange step before a freeze-drying (lyophilization) step.

Abstract: Apparatus, methods and instructions for disinfecting air. The apparatus may include, and the methods may involve, a fixture. The fixture may include a germicidal light source. The fixture may include a fan. The fan may circulate air through a volume into which the germicidal light source propagates germicidal light. The light source may be configured to emit, upward from a horizontal plane, a beam that, absent reflection off an environmental object, does not cross the horizontal plane. The apparatus may include a shield that prevents light from the light source from crossing the horizontal plane. The sensor may face upward from the horizontal plane. The sensor may face downward from the horizontal plane.

Abstract: The invention provides processes of purifying a peptide including a GCC agonist sequence selected from the group consisting of SEQ ID NOs: 1-251 described herein. The processes include a solvent exchange step before a freeze-drying (lyophilization) step.

Abstract: Apparatus and method for deployment of fixtures. The apparatus may include an inground fixture. The apparatus may include a landscape lighting fixture. The apparatus may include a fixture housing. The apparatus may include a light engine frame. The light engine frame may be inserted into the fixture housing. The light engine frame may be rotated about a central axis of the fixture housing. The light engine frame may support a light emitting diode (“LED”) light source. The light engine frame may support a light source inclination retainer. The light source inclination retainer may incline the LED light source to different angles. The light engine frame may support a heat exchange assembly. The heat exchange assembly may include heat exchange fins.

Abstract: Apparatus, methods and instructions for disinfecting air. The apparatus may include, and the methods may involve, a fixture. The fixture may include a germicidal light source. The fixture may include a fan. The fan may circulate air through a volume into which the germicidal light source propagates germicidal light. The light source may be configured to emit, upward from a horizontal plane, a beam that, absent reflection off an environmental object, does not cross the horizontal plane. The apparatus may include a shield that prevents light from the light source from crossing the horizontal plane. The sensor may face upward from the horizontal plane. The sensor may face downward from the horizontal plane.

Abstract: The invention provides processes of purifying a peptide including a GCC agonist sequence selected from the group consisting of SEQ ID NOs: 1-251 described herein. The processes include a solvent exchange step before a freeze-drying (lyophilization) step.

Abstract: The invention provides processes of purifying a peptide including a GCC agonist sequence selected from the group consisting of SEQ ID NOs: 1-251 described herein. The processes include a solvent exchange step before a freeze-drying (lyophilization) step.

Abstract: Apparatus and methods for lighting. The apparatus may include an LED light source. The light source may be disposed in housing. The apparatus may include a circuit. The circuit may be configured to cause the LED light source to emit light at: a first intensity; and a second intensity that is different from the first intensity. The apparatus may include a mechanical power state selector. A user may use the power state selector to select between LED light sources that are arranged to illuminate in different directions. The apparatus may include a CCT state selector. A user may use the CCT state selector to select a CCT for one or more LED light sources. The CCT may be produced by combining light from one or more LEDs of different CCTs.

Abstract: Apparatus, methods and instructions for disinfecting air. The apparatus may include, and the methods may involve, a fixture. The fixture may include a germicidal light source. The fixture may include a fan. The fan may circulate air through a volume into which the germicidal light source propagates germicidal light. The light source may be configured to emit, upward from a horizontal plane, a beam that, absent reflection off an environmental object, does not cross the horizontal plane. The apparatus may include a shield that prevents light from the light source from crossing the horizontal plane. The sensor may face upward from the horizontal plane. The sensor may face downward from the horizontal plane.

Abstract: Apparatus and methods for lighting. The apparatus may include an LED light source. The light source may be disposed in housing. The apparatus may include a circuit. The circuit may be configured to cause the LED light source to emit light at: a first intensity; and a second intensity that is different from the first intensity. The apparatus may include a mechanical power state selector. A user may use the power state selector to select between LED light sources that are arranged to illuminate in different directions. The apparatus may include a CCT state selector. A user may use the CCT state selector to select a CCT for one or more LED light sources. The CCT may be produced by combining light from one or more LEDs of different CCTs.

Abstract: Apparatus, methods and instructions for disinfecting air. The apparatus may include, and the methods may involve, a fixture. The fixture may include a germicidal light source. The fixture may include a fan. The fan may circulate air through a volume into which the germicidal light source propagates germicidal light. The light source may be configured to emit, upward from a horizontal plane, a beam that, absent reflection off an environmental object, does not cross the horizontal plane. The apparatus may include a shield that prevents light from the light source from crossing the horizontal plane. The sensor may face upward from the horizontal plane. The sensor may face downward from the horizontal plane.

Abstract: Apparatus, methods and instructions for disinfecting air. The apparatus may include, and the methods may involve, a fixture. The fixture may include a germicidal light source. The fixture may include a fan. The fan may circulate air through a volume into which the germicidal light source propagates germicidal light. The light source may be configured to emit, upward from a horizontal plane, a beam that, absent reflection off an environmental object, does not cross the horizontal plane. The apparatus may include a shield that prevents light from the light source from crossing the horizontal plane. The sensor may face upward from the horizontal plane. The sensor may face downward from the horizontal plane.

Abstract: Apparatus, methods and instructions for disinfecting air. The apparatus may include, and the methods may involve, a fixture. The fixture may include a germicidal light source. The fixture may include a fan. The fan may circulate air through a volume into which the germicidal light source propagates germicidal light. The light source may be configured to emit, upward from a horizontal plane, a beam that, absent reflection off an environmental object, does not cross the horizontal plane. The apparatus may include a shield that prevents light from the light source from crossing the horizontal plane. The sensor may face upward from the horizontal plane. The sensor may face downward from the horizontal plane.

Abstract: In one example, a system for gesture buttons can include a processing resource and a non-transitory computer readable medium having stored thereon instructions to cause the processing resource to perform a first function in response to a gesture provided to the user interface, display a gesture button on the user interface, and perform a second function that is different than the first function in response to the gesture provided on the gesture button displayed on the user interface.

Abstract: Apparatus, methods and instructions for disinfecting air. The apparatus may include, and the methods may involve, a fixture. The fixture may include a germicidal light source. The fixture may include a fan. The fan may circulate air through a volume into which the germicidal light source propagates germicidal light. The light source may be configured to emit, upward from a horizontal plane, a beam that, absent reflection off an environmental object, does not cross the horizontal plane. The apparatus may include a shield that prevents light from the light source from crossing the horizontal plane. The sensor may face upward from the horizontal plane. The sensor may face downward from the horizontal plane.

Abstract: Apparatus and methods for lighting. The apparatus may include a beam-angle changing lens. The beam-angle changing lens may be movable from a first position in front of a slotted cylinder to a second position in front of the slotted cylinder. The slotted cylinder may be fixed with respect to translation along the central axis. The slotted cylinder may be configured to move the beam-angle changing lens from the first position to the second position when the slotted cylinder is rotated. The slotted cylinder may be configured to displace the support to move the lens to the positions. The apparatus may include a guide pin. Rotation of the slotted cylinder may displace the guide pin linearly in a direction parallel to the axis. Motion of the guide pin may move the lens. The apparatus may include a rotatable shaft. The rotatable shaft may be configured to rotate the slotted cylinder.

Abstract: Apparatus, methods and instructions for disinfecting air. The apparatus may include, and the methods may involve, a fixture. The fixture may include a germicidal light source. The fixture may include a fan. The fan may circulate air through a volume into which the germicidal light source propagates germicidal light. The light source may be configured to emit, upward from a horizontal plane, a beam that, absent reflection off an environmental object, does not cross the horizontal plane. The apparatus may include a shield that prevents light from the light source from crossing the horizontal plane. The sensor may face upward from the horizontal plane. The sensor may face downward from the horizontal plane.

Abstract: Apparatus and methods for lighting. The apparatus may include an LED light source. The light source may be disposed in housing. The apparatus may include a circuit. The circuit may be configured to cause the LED light source to emit light at: a first intensity; and a second intensity that is different from the first intensity. The apparatus may include a mechanical power state selector. A user may use the power state selector to select between LED light sources that are arranged to illuminate in different directions. The apparatus may include a CCT state selector. A user may use the CCT state selector to select a CCT for one or more LED light sources. The CCT may be produced by combining light from one or more LEDs of different CCTs.

Abstract: The invention provides processes of purifying a peptide including a GCC agonist sequence selected from the group consisting of SEQ ID NOs: 1-251 described herein. The processes include a solvent exchange step before a freeze-drying (lyophilization) step.