Abstract: The present disclosure provides use of Clostridium ghonii combined with a tumor angiogenesis inhibitor in preparing a pharmaceutical product for treating a tumor. The present disclosure further provides a drug for treating a tumor, where the drug includes active ingredients of Clostridium ghonii and a tumor angiogenesis inhibitor.

Abstract: The present disclosure relates to use of a Clostridium ghonii spore combined with pembrolizumab in cancer treatment. It is found for the first time that the Clostridium ghonii spore combined with pembrolizumab can significantly improve a curative effect of colon cancer and reduce a dose of the pembrolizumab, and thus is efficient and low-toxic. Oncolysis by Clostridium ghonii can affect immunogenicity of a tumor microenvironment (TME) by various ways, converts an immunosuppressive state of the TME into an immune-activated state, adjusts the immunosuppressive TME, and breaks an immune tolerance. An optimal combination of the Clostridium ghonii spore and the pembrolizumab thoroughly removes about 20% of mouse tumor tissues. A benefit range of patients with tumors treated by a PD-1 antibody is expanded. The combination even has an obvious curative effect on patients failed the treatment by the PD-1 antibody.

Abstract: The present invention is directed to novel chemical compositions of matter, and in particular a novel MDMA class of compounds MDMA analogs having 1,3-benzothiazoles substituted at the 5 and 6-position with a MDMA basic or modified side chain.

Abstract: Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of 5-hydroxytryptamine receptor 7 activity.

Abstract: An array substrate and a display terminal are provided. The display panel includes the plurality of stacked metal sub-layers and the first passivation sub-layer and the second passivation sub-layer stacked. The first passivation sub-layer is disposed between the metal layer and the second passivation layer. Material of the first passivation sub-layer includes silicon nitride. The first passivation sub-layer covers the untidy area at the ends of the molybdenum-titanium alloy thin layer to avoid from detachment of the passivation layer, and meanwhile to solve the issues of simplifying the manufacturing process of the display panel, and to avoid from oxidation of the bonding pads.

Abstract: Aspects of the present disclosure address systems and methods for driver resizing using a transition-based capacitance increase margin. An integrated circuit (IC) design stored in a database in memory is accessed. The IC design comprises a net comprising a set of driver cells. A capacitance increase margin for resizing an initial driver cell is determined based on a total capacitance of the net and transition time target associated with the initial driver cell. An alternative driver cell is selected from a library to resize the initial driver cell and is used to replace the initial driver cell in the net. The alternative driver is selected such that a pin capacitance of the alternative driver cell exceeds an initial pin capacitance corresponding to the initial driver cell by no more than the capacitance increase margin.

Abstract: The present application discloses a display panel. The display panel is defined with a display region and a dummy region and include a first substrate and a second substrate. The first substrate comprises a first black matrix disposed in the display region and a second black matrix disposed in the dummy region. A thickness of the second black matrix is greater than a thickness of the first black matrix such that the dummy region of the first substrate forms a first thickened layer relative to the display region. The second substrate is disposed opposite to the first substrate. The present application can reduce a film thickness difference between the display region and the dummy region, weaken a seesaw effect, and improve poor display on a periphery of the display panel.

Abstract: A preparation method for a copolymer includes the step(s) of contacting an olefin and an unsaturated carboxylic acid shown in Formula II or a derivative of the unsaturated carboxylic acid shown in Formula II with a catalyst and optionally a chain transfer agent for reaction in the presence of an alkane solvent to obtain the copolymer. The copolymer is a spherical and/or spherical-like copolymer.

Abstract: Described herein, inter alia, are Ras inhibitors and uses thereof.

Abstract: Modified microorganisms, pharmaceutical compositions thereof, and methods of preventing and treating the coronavirus disease 2019 (COVID-19) are disclosed.

Abstract: A system includes a machine configured to perform operations including accessing an integrated circuit design including a buffer tree that interconnects a plurality of inputs and buffers. The buffer tree includes a baseline timing characteristic. The operations include identifying a set of candidate solutions for improving the baseline timing characteristic using an initial timing model and selecting a subset of candidate solutions that have a timing characteristic lower than the baseline timing characteristic. Then the subset of candidate solutions are evaluated using a detailed timing model and based on determining that at least one candidate solution in the subset has a timing characteristic that is better than the baseline timing characteristic, selecting a candidate solution from the set of candidate solutions, and updating the buffer tree based on the candidate solution.

Abstract: The present disclosure provides recombinant bacteria for production of indole-3-acetic acid (IAA). Pharmaceutical compositions and methods of treating diseases are also included.

Abstract: The present disclosure provides recombinant bacterial cells that have been engineered with genetic circuitry which allow the recombinant bacterial cells to sense a patient's internal environment and respond by turning an engineered metabolic pathway on or off. When turned on, the recombinant bacterial cells complete all of the steps in a metabolic pathway to achieve a therapeutic effect in a host subject. These recombinant bacterial cells are designed to drive therapeutic effects throughout the body of a host from a point of origin of the microbiome. Specifically, the present disclosure provides recombinant bacterial cells that comprise a uric acid catabolism enzyme, e.g., a uric acid degrading enzyme, for the treatment of diseases and disorders associated with uric acid, including hyperuricemia and gout, in a subject. The disclosure further provides pharmaceutical compositions and methods of treating disorders associated with uric acid, such as hyperuricemia.

Abstract: The invention provides an olefin-olefinic alcohol copolymer and a preparation method thereof, said copolymer comprising a spherical and/or spherical-like polymer. The copolymer provided by the invention exhibits a good morphology and has good prospects in industrial use.

Abstract: An amino-imine metal complex represented by Formula I, its preparation method and an application thereof are provided. The complex is used as a main catalyst in catalysts for olefin polymerization, and can catalyze the polymerization of ethylene at a relatively high temperature to prepare branched polyethylene having high molecular weight.

Abstract: A method for preparing an olefin-olefinic alcohol copolymer and an olefin-olefinic alcohol copolymer prepared by the method are provided. The catalyst used in the method for preparing the olefin-olefinic alcohol copolymer has a diimine metal complex as shown in Formula I.

Abstract: A system includes one or more processors and a computer storage medium storing instructions that cause a machine to perform operations including accessing an integrated circuit (IC) design including an initial clock tree. The operations include selecting a first driver to evaluate for resizing, the first driver being a first size and having a first leakage current and determining a baseline power consumption measurement of clock tree based on the first size and the first leakage current of the first driver. The operations include identifying a plurality of replacement drivers to replace the first driver and determining a power consumption measurement for a second driver. Based on determining that the power consumption measurement for the second driver is less than the baseline power consumption measurement replacing the first driver with the second driver and generating a layout instance based on the second driver.

Abstract: An integrated circuit (IC) design is accessed from a database in memory. The IC design comprises a route connecting a source to a sink. A set of buffering candidates for buffering are generated for the net. A timing improvement associated with a buffering candidate in the set of buffering candidates is determined using a first timing model. The buffering candidate is pruned from the set of buffering candidates based on the timing improvement and a cost associated with the buffering candidate. The pruned set of buffering candidates is evaluated using a second timing model, and a buffering solution for the net is selected from the pruned set of buffering candidates based on a result of the evaluating. The IC design is updated to include the buffering solution selected for the net.

Abstract: A device and a method for acquiring brain electrical signal. The device for acquiring brain electrical signal includes a plurality of electrodes and an electrode base. The electrode base is provided with a plurality of screw holes, and each of the plurality of electrodes passes through a corresponding screw hole of the plurality of screw holes.

Abstract: An integrated circuit (IC) design is accessed from a database in memory. The IC design comprises a routing topology for a net comprising interconnections between a set of pins. The IC design further comprises a set of candidate locations for inserting buffers. A set of cells from a cell library in memory is accessed. A candidate location from the set of candidate locations is assessed to determine whether at least one cell in the set of cells fits at the location. Based on determining that at least one cell in the set of cells fits at the candidate location, the location is marked as bufferable. A largest cell width that fits at the candidate location is determined based on the set of cells and a buffering solution is generated for the net using the largest cell width as a constraint on buffer insertion performed at the candidate location.