Abstract: The present disclosure provides recombinant bacterial cells that have been engineered with genetic circuitry which allow the recombinant bacterial cells to sense a patients internal environment and respond by turning an engineered metabolic pathway on or off. When turned on, the recombinant bacterial cells complete all of the steps in a metabolic pathway to achieve a therapeutic effect in a host subject. These recombinant bacterial cells are designed to drive therapeutic effects throughout the body of a host from a point of origin of the microbiome. Specifically, the present disclosure provides recombinant bacterial cells comprising a heterologous gene encoding an improved leucine catabolism enzyme with higher activity and/or specificity for leucine over other branched chain amino acids, such as isoleucine or valine.

Abstract: A system includes a machine configured to perform operations including accessing an integrated circuit design including a buffer tree that interconnects a plurality of inputs and buffers. The buffer tree includes a baseline timing characteristic. The operations include identifying a set of candidate solutions for improving the baseline timing characteristic using an initial timing model and selecting a subset of candidate solutions that have a timing characteristic lower than the baseline timing characteristic. Then the subset of candidate solutions are evaluated using a detailed timing model and based on determining that at least one candidate solution in the subset has a timing characteristic that is better than the baseline timing characteristic, selecting a candidate solution from the set of candidate solutions, and updating the buffer tree based on the candidate solution.

Abstract: Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of 5-hydroxytryptamine receptor 7 activity.

Abstract: A diimine metal complex represented by Formula I, a preparation method therefor, and application thereof are provided. The complex is used as a main catalyst in catalysts for olefin polymerization, and can achieve catalytic ethylene polymerization at a high temperature to prepare high molecular weight branched polyethylene.

Abstract: An integrated circuit (IC) design is accessed from a database in memory. The IC design comprises an initial buffer tree for a net in the IC design. A maximum cost constraint for rebuffering the net is determined based on the initial buffer tree. A partial rebuffering solution is generated for net and a cost associated with the partial rebuffering solution is determined. Based on determining the cost of the partial rebuffering solution satisfies the maximum cost constraint, the partial rebuffering solution is saved in a set of partial rebuffering solutions for the net. A set of candidate rebuffering solutions for the net is generated based on the set of partial rebuffering solutions, and a rebuffering solution for the net is selected from the set of candidate rebuffering solutions. The database is updated to replace the initial buffer tree in the IC design with the rebuffering solution selected for the net.

Abstract: Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of sigma-2 receptor activity.

Abstract: Concealed mark preparation with core-shell luminosphores for customs security check system and application thereof, to address that infrared luminescent materials have not been used in senseless customs clearance field, absorption cross sections of infrared luminescent materials currently available are not big enough, and upconversion luminescence intensity thereof is low, consequently, the luminescent marks are not clear enough to recognize marked abnormal luggage, and provide a following solution: step 1: preparing TiQ2; step 2: preparing Ag@TiO2 composite nanoparticles; step 3: preparing Ag@TiQ2@NaYF4:Yb3+, Er3+ luminescent nanoparticles; step 4: making concealed luggage marks.

Abstract: Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of 5-hydroxytryptamine receptor 7 activity.

Abstract: Aspects of the present disclosure address improved systems and methods for buffer insertion in an integrated circuit (IC) design using a cost function that accounts for edge spacing and stack via constraints associated with cells in the IC design. An integrated circuit (IC) design comprising a routing topology for a net is accessed. A set of candidate insertion locations along the routing topology are identified. A set of buffering candidates is generated based on the candidate insertion locations. A buffering candidate comprises a cell inserted at a candidate insertion location along the routing topology. A cost associated with the buffering candidate is determined based on a number of potential edge spacing conflicts and a number of stack vias associated with the cell. A buffering solution for the net is selected from the buffering candidate based on the cost associated with the buffering candidate.

Abstract: Aspects of the present disclosure address improved systems and methods for rebuffering an integrated circuit (IC) design using a unified improvement scoring algorithm. A plurality of rebuffering candidates are generated based on an initial buffer tree in an integrated circuit (IC) design. A rebuffering candidate in the plurality of rebuffering candidates comprises a modified buffer tree based on the initial buffer tree. A buffering cost of each rebuffering candidate is determined. A reference buffer tree is selected from among the rebuffering candidates based on the buffering cost of each rebuffering candidate. An improvement score of each rebuffering candidate is determined based on the buffering cost of each rebuffering candidate relative to the reference buffer tree. A new buffer tree is selected from among the plurality of rebuffering candidates to replace the initial buffer tree based on the improvement score of each rebuffering candidate.

Abstract: Systems and methods for customizing and providing automated voice prompts for text displayed on a security system keypad are provided. Some methods can include receiving a security system message from a security system control panel, identifying a customized message that corresponds to the security system message, and transmitting the customized message to a user device for audible transmission of the customized message.

Abstract: A net lamp and a decorative lamp, the net lamp including a plurality of conductive wires, a plurality of insulated wires, a plurality of lamp bodies disposed on the conductive wires, and a plurality of fasteners for fastening the conductive wires and the insulated wires; wherein the plurality of conductive wires and the plurality of insulated wires are connected to form a net-like structure by means of the plurality of fasteners. The decorative lamp includes the above described the net lamp.

Abstract: Aspects of the present disclosure address improved systems and methods for layer assignment to improve timing in integrated circuit (IC) designs. An initial placement layout of a net of an IC design is accessed. A plurality of buffer insertion candidates is generated using multiple candidate buffer insertion points and multiple layer assignments from among multiple layers of the IC design. Timing characteristics of each buffer insertion candidate are determined, and timing improvements provided by each buffer insertion candidate are determined based on respective timing characteristics. A buffer insertion candidate is selected from the plurality of buffer insertion candidates based on the timing improvement provided by the buffer insertion candidate. A layout instance for the IC is generated based in part on the selected buffer insertion candidate.

Abstract: The invention provides an olefin-olefinic alcohol copolymer and a preparation method thereof, said copolymer comprising a spherical and/or spherical-like polymer. The copolymer provided by the invention exhibits a good morphology and has good prospects in industrial use.

Abstract: The present invention provides a copolymer of an olefin and an unsaturated carboxylic acid or an unsaturated carboxylic acid derivative, said copolymer being a spherical and/or spherical-like polymer. The copolymer provided by the invention exhibits a good morphology and has good prospects in industrial use.

Abstract: Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of 5-hydroxytryptamine receptor 7 activity.

Abstract: Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of 5-hydroxytryptamine receptor 7 activity.

Abstract: Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of 5-hydroxytryptamine receptor 7 activity.