Abstract: The present invention encompasses prostaglandin E2 (PGE2) binding proteins. The invention relates to antibodies that are wild-type, chimeric, CDR grafted and humanized. Preferred antibodies have high affinity for prostaglandin E2 and neutralize prostaglandin E2 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody, or an antigen-binding portion thereof. Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antigen-binding portions, of the invention are useful for detecting prostaglandin E2 and for inhibiting prostaglandin E2 activity, e.g., in a human subject suffering from a disorder in which prostaglandin E2 activity is detrimental.

Abstract: A solid-phase nano extraction device includes an extraction tube whose inner surface has a nanostructure for a large contact area with object to be detected. The nanostructure can adsorb objects in an extremely short reaction time. A driving structure is designed for the solid-phase micro extraction device. The extraction tube is connected to the driving structure for the objects to enter the fiber under the force of concentration gradient, pressure difference, or capillary force, thereby being adsorbed onto the nanostructure.

Abstract: A solid-phase nano extraction device includes an extraction tube whose inner surface has a nanostructure for a large contact area with object to be detected. The nanostructure can adsorb objects in an extremely short reaction time. A driving structure is designed for the solid-phase micro extraction device. The extraction tube is connected to the driving structure for the objects to enter the fiber under the force of concentration gradient, pressure difference, or capillary force, thereby being adsorbed onto the nanostructure.