Abstract: A compound having a structure as shown in general formula (I), a deuterated compound, a stereoisomer, or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising same, and use thereof. The compound has a good PIM kinase inhibitory effect, is a novel and ideal PIM inhibitor having high activity and low toxicity, and can be used for treating and/or preventing hematoma such as acute myeloid leukemia, bone marrow fibrosis and chronic lymphocytic leukemia, solid tumors such as gastric cancer and prostate cancer, and other diseases.

Abstract: A method for knowledge representation and deduction of service logic includes: generating, based on a knowledge representation model, a semantic graph corresponding to conceptual-layer service logic, where the semantic graph includes one or more types of nodes and edges for connecting the one or more types of nodes, and the nodes include at least a node of a variable type; generating, based on the semantic graph and a physical table to which a service object is mapped, an instance graph, where the instance graph includes the nodes and edges in the semantic graph; generating executable code based on a service logic relationship between the nodes in the instance graph; and determining, based on the executable code and a data instance corresponding to a node whose in-degree is 0 in the instance graph, a data instance corresponding to each node in the instance graph.

Abstract: A system for a semiconductor fabrication facility comprises a transporting tool configured to move a carrier, a first manufacturing tool configured to accept the carrier facing in a first direction, a second manufacturing tool configured to accept the carrier facing in the second direction, and an orientation tool. The carrier is moved to the orientation tool by the transporting tool prior to being moved to the first manufacturing tool or the second manufacturing tool by the transporting tool. The orientation tool rotates the carrier so that the carrier is accepted by the first manufacturing tool or the second manufacturing tool. The transporting tool, the first manufacturing tool, the second manufacturing tool and the orientation tool are physically separated from each other.

Abstract: Described herein are systems and methods for a type of paradigm-shift nanoparticles functionalized endothelial optical exosomes for vascular malformation treatment, including Port Wine Stain, using exosomes as a drug delivery vehicle in combination with Near-Infrared-mediated laser therapy.

Abstract: An apparatus for imparting false twist to a staple yarn comprising a yarn guide for guiding a staple yarn along a path and a false twist device comprising a convex surface for engagement with a staple yarn so as to impart a force to the staple yarn when the staple yarn engages with and traverses the convex surface of the false twist device, and wherein the relative positioning between the yarn guide and the convex surface of the false twist device is adjustable such that, when a staple yarn is engaged with the convex surface of the false twist device and extends between the yarn guide and the false twist device, the amount of contact between the staple yarn and the convex surface of the false twist device can be controlled.

Abstract: The present invention relates to a trabectedin-inclusive injectable pharmaceutical composition for gastrointestinal external use and a method for manufacturing the same. Specifically, the composition contains trabectedin and a first excipient, the first excipient being selected from one or more of monosaccharide or polylols. The preparation in the present invention has a stable quality, and can be applied to mass production.

Abstract: An apparatus for imparting false twist to a staple yarn comprising a yarn guide for guiding a staple yarn along a path and a false twist device comprising a convex surface for engagement with a staple yarn so as to impart a force to the staple yarn when the staple yarn engages with and traverses the convex surface of the false twist device, and wherein the relative positioning between the yarn guide and the convex surface of the false twist device is adjustable such that, when a staple yarn is engaged with the convex surface of the false twist device and extends between the yarn guide and the false twist device, the amount of contact between the staple yarn and the convex surface of the false twist device can be controlled.

Abstract: The present invention relates to a trabectedin-inclusive injectable pharmaceutical composition for gastrointestinal external use and a method for manufacturing the same. Specifically, the composition contains trabectedin and a first excipient, the first excipient being selected from one or more of monosaccharide or polylols. The preparation in the present invention has a stable quality, and can be applied to mass production.

Abstract: A system, method, and apparatus for receiving notifications from a notifying device, and alerting a user as to the notification are provided. Embodiments of the present invention include a connectivity transceiver, and a notifying device transceiver positioned within a signal distance of a signal transmitted by the connectivity transceiver, wherein the connectivity controller is configured to set the signal distance to a reduced signal distance upon initiating a pairing operation with the notifying device transceiver. Further, the connectivity transceiver may be communicably coupled to a system controller that adjusts an interval duty cycle of inquiry scans and page scans based on a connection with the notifying device transceiver.

Abstract: A reset ramp control structure and method is described. A fast ramp down condition of a monitored voltage is detected and used to force the state of system reset. Delay between fast ramp detection and the forcing of system reset is adjustable. Operation is adaptable to include all DC power systems. The reset ramp control structure provides operational protection during fast ramp down conditions when standard reset circuitry may not be operational.

Abstract: A circuit and method are disclosed for monitoring the state of at least one switch. The circuit may include a first circuit, coupled to a switch, for detecting whether the switch is in one of a closed state and an open state and generating a signal having a value based upon the detection. The circuit may further include a second circuit, coupled to the first circuit, for configuring the first circuit to selectively detect the switch switching from a normally open state and to selectively detect the switch switching from a normally closed state.

Abstract: A method and circuit are disclosed for detecting the performance of an oscillator circuit. In particular, the circuit may detect a signal, such as the output of the oscillator circuit, failing to oscillate as desired. The second circuit may be capable of detecting whether the signal oscillates at a frequency that is less than a predetermined frequency. The second circuit may include timing circuits for determining whether the signal remains in a first logic state for at least a predetermined period of time and whether the signal remains in a second logic state for at least the predetermined period of time.

Abstract: A reset ramp control structure and method is described. A fast ramp down condition of a monitored voltage is detected and used to force the state of system reset. Delay between fast ramp detection and the forcing of system reset is adjustable. Operation is adaptable to include all DC power systems. The reset ramp control structure provides operational protection during fast ramp down conditions when standard reset circuitry may not be operational.

Abstract: A method and circuit are disclosed for enabling an oscillator circuit to oscillate a predetermined period of time following completion of a power-up operation. The circuit may include a counter having a control for receiving a control signal from a system power-on-reset circuit, and a clock input. A ring oscillator has an output coupled to the clock input of the counter.

Abstract: A circuit and method are disclosed for detecting activation of a switch, such as a mechanical switch. The circuit may include a first circuit for temporarily driving the second terminal of the switch to a second logic level. A second circuit, coupled to the switch, senses a voltage level of the second terminal of the switch and generates an output signal representative of the voltage sensed. A sequential logic circuit is responsive to the output signal of the second circuit so as to maintain a logic value representative of the switch having been closed.

Abstract: A circuit and method are disclosed for controlling current dissipated by an oscillator circuit. The circuit includes a current source adapted to source current to or sink current from the oscillator circuit. A control circuit is adapted to count a predetermined period of time following the occurrence of an event, such as completion of a power-up operation. An output of the control circuit, having a value indicative of whether the predetermined period of time has elapsed, is coupled to a control input of the current source. In this way, the output of the control circuit sets a current level sourced to or sunk from the oscillator circuit by the current source.

Abstract: A method and circuit are disclosed for enabling an oscillator circuit to oscillate a predetermined period of time following completion of a power-up operation. The circuit may include a counter having a control for receiving a control signal from a system power-on-reset circuit, and a clock input. A ring oscillator has an output coupled to the clock input of the counter.

Abstract: A circuit and method are disclosed for controlling current dissipated by an oscillator circuit. The circuit includes a current source adapted to source current to or sink current from the oscillator circuit. A control circuit is adapted to count a predetermined period of time following the occurrence of an event, such as completion of a power-up operation. An output of the control circuit, having a value indicative of whether the predetermined period of time has elapsed, is coupled to a control input of the current source. In this way, the output of the control circuit sets a current level sourced to or sunk from the oscillator circuit by the current source.

Abstract: A method and circuit are disclosed for detecting the performance of an oscillator circuit. In particular, the circuit may detect a signal, such as the output of the oscillator circuit, failing to oscillate as desired. The second circuit may be capable of detecting whether the signal oscillates at a frequency that is less than a predetermined frequency. The second circuit may include timing circuits for determining whether the signal remains in a first logic state for at least a predetermined period of time and whether the signal remains in a second logic state for at least the predetermined period of time.

Abstract: A circuit and method are disclosed for monitoring the state of at least one switch. The circuit may include a first circuit, coupled to a switch, for detecting whether the switch is in one of a closed state and an open state and generating a signal having a value based upon the detection. The circuit may further include a second circuit, coupled to the first circuit, for configuring the first circuit to selectively detect the switch switching from a normally open state and to selectively detect the switch switching from a normally closed state.