Abstract: A method for determining the positions of contacts through a global positioning system (GPS) is disclosed. The method includes sending position requests to the contacts, feeding back the current position information of the contacts to a GPS receiver of a user after receiving position requests, searching the contacts located within a same geographical region as the user according to the feedback information and displaying a list of the contacts to the user in the same geographical region.

Abstract: A radioactive halogen-labeled phenyoxyaniline derivative represented by the following formula: wherein R1 represents a group such as an alkyl group; X1, X2, X3 and X4 represent each a hydrogen atom, an alkyl group, an alkoxy group, an alkoxy group carrying 11C introduced thereinto or a radioactive halogen atom, provided that at least one of X1, X2, X3 and X4 represents an alkoxy group carrying 11C introduced thereinto or a radioactive halogen atom; which is a compound useful as a PBR ligand having a high affinity and a high selectivity. In in vitro measurement of PBR, a PBR ligand having a high affinity and a high selectivity is labeled with a radioactive halogen nuclear species so as to enable the measurement of PBR in vivo with the use of means including not only PET but also SPECT. Thus, a compound which is useful in early diagnosing, preventing and treating diseases such as Alzheimer type dementia can be obtained.

Abstract: Provided herein are PDGF-R? imaging agents that are polypeptides labeled with a signal generator (e.g., paramagnetic label, a radionuclide, or a fluorophore), wherein the imaging agents bind specifically to PDGFR-?. Also provided are in vivo imaging methods using the imaging agents.

Abstract: A method of estimating an air charge in at least one combustion cylinder of an internal combustion engine includes calculating cylinder mass air flow based upon a modified volumetric efficiency parameter; and calculating the intake throttle mass air flow based upon a throttle air flow discharge parameter and a fuel enrichment factor. Three models including a mean-value cylinder flow model, a manifold dynamics model, and a throttle flow model are provided to estimate the air charge in the at least one combustion cylinder and to control delivery of fuel to the fuel delivery system.

Abstract: An apparatus and method for transmitting a signal for optical network applications with automatic chromatic dispersion compensation. The apparatus includes a first optical transmitter. The first optical transmitter includes a first light source configured to generate a first laser signal in response to a first laser drive signal, a first data modulator configured to receive the first laser signal and a first data drive signal and output a first chirped return-to-zero signal, and a first signal source configured to generate a first non-return-to-zero signal. Additionally, the apparatus includes a first clock and data recovery system, a first data driver, a first adjustment system, and a first control system.

Abstract: The present invention discloses methods for detection of small molecule compounds and its specific biochips. Biochips of the present invention comprise a solid support and carrier-linked small molecules immobilized onto the solid support. The invention also provides methods and kits for detection of small molecule compounds using the biochips of the invention.

Abstract: A phenyl tin compound is synthesized by using a derivative having various functional groups and a bromo- or iodo-benzene ring as a labeling material of a radioactive ligand. On the other hand, a novel hydroxytosyl iodobenzene compound having an electron-donating group is obtained by oxidizing iodobenzene having one or more electron-donating groups and reacting it with tosylic acid. Then, a diphenyliodonium salt which is a labeling precursor is synthesized by reacting the resulting compound with various phenyl tin compounds. Finally, a 18F-labeled ligand having various functional groups and a [18F] fluorobenzene ring is synthesized by reacting the resulting diphenyliodonium salt with [18F]F?.

Abstract: A method of estimating an air charge in at least one combustion cylinder of an internal combustion engine includes calculating cylinder mass air flow based upon a modified volumetric efficiency parameter; and calculating the intake throttle mass air flow based upon a throttle air flow discharge parameter and a fuel enrichment factor. Three models including a mean-value cylinder flow model, a manifold dynamics model, and a throttle flow model are provided to estimate the air charge in the at least one combustion cylinder and to control delivery of fuel to the fuel delivery system.

Abstract: An optical network transmitter comprising a fractional-bit delay module, an optical modulator coupled to the fractional-bit delay module, and a band-limiting optical filter coupled to the optical modulator. Also disclosed is a transmission system comprising a source configured to generate two complementary binary data streams, a fractional-bit delay module in communication with the source and configured to delay one of the complementary binary data streams, a modulation module in communication with the source and the fractional-bit delay module and configured to convert the undelayed complementary binary data streams and the delayed complementary binary data streams into a fractional-bit delayed optical duobinary signal, and a band-limiting node in communication with the modulation module and configured to filter and transmit the optical duobinary signal.

Abstract: Methods for introducing fluorine atom onto a polypeptide are provided. Also provided are linkers, bioconjugates, and bifunctional compound agents made using the methods, linkers, and bioconjugates. The methods comprise: (i) providing a linker comprising a thiol-reactive terminus and an aldehyde-reactive terminus; (ii) reacting the thiol-reactive terminus of the linker with a polypeptide comprising at least one thiol group or a reactive derivative thereof; and (iii) subsequently reacting the aldehyde-reactive terminus of the linker with a fluorine-substituted aldehyde.

Abstract: A method and system for calculating a customer value is provided. At least one relationship type for at least one pair of customers which are selected from a plurality of customers is determined. A first customer from the plurality of customers is selected. At least one second customer having a direct relationship or an indirect relationship with the first customer based on the at least one relationship type which is selected from the relationship types is determined. The first customer value based on the first predetermined calculation rule by using first values and base values is calculated.

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

Abstract: The present invention provides a system and method for enabling the synchronization of a switch and an interface device. Based on a comparison of cell sequence numbers included in cells received from the interface device to a current cell time within the switch, cell time adjustment information can be transmitted to the interface device. The cell time adjustment information is used by the interface device to determine the cell sequence number that is included in cells transmitted to the switch.

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

Abstract: A method and system to improve fuel economy of an engine on a vehicle is offered. An electronic throttle control device is commanded to a wide open throttle position during vehicle coast down, thus improving engine breathing and reducing pumping losses, and improving engine efficiency. This includes monitoring operator inputs to: an accelerator device, a braking device, and a cruise control device, and, monitoring throttle position control input from the electronic controller to the electronically controlled throttle mechanism. The electronically controlled throttle mechanism is commanded to a substantially wide-open throttle condition only when the monitored operator inputs to the accelerator device, the braking device, and the cruise control device are each at a null position. A further limitation on the wide-open throttle command includes monitoring other inputs from the electronic controller to the throttle mechanism.

Abstract: A method and system to improve fuel economy of an engine on a vehicle is offered. An electronic throttle control device is commanded to a wide open throttle position during vehicle coast down, thus improving engine breathing and reducing pumping losses, and improving engine efficiency. This includes monitoring operator inputs to: an accelerator device, a braking device, and a cruise control device, and, monitoring throttle position control input from the electronic controller to the electronically controlled throttle mechanism. The electronically controlled throttle mechanism is commanded to a substantially wide-open throttle condition only when the monitored operator inputs to the accelerator device, the braking device, and the cruise control device are each at a null position. A further limitation on the wide-open throttle command includes monitoring other inputs from the electronic controller to the throttle mechanism.

Abstract: A transfer printing method for printing a pattern on a non-planar surface of an object, includes shaping a transfer printing sheet including a base layer and a printing layer to the same shape as the non-planar surface of the object; placing the transfer printing sheet inside a mould with the printing layer facing inwards; introducing a moulding material into the mould, producing the object, transferring the printing layer to the non-planar surface of the object, and integrating the printing layer with the non-planar surface; and removing the base layer.

Abstract: An apparatus and method for transmitting a signal for optical network applications with automatic chromatic dispersion compensation. The apparatus includes a first optical transmitter. The first optical transmitter includes a first light source configured to generate a first laser signal in response to a first laser drive signal, a first data modulator configured to receive the first laser signal and a first data drive signal and output a first chirped return-to-zero signal, and a first signal source configured to generate a first non-return-to-zero signal. Additionally, the apparatus includes a first clock and data recovery system, a first data driver, a first adjustment system, and a first control system.

Abstract: The present invention provides an HCV polymerase inhibiting compound having the formula (I) and a composition comprising a therapeutically effective amount of said compound. The present invention also provides a method for inhibiting hepatitis C virus (HCV) polymerase, a method for inhibiting HCV viral replication, and a method for treating or preventing HCV infection. Processes for making said compounds, and synthetic intermediates employed in said processes, are also provided.