Abstract: The invention provides an isolated recombinant oncolytic vaccinia virus, pharmaceutical compositions and uses thereof for drugs for treatment of tumors and/or cancers. The isolated recombinant oncolytic vaccinia virus is functionally deficient in the TK gene and the VGF gene, and the genome of the recombinant oncolytic vaccinia virus is integrated with an exogenous IL-21 gene, and wherein the IL-21 gene is capable of being expressed in tumor cells. The recombinant oncolytic vaccinia virus can selectively replicate in tumor cells, and can also fully exert the anti-tumor immune effect of the exogenous IL-21, such that the oncolytic killing effect of the oncolytic virus and the anti-tumor immune stimulation effect of IL-21 achieve a synergic effect.

Abstract: A method for preparing a GaN substrate material includes: performing in-situ epitaxy on a Ga2O3 thin film and a GaN thin film in a multifunctional HVPE growth system. First, the Ga2O3 thin film is grown on a substrate such as sapphire by an HVPE-like method, and the Ga2O3 is nitrided in an ammonia gas atmosphere to form a GaN/Ga2O3 composite thin film. Then, a GaN thick film is grown on the GaN/Ga2O3 composite thin film by HVPE to obtain a high-quality GaN thick film material. The Ga2O3 layer is removed by chemical etching to obtain a self-supporting GaN substrate material. Or, the conventional laser lift-off method is used to separate the GaN thick film from the heterogeneous substrate such as the sapphire to obtain a GaN self-supporting substrate material.

Abstract: The present invention discloses a data acquisition point deployment method and system. The method includes constructing a fitness function by combining a grid coverage rate of a to-be-detected water area and a scalar field reconstruction error of an environment field of non-uniformly distributed water quality features, then optimizing a location set of sampling points by a particle swarm optimization algorithm and a gravitational search algorithm, to determine the best solution of the location set of the sampling points and a fitness value corresponding to the best solution, and deploying a sampling point according to the best solution of the location set of the sampling points. The method realizes maximized coverage monitoring of the water area and better reconstructs the water quality distribution features of the entire water area to better reflect the water quality status of the entire water environment monitoring area according to a sampled value.

Abstract: Some embodiments of the disclosure use human peripheral blood for ctDNA sequencing or tumor tissues for whole exome sequencing, screen out mutation sites to perform antigen epitope prediction, connect and synthesize an expression gene sequence of mutant peptides. Other embodiments of the disclosure construct a lentiviral vector, package the lentivirus, transfect an APC cell to complete transformation of a specific LV cell, co-culture in vitro with PBMC separated from the peripheral blood, screen out an effective polypeptide, and transform common T cells into RFF cells. Suppressive signaling molecules include one or more of PD-1, Tim-3, LAG3, CTLA-4, BTLA, VISTA, CD160, and 2B4 (CD244). Antigen presenting cells include one or more of PBMC, a dendritic cell, neutrophil, B lymphocyte, and macrophage.

Abstract: The disclosure relates to an AFFT2 cell and a preparation method thereof. According to an embodiment, the cell is transformed with the TCR-T technology. The transformed T cells are blocked in vitro by an antibody drug of suppressive signaling molecules. According to another embodiment, a predicted antigen epitope is centered on a mutant amino acid site, the predicted antigen epitope extends 10 amino acids to each side of the mutant amino acid site, and the predicted antigen epitope serves as a potential antigen epitope. According to a further embodiment, TCR genes in a peripheral blood cell of a patient are knocked out by a CRISPR technology.

Abstract: A resource security system may generate access rules for use in determining whether to grant or deny a request for access to a resource. In order to generate the access rules, the resource security system may select certain access request parameters and determine conditions associated with those parameters. The resource security system may generate mutually exclusive segments associated with a condition of each of the parameters. The resource security system may generate independent access rules based on the segments. The resource security system may then evaluate the performance of each of the access rules based on validity information corresponding to previously received access requests that satisfy the conditions of a particular access rule.

Abstract: Systems, apparatuses, and methods for reducing memory cache control command hops through a fabric are disclosed. A system includes an interconnect fabric, a plurality of transaction processing queues, and a plurality of memory pipelines. Each memory pipeline includes an arbiter, a combined coherence point and memory cache controller unit, and a memory controller coupled to a memory channel. Each combined unit includes a memory cache controller, a memory cache, and a duplicate tag structure. A single arbiter per memory pipeline performs arbitration across the transaction processing queues to select a transaction address to feed the memory pipeline's combined unit. The combined unit performs coherence operations and a memory cache lookup for the selected transaction. Only after processing is completed in the combined unit is the transaction moved out of its transaction processing queue, reducing power consumption caused by data movement through the fabric.

Abstract: A sub-printing method for a 3D printer (1) includes following steps: obtaining slicing data (3) of a printing layer by the 3D printer (1) when performing printing; executing a logical segmentation action on the slicing data (3) according to a default segment-template (101) for generating multiple printing blocks (4); labelling each printing block (4) according to a default printing rule for deciding printing orders of the multiple printing blocks (4); controlling the 3D printer (1) to perform multiple sub-printing actions successively according to the printing blocks (4) based on the decided printing orders; and, re-executing above steps before all printing layers of a 3D model are completely printed.

Abstract: A system for tracking a vehicle includes a transceiver configured to receive a first signal including first surveillance data from the vehicle at a first time, and receive a second signal from the vehicle at a second time. The system further includes processing circuitry configured to determine a first location and a first course of the vehicle at the first time based on the first surveillance data, and determine a change in power level from the first signal to the second signal. The processing circuitry is further configured to predict a maneuver for the vehicle based on the first location, the first course, and the change in power level from the first signal to the second signal.

Abstract: A method for extracting and separating zirconium and hafnium in nitric acid medium mainly includes extraction of acidic raw liquid containing zirconium compounds with a synergistic extraction system consisting of DIBK and a phosphonic acids extraction agent, so that the zirconium goes to the aqueous phase and the hafnium goes to the organic phase, thus achieving separation. There is no need of use of toxic substance throughout the process.

Abstract: Provided is a method of extracting and separating zirconium and hafnium from hydrochloric acid medium, which relates to the technical field of fine separation of substance. Primarily, extraction is performed to acidic raw liquid containing zirconium compounds by a synergistic extraction system consisting of DIBK and phosphonic acids extraction agent, so that the zirconium goes to the aqueous phase and the hafnium goes to the organic phase, thus the separation is achieved. No toxic substance is involved throughout the process, so clean production is achieved.

Abstract: Various embodiments of the invention relate to a high performance analog bandpass filter (BPF) with improved performance in suppressing parasitic passband. The BPF comprises a first loss-pass filter (LPF) coupled to a first RF port, a second LPF coupled to a second RF port, and at least one high-pass module coupled in series between the first LPF and the second LPF for band-pass tuning. A resonant circuit is composed by a shunt capacitor from the LPF, a shunt inductor from the high-pass module and a series inductor from the LPF coupled in between. Such layout empowers the LPFs triple functions: to function as a low-pass filter, to participate in resonant circuit for center frequency tuning of the BPF, and to suppress parasitic resonance. Such a triple-function of the LPFs gives the BPF an improvement in a compact but effective topology.

Abstract: In some embodiments, a resource security system may determine an access request outcome (e.g., accept, reject, or review) for an access request based on access rules. The resource security system may generate and select the access rules to be used for using stability information. For instance, the resource security system may select a training set from the received access requests, e.g., including recently received access requests, and generate a plurality of potential access rules based on the training set. The resource security system may determine and compare the detection performance and the stability performance of the potential access rules. The resource security system may select the best performing potential access rules to be used in operation for determining the outcome of access requests.

Abstract: A turbocharger can include a center housing; a compressor assembly operatively coupled to the center housing; and a turbine assembly operatively coupled to the center housing, where the center housing includes a bearing boss that includes a bore wall with opposing axial ends that define an axial through bore having opposing axial openings, an oil inlet, an oil outlet, an arcuate oil passage in fluid communication with the oil inlet, an oil passage in fluid communication with the arcuate oil passage and an opening in the bore wall, and an oil drainage passage in fluid communication with the opposing axial openings of the through bore and in fluid communication with the oil outlet.

Abstract: In some embodiments, a resource security system may determine an access request outcome (e.g., accept, reject, or review) for an access request based on access rules. The resource security system may generate and select the access rules to be used for using stability information. For instance, the resource security system may select a training set from the received access requests, e.g., including recently received access requests, and generate a plurality of potential access rules based on the training set. The resource security system may determine and compare the detection performance and the stability performance of the potential access rules. The resource security system may select the best performing potential access rules to be used in operation for determining the outcome of access requests.

Abstract: The present invention provides a method for in-depth profile control and displacement of low-permeability oil reservoirs, comprising: sequentially injecting a flexible and elastic particle-containing pre-slug, a polymer microsphere-containing main slug and a flexible and elastic particle-containing protective slug into an oil layer, and the three slugs have a volume ratio of total injection amount of 1-2:6-8:1-2. The invention provides a method for in-depth profile control and displacement by using styrene-based flexible and elastic particles in combination with the polyacrylamide polymer microsphere, wherein the flexible elastic particles can block cracks and large pore channels of the oil layer, and the polymer microsphere can displace the remaining oil in the oil layer. In the present invention, different slugs of profile control and displacement system are combined to achieve the objective of blocking cracks and large pore channels, displacing crude oil, and improving oil well recovery.

Abstract: A variable valve train module selectively controls the opening and closing of a valve of an engine. The variable valve train module includes a drive element configured to be driven by a cam which rotates on a camshaft, a pump which is driven by the drive element, and a hydraulic control unit. The hydraulic control unit is configured to control the engine valve. The hydraulic control unit has a high pressure chamber containing hydraulic fluid which is selectively pressurized by the pump. The hydraulic control unit also has a control valve which is configured to depressurize the high pressure chamber, and a damper which is configured to increase an effective volume of the high pressure chamber when a pressure in the high pressure chamber exceeds a threshold value.

Abstract: An insulation assembly comprises an insulation pipe, an insulation umbrella group, and an insulation base. The insulation pipe has a first end and a second end opposite to the first end. The insulation umbrella group is formed on an outer wall of the insulation pipe. The insulation base is made of an insulating material and connected to the first end of the insulation pipe.

Abstract: A resource security system may generate access rules for use in determining whether to grant or deny a request for access to a resource. In order to generate the access rules, the resource security system may select certain access request parameters and determine conditions associated with those parameters. The resource security system may generate mutually exclusive segments associated with a condition of each of the parameters. The resource security system may generate independent access rules based on the segments. The resource security system may then evaluate the performance of each of the access rules based on validity information corresponding to previously received access requests that satisfy the conditions of a particular access rule.

Abstract: Imaging agents comprising an isolated polypeptide conjugated with a radionuclide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.