Patents by Inventor Rosanne M. Crooke

Rosanne M. Crooke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTISENSE MODULATION OF APOLIPOPROTEIN B EXPRESSION
    Publication number: 20090326040
    Abstract: Methods for the rapid and long-term lowering of lipid levels in human subjects and for the treatment of conditions associated with elevated LDL-cholesterol and elevated apolipoprotein B are provided.
    Type: Application
    Filed: August 10, 2005
    Publication date: December 31, 2009
    Applicant: ISIS PHARMACEUTICALS, INC.
    Inventors: Richard S. Geary, Zhengrong Yu, Rosanne M. Crooke
  • METHODS FOR TREATING HYPERCHOLESTEROLEMIA
    Publication number: 20090318536
    Abstract: Disclosed herein are antisense compounds and methods for decreasing LDL-C in an individual having elevated LDL-C. Additionally disclosed are antisense compounds and methods for treating, preventing, or ameliorating hypercholesterolemia and/or atherosclerosis. Further disclosed are antisense compounds and methods for decreasing coronary heart disease risk. Such methods include administering to an individual in need of treatment an antisense compound targeted to a PCSK9 nucleic acid. The antisense compounds administered include gapmer antisense oligonucleotides.
    Type: Application
    Filed: June 4, 2009
    Publication date: December 24, 2009
    Applicant: ISS PHARMACEUTICALS, INC.
    Inventors: Susan M. FREIER, Rosanne M. Crooke, Mark J. Graham, Kristina L. Lemonidis, Sanjay Bhanot, Diane Tribble, Andrew T. Watt
  • ANTISENSE MODULATION OF C-REACTIVE PROTEIN EXPRESSION
    Publication number: 20090275133
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of C-reactive protein. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding C-reactive protein. Methods of using these compounds for modulation of C-reactive protein expression and for treatment of diseases associated with expression of C-reactive protein are provided.
    Type: Application
    Filed: January 12, 2009
    Publication date: November 5, 2009
    Applicant: Isis Pharmaceuticals, Inc.
    Inventors: Rosanne M. Crooke, Mark J. Graham
  • Modulation of apolipoprotein C-III expression
    Patent number: 7598227
    Abstract: Compounds, compositions and methods are provided for modulating the expression of apolipoprotein C-III. The compositions comprise oligonucleotides, targeted to nucleic acid encoding apolipoprotein C-III. Methods of using these compounds for modulation of apolipoprotein C-III expression and for diagnosis and treatment of disease associated with expression of apolipoprotein C-III are provided.
    Type: Grant
    Filed: April 16, 2003
    Date of Patent: October 6, 2009
    Assignee: Isis Pharmaceuticals Inc.
    Inventors: Rosanne M. Crooke, Mark J. Graham, Kristina M. Lemonidis, Kenneth W. Dobie
  • MODULATION OF C-REACTIVE PROTEIN EXPRESSION
    Publication number: 20090170799
    Abstract: Compounds, compositions and methods are provided for modulating the expression of C-reactive protein. The compositions comprise oligonucleotides, targeted to nucleic acid encoding C-reactive protein. Methods of using these compounds for modulation of C-reactive protein expression and for diagnosis and treatment of disease associated with expression of C-reactive protein are provided.
    Type: Application
    Filed: January 3, 2008
    Publication date: July 2, 2009
    Inventors: Rosanne M. Crooke, Mark J. Graham
  • MODULATION OF APOLIPOPROTEIN (a) EXPRESSION
    Publication number: 20090075924
    Abstract: Compounds, compositions and methods are provided for modulating the expression of apolipoprotein(a). The compositions comprise oligonucleotides, targeted to nucleic acid encoding apolipoprotein(a). Methods of using these compounds for modulation of apolipoprotein(a) expression and for diagnosis and treatment of disease associated with expression of apolipoprotein(a) are provided.
    Type: Application
    Filed: July 30, 2007
    Publication date: March 19, 2009
    Inventors: Rosanne M. Crooke, Mark J. Graham
  • Antisense modulation of C-reactive protein expression
    Patent number: 7491815
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of C-reactive protein. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding C-reactive protein. Methods of using these compounds for modulation of C-reactive protein expression and for treatment of diseases associated with expression of C-reactive protein are provided.
    Type: Grant
    Filed: August 25, 2005
    Date of Patent: February 17, 2009
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Rosanne M. Crooke, Mark J. Graham
  • ANTISENSE MODULATION OF APOLIPOPROTEIN B EXPRESSION
    Publication number: 20080242629
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of apolipoprotein B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding apolipoprotein B. Methods of using these compounds for modulation of apolipoprotein B expression and for treatment of diseases associated with expression of apolipoprotein B are provided.
    Type: Application
    Filed: January 3, 2008
    Publication date: October 2, 2008
    Applicant: ISIS Pharmaceuticals, Inc.
    Inventors: Rosanne M. Crooke, Mark J. Graham
  • Modulation of C-reactive protein expression
    Patent number: 7425545
    Abstract: Compounds, compositions and methods are provided for modulating the expression of C-reactive protein. The compositions comprise oligonucleotides, targeted to nucleic acid encoding C-reactive protein. Methods of using these compounds for modulation of C-reactive protein expression and for diagnosis and treatment of disease associated with expression of C-reactive protein are provided.
    Type: Grant
    Filed: June 1, 2004
    Date of Patent: September 16, 2008
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Rosanne M. Crooke, Mark J. Graham
  • Antisense modulation of apolipoprotein B expression
    Patent number: 7407943
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of apolipoprotein B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding apolipoprotein B. Methods of using these compounds for modulation of apolipoprotein B expression and for treatment of diseases associated with expression of apolipoprotein B are provided.
    Type: Grant
    Filed: May 15, 2002
    Date of Patent: August 5, 2008
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Rosanne M. Crooke, Mark J. Graham
  • ANTISENSE MODULATION OF ACYL COA CHOLESTEROL ACYLTRANSFERASE-2 EXPRESSION
    Publication number: 20080182810
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of acyl CoA cholesterol acyltransferase-2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding acyl CoA cholesterol acyltransferase-2. Methods of using these compounds for modulation of acyl CoA cholesterol acyltransferase-2 expression and for treatment of diseases associated with expression of acyl CoA cholesterol acyltransferase-2 are provided.
    Type: Application
    Filed: December 19, 2007
    Publication date: July 31, 2008
    Applicant: Isis Pharmaceuticals, Inc.
    Inventors: Rosanne M. Crooke, Kristina Lemonidis Tarbet, Mark J. Graham
  • Antisense modulation of acyl CoA cholesterol acyltransferase-2 expression
    Patent number: 7335764
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of acyl CoA cholesterol acyltransferase-2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding acyl CoA cholesterol acyltransferase-2. Methods of using these compounds for modulation of acyl CoA cholesterol acyltransferase-2 expression and for treatment of diseases associated with expression of acyl CoA cholesterol acyltransferase-2 are provided.
    Type: Grant
    Filed: February 20, 2007
    Date of Patent: February 26, 2008
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Rosanne M. Crooke, Kristina Lemonidis Tarbet, Mark J. Graham
  • Antisense modulation of c-reactive protein expression
    Patent number: 7326693
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of C-reactive protein. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding C-reactive protein. Methods of using these compounds for modulation of C-reactive protein expression and for treatment of diseases associated with expression of C-reactive protein are provided.
    Type: Grant
    Filed: July 15, 2002
    Date of Patent: February 5, 2008
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Rosanne M. Crooke, Mark J. Graham
  • Modulation of apolipoprotein (a) expression
    Patent number: 7259150
    Abstract: Compounds, compositions and methods are provided for modulating the expression of apolipoprotein(a). The compositions comprise oligonucleotides, targeted to nucleic acid encoding apolipoprotein(a). Methods of using these compounds for modulation of apolipoprotein(a) expression and for diagnosis and treatment of disease associated with expression of apolipoprotein(a) are provided.
    Type: Grant
    Filed: October 15, 2003
    Date of Patent: August 21, 2007
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Rosanne M. Crooke, Mark J. Graham
  • Antisense modulation of apolipoprotein (a) expression
    Patent number: 7227014
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of apolipoprotein(a). The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding apolipoprotein(a). Methods of using these compounds for modulation of apolipoprotein(a) expression and for treatment of diseases associated with expression of apolipoprotein(a) are provided.
    Type: Grant
    Filed: August 7, 2001
    Date of Patent: June 5, 2007
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Rosanne M. Crooke, Mark J. Graham
  • Antisense modulation of acyl CoA cholesterol acyltransferase-2 expression
    Patent number: 7202357
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of acyl CoA cholesterol acyltransferase-2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding acyl CoA cholesterol acyltransferase-2. Methods of using these compounds for modulation of acyl CoA cholesterol acyltransferase-2 expression and for treatment of diseases associated with expression of acyl CoA cholesterol acyltransferase-2 are provided.
    Type: Grant
    Filed: July 15, 2002
    Date of Patent: April 10, 2007
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Rosanne M. Crooke, Mark J. Graham, Kristina Lemonidis Tarbet
  • Antisense modulation of stearoyl-CoA desaturase expression
    Patent number: 7132529
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of stearoyl-CoA desaturase. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding stearoyl-CoA desaturase. Methods of using these compounds for modulation of stearoyl-CoA desaturase expression and for treatment of diseases associated with expression of stearoyl-CoA desaturase are provided.
    Type: Grant
    Filed: July 30, 2001
    Date of Patent: November 7, 2006
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Rosanne M. Crooke, Mark J. Graham
  • Antisense modulation of C-reactive protein expression
    Patent number: 6964950
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of C-reactive protein. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding C-reactive protein. Methods of using these compounds for modulation of C-reactive protein expression and for treatment of diseases associated with expression of C-reactive protein are provided.
    Type: Grant
    Filed: July 25, 2001
    Date of Patent: November 15, 2005
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Rosanne M. Crooke, Mark J. Graham
  • Antisense modulation of acyl coa cholesterol acyltransferase-2 expression
    Publication number: 20040266705
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of acyl CoA cholesterol acyltransferase-2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding acyl CoA cholesterol acyltransferase-2. Methods of using these compounds for modulation of acyl CoA cholesterol acyltransferase-2 expression and for treatment of diseases associated with expression of acyl CoA cholesterol acyltransferase-2 are provided.
    Type: Application
    Filed: August 13, 2004
    Publication date: December 30, 2004
    Inventors: Rosanne M Crooke, Mark J Graham, Kristina Lemonidis Tarbet
  • Antisense modulation of stearoyl-coa desaturase expression
    Publication number: 20040254359
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of stearoyl-CoA desaturase. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding stearoyl-CoA desaturase. Methods of using these compounds for modulation of stearoyl-CoA desaturase expression and for treatment of diseases associated with expression of stearoyl-CoA desaturase are provided.
    Type: Application
    Filed: July 21, 2004
    Publication date: December 16, 2004
    Inventors: Rosanne M. Crooke, Mark J. Graham