Patents by Inventor Roy Hom

Roy Hom has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds for the treatment of alzheimer's disease
    Patent number: 7763646
    Abstract: The invention relates to compounds of formula (I). Useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
    Type: Grant
    Filed: September 26, 2003
    Date of Patent: July 27, 2010
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Roy Hom, Varghese John
  • N,N?-substituted-1,3-diamino-2-hydroxypropane derivatives
    Patent number: 7727997
    Abstract: Disclosed are compounds of the formula wherein the variables RN, RC, R1, R25, R2, and R3 are as defined herein. These compounds have activity as inhibitors of beta-secretase and are therefore useful in treating a variety of disorders such as Alzheimer's Disease.
    Type: Grant
    Filed: December 11, 2006
    Date of Patent: June 1, 2010
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Varghese John, Michel Maillard, Barbara Jagodzinska, James Beck, Andrea Gailunas, John Freskos, John Mickelson, Lakshman Samala, Jennifer Sealey, Ruth Tenbrink, Larry Fang, Roy Hom
  • Compounds to treat Alzheimer's disease
    Patent number: 7553831
    Abstract: The present invention is disubstituted amines of formula (I) and disubstituted amines of formula (II) useful in treating Alzheimer's disease and other similar diseases.
    Type: Grant
    Filed: January 25, 2005
    Date of Patent: June 30, 2009
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: James Beck, Andrea Gailunas, Roy Hom, Barbara Jagodinska, Varghese John, Michael Maillaird
  • 2-amino- and 2-thio- substituted 1,3-diaminopropanes
    Patent number: 7544717
    Abstract: Disclosed are compounds of the formula: where variables Q, Z, X, R15, R2, R3, and Rc are defined herein. Compounds disclosed herein are inhibitors of the beta-secretase enzyme and are therefore useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal.
    Type: Grant
    Filed: March 25, 2005
    Date of Patent: June 9, 2009
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Roy Hom, John Tucker, Varghese John, Neerav Shah
  • Compounds to treat alzheimer's disease
    Publication number: 20090074746
    Abstract: The present invention is substituted amines of formula (X) useful in treating Alzheimer's disease and other similar diseases.
    Type: Application
    Filed: September 24, 2004
    Publication date: March 19, 2009
    Inventors: Lawrence Y. Fang, Roy Hom, Varghese John, Michel Maillard
  • Benzamide 2-hydroxy-3-diaminoalkanes
    Publication number: 20080249139
    Abstract: The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are also useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
    Type: Application
    Filed: May 30, 2007
    Publication date: October 9, 2008
    Inventors: Jose Aquino, Varghese John, John Tucker, Roy Hom, Shon Pulley, Ruth Tenbrink
  • Phenacyl 2-Hydroxy-3-Diaminoalkanes
    Publication number: 20080207696
    Abstract: The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are also useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
    Type: Application
    Filed: November 21, 2007
    Publication date: August 28, 2008
    Inventors: Jose Aquino, Varghese John, John Tucker, Roy Hom, Shon Pulley, Ruth Tenbrink
  • Methods of Treatment of Amyloidosis Using Subsituted Ethanolcyclicamine Aspartyl Protease Inhibitors
    Publication number: 20080166332
    Abstract: The invention relates to novel compounds and methods of treating diseases, disorders, and conditions associated with amyloidosis.
    Type: Application
    Filed: August 26, 2005
    Publication date: July 10, 2008
    Applicant: ELAN PHARMACEUTICALS, INC.
    Inventors: Roy Hom, Lawrence Fang, Varghese John
  • Bridged N-Cyclic Sulfonamido Inhibitors of Gamma Secretase
    Publication number: 20080090817
    Abstract: The invention provides N-cyclic sulfonamido compounds and salts of Formula I: wherein A is as described in the specification and R1 and R2 combine to form a [3.3.1] or a [3.2.1] ring system, where the nitrogen is attached to the two bridgehead carbons, and the [3.3.1] or [3.2.1] ring systems are optionally fused with an heteroaryl or heterocycloalkyl ring. Compounds of Formula I are useful in treating or preventing cognitive disorders, such as Alzheimer's Disease. The invention also encompasses pharmaceutical compositions comprising compounds of Formula I, methods of treating cognitive disorders, such as Alzheimer's disease, and the intermediates useful in preparing the compounds of Formula I.
    Type: Application
    Filed: December 5, 2007
    Publication date: April 17, 2008
    Inventors: Simeon Bowers, Albert Garofalo, Roy Hom, Andrei Konradi, Matthew Mattson, Martin Neitzel, Christopher Semko, Anh Truong, Jing Wu, Ying-zi Xu
  • Methods to Treat Alzheimer's Disease
    Publication number: 20080058336
    Abstract: The present invention is directed toward substituted hydroxyethylene compounds of formula (XII) useful in treating Alzheimer's disease and other similar diseases.
    Type: Application
    Filed: October 10, 2006
    Publication date: March 6, 2008
    Inventors: Roy Hom, Shumeye S. Mamo, Jay Tung, Andrea Gailunas, Varghese John, Lawrence Y. Fang
  • Fused, Tricyclic Sulfonamide Inhibitors of Gamma Secretase
    Publication number: 20080021056
    Abstract: The invention provides compounds of formula I: or pharmaceutically salts thereof where R1, R2, and the A, B, and C-rings are as defined herein. Compounds of formula I are useful in treating or preventing cognitive disorders, such as Alzheimer's disease. The invention also encompasses pharmaceutical compositions comprising compounds or salts of formula I, methods of preparing the desired compounds, and methods of treating cognitive disorders, such as Alzheimer's disease, using the compounds or salts of formula I.
    Type: Application
    Filed: June 1, 2007
    Publication date: January 24, 2008
    Inventors: Andrei Konradi, Gary Probst, Danielle Aubele, Albert Garofalo, Roy Hom, Martin Neitzel, Christopher Semko, Anh Truong
  • Dipeptide inhibitors of ?-secretase
    Patent number: 7276484
    Abstract: Dipeptide derived inhibitors of the ?-secretase enzyme are provided which are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A? peptide in a mammal. The compounds of the invention provide useful methods of treatment by administration of these inhibitors to reduce A? peptide formation and in pharmaceutical compositions.
    Type: Grant
    Filed: March 8, 2005
    Date of Patent: October 2, 2007
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Varghese John, Jay Tung, Roy Hom, Ashley Guinn, Lawrence Fang, Andrea Gailunas, Shumeye S. Mamo
  • N,N'-substituted-1,3-diamino-2-hydroxypropane derivatives
    Publication number: 20070213316
    Abstract: Disclosed are compounds of the formula wherein the variables RN, RC, R1, R25, R2, and R3 are as defined herein. These compounds have activity as inhibitors of beta-secretase and are therefore useful in treating a variety of discorders such as Alzheimer's Disease.
    Type: Application
    Filed: December 11, 2006
    Publication date: September 13, 2007
    Inventors: Varghese John, Michel Maillard, Barbara Jagodzinska, James Beck, Andrea Gailunas, John Freskos, John Mickelson, Lakshman Samala, Jennifer Sealy, Ruth TenBrink, Lawrence Fang, Roy Hom
  • Compounds to treat Alzheimer's disease
    Publication number: 20070213407
    Abstract: The present invention is substituted amines of formula (X) useful in treating Alzheimer's disease and other similar diseases.
    Type: Application
    Filed: September 28, 2006
    Publication date: September 13, 2007
    Inventors: Lawrence Fang, Andrea Gailunas, Roy Hom, Barbara Jagodzinska, Michel Maillard, Varghese John, Shon Pulley, James Beck, Ruth TenBrink, John Freskos
  • Methods of treating amyloidosis using aryl-cyclopropyl derivative aspartyl protease inhibitors
    Publication number: 20070149525
    Abstract: The invention relates to novel compounds and methods of treating diseases, disorders, and conditions associated with amyloidosis. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.
    Type: Application
    Filed: October 12, 2006
    Publication date: June 28, 2007
    Inventors: Roy Hom, Gergely Toth, Gary Probst, Simeon Bowers, Anh Truong, Jay Tung
  • Benzamide 2-hydroxy-3-diaminoalkanes
    Patent number: 7223774
    Abstract: The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are also useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
    Type: Grant
    Filed: April 21, 2004
    Date of Patent: May 29, 2007
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Jose Aquino, Varghese John, John Tucker, Roy Hom, Shon Pulley, Ruth Tenbrink
  • Compounds to treat Alzheimer's disease
    Patent number: 7214715
    Abstract: The present invention is substituted amines of formula (X) and of the formula (X?) useful in treating Alzheimer's disease and other similar diseases.
    Type: Grant
    Filed: June 29, 2001
    Date of Patent: May 8, 2007
    Assignees: Pharmacia & Upjohn, Elan Pharmaceuticals
    Inventors: James P. Beck, Lawrence Y. Fang, John N. Freskos, Andrea Gailunas, Roy Hom, Barbara Jagodzinska, Varghese John, Michel Maillard, Shon R. Pulley, Ruth E. TenBrink
  • Bridged N-Cyclic Sulfonamido Inhibitors of Gamma Secretase
    Publication number: 20070049612
    Abstract: The invention provides N-cyclic sulfonamido compounds and salts of Formula I: wherein A is as described in the specification and R1 and R2 combine to form a [3.3.1] or a [3.2.1] ring system, where the nitrogen is attached to the two bridgehead carbons, and the [3.3.1] or [3.2.1] ring systems are optionally fused with an heteroaryl or heterocycloalkyl ring. Compounds of Formula I are useful in treating or preventing cognitive disorders, such as Alzheimer's Disease. The invention also encompasses pharmaceutical compositions comprising compounds of Formula I, methods of treating cognitive disorders, such as Alzheimer's disease, and the intermediates useful in preparing the compounds of Formula I.
    Type: Application
    Filed: August 18, 2006
    Publication date: March 1, 2007
    Inventors: Simeon Bowers, Albert Garofalo, Roy Hom, Andrei Konradi, Matthew Mattson, Martin Neitzel, Christopher Semko, Anh Truong, Jing Wu, Ying-zi Xu
  • N,N?-substituted-1,3-diamino-2-hydroxypropane derivatives
    Patent number: 7176242
    Abstract: Disclosed are compounds of the formula wherein the variables RN, RC, R1, R25, R2, and R3 are as defined herein. These compounds have activity as inhibitors of beta-secretase and are therefore useful in treating a variety of discorders such as Alzheimer's Disease.
    Type: Grant
    Filed: November 8, 2002
    Date of Patent: February 13, 2007
    Assignees: Elan Pharmaceuticals, Inc., Pharmacia & Upjohn Company
    Inventors: Varghese John, Michel Maillard, Barbara Jagodzinska, James Beck, Andrea Gailunas, John Freskos, John Mickelson, Lakshman Samala, Jennifer Sealy, Ruth TenBrink, Lawrence Fang, Roy Hom
  • Compounds to treat alzheimer's disease
    Publication number: 20060287306
    Abstract: The present invention is directed toward substituted hydroxyethylene compounds of formulas (XII) (XIII), and (XIV) useful in treating Alzheimer's disease and other similar diseases.
    Type: Application
    Filed: January 31, 2006
    Publication date: December 21, 2006
    Inventors: Roy Hom, Shumeye Mamo, Jay Tung, Andrea Gailunas, Varghese John, Lawrence Fang