Patents by Inventor Roy Hom

Roy Hom has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds to treat Alzheimer's disease
    Publication number: 20060276642
    Abstract: The present invention is directed toward substituted hydroxyethylene compounds of formula (XII) useful in treating Alzheimer's disease and other similar diseases.
    Type: Application
    Filed: April 17, 2006
    Publication date: December 7, 2006
    Inventors: Roy Hom, Shumeye Mamo, Jay Tung, Andrea Gailunas, Varghese John, Lawrence Fang
  • Methods to treat alzheimer's disease
    Patent number: 7119085
    Abstract: The present invention is directed toward substituted hydroxyethylene compounds of formula (XII) useful in treating Alzheimer's disease and other similar diseases.
    Type: Grant
    Filed: March 23, 2001
    Date of Patent: October 10, 2006
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Roy Hom, Shumeye S. Mamo, Jay Tung, Andrea Gailunas, Varghese John, Lawrence Y. Fang
  • Substituted alcohols useful in treatment of Alzheimer's disease
    Publication number: 20060178345
    Abstract: The invention relates to substituted alcohol compounds of the formula (I): wherein X, R1, R2, R3, RN, R20 and RC are defined herein. The compounds are useful in the treatment or prevention of Alzheimer's disease and more specifically to compounds that are capable of inhibiting beta-secretase, an enzyme that cleaves amyloid precursor protein to produce amyloid beta peptide (A-beta), a major component of the amyloid plaques found in the brains of Alzheimer's sufferers.
    Type: Application
    Filed: January 3, 2006
    Publication date: August 10, 2006
    Inventors: Varghese John, Roy Hom, John Tucker
  • Oxime derivative hydroxyethylamine aspartyl-protease inhibitors
    Publication number: 20060128715
    Abstract: The invention relates to novel compounds and methods of treating diseases, disorders, and conditions associated with amyloidosis. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.
    Type: Application
    Filed: July 11, 2005
    Publication date: June 15, 2006
    Inventors: Jennifer Sealy, Roy Hom, Varghese John, Gary Probst, Jay Tung
  • Compounds for the treatment of alzheimer's disease
    Publication number: 20060128786
    Abstract: The invention relates to compounds of formula (I). Useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
    Type: Application
    Filed: September 26, 2003
    Publication date: June 15, 2006
    Inventors: Roy Hom, Varghese John
  • Compounds to treat Alzheimer's disease
    Patent number: 7030239
    Abstract: The present invention is directed toward substituted hydroxyethylene compounds of formula (XII) useful in treating Alzheimer's disease and other similar diseases.
    Type: Grant
    Filed: May 18, 2004
    Date of Patent: April 18, 2006
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Roy Hom, Shumeye S. Mamo, Jay Tung, Andrea Gailunas, Varghese John, Lawrence Y. Fang
  • Methods of treatment of amyloidosis using ethanolcyclicamine aspartyl protease inhibitors
    Publication number: 20060074098
    Abstract: The invention relates to novel compounds and methods of treating diseases, disorders, and conditions associated with amyloidosis. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.
    Type: Application
    Filed: August 26, 2005
    Publication date: April 6, 2006
    Inventors: Roy Hom, Lawrence Fang, Varghese John
  • Compounds to treat Alzheimer's disease
    Patent number: 6992081
    Abstract: The present invention is directed toward substituted hydroxyethylene compounds of formulas (XII) (XIII), and (XIV) useful in treating Alzheimer's disease and other similar diseases.
    Type: Grant
    Filed: September 21, 2001
    Date of Patent: January 31, 2006
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Roy Hom, Shumeye Mamo, Jay Tung, Andrea Gailunas, Varghese John, Lawrence Fang
  • Methods of treatment of amyloidosis using spirocyclohexane aspartyl-protease inhibitors
    Publication number: 20060014790
    Abstract: The invention relates to acetyl 2-hydroxy-1,3-diaminospirocyclohexanes and derivatives thereof that are useful in treating diseases, disorders, and conditions associated with amyloidosis. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.
    Type: Application
    Filed: January 21, 2005
    Publication date: January 19, 2006
    Inventors: Varghese John, Roy Hom, Jennifer Sealy, Jose Aquino, Gary Probst, Jay Tung, Lawrence Fang
  • Methods of treatment of amyloidosis using bi-aryl aspartyl protease inhibitors
    Publication number: 20060014737
    Abstract: The invention relates to novel compounds and methods of treating diseases, disorders, and conditions associated with amyloidosis. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.
    Type: Application
    Filed: March 9, 2005
    Publication date: January 19, 2006
    Inventors: Varghese John, Roy Hom, Jennifer Sealy, John Tucker
  • Substituted alcohols useful in treatment of Alzheimer's disease
    Patent number: 6982264
    Abstract: The invention relates to substituted alcohol compounds of the formula (I): wherein X, R1, R2, R3, RN, R20 and RC are defined herein. The compounds are useful in the treatment or prevention of Alzheimer's disease and more specifically to compounds that are capable of inhibiting beta-secretase, an enzyme that cleaves amyloid precursor protein to produce amyloid beta peptide (A-beta), a major component of the amyloid plaques found in the brains of Alzheimer's sufferers.
    Type: Grant
    Filed: June 27, 2002
    Date of Patent: January 3, 2006
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Varghese John, Roy Hom, John Tucker
  • 2-Amino- and 2-thio- substituted 1,3-diaminopropanes
    Publication number: 20050267199
    Abstract: Disclosed are compounds of the formula: where variables Q, Z, X, R15, R2, R3, and Rc are defined herein. Compounds disclosed herein are inhibitors of the beta-secretase enzyme and are therefore useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal.
    Type: Application
    Filed: March 25, 2005
    Publication date: December 1, 2005
    Inventors: Roy Hom, John Tucker, Varghese John, Neerav Shah
  • Substituted urea and carbamate, phenacyl-2-hydroxy-3-diaminoalkane, and benzamide-2-hydroxy-3-diaminoalkane aspartyl-protease inhibitors
    Publication number: 20050261273
    Abstract: The invention relates to acetyl 2-hydroxy-1,3-diaminospirocyclohexanes and derivatives thereof that are useful in treating at least one disease, disorder, and condition associated with amyloidosis. Amyloidosis refers to a collection of diseases, disorders, and condition associated with abnormal deposition of A-beta protein.
    Type: Application
    Filed: March 9, 2005
    Publication date: November 24, 2005
    Inventors: Varghese John, Michel Maillard, John Tucker, Jose Aquino, Roy Hom, Jay Tung, Darren Dressen, Neerav Shah, R. Neitz
  • Compounds to treat Alzheimer's disease
    Publication number: 20050203096
    Abstract: The present invention is disubstituted amines of formula (I) and disubstituted amines of formula (II) useful in treating Alzheimer's disease and other similar diseases.
    Type: Application
    Filed: January 25, 2005
    Publication date: September 15, 2005
    Inventors: James Beck, Andrea Gailunas, Roy Hom, Barbara Jagodzinska, Varghese John, Michel Maillard
  • Dipeptide inhibitors of beta-secretase
    Publication number: 20050182138
    Abstract: Dipeptide derived inhibitors of the ?-secretase enzyme are provided which are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A? peptide in a mammal. The compounds of the invention provide useful methods of treatment by administration of these inhibitors to reduce A? peptide formation and in pharmaceutical compositions.
    Type: Application
    Filed: March 8, 2005
    Publication date: August 18, 2005
    Inventors: Varghese John, Jay Tung, Roy Hom, Ashley Guinn, Lawrence Fang, Andrea Gailunas, Shumeye Mamo
  • Phenacyl 2-hydroxy-3-diaminoalkanes
    Publication number: 20050054690
    Abstract: The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are also useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
    Type: Application
    Filed: April 21, 2004
    Publication date: March 10, 2005
    Inventors: Jose Aquino, Varghese John, John Tucker, Roy Hom, Shon Pulley, Ruth Tenbrink
  • Dipeptide inhibitors of ?-secretase
    Patent number: 6864240
    Abstract: Dipeptide derived inhibitors of the ?-secretase enzyme are provided which are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A? peptide in a mammal. The compounds of the invention provide useful methods of treatment by administration of these inhibitors to reduce A? peptide formation and in pharmaceutical compositions.
    Type: Grant
    Filed: June 15, 2000
    Date of Patent: March 8, 2005
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Varghese John, Jay Tung, Roy Hom, Ashley Guinn, Lawrence Fang, Andrea Gailunas, Shumeye S. Mamo
  • Benzamide 2-hydroxy-3-diaminoalkanes
    Publication number: 20050032848
    Abstract: The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are also useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
    Type: Application
    Filed: April 21, 2004
    Publication date: February 10, 2005
    Inventors: Jose Aquino, Varghese John, John Tucker, Roy Hom, Shon Pulley, Ruth Tenbrink
  • Allylamides useful in the treatment of alzheimer's disease
    Publication number: 20050027007
    Abstract: Disclosed are methods for treating Alzheimer's disease, and other diseases, and/or inhibiting beta-secretase enzyme, and/or inhibiting deposition of A beta peptide in a mammal, by use of compounds of formula (I) where R1, R2, R3, B, J1, J2, X and Z are as defined herein.
    Type: Application
    Filed: October 4, 2002
    Publication date: February 3, 2005
    Inventor: Roy Hom
  • Compounds to treat alzheimer's disease
    Patent number: 6846813
    Abstract: The present invention is disubstituted amines of formula (I) and disubstituted amines of formula (II) useful in treating Alzheimer's disease and other similar diseases.
    Type: Grant
    Filed: June 29, 2001
    Date of Patent: January 25, 2005
    Assignees: Pharmacia & Upjohn Company, Elan Pharmaceuticals, Inc.
    Inventors: James P. Beck, Andrea Gailunas, Roy Hom, Barbara Jagodzinska, Varghese John, Michel Maillard